| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianlin Chen, Liqun Xia, Wenji Wang, Zhiwen Wang, Suying Hou, Caixia Xie, Jia Cai, Yishan L. Identification of a mitochondrial-targeting secretory protein from Nocardia seriolae which induces apoptosis in fathead minnow cells. Journal of fish diseases. vol 42. issue 11. 2020-02-04. PMID:31482589. |
moreover, quantitative assays of mitochondrial membrane potential (ΔΨm) value, caspase-3 activity and apoptosis-related gene (bcl-2, bax, bad, bid and p53) mrna expression suggested that cell apoptosis was induced in fhm cells by the overexpression of both mtsp3141 and mtsp3141Δtp (with the n-terminal tp deleted) proteins. |
2020-02-04 |
2023-08-13 |
Not clear |
| Mohamed S Abdelfattah, Mohammed I Y Elmallah, Hassan Y Ebrahim, Rafa S Almeer, Rasha M A Eltanany, Ahmed E Abdel Monei. Prodigiosins from a marine sponge-associated actinomycete attenuate HCl/ethanol-induced gastric lesion via antioxidant and anti-inflammatory mechanisms. PloS one. vol 14. issue 6. 2020-02-03. PMID:31194753. |
pdgs prevented gastric mucosal apoptosis by downregulating bax and caspase-3 expression and upregulating bcl-2 expression, thereby increasing prostaglandin e2 production. |
2020-02-03 |
2023-08-13 |
rat |
| Alanna Maguire, Xianfeng Chen, Lee Wisner, Smriti Malasi, Colleen Ramsower, Samantha Kendrick, Michael T Barrett, Betty Glinsmann-Gibson, Michael McGrath, Lisa M Rimsz. Enhanced DNA repair and genomic stability identify a novel HIV-related diffuse large B-cell lymphoma signature. International journal of cancer. vol 145. issue 11. 2020-01-31. PMID:31044434. |
in contrast, genes associated with cell cycle inhibition (cdkn1a, cdkn1b) as well as apoptosis regulating bcl2 family members (bcl2, bax, bim, bmf, puma) were significantly decreased in the hiv(+) cohort. |
2020-01-31 |
2023-08-13 |
Not clear |
| Bing Gao, Song Li, Guo L. Long Noncoding RNA (lncRNA) Small Nucleolar RNA Host Gene 5 (SNHG5) Regulates Proliferation, Differentiation, and Apoptosis of K562 Cells in Chronic Myeliod Leukemia. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-01-31. PMID:31506418. |
flow cytometry analysis indicated that inhibition of snhg5 significantly induced cell apoptosis with decreased expression of bcl-2 and increased expression of bax and cleaved capase-3. |
2020-01-31 |
2023-08-13 |
human |
| Xiaokang Liu, Yu Li, Qiang Ma, Yanwei Wang, Ai Lin Son. Withaferin-A Inhibits Growth of Drug-Resistant Breast Carcinoma by Inducing Apoptosis and Autophagy, Endogenous Reactive Oxygen Species (ROS) Production, and Inhibition of Cell Migration and Nuclear Factor kappa B (Nf-κB)/Mammalian Target of Rapamycin (m-TOR) Signalling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-01-31. PMID:31512681. |
withaferin-a prompted mitochondrial apoptosis, which was also associated with increased level of bax and decreased bcl-2 in mda-mb-231 cells. |
2020-01-31 |
2023-08-13 |
mouse |
| Weihua Zhang, Weijing Li, Cuiying Zhang, Chunfang Zhu, Xiangling Yi, Yan Zhou, Yan L. Effects of Vitamin A on Expressions of Apoptosis Genes Bax and Bcl-2 in Epithelial Cells of Corneal Tissues Induced by Benzalkonium Chloride in Mice with Dry Eye. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-01-30. PMID:31257361. |
effects of vitamin a on expressions of apoptosis genes bax and bcl-2 in epithelial cells of corneal tissues induced by benzalkonium chloride in mice with dry eye. |
2020-01-30 |
2023-08-13 |
mouse |
| Weihua Zhang, Weijing Li, Cuiying Zhang, Chunfang Zhu, Xiangling Yi, Yan Zhou, Yan L. Effects of Vitamin A on Expressions of Apoptosis Genes Bax and Bcl-2 in Epithelial Cells of Corneal Tissues Induced by Benzalkonium Chloride in Mice with Dry Eye. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-01-30. PMID:31257361. |
