| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng Liu, Fuhai Wang, Xiaofeng Dong, Peng Xiu, Pengfei Sun, Zhongchao Li, Xuetao Shi, Jingtao Zhon. T7 peptide cytotoxicity in human hepatocellular carcinoma cells is mediated by suppression of autophagy. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173192. |
the t7 peptide induced apoptosis in hcc cells through upregulation of bax, fas, and fas ligand, and through upregulation of the anti‑apoptotic protein bcl‑2. |
2019-12-23 |
2023-08-13 |
human |
| Ruicong Guan, Jing Lv, Fei Xiao, Youbing Tu, Yubo Xie, Li L. Potential role of the cAMP/PKA/CREB signalling pathway in hypoxic preconditioning and effect on propofol‑induced neurotoxicity in the hippocampus of neonatal rats. Molecular medicine reports. vol 20. issue 2. 2019-12-23. PMID:31257533. |
the results indicate that propofol increased the level of cleaved caspase‑3 and bax by suppressing the activity of camp‑dependent proteins and bcl‑2; thus, hpc prevents propofol from triggering apoptosis via the camp/pka/creb signalling pathway. |
2019-12-23 |
2023-08-13 |
rat |
| Ewies F Ewies, Marwa El-Hussieny, Naglaa F El-Sayed, Marwa A Foua. Design, synthesis and biological evaluation of novel α-aminophosphonate oxadiazoles via optimized iron triflate catalyzed reaction as apoptotic inducers. European journal of medicinal chemistry. vol 180. 2019-12-23. PMID:31323616. |
additionally, their capacity to activate apoptosis cascade was studied in hct116 cell line by investigating the activation of proteolytic caspases cascade, the levels of cytochrome c, bax and bcl-2. |
2019-12-23 |
2023-08-13 |
human |
| Alexander V Sirotkin, Andrej Benco, Milos Mlyncek, Jan Kotwica, Saleh Alwasel, Abdel Halim Harrat. Transcription factor p53 regulates healthy human ovarian cells function. Comptes rendus biologies. vol 342. issue 5-6. 2019-12-23. PMID:31495738. |
the intracellular accumulation of p53, of the apoptosis marker bax, and of the proliferation marker pcna, as well as the release of progesterone (p4), insulin-like growth factor i (igf-i), oxytocin (ot), and prostaglandin f (pgf) and e2 (pge) were evaluated by quantitative immunocytochemistry and ria/irma. |
2019-12-23 |
2023-08-13 |
human |
| Boris Sabirzhanov, Alan I Faden, Taryn Aubrecht, Rebecca Henry, Ethan Glaser, Bogdan A Stoic. MicroRNA-711-Induced Downregulation of Angiopoietin-1 Mediates Neuronal Cell Death. Journal of neurotrauma. vol 35. issue 20. 2019-12-20. PMID:29774773. |
ang-1 treatment inhibits etoposide-induced upregulation of proapoptotic b-cell lymphoma 2 (bcl-2) family members noxa, p53 upregulated modulator of apoptosis (puma), bcl-2 interacting mediator of cell death (bim), and bcl-2-associated x protein (bax); reduces markers of caspase-dependent (cytochrome c release/caspase activation) and caspase-independent (apoptosis-inducing factor release) pathways; and limits neuronal cell death. |
2019-12-20 |
2023-08-13 |
mouse |
| Boris Sabirzhanov, Alan I Faden, Taryn Aubrecht, Rebecca Henry, Ethan Glaser, Bogdan A Stoic. MicroRNA-711-Induced Downregulation of Angiopoietin-1 Mediates Neuronal Cell Death. Journal of neurotrauma. vol 35. issue 20. 2019-12-20. PMID:29774773. |
administration of mir-711 inhibitor elevates ang-1 after tbi whereas ang-1 administration increases akt activation; reduces puma, noxa, bim, and bax levels; and attenuates caspase-dependent and -independent neuronal apoptosis 24 h after tbi. |
2019-12-20 |
2023-08-13 |
mouse |
| Chenfei Kong, Miao Hao, Xi Chen, Xiaoming Zhao, Yuqian Wang, Jing Li, Yiyao Gao, Hao Zhang, Bai Yang, Jinlan Jian. NF-κB inhibition promotes apoptosis in androgen-independent prostate cancer cells by the photothermal effect via the IκBα/AR signaling pathway. Biomaterials science. vol 7. issue 6. 2019-12-20. PMID:30977484. |
