| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xia Zhao, Chen Zhang, Mingqiang Hua, Ruiqing Wang, Chaoqin Zhong, Jie Yu, Fengjiao Han, Na He, Yanan Zhao, Guoqiang Liu, Ni Zheng, Chunyan Ji, Daoxin M. NLRP3 inflammasome activation plays a carcinogenic role through effector cytokine IL-18 in lymphoma. Oncotarget. vol 8. issue 65. 2019-11-20. PMID:29312552. |
nlrp3 inflammasome activation promoted lymphoma cells proliferation and inhibited apoptosis through up-regulation of c-myc and bcl-2, and down-regulation of tp53 and bax, and then reduced the anti-tumor effect of dexamethasone. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xin Jiang, Yaqiong Hong, Di Zhao, Xinxin Meng, Lijing Zhao, Yanwei Du, Zan Wang, Yan Zheng, Lu Cai, Hongyu Jian. Low dose radiation prevents doxorubicin-induced cardiotoxicity. Oncotarget. vol 9. issue 1. 2019-11-20. PMID:29416617. |
pretreatment of dox-treated mice with ldr also decreased dox-induced cardiac cell apoptosis (tunel staining and cleaved caspase-3) and mitochondrial apoptotic pathway (increased p53, bax, and caspase-9 expression and decreased bcl2 expression and ΔΨm dissipation). |
2019-11-20 |
2023-08-13 |
mouse |
| Luciene Cristina Gastalho Campos, João Carlos Ribeiro-Silva, Alessandra Santos Menegon, Valerio Garrone Barauna, Ayumi Aurea Miyakawa, Jose Eduardo Kriege. Cyclic stretch-induced Crp3 sensitizes vascular smooth muscle cells to apoptosis during vein arterialization remodeling. Clinical science (London, England : 1979). 2019-11-20. PMID:29437853. |
immunoblotting analysis indicated that ceramide stretch-induced apoptosis in smc is accompanied by a decrease in the phosphorylation status of both fak and akt, leading to an increase in bax expression and caspase-3 cleavage. |
2019-11-20 |
2023-08-13 |
human |
| Keigo Okada, Ayako Nogami, Shinya Ishida, Hiroki Akiyama, Cheng Chen, Yoshihiro Umezawa, Osamu Miur. FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway. Oncotarget. vol 9. issue 10. 2019-11-20. PMID:29507660. |
the specific pan-pim kinase inhibitor azd1208 as well as pim447 in combination with the pi3k inhibitor gdc-0941 or the akt inhibitor mk-2206 cooperatively downregulated the mtorc1/4ebp1 pathway, formation of the eif4e/eif4g complex, and mcl-1 expression leading to activation of bak and bax to induce caspase-dependent apoptosis synergistically in these cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Matharage Gayani Dilshara, Rajapaksha Gedara Prasad Tharanga Jayasooriya, Ilandarage Menu Neelaka Molagoda, Jin-Woo Jeong, Seungheon Lee, Sang Rul Park, Gi-Young Kim, Yung Hyun Cho. Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca Oncotarget. vol 9. issue 12. 2019-11-20. PMID:29535810. |
combined treatment with silibinin and trail (silibinin/trail) induced apoptosis accompanied by the activation of caspase-3, caspase-8, caspase-9, and bax, and cytosolic accumulation of cytochrome c. anti-apoptotic proteins such as bcl-2, iap-1, and iap-2 were inhibited as well. |
2019-11-20 |
2023-08-13 |
Not clear |
| Haolong Cong, Ning Du, Yang Yang, Lei Song, Wenliang Zhang, Po Tie. Correction for Cong et al., "Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax". Journal of virology. vol 92. issue 7. 2019-11-20. PMID:29540561. |
correction for cong et al., "enterovirus 71 2b induces cell apoptosis by directly inducing the conformational activation of the proapoptotic protein bax". |
2019-11-20 |
2023-08-13 |
Not clear |
| Debasish Maiti, Ashish Kumar Singha, Chaitali Sarkar, Soham Sarkar, Indrajit Sil Sarma, Kuntal Manna, Biswanath Dind. Friedelane, isolated from Pouzolzia indica Gaud. exhibits toxic effect against melanoma. Cytotechnology. vol 70. issue 4. 2019-11-20. PMID:29582201. |
caspase-3, caspase-9, cyt-c, bad and bax protein were assayed to evidence the apoptosis induction. |
2019-11-20 |
2023-08-13 |
mouse |
| G Sun, X Wang, T Li, S Qu, J Su. Taurine attenuates acrylamide-induced apoptosis via a PI3K/AKT-dependent manner. Human & experimental toxicology. 2019-11-20. PMID:29607694. |
tau attenuated apoptosis caused by acr through observing terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel)-positive cells, measure of protein expression of bcl-2, bax, and caspase 3 activity. |
2019-11-20 |
2023-08-13 |
rat |
| Adriana Harbuzariu, Ruben Rene Gonzalez-Pere. Leptin-Notch axis impairs 5-fluorouracil effects on pancreatic cancer. Oncotarget. vol 9. issue 26. 2019-11-20. PMID:29719602. |
in addition, leptin reduced the 5-fu effects on apoptosis by decreasing pro-apoptotic (bax, caspase-3 activation and parp degradation) and increasing anti-apoptotic factors (rip and bcl-xl). |
2019