| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Wang, Hongjing Zhao, Xin Yang, Mengyao Mu, Hui Zong, Liyang Luo, Mingwei Xin. Excessive Cu Chemosphere. vol 239. 2020-01-14. PMID:31514009. |
consequently, nuclear damage and organelle lesions, especially mitochondria were observed under cu or/and as stress, in which positive regulation of key proteins, dynamin-related protein 1 (drp1), cytochrome c (cyt c), bcl2-associated x (bax), caspases 3 and p53 was detected by qrcr and western blot analyses, indicating disturbed mitochondrial dynamic equilibrium and apoptosis execution. |
2020-01-14 |
2023-08-13 |
Not clear |
| Soheil Fereidouni, Ravi Ranjan Kumar, Vijayta D Chadha, Devinder Kumar Dhawa. Quercetin plays protective role in oxidative induced apoptotic events during chronic chlorpyrifos exposure to rats. Journal of biochemical and molecular toxicology. vol 33. issue 8. 2020-01-13. PMID:30990955. |
further, for appraisal of neurodegeneration as a consequence of apoptosis, protein expressions of bcl-2, bax, cytochrome c, caspase-8, and caspase-9 were assessed. |
2020-01-13 |
2023-08-13 |
rat |
| Ting-Ting Wang, Zhen-Zhang Chen, Peng Xie, Wen-Jun Zhang, Ming-Yu Du, Ya-Tian Liu, Hua-Yun Zhu, Ye-Song Gu. Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma. European journal of pharmacology. vol 856. 2020-01-13. PMID:31004603. |
in addition, isoliquiritigenin promoted nasopharyngeal carcinoma cell apoptosis, with the up-regulations of bax, caspase-3 and caspase-9 and the down-regulation of bcl-2. |
2020-01-13 |
2023-08-13 |
mouse |
| Carmen Rubio, César Mendoza, Cristina Trejo, Verónica Custodio, Moisés Rubio-Osornio, Leonardo Hernández, Emmanuel González, Carlos Pa. Activation of the Extrinsic and Intrinsic Apoptotic Pathways in Cerebellum of Kindled Rats. Cerebellum (London, England). vol 18. issue 4. 2020-01-13. PMID:31062284. |
however, it also can activate the intrinsic pathway releasing bid, which performs mitochondrial translocation of bax, inactivating bcl-2 and allowing the release of cytochrome c through the opening of the mitochondrial permeability transition pore, promoting the activation of caspase-9 which activates caspase-3, the main executor caspase of apoptosis. |
2020-01-13 |
2023-08-13 |
rat |
| Yani Lin, Miaomiao Yu, Tingjun Fa. Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells. Toxicology letters. vol 320. 2020-01-13. PMID:31765691. |
while low concentrations of ppf treatment (0.00625 %) induced dna fragmentation, apoptotic body formation, ros generation, activation of caspases and increase in cytoplasmic content of bad, bax and cytoplasmic cytochrome c that suggested apoptosis happened through ros-mediated caspase-dependent and caspase-independent pathways. |
2020-01-13 |
2023-08-13 |
human |
| Zhengfei Shan, Liqin Wei, Shengqiang Yu, Shanling Jiang, Yue Ma, Chengjun Zhang, Jiantao Wang, Zhenli Gao, Fengchun Wan, Guimin Zhuang, Jitao Wu, Dongfu Li. Ketamine induces reactive oxygen species and enhances autophagy in SV-HUC-1 human uroepithelial cells. Journal of cellular physiology. vol 234. issue 3. 2020-01-09. PMID:30145832. |
cck-8 assay and tunel staining indicated that ketamine effectively decreased the viability of sv-huc-1 cells and accelerated apoptosis of sv-huc-1 cells through regulating the expression level of ikbα (phospho), nuclear factor кb (p65), bcl-2, and bax proteins. |
2020-01-09 |
2023-08-13 |
human |
| Lili Zhuang, Hongmei Qu, Jianxiang Cong, Huangguan Dai, Xiaoyan Li. MiR-181c affects estrogen-dependent endometrial carcinoma cell growth by targeting PTEN. Endocrine journal. vol 66. issue 6. 2020-01-09. PMID:30971627. |