photothermal therapy resulted in oxidative stress in prostate cancer cells and activated the mitochondrial-related apoptosis pathway, increasing the bax expression. |
2019-12-20 |
2023-08-13 |
Not clear |
| Liqiang Ji, Yifang Chen, Hongqiang Wang, Wei Zhang, Lanxiang He, Jingmin Wu, Yinghui Li. Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy. International journal of oncology. vol 55. issue 1. 2019-12-20. PMID:31115579. |
these protective effects were evidenced by the inhibition of apoptosis, the upregulation of the expression levels of bcl‑2 and cd206, as well as by the decreased expression levels of bax and cd86. |
2019-12-20 |
2023-08-13 |
rat |
| Dilip Shah, Pragnya Das, Mohammad Afaque Alam, Nidhi Mahajan, Freddy Romero, Mohd Shahid, Harpreet Singh, Vineet Bhandar. MicroRNA-34a Promotes Endothelial Dysfunction and Mitochondrial-mediated Apoptosis in Murine Models of Acute Lung Injury. American journal of respiratory cell and molecular biology. vol 60. issue 4. 2019-12-18. PMID:30512967. |
mechanistically, we show that mir-34a leads to translocation of p53 and bax to the mitochondrial compartment with disruption of mitochondrial membrane potential to release cytochrome c into the cytosol, initiating a cascade of mitochondrial-mediated apoptosis in lungs. |
2019-12-18 |
2023-08-13 |
mouse |
| Yanping Wu, Baikui Wang, Zhonghua Zeng, Rongrong Liu, Li Tang, Li Gong, Weifen L. Effects of probiotics Lactobacillus plantarum 16 and Paenibacillus polymyxa 10 on intestinal barrier function, antioxidative capacity, apoptosis, immune response, and biochemical parameters in broilers. Poultry science. vol 98. issue 10. 2019-12-18. PMID:31064013. |
immunohistochemistry of bax, bcl-2 and proliferating cell nuclear antigen and tunel-immunofluorescence assay demonstrated that lac16 and bsc10 exerted beneficial effects on cell apoptosis and proliferation, as indicated by the gene expression of down-regulated bax and p53 as well as a significant upregulation of bcl-2 (p < 0.05). |
2019-12-18 |
2023-08-13 |
cat |
| Ganiou Assani, Akadiri Yessoufou, Yudi Xiong, Julien Segbo, Xiaoyuan Yu, Fuxiang Zhou, Yunfeng Zho. Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation. Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 6. 2019-12-18. PMID:31244309. |
moreover, western blot was used to detect the expression of certain proteinsrelated to cell apoptosis (bax and bcl2) signaling pathway and telomere maintenance (pot1, tpp1, and ube2d3).cell cycle and cell apoptosis were also analyzed by using the flow cytometry analysis. |
2019-12-18 |
2023-08-13 |
Not clear |
| Prafull Kumar Singh, Arnim Weber, Georg Häcke. The established and the predicted roles of dynein light chain in the regulation of mitochondrial apoptosis. Cell cycle (Georgetown, Tex.). vol 17. issue 9. 2019-12-17. PMID:30019621. |
within this family, bh3-only proteins are the sensors of apoptotic stimuli and can trigger apoptosis either by inhibiting the anti-apoptotic bcl-2-family proteins or by directly activating the effectors bax and bak. |
2019-12-17 |
2023-08-13 |
Not clear |
| Milad Zadi Heydarabad, Mousa Vatanmakanian, Jalal Abdolalizadeh, Hamed Mohammadi, Ako Azimi, Reza Mousavi Ardehaie, Aliakbar Movasaghpour, Majid Farshdousti Hag. Apoptotic effect of resveratrol on human T-ALL cell line CCRF-CEM is unlikely exerted through alteration of BAX and BCL2 promoter methylation. Journal of cellular biochemistry. vol 119. issue 12. 2019-12-17. PMID:30132966. |
based on our previous study, the resveratrol treatment can trigger apoptosis in ccrf-cem cell line via upregulation of apoptotic bax gene and downregulation of antiapoptotic bcl2 gene. |
2019-12-17 |
2023-08-13 |
human |
