| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tesfaye Worku, Kai Wang, Duncan Ayers, Di Wu, Zia Ur Rehman, Hao Zhou, Liguo Yan. Regulatory roles of ephrinA5 and its novel signaling pathway in mouse primary granulosa cell apoptosis and proliferation. Cell cycle (Georgetown, Tex.). vol 17. issue 7. 2019-12-02. PMID:29619874. |
efna5 silencing suppressed gc apoptosis by downregulating bax and upregulating bcl-2 in a caspase 8-dependent manner. |
2019-12-02 |
2023-08-13 |
mouse |
| AmirReza Hesari, Faezeh Ghasemi, Arrigo F G Cicero, Mohammad Mohajeri, Omid Rezaei, Seyed Mohammad Gheibi Hayat, Amirhossein Sahebka. Berberine: A potential adjunct for the treatment of gastrointestinal cancers? Journal of cellular biochemistry. vol 119. issue 12. 2019-12-02. PMID:30125974. |
several mechanisms of action have been hypothesized and demonstrated: immunomodulation, inhibition of topoisomerase enzymes, suppression of the egf receptor, her2/neu, and the vegf receptor, induction of p53, cip1/p21, kip1/p27, rb expression, induction of apoptosis (by regulation of mmps pathway, caspases, bax, and smac/diablo), inhibition of arylamin n-acetyltransferase activity, and regulation of micrornas expression. |
2019-12-02 |
2023-08-13 |
human |
| Meijuan Zhou, Gaoying Sun, Lili Zhang, Guodong Zhang, Qianqian Yang, Haiyan Yin, Hongrui Li, Wenwen Liu, Xiaohui Bai, Jianfeng Li, Haibo Wan. STK33 alleviates gentamicin-induced ototoxicity in cochlear hair cells and House Ear Institute-Organ of Corti 1 cells. Journal of cellular and molecular medicine. vol 22. issue 11. 2019-12-02. PMID:30256516. |
stk33 knockdown resulted in an increase in the cleaved caspase-3 and bax expressions as well as cell apoptosis after gentamicin damage in hei-oc1 cells. |
2019-12-02 |
2023-08-13 |
mouse |
| S M Zaki, Wa Abd Algaleel, R A Imam, M M Abdelmoat. Mesenchymal stem cells pretreated with platelet-rich plasma modulate doxorubicin-induced cardiotoxicity. Human & experimental toxicology. vol 38. issue 7. 2019-12-02. PMID:30991846. |
the major factors in the dox-induced cardiotoxicity were the oxidative stress (elevated mda/decreased sod), inflammation (elevated tnf-α/decreased il-10), and cardiac apoptosis (lower bcl2, higher bax, and lower bcl2/bax ratio). |
2019-12-02 |
2023-08-13 |
rat |
| Chenxuan Wu, Jun Liu, Yanbin Tang, Yanxiao Li, Qiaojuan Yan, Zhengqiang Jian. Hepatoprotective Potential of Partially Hydrolyzed Guar Gum against Acute Alcohol-Induced Liver Injury in Vitro and Vivo. Nutrients. vol 11. issue 5. 2019-11-28. PMID:31035540. |
moreover, mediated expression of bcl-2 and bax was responsible for inhibited acute alcohol-induced apoptosis with suppressed cleavage of caspase 3 and parp. |
2019-11-28 |
2023-08-13 |
mouse |
| Qixing Zhou, Zongkai Yue, Qingzhao Li, Ruiren Zhou, Lu Li. Exposure to PbSe Nanoparticles and Male Reproductive Damage in a Rat Model. Environmental science & technology. vol 53. issue 22. 2019-11-28. PMID:31362495. |
endoplasmic reticulum and mitochondria-mediated cell apoptosis were triggered via oxidative stress, as shown by upregulation of cytoplasmic cyt-c, bax, cleaved caspase-3, grp78, and caspase-12. |
2019-11-28 |
2023-08-13 |
rat |
| Chao Zhao, Zhi Tang, Peisi Xie, Kaili Lin, Arthur Chi Kong Chung, Zongwei Ca. Immunotoxic Potential of Bisphenol F Mediated through Lipid Signaling Pathways on Macrophages. Environmental science & technology. vol 53. issue 19. 2019-11-28. PMID:31453682. |