besides, overexpression of pten markedly promoted the apoptosis of e2-induced rl95-2 cells through regulating the bax and bcl-2 expression, and modulated the expression of akt pathway, p53 and cyclin d. in conclusion, our findings revealed that mir-181c affected the estrogen-dependent endometrial carcinoma cell growth by targeting pten. |
2020-01-09 |
2023-08-13 |
human |
| Jun Cheng, Xiaofeng Wang, Lei Qiu, Yunkai Li, Najat Marraiki, Abdallah M Elgorban, Li Xu. Green synthesized zinc oxide nanoparticles regulates the apoptotic expression in bone cancer cells MG-63 cells. Journal of photochemistry and photobiology. B, Biology. vol 202. 2020-01-09. PMID:31770706. |
decreased mmp has resulted in increased levels of apoptotic proteins bax, caspase-3 and caspase-9 and induction of apoptosis was substantiated by western blot analysis. |
2020-01-09 |
2023-08-13 |
Not clear |
| Xing Tu, Mengxia Wang, Yilin Liu, Wenyan Zhao, Xuxin Ren, Yuanjun Li, Hongqing Liu, Ziting Gu, Hui Jia, Jing Liu, Guoying Li, Li Lu. Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property. Cellular and molecular neurobiology. vol 39. issue 7. 2020-01-08. PMID:31147852. |
tunel staining was used to detect cells apoptosis, and the expressions of apoptosis-related proteins: bax, bcl2, and cleaved caspase-3 were assayed by western blot. |
2020-01-08 |
2023-08-13 |
mouse |
| Xing Tu, Mengxia Wang, Yilin Liu, Wenyan Zhao, Xuxin Ren, Yuanjun Li, Hongqing Liu, Ziting Gu, Hui Jia, Jing Liu, Guoying Li, Li Lu. Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property. Cellular and molecular neurobiology. vol 39. issue 7. 2020-01-08. PMID:31147852. |
gspe was proved to suppress apoptosis through inhibition of bax and cleaved caspase-3 expression. |
2020-01-08 |
2023-08-13 |
mouse |
| You-Min Mei, Lu Li, Xiao-Qian Wang, Min Zhang, Li-Fang Zhu, Yong-Wei Fu, Yan X. AGEs induces apoptosis and autophagy via reactive oxygen species in human periodontal ligament cells. Journal of cellular biochemistry. 2020-01-08. PMID:31680325. |
the mitochondrial-dependent apoptosis was induced in ages-treated hpdlcs, as confirmed by the mitochondrial membrane potential depolarization, decreased bcl-2 expression, increased bax expression, and increased caspase-3 and parp cleavage. |
2020-01-08 |
2023-08-13 |
human |
| Lan Ling, Hai-Feng Wang, Jing Li, Yan Li, Cheng-Dong G. Downregulated microRNA-92a-3p inhibits apoptosis and promotes proliferation of pancreatic acinar cells in acute pancreatitis by enhancing KLF2 expression. Journal of cellular biochemistry. 2020-01-08. PMID:31713921. |
the downregulation of mir-92a-3p and overexpression of klf2 led to decline in expression of nuclear factor-κb (nf-κb), survivin, tumor necrosis factor-α, and bax as well as extent of nf-κb phosphorylation, contents of inflammatory factors, and apoptosis rate of pacs, but to increased klf2 and b-cell lymphoma-2 levels and proliferation rate of pacs. |
2020-01-08 |
2023-08-13 |
rat |
| Zahra Samadian, Javad Tolouei Azar, Sana Moshari, Mazdak Razi, Asghar Tofigh. Moderate-intensity Exercise Training in Sole and Simultaneous Forms with Insulin Ameliorates the Experimental Type 1 Diabetes-induced Intrinsic Apoptosis in Testicular Tissue. International journal of sports medicine. vol 40. issue 14. 2020-01-07. PMID:31639864. |
the moderate-intensity exercise training in the sole and when simultaneously considered with insulin (dei) maintained testicular cellularity, up-regulated bcl-2 expression, reduced bax expression and ameliorated the diabetes-induced apoptosis. |
2020-01-07 |
2023-08-13 |
rat |