| Md Irshad Ahmad, Mohd Faraz Zafeer, Mehjbeen Javed, Masood Ahma. Pendimethalin-induced oxidative stress, DNA damage and activation of anti-inflammatory and apoptotic markers in male rats. Scientific reports. vol 8. issue 1. 2019-12-17. PMID:30459330. |
a pronounced increase in bax expression, caspase-3 activities and decreased bcl-2 expressions were also associated with pnd-induced apoptosis. |
2019-12-17 |
2023-08-13 |
rat |
| Bing Zhu, Shanxin Li, Lei Yu, Wei Hu, Dandan Sheng, Jing Hou, Naping Zhao, Xiaojuan Hou, Yechen Wu, Zhipeng Han, Lixin Wei, Li Zhan. Inhibition of Autophagy with Chloroquine Enhanced Sinoporphyrin Sodium Mediated Photodynamic Therapy-induced Apoptosis in Human Colorectal Cancer Cells. International journal of biological sciences. vol 15. issue 1. 2019-12-16. PMID:30662343. |
shrunken cells, condensed nuclei and increased levels of cleaved caspase-3 and bax were observed in dvdms-pdt treated hct116 cells, reminiscent of apoptosis. |
2019-12-16 |
2023-08-13 |
human |
| Boutheina Cherif, Hana Triki, Sana Sahnoun, Khaled Hamden, Afifa Sallemi, Slim Charfi, Saloua Lassoue. Imipenem toxicity in male reproductive organs as a result of inflammatory microenvironment and oxidative stress in germinal cells. Toxicology. vol 416. 2019-12-16. PMID:30721722. |
apoptosis and inflammatory behaviors were investigated by immunohistochemical proteins expression analysis of apoptosis regulator bax (bax), b-cell lymphoma 2 (bcl-2), and interleukin-1 beta (il-1 beta) in testis. |
2019-12-16 |
2023-08-13 |
rat |
| Yanji Zhu, Qian Li, Wenlong Xun, Yuan Chen, Caihui Zhang, Shuzhen Su. Blocking P2X7 receptor ameliorates oxidized LDL-mediated podocyte apoptosis. Molecular biology reports. vol 46. issue 4. 2019-12-16. PMID:31004300. |
p2x7r, bax, and caspase-3 protein expression were detected by western blot and immunofluorescence analysis.the expression of p2x7r, ros, bax, and caspase-3 in human podocytes incubated with oxldl was significantly up-regulated and was found to have higher intracellular lipid accumulation and podocyte apoptosis compared with the nc group. |
2019-12-16 |
2023-08-13 |
human |
| Yanji Zhu, Qian Li, Wenlong Xun, Yuan Chen, Caihui Zhang, Shuzhen Su. Blocking P2X7 receptor ameliorates oxidized LDL-mediated podocyte apoptosis. Molecular biology reports. vol 46. issue 4. 2019-12-16. PMID:31004300. |
however, co-administration with a438079, ros, bax, and caspase-3 expression both significantly down-regulate as well as lower lipid accumulation and cellular apoptosis in the oxldl-induced podocyte group. |
2019-12-16 |
2023-08-13 |
human |
| Jinsen Lu, Yongshun Zheng, Jiazhao Yang, Junqiang Zhang, Wei Cao, Xiaoyu Chen, Shiyuan Fan. Resveratrol alleviates inflammatory injury and enhances the apoptosis of fibroblast‑like synoviocytes via mitochondrial dysfunction and ER stress in rats with adjuvant arthritis. Molecular medicine reports. vol 20. issue 1. 2019-12-16. PMID:31180523. |
in addition, resveratrol was revealed to induce the apoptosis of flss when administered with 5 µm h2o2 as determined by elevated levels of bax, caspase‑3, caspase‑12 and c/ebp‑homologous protein, and the downregulation of b‑cell lymphoma 2 (bcl‑2), suggesting that resveratrol is able to induce apoptosis in flss via the mitochondrial pathway and endoplasmic reticulum (er) stress in a milieu containing 5 µm h2o2. |
2019-12-16 |
2023-08-13 |
rat |
| Hui Zhu, Xinyue Qi, Yuehe Liu, Wei Liao, Xiangshui Sun, Yuping Tan. The role and underlying mechanisms of microRNA‑214 in Legg‑Calvé‑Perthes disease. Molecular medicine reports. vol 20. issue 1. 2019-12-16. PMID:31180556. |
a luciferase reporter assay was conducted to investigate the association between mir‑214 and bax, while cell viability was determined via an mtt assay, and flow cytometry was performed to investigate cell apoptosis. |
2019-12-16 |
2023-08-13 |
Not clear |