the apoptosis was induced by activating both sphingomyelin-ceramide signaling pathway and oxidative stress, which included intrinsic (bax and caspase-9) and extrinsic apoptotic pathways (tumor necrosis factor receptor 1, caspase-8, and caspase-3). |
2019-11-28 |
2023-08-13 |
Not clear |
| Guo-Qian He, Guang-Yu Liu, Wen-Ming Xu, Hui-Juan Liao, Xing-Hui Liu, Guo-Lin H. p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro. International journal of molecular medicine. vol 44. issue 1. 2019-11-27. PMID:31059007. |
exogenous p57kip2 overexpression significantly decreased the expression of pro‑apoptosis proteins, including p53, bax and cleaved caspase3, under hypoxic conditions for 24 h. in addition, knockdown of p57kip2 increased the response to apoptosis following hypoxia for 24 h. the present study revealed that overexpression of p57kip2 decreased the levels of phosphorylated‑jnk. |
2019-11-27 |
2023-08-13 |
human |
| Hai-Xiang Xu, Wen Pan, Jian-Feng Qian, Feng Liu, Hai-Qi Dong, Qing-Jun Li. MicroRNA‑21 contributes to the puerarin‑induced cardioprotection via suppression of apoptosis and oxidative stress in a cell model of ischemia/reperfusion injury. Molecular medicine reports. vol 20. issue 1. 2019-11-26. PMID:31115556. |
additionally, mir‑21 inhibition attenuated the puerarin‑induced decrease in the rate of apoptosis, caspase‑3 activity and the expression of apoptosis regulator bax, and increased apoptosis regulator bcl‑2 expression, under h/r conditions. |
2019-11-26 |
2023-08-13 |
rat |
| Guangyan Yu, Chunhua Wang, Xiangfu Song, Shimeng Liu, Yixin Zhang, Lida Fan, Yixue Yang, Yulu Huang, Jiayi Son. Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway. Molecular medicine reports. vol 20. issue 1. 2019-11-26. PMID:31115571. |
following treatment with fa for 24 h, cell viability, the cell cycle, apoptosis, and the expression of pten, pi3k and akt, as well as the protein expression of b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x (bax), and caspases‑3 and ‑9 were examined. |
2019-11-26 |
2023-08-13 |
mouse |
| Xin-Rui Han, Xin Wen, Yong-Jian Wang, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu, Yuan-Lin Zhen. MicroRNA-140-5p elevates cerebral protection of dexmedetomidine against hypoxic-ischaemic brain damage via the Wnt/β-catenin signalling pathway. Journal of cellular and molecular medicine. vol 22. issue 6. 2019-11-25. PMID:29536658. |
furthermore, observations of increased levels of cerebral infarction volume, total mortality rate, response times, total response duration, expressions of wnt1, β-catenin, tcf-4, e-cadherin, apoptosis rate of neurons, and bax expression were elevated. |
2019-11-25 |
2023-08-13 |
rat |
| Zenghui Li, Ning Li, Xiaomei Sun, Jing Wan. FAM98A promotes cancer progression in endometrial carcinoma. Molecular and cellular biochemistry. vol 459. issue 1-2. 2019-11-21. PMID:31114934. |
in addition, fam98a-knockdown stimulated remarkable cell apoptosis, which might be mediated by down-regulation of bcl2 and up-regulation of bax. |
2019-11-21 |
2023-08-13 |
Not clear |
| Buttyan, Shabsigh, Perlman, Colombe. Regulation of Apoptosis in the Prostate Gland by Androgenic Steroids. Trends in endocrinology and metabolism: TEM. vol 10. issue 2. 2019-11-20. PMID:10322394. |