| Zahra Samadian, Javad Tolouei Azar, Sana Moshari, Mazdak Razi, Asghar Tofigh. Moderate-intensity Exercise Training in Sole and Simultaneous Forms with Insulin Ameliorates the Experimental Type 1 Diabetes-induced Intrinsic Apoptosis in Testicular Tissue. International journal of sports medicine. vol 40. issue 14. 2020-01-07. PMID:31639864. |
in conclusion, the moderate-intensity exercise training is able to potentially protect testicular cells from t1d-induced intrinsic apoptosis via up-regulating bcl-2 and downregulating bax expressions. |
2020-01-07 |
2023-08-13 |
rat |
| Verônica N Lobach, Maíra Casalechi, Cynthia Dela Cruz, Maria T Pereira, Helen L Del Puerto, Fernando M Rei. Caspase-3 gene expression in human luteinized granulosa cells is inversely correlated with the number of oocytes retrieved after controlled ovarian stimulation. Human fertility (Cambridge, England). vol 22. issue 1. 2020-01-06. PMID:28738699. |
luteinized granulosa cells were isolated from follicular fluid and the rna was extracted, reverse-transcribed and the gene expression of apoptosis inducers (caspase-3, caspase-8 and bax) and inhibitor (bcl-2) was quantified by real-time polymerase chain reaction. |
2020-01-06 |
2023-08-13 |
human |
| Jinlei Xi, Juan Liu, Shijing He, Wanyao Shen, Cizhao Wei, Ke Li, Yufeng Zhang, Jiang Yue, Zheqiong Yan. Effects of norfloxacin exposure on neurodevelopment of zebrafish (Danio rerio) embryos. Neurotoxicology. vol 72. 2020-01-06. PMID:30769002. |
by measuring the level of active caspase 3 and the expression ratio of bax to bcl2, we discovered that norfloxacin induced obvious cell apoptosis in the brain of zebrafish embryos. |
2020-01-06 |
2023-08-13 |
zebrafish |
| Feibo Xu, Peiyan Wang, Qiucheng Yao, Bing Shao, Hongyan Yu, Kaiyuan Yu, Yanfei L. Lycopene alleviates AFB Food & function. vol 10. issue 7. 2020-01-06. PMID:31184641. |
in addition, lyc also restrained splenic apoptosis through blocking mitochondria-mediated apoptosis in afb1 intoxicated mice, presenting as the increase of mitochondrial membrane potential, and the decrease of cytoplasmic cyt-c protein expression, cleaved caspase-3 protein expression, caspase-3/9 activities and mrna expressions, as well as balancing the mitochondrial protein and mrna expressions of bax and bcl-2. |
2020-01-06 |
2023-08-13 |
mouse |
| Cuisheng Zhang, Ying Yu, Qingxian Huang, Kun Tan. SIRT6 regulates the proliferation and apoptosis of hepatocellular carcinoma via the ERK1/2 signaling pathway. Molecular medicine reports. vol 20. issue 2. 2020-01-06. PMID:31257493. |
sirna‑mediated silencing of sirt6 decreased the proliferation and increased the apoptosis of huh‑7 cells, downregulated the expression of bcl‑2 and phosphorylated‑erk, and promoted the expression of cleaved‑caspase‑3 and bax. |
2020-01-06 |
2023-08-13 |
Not clear |
| Xia Li, Naijin Zhang, Ying Zhang, Pengyu Jia, Yuxuan Guo, Yichen Tian, Shilong You, Shaojun Wu, Yingxian Su. E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1. Molecular medicine reports. vol 20. issue 2. 2020-01-06. PMID:31257502. |
mcl‑1 inhibits the functions of bcl‑2 family members, including the mitochondrial apoptosis factor bax, to maintain cell viability; however, the present study suggested that fbw7 may degrade mcl‑1 and impaired this process. |
2020-01-06 |
2023-08-13 |
Not clear |
| Y Wang, L Ai, B Hai, Y Cao, R Li, H Li, Y L. Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis. Physiological research. vol 68. issue 3. 2020-01-06. PMID:31301730. |
moreover, tempol inhibited ih-induced apoptosis in pancreatic tissue as evidenced by upregulated bcl-2 level, and downregulated bax and cleaved caspase-3 levels. |
2020-01-06 |
2023-08-13 |
rat |