| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiaojian Zhang, Shufang Zheng, Shengchen Wang, Wei Wang, Houjuan Xing, Shiwen X. Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp. Fish & shellfish immunology. vol 93. 2020-01-03. PMID:31310849. |
furthermore, the detection of apoptosis and autophagy relative genes showed that the expressions of tsc complex subunit 2 (tsc2), light chain 3 (lc3), dynein, tumor protein 53 (p53), bcl-2 associated x protein (bax), caspase-3 and caspase-9 were enhanced and the expressions of nechanistic target of rapamycin (mtor), ras homolog mtorc1 binding (rheb) and b-cell lymphoma (bcl-2) were reduced in dose-dependent way. |
2020-01-03 |
2023-08-13 |
Not clear |
| Jing Xu, Qianqian Qi, Peiyuan Lv, Yanhong Dong, Xin Jiang, Zhijuan Li. Oxiracetam ameliorates cognitive deficits in vascular dementia rats by regulating the expression of neuronal apoptosis/autophagy-related genes associated with the activation of the Akt/mTOR signaling pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 11. 2020-01-03. PMID:31721903. |
mechanistically, the protein levels of a panel of genes associated with neuronal apoptosis (bcl-2, bax) and autophagy (microtubule-associated protein 1 chain 3, beclin1, p62) were significantly altered by orc treatment compared with vad, suggesting a protective role of orc against vad-induced neuronal apoptosis and autophagy. |
2020-01-03 |
2023-08-13 |
rat |
| G Guan, L Lei, Q Lv, Y Gong, L Yan. Curcumin attenuates palmitic acid-induced cell apoptosis by inhibiting endoplasmic reticulum stress in H9C2 cardiomyocytes. Human & experimental toxicology. vol 38. issue 6. 2020-01-02. PMID:30859861. |
treatment with pa reduced cell viability, induced apoptosis, enhanced apoptosis-related protein expression (caspase 3 and bcl-2 associated x protein (bax)), and activated er stress marker protein expression (glucose-regulated protein 78 (grp78) and ccaat/enhancer binding protein homologous protein (chop)). |
2020-01-02 |
2023-08-13 |
Not clear |
| G Guan, L Lei, Q Lv, Y Gong, L Yan. Curcumin attenuates palmitic acid-induced cell apoptosis by inhibiting endoplasmic reticulum stress in H9C2 cardiomyocytes. Human & experimental toxicology. vol 38. issue 6. 2020-01-02. PMID:30859861. |
curcumin attenuated pa-induced reduction in cell viability and activation of apoptosis, caspase 3 activity, bax, chop, and grp78 expression. |
2020-01-02 |
2023-08-13 |
Not clear |
| S Gheena, D Ezhilarasa. Syringic acid triggers reactive oxygen species-mediated cytotoxicity in HepG2 cells. Human & experimental toxicology. vol 38. issue 6. 2020-01-02. PMID:30924378. |
apoptotic markers such as caspases 3 and 9, cytochrome c, apaf-1, bax, and p53 gene expressions were significantly increased upon sa treatment indicating the possibility of apoptosis induction in hepg2 cells. |
2020-01-02 |
2023-08-13 |
human |
| Anna Willms, Hella Schittek, Sascha Rahn, Justyna Sosna, Ufuk Mert, Dieter Adam, Anna Trauzol. Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells. PloS one. vol 14. issue 4. 2020-01-02. PMID:30947287. |
our data demonstrate that the contribution of p53 in regulating trail-r-induced apoptosis does not correlate to the levels of trail-rs at the plasma membrane, but rather to p53-mediated upregulation of bax, favouring the mitochondrial amplification loop. |
2020-01-02 |
2023-08-13 |
Not clear |
| Xiang-Yu Cao, Dan Liu, Ruo-Chen Bi, Yong-Lin He, Yin He, Jian-Li Li. The protective effects of a novel polysaccharide from Lentinus edodes mycelia on islet β (INS-1) cells damaged by glucose and its transportation mechanism with human serum albumin. International journal of biological macromolecules. vol 134. 2020-01-02. PMID:31075333. |
furthermore, the glucose-induced cell apoptosis in cells were inhibited by regulating the expression of bax, bcl-2, cleaved caspase‑3 and cleaved caspase‑1. |
2020-01-02 |
2023-08-13 |
human |