there is now evidence for a critical cell signaling pathway, regulated by c-fos expression, necessary for castration-induced apoptosis, as well as evidence that this signaling initiates an abrupt and transient alteration in the synthesis of fas antigen, p53, bax and bcl-2 proteins in the androgen receptor-expressing prostate epithelial cells, the cellular compartment that appears to be the most affected by castration. |
2019-11-20 |
2023-08-12 |
Not clear |
| Wu, Li. Deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain. Environmental toxicology and pharmacology. vol 8. issue 3. 2019-11-20. PMID:10925071. |
deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain. |
2019-11-20 |
2023-08-12 |
rat |
| Wu, Li. Deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain. Environmental toxicology and pharmacology. vol 8. issue 3. 2019-11-20. PMID:10925071. |
to determine whether molecular characteristics of apoptosis is involved in neurodegeneration in rat brain after deltamethrin treatment, we investigated the effects of deltamethrin on the mrna expression of p53 and bax and their correlation with deltamethrin-induced apoptotic cell death in rat brain. |
2019-11-20 |
2023-08-12 |
rat |
| Wu, Li. Deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain. Environmental toxicology and pharmacology. vol 8. issue 3. 2019-11-20. PMID:10925071. |
these results indicate that (1) deltamethrin induces delayed apoptotic cell death, which may play an important role in deltamethrin-elicited neurodegeneration; (2) deltamethrin leads to the persistent increase of p53 and bax mrna levels, which may contribute to delayed apoptosis in rat brain following deltamethrin treatment. |
2019-11-20 |
2023-08-12 |
rat |
| K. Mujoo, L. Zhang, J. Klostergaard, N. J. Donat. Emergence of cisplatin-resistant cells from the OVCAR-3 ovarian carcinoma cell line with p53 mutations, altered tumorigenicity, and increased apoptotic sensitivity to p53 gene replacement. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 10. issue 2. 2019-11-20. PMID:11240661. |
rad-p53 induced high levels of p21waf1, p27kip1, activated caspase 3 and apoptosis in c-1 cells, without causing major changes in bax or bcl-xl levels. |
2019-11-20 |
2023-08-12 |
mouse |
| Jiong Wu, Zhi-Ming Shao, Zhen-Zhou Shen, Jing-Song Lu, Qi-Xia Han, Joseph A. Fontana, Sanford H. Barsk. Significance of Apoptosis and Apoptotic-Related Proteins, Bcl-2, and Bax in Primary Breast Cancer. The breast journal. vol 6. issue 1. 2019-11-20. PMID:11348334. |
significance of apoptosis and apoptotic-related proteins, bcl-2, and bax in primary breast cancer. |
2019-11-20 |
2023-08-12 |
human |
| Jiong Wu, Zhi-Ming Shao, Zhen-Zhou Shen, Jing-Song Lu, Qi-Xia Han, Joseph A. Fontana, Sanford H. Barsk. Significance of Apoptosis and Apoptotic-Related Proteins, Bcl-2, and Bax in Primary Breast Cancer. The breast journal. vol 6. issue 1. 2019-11-20. PMID:11348334. |
apoptosis and expression of apoptosis-regulating proteins, bcl-2 and bax, have been observed in human breast carcinomas. |
2019-11-20 |
2023-08-12 |
human |
| T W. McGarvey, R D. Meng, O Johnson, W El-Deiry, S B. Malkowic. Growth inhibitory effect of p21 and p53 containing adenoviruses on transitional cell carcinoma cell lines in vitro and in vivo. Urologic oncology. vol 6. issue 4. 2019-11-20. PMID:11418322. |
apoptosis was measured by dna fragmentation and bax expression. |
2019-11-20 |
2023-08-12 |
mouse |