| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyun Zhang, Yalei Zhao, Peng Kong, Mei Han, Binghui L. Expression of circZNF609 is Down-Regulated in Colorectal Cancer Tissue and Promotes Apoptosis in Colorectal Cancer Cells by Upregulating p53. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-01-24. PMID:31401644. |
expression of circznf609 induced apoptosis and upregulated expression of the pro-apoptotic protein, bax, down-regulated the expression of the anti-apoptotic protein, bcl-2, and upregulated p53. |
2020-01-24 |
2023-08-13 |
human |
| Lin Mu, Guoxin Hu, Jian Liu, Yan Chen, Wenjuan Cui, Lujun Qia. Protective Effects of Naringenin in a Rat Model of Sepsis-Triggered Acute Kidney Injury via Activation of Antioxidant Enzymes and Reduction in Urinary Angiotensinogen. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-01-24. PMID:31401645. |
admistration of naringenin at the dosage of 10 and 20 mg/kg to sepsis rats caused significant reduction in the sepsis-induced apoptosis of kidney cells, accompanied by decrease in bax and increase in bcl-2 expression. |
2020-01-24 |
2023-08-13 |
rat |
| Jingcao Shen, Dan Yang, Xingfan Zhou, Yuqian Wang, Shichuan Tang, Hong Yin, Jinglei Wang, Rui Chen, Jiaxiang Che. Role of Autophagy in Zinc Oxide Nanoparticles-Induced Apoptosis of Mouse LEYDIG Cells. International journal of molecular sciences. vol 20. issue 16. 2020-01-23. PMID:31430870. |
the induction of apoptosis and autophagy in the testis tissues was disclosed by up-regulating the protein levels of cleaved caspase-8, cleaved caspase-3, bax, lc3-ii, atg 5, and beclin 1, accompanied by down-regulation of bcl 2. |
2020-01-23 |
2023-08-13 |
mouse |
| Maryam Kaviani, Somayeh Keshtkar, Negar Azarpira, Mahdokht Hossein Aghdaei, Bita Geramizadeh, Mohammad Hossein Karimi, Alireza Shamsaeefar, Nasrin Motazedian, Saman Nikeghbalian, Ismail H Al-Abdulla. Amelioration of the apoptosis-mediated death in isolated human pancreatic islets by minocycline. European journal of pharmacology. vol 858. 2020-01-21. PMID:31265840. |
apoptosis markers including bax, bcl2, and caspase-3 were determined at gene and protein level. |
2020-01-21 |
2023-08-13 |
human |
| Liang Wei, Jian-Shui Zhang, Sheng-Feng Ji, Hao Xu, Zhao-Hua Zhao, Li Zhang, Long Pang, Jun-Feng Zhang, Peng-Bo Yang, Hai M. Knockdown of TRIM32 Protects Hippocampal Neurons from Oxygen-Glucose Deprivation-Induced Injury. Neurochemical research. vol 44. issue 9. 2020-01-20. PMID:31410708. |
knockdown of trim32 suppressed cell apoptosis, as proved by the increased bcl-2 expression along with decreased bax expression and caspase-3 activity. |
2020-01-20 |
2023-08-13 |
Not clear |
| Tao Shan, Shuo Chen, Xi Chen, Deling Kong, Wanrun Lin, Wei Li, Jiancang Ma, Yiming Li, Xijuan Cui, Ya'an Kan. Impact of AQP-5 on the growth of colorectal cancer cells and the underlying mechanism. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938087. |
then, cell proliferation was assessed via the mtt assay, apoptosis was assessed by annexin v-fitc/pi and tunel assays, and expression changes in bax and bcl-2 were assessed by rt-pcr and western blotting. |
2020-01-19 |
2023-08-13 |
human |
| Zhiqiang Wang, Lili Ding, Jun Zhu, Yinxia Su, Li Wang, Lina Liu, Qi Ma, Hua Ya. Long non-coding RNA MEG3 mediates high glucose-induced endothelial cell dysfunction. International journal of clinical and experimental pathology. vol 11. issue 3. 2020-01-19. PMID:31938204. |