| Yong Cheng, Peng Xi. Ganoderic acid A holds promising cytotoxicity on human glioblastoma mediated by incurring apoptosis and autophagy and inactivating PI3K/AKT signaling pathway. Journal of biochemical and molecular toxicology. vol 33. issue 11. 2019-12-31. PMID:31503386. |
additionally, ga-a markedly triggered cell apoptosis, which incarnated an elevation trend in apoptotic percentage, simultaneously, an increased level of proapoptosis protein (bax and active caspase-3) and a decreased level of antiapoptosis protein (bcl-2), induced by ga-a treatment. |
2019-12-31 |
2023-08-13 |
human |
| Neelima Ayyalasomayajula, Rajanna Ajumeera, Chetty S Chellu, Suresh Chall. Mitigative effects of epigallocatechin gallate in terms of diminishing apoptosis and oxidative stress generated by the combination of lead and amyloid peptides in human neuronal cells. Journal of biochemical and molecular toxicology. vol 33. issue 11. 2019-12-31. PMID:31518035. |
the results indicated that egcg mitigated both pb- and β-ap-induced oxidative stress in scavenging reactive oxygen species and apoptosis by improving the expression levels of bax and bcl2 and inhibiting annexin v and caspase-3. |
2019-12-31 |
2023-08-13 |
human |
| Eunjin Sohn, Hye-Sun Lim, Yu Jin Kim, Bu-Yeo Kim, Joo-Hwan Kim, Soo-Jin Jeon. Nutrients. vol 11. issue 6. 2019-12-30. PMID:31141948. |
egfo treatment also attenuated neural apoptosis in scopolamine-treated mice by decreasing the expression of apoptosis-related proteins such as bax, bcl2, cleaved caspase-3, and tunel staining. |
2019-12-30 |
2023-08-13 |
mouse |
| Jing-Wen Zhang, Ding-Qi Xu, Xi-Zeng Fen. The toxic effects and possible mechanisms of glyphosate on mouse oocytes. Chemosphere. vol 237. 2019-12-30. PMID:31352102. |
the protein expression levels of apoptosis factors (bax, bcl-2) and the mrna expression levels of apoptosis-related genes (bax, bcl-2, caspase3) were measured by western blot and qrt-pcr, respectively. |
2019-12-30 |
2023-08-13 |
mouse |
| Guanglei Gao, Rongli Ge, Yuzhou Li, Shengcui Li. Luteolin exhibits anti-breast cancer property through up-regulating miR-203. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-30. PMID:31368817. |
luteolin remarkably declined mda-mb-453 and mcf-7 cells viability and accelerated apoptosis which accompanied by bax up-regulation, bcl-2 down-regulation and caspase-3 cleavage. |
2019-12-30 |
2023-08-13 |
Not clear |
| Praveen Manivannan, Vidita Reddy, Sushovita Mukherjee, Kirsten Neytania Clark, Krishnamurthy Malath. RNase L Induces Expression of A Novel Serine/Threonine Protein Kinase, DRAK1, to Promote Apoptosis. International journal of molecular sciences. vol 20. issue 14. 2019-12-27. PMID:31330998. |
overexpression of drak1 triggers apoptosis in the absence of rnase l activation by activating c-jun n-terminal kinase (jnk), translocation of bcl2 associated x (bax) to the mitochondria accompanied by cytochrome c release and loss of mitochondrial membrane potential promoting cleavage of caspase 3 and poly(adp-ribose) polymerase 1 (parp). |
2019-12-27 |
2023-08-13 |
Not clear |
| Jonathan P Bernardini, Jason M Brouwer, Iris Kl Tan, Jarrod J Sandow, Shuai Huang, Che A Stafford, Aleksandra Bankovacki, Christopher D Riffkin, Ahmad Z Wardak, Peter E Czabotar, Michael Lazarou, Grant Dewso. Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy. The EMBO journal. vol 38. issue 2. 2019-12-26. PMID:30573668. |
parkin also suppresses bax-mediated apoptosis, but in the absence of bax ubiquitination suggesting an indirect mechanism. |
2019-12-26 |
2023-08-13 |
Not clear |
| Lina Zhou, Jiangdong Xiang, Linxia Li, Wei Chen, Xiaowei X. [Effect of umbilical cord mesenchymal stem cells on proliferation and apoptosis of ovarian cancer cells]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 10. 2019-12-26. PMID:31857505. |
real-time pcr was used to detect the expression levels of ki-67, bcl-2 and bax genes-relevant to proliferation and apoptosis of skov3 cells.