conclusions va can inhibit upregulation of the expressions of bax and bcl-2 in the epithelial cells of mice with dry eye induced by bac, so as to suppress the apoptosis of epithelial cells in mice with dry eye. |
2020-01-30 |
2023-08-13 |
mouse |
| Wei Gong, Jiayu Song, Xi Chen, Shuzhen Li, Jing Yu, Weiwei Xia, Guixia Ding, Yue Zhang, Zhanjun Jia, Aihua Zhang, Songming Huan. Estrogen-related receptor-α mediates puromycin aminonucleoside-induced mesangial cell apoptosis and inflammatory injury. American journal of physiology. Renal physiology. vol 316. issue 5. 2020-01-29. PMID:30698047. |
the apoptosis was further evidenced by increments of apoptosis regulator bax (bax) and caspase-3 expression. |
2020-01-29 |
2023-08-13 |
rat |
| Wei Gong, Jiayu Song, Xi Chen, Shuzhen Li, Jing Yu, Weiwei Xia, Guixia Ding, Yue Zhang, Zhanjun Jia, Aihua Zhang, Songming Huan. Estrogen-related receptor-α mediates puromycin aminonucleoside-induced mesangial cell apoptosis and inflammatory injury. American journal of physiology. Renal physiology. vol 316. issue 5. 2020-01-29. PMID:30698047. |
more importantly, overexpression of errα in mcs significantly triggered mc apoptosis in line with increased bax and caspase-3 expression. |
2020-01-29 |
2023-08-13 |
rat |
| Juan Du, Xin Fan, Bo Yang, Ye Chen, Ke-Xuan Liu, Jun Zho. Irisin pretreatment ameliorates intestinal ischemia/reperfusion injury in mice through activation of the Nrf2 pathway. International immunopharmacology. vol 73. 2020-01-28. PMID:31108387. |
furthermore, irisin pretreatment downregulated bax and cleaved caspase-3 at the protein level, and increased bcl-2 protein amounts, significantly reducing apoptosis in the intestine of i/r mice. |
2020-01-28 |
2023-08-13 |
mouse |
| Jiaxin Zheng, Shoulin Zhang, Huijun Chen, Xiaojun Cai, Chunjian Zhang, Shuhua Li, Yabin Zhou, Jing Shang, Shunyu Liang, Fengzhen Ya. Protosappanin-A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT-mTOR signaling. Cell biology international. 2020-01-28. PMID:31441181. |
the sc5b-9-induced podocyte apoptosis was inhibited in injured podocytes treated with pra and oa, accompanied by increased protein levels of nephrin, podocin, cd2ap, and bcl2 and decreased levels of desmin and bax. |
2020-01-28 |
2023-08-13 |
Not clear |
| Qing Tang, Haiyan Xia, Wei Liang, Xinying Huo, Xiaowei We. Synthesis and characterization of zinc oxide nanoparticles from Morus nigra and its anticancer activity of AGS gastric cancer cells. Journal of photochemistry and photobiology. B, Biology. vol 202. 2020-01-28. PMID:31734436. |
moreover, the status of apoptosis gene such as bax, caspase-9, caspase-3 and bcl-2 expressions was analysed by using rt-pcr techniques. |
2020-01-28 |
2023-08-13 |
cat |
| Shao-Yang Zhao, Li-Xi Liao, Peng-Fei Tu, Wei-Wei Li, Ke-Wu Zen. Icariin Inhibits AGE-Induced Injury in PC12 Cells by Directly Targeting Apoptosis Regulator Bax. Oxidative medicine and cellular longevity. vol 2019. 2020-01-27. PMID:31178973. |
icariin inhibits age-induced injury in pc12 cells by directly targeting apoptosis regulator bax. |
2020-01-27 |
2023-08-13 |
Not clear |
| Arul Maximus Rabel, S Karthick Raja Namasivayam, M Prasanna, R S Arvind Bharan. A green chemistry to produce iron oxide - Chitosan nanocomposite (CS-IONC) for the upgraded bio-restorative and pharmacotherapeutic activities - Supra molecular nanoformulation against drug-resistant pathogens and malignant growth. International journal of biological macromolecules. vol 138. 2020-01-27. PMID:31362021. |
anticancer activity was examined against the a549 cell line by the assurance of cell feasibility as opposed to oxidative proteins, articulation example of tnf-α, bax, parp qualities and apoptosis. |