interestingly, meg3 knockdown in huvecs significantly induced proliferation and inhibited apoptosis by upregulating bcl-2 and downregulating bax, caspase-3, and p53. |
2020-01-19 |
2023-08-13 |
Not clear |
| Yangyong Ou, Weisheng Lia. Silencing profilin-1 confers protection from oxLDL injury in human vascular endothelial cells. International journal of clinical and experimental pathology. vol 11. issue 6. 2020-01-19. PMID:31938431. |
expression of protein and mrna for profilin-1 and genes (caspase-3, bax, bcl-2, nf-κb and survivin) associated with apoptosis were determined using real-time pcr and western blot analysis, respectively. |
2020-01-19 |
2023-08-13 |
human |
| Tao Zhang, Gan Zhao, Xinying Zhu, Kangfeng Jiang, Haichong Wu, Ganzhen Deng, Changwei Qi. Sodium selenite induces apoptosis via ROS-mediated NF-κB signaling and activation of the Bax-caspase-9-caspase-3 axis in 4T1 cells. Journal of cellular physiology. vol 234. issue 3. 2020-01-17. PMID:30218457. |
the inhibition of nf-κb subsequently increased the expression of the apoptosis gene b-cell lymphoma-2-associated x (bax) and downregulated the transcription of antiapoptosis genes, such as b-cell lymphoma-2, cellular inhibitor of apoptosis 1, and x-linked inhibitor of apoptosis. |
2020-01-17 |
2023-08-13 |
Not clear |
| Christiano R R Alves, Tara L MacDonald, Pasquale Nigro, Prerana Pathak, Michael F Hirshman, Laurie J Goodyear, Sarah J Lessar. Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 117. 2020-01-17. PMID:31387190. |
moreover, sdn tumor-bearing mice had increased skeletal muscle bax protein expression, a marker of apoptosis, compared to other groups.thus, lack of snark in skeletal muscle aggravates cancer-induced skeletal muscle wasting. |
2020-01-17 |
2023-08-13 |
mouse |
| Chunrui Wang, Zhidong Zh. MiR-499a suppresses LPS-induced human vascular endothelial cell inflammatory response and apoptosis by regulating STAT1. International journal of clinical and experimental pathology. vol 12. issue 11. 2020-01-17. PMID:31933823. |
overexpressed mir-499a inhibited lps-activated expression of il-6, vcam-1 and icam-1, and protected huvecs against lps-induced apoptosis by suppressing the expression of bax and cleaved caspase 3 expressions. |
2020-01-17 |
2023-08-13 |
human |
| Tian Zhang, Chunhua Ji, Ruxia Sh. miR-142-3p promotes pancreatic β cell survival through targeting FOXO1 in gestational diabetes mellitus. International journal of clinical and experimental pathology. vol 12. issue 5. 2020-01-17. PMID:31933970. |
overexpression of mir-142-3p and knockdown of foxo1 both promoted ins-1 cell proliferation, inhibited apoptosis, increased proliferating cell nuclear antigen (pcna) and bcl-2 expression, as well as reduced the expression level of p27, bax and cleaved caspase-3. |
2020-01-17 |
2023-08-13 |
mouse |
| Chang Xu, Jiao-Jiao Niu, Jun-Fei Zhou, Yin-Sheng We. MicroRNA-96 is responsible for sevoflurane-induced cognitive dysfunction in neonatal rats via inhibiting IGF1R. Brain research bulletin. vol 144. 2020-01-16. PMID:30217735. |
the mrna and protein levels of igf1r, bcl-2, bax, and caspase-3 were measured followed by the determination of hippocampal neuron apoptosis. |
2020-01-16 |
2023-08-13 |
mouse |
| Chang Xu, Jiao-Jiao Niu, Jun-Fei Zhou, Yin-Sheng We. MicroRNA-96 is responsible for sevoflurane-induced cognitive dysfunction in neonatal rats via inhibiting IGF1R. Brain research bulletin. vol 144. 2020-01-16. PMID:30217735. |