results: uc-mscs targeted skov3 cells in vitro. |
2019-12-26 |
2023-08-13 |
human |
| Lina Zhou, Jiangdong Xiang, Linxia Li, Wei Chen, Xiaowei X. [Effect of umbilical cord mesenchymal stem cells on proliferation and apoptosis of ovarian cancer cells]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 10. 2019-12-26. PMID:31857505. |
the apoptosis-related gene bcl-2 expression was decreased dramatically (p<0.01), and bax expression was increased significantly (p<0.01).
conclusion: uc-mscs can target ovarian cancer cells in vitro, inhibit the proliferation of skov3 cells by regulating the expression of ki-67, and promote the apoptosis of skov3 cells by regulating the expression of bcl-2 and bax. |
2019-12-26 |
2023-08-13 |
human |
| Ning Gao, Zhihui Huang, Haiqiang Liu, Jing Hou, Xinhui Li. Advances on the toxicity of uranium to different organisms. Chemosphere. vol 237. 2019-12-24. PMID:31549660. |
it also induce the expression of apoptosis factors such as bcl-2, bid, bax, and caspase family to cause apoptosis cascade reaction, leading to dna degradation and cell death. |
2019-12-24 |
2023-08-13 |
Not clear |
| Khaliunaa Lkhagvasuren, Jin-Kyung Ki. Ziyuglycoside II induces caspases-dependent and caspases-independent apoptosis in human colon cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 59. 2019-12-23. PMID:31029785. |
apoptosis caused by p53 phosphorylation following ziyuglycoside ii treatment in hct116 cells involved activation of caspases, increased expression of bax, mitochondrial cytochrome c and apoptosis inducing factor (aif) release, while bcl-2 became down-regulated. |
2019-12-23 |
2023-08-13 |
human |
| De-Zhe Chen, Wei-Wei Wang, Yan-Ling Chen, Xia-Feng Yang, Min Zhao, Yan-Yan Yan. miR‑128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173166. |
subsequently, results from an in vitro epilepsy model demonstrated that overexpression of mir‑128 promoted nerve cell apoptosis, increased the protein expression of tumor protein p53, bcl2 associated x (bax) and cytochrome c, and enhanced caspase‑3/9 activity, whereas it suppressed the protein expression of sirtuin 1 (sirt1). |
2019-12-23 |
2023-08-13 |
rat |
| Shuo Yang, Yueli Gu, Genjie Wang, Qingzhu Hu, Shuxia Chen, Yong Wang, Mingfeng Zha. HMGA2 regulates acute myeloid leukemia progression and sensitivity to daunorubicin via Wnt/β-catenin signaling. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173171. |
in addition, low expression of hmga2 attenuated x‑linked inhibitor of apoptosis and bcl‑2 mrna and protein levels, and upregulated the expression of bax and cleaved‑caspase‑3. |
2019-12-23 |
2023-08-13 |
Not clear |