2020-01-27 |
2023-08-13 |
human |
| Hyun-Dong Cho, Jeong-Ho Kim, Yeong-Seon Won, Kwang-Deok Moon, Kwon-Il Se. Inhibitory Effects of Pectinase-Treated Prunus Mume Fruit Concentrate on Colorectal Cancer Proliferation and Angiogenesis of Endothelial Cells. Journal of food science. vol 84. issue 11. 2020-01-27. PMID:31618463. |
furthermore, pc-induced caspase-dependent apoptosis in sw480 cells, which was characterized by accumulation of apoptotic cell population, cell shrinkage, formation of apoptotic bodies, upregulation of proapoptotic bax, cleaved parp, caspase-3, caspase-8, and caspase-9, and downregulation of antiapoptotic bcl-2. |
2020-01-27 |
2023-08-13 |
human |
| Zonghao Tang, Yuxiu Huang, Zhenghong Zhang, Yedong Tang, Jiajie Chen, Fengqi Sun, Hongqin Yang, Zhengchao Wan. Accumulated autophagosomes and excessive apoptosis during the luteal development of pregnant rats. International journal of clinical and experimental pathology. vol 10. issue 12. 2020-01-26. PMID:31966494. |
the results of autophagy-associated protein lc-3 clearly showed that autophagy expressed during the pregnant cl and significantly increased at llp, while the expression changes of apoptosis related proteins cleaved caspase-3 and bax were similar with lc-3 expression changes, indicating autophagy may be involved in the initiation of pregnant luteolysis through the induction of cellular apoptosis at llp of pregnant ovaries. |
2020-01-26 |
2023-08-13 |
rat |
| Miaohua Zhu, Xiaoming Zhou, Jing Zhang, Yingzhi Zhan. MicroRNA-590-5p promotes cell survival in endometrioid endometrial cancer by suppressing tumor suppressor PTEN. International journal of clinical and experimental pathology. vol 10. issue 7. 2020-01-26. PMID:31966631. |
subsequently, we confirmed that knockdown of mir-590-5p inhibits cell proliferation, and induces cell cycle arrest and apoptosis, and activates the intrinsic apoptotic pathway including upregulating cleaved-caspase-3, bax and cleaved-parp. |
2020-01-26 |
2023-08-13 |
human |
| Wei Huang, Xinzhi Li, Lin Ca. Effects of ASPP2 on proliferation and apoptosis of malignant spinal tumor cells. International journal of clinical and experimental pathology. vol 10. issue 7. 2020-01-26. PMID:31966654. |
aspp2-overexpression vector transfection tumor cells increased apoptosis and inhibited proliferation, accompanied with lower bcl-2, higher bax, caspase 3 and p53 (p<0.05 compared to control group). |
2020-01-26 |
2023-08-13 |
Not clear |
| Ming-Xia Li, Yi-Feng Zhao, Hai-Xia Qiao, Yu-Ping Zhang, Xiu-Juan Li, Wei-Dong Ren, Pei Y. CXCR3 knockdown protects against high glucose-induced podocyte apoptosis and inflammatory cytokine production at the onset of diabetic nephropathy. International journal of clinical and experimental pathology. vol 10. issue 8. 2020-01-26. PMID:31966749. |
moreover, knockdown of cxcr3 reduced the podocytes injury in cell apoptosis and inflammation through increasing the expression of nephrin, podocin and bcl-2, and decreasing the expression of bax and caspase-3. |
2020-01-26 |
2023-08-13 |
mouse |
| Mina Motamedi, Laura Lindenthal, Anita Wagner, Margherita Kemper, Jasmin Moneer, Mona Steichele, Alexander Klimovich, Jörg Wittlieb, Marcell Jenewein, Angelika Böttge. Apoptosis in Hydra: function of HyBcl-2 like 4 and proteins of the transmembrane BAX inhibitor motif (TMBIM) containing family. The International journal of developmental biology. vol 63. issue 6-7. 2020-01-24. PMID:31250909. |
apoptosis in hydra: function of hybcl-2 like 4 and proteins of the transmembrane bax inhibitor motif (tmbim) containing family. |
2020-01-24 |
2023-08-13 |
human |