our analyses indicated that 4% sevoflurane had a significantly stronger effect on reducing the levels of igf1r and bcl-2, while elevating the levels of mir-96, bax and caspase-3 more so than that of 1% or 2% sevoflurane, which resulted in increased hippocampal neuron apoptosis but diminished the learning and memory performance of the rats. |
2020-01-16 |
2023-08-13 |
mouse |
| Tan Guiying, Li Yue, Xiong Chao, Yu Jinhai, Xu Qihu. Antitumor Effects of 8-Deoxylactucin in RB355 Human Retinoblastoma Cells Are Mediated via Apoptosis Induction, Reactive Oxygen Species Production, and Cell Cycle Arrest. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-01-16. PMID:31219101. |
the induction of 8-deoxylactucin-induced apoptosis was also accompanied with increased cleavage of caspase 3, upregulation of bax, and downregulation of bcl-2. |
2020-01-16 |
2023-08-13 |
human |
| Guodong Chang, Yingwei Chen, Hongwei Zhang, Wen Zho. Trans sodium crocetinate alleviates ischemia/reperfusion-induced myocardial oxidative stress and apoptosis via the SIRT3/FOXO3a/SOD2 signaling pathway. International immunopharmacology. vol 71. 2020-01-14. PMID:30952100. |
tsc administration relieved i/r-induced myocardial apoptosis in vivo and in vitro, as evidenced by reduced number of tunel positive cells, accompanying with marked decreases in caspase-3 activity and bax protein level and an increase in bcl-2 protein level. |
2020-01-14 |
2023-08-13 |
rat |
| Qing Chen, Juan Hou, Zhiwei Wu, Jie Zhao, De M. miR-145 Regulates the sensitivity of esophageal squamous cell carcinoma cells to 5-FU via targeting REV3L. Pathology, research and practice. vol 215. issue 7. 2020-01-14. PMID:31072625. |
additionally, transfection of mir-145 mimic further altered expression of key genes involved in cell apoptosis (bcl-2, bax, caspase3) in escc cells treated with 5-fu. |
2020-01-14 |
2023-08-13 |
Not clear |
| Haidy E Michel, Esther T Menz. Tetramethylpyrazine guards against cisplatin-induced nephrotoxicity in rats through inhibiting HMGB1/TLR4/NF-κB and activating Nrf2 and PPAR-γ signaling pathways. European journal of pharmacology. vol 857. 2020-01-14. PMID:31152701. |
cisplatin-induced apoptosis was depicted by elevated bax mrna expression and caspase-3 activity, as well as decreased bcl2 mrna expression. |
2020-01-14 |
2023-08-13 |
rat |
| Yanglei Li, Fang Shen, Yiqi Bao, Dongming Chen, Hong L. Apoptotic effects of rhein through the mitochondrial pathways, two death receptor pathways, and reducing autophagy in human liver L02 cells. Environmental toxicology. vol 34. issue 12. 2020-01-14. PMID:31436023. |
meanwhile, rhein upregulates the expression of bax and downregulates the expression of procaspase-9 and -3, and it is suggested that the mitochondrial pathway is activated and rhein-induced apoptosis may be involved. |
2020-01-14 |
2023-08-13 |
human |
| Mayara M D C A Weller, Isabela Fonseca, Ana P Sbardella, Isabella S B Pinto, Lyderson F Viccini, Humberto M Brandão, Juliana C Gern, Wanessa A Carvalho, Alessandro S Guimarães, Maria A V P Brito, Danísio P Munari, Marcos V G B Silva, Marta F Martin. Isolated perfused udder model for transcriptome analysis in response to The Journal of dairy research. vol 86. issue 3. 2020-01-14. PMID:31451129. |
the expression profiles of casp1 and bax for any contrasts were unaffected whereas bcl2 was increased in iq, which suggests no induction of apoptosis during the first hours after infection. |
2020-01-14 |
2023-08-13 |
Not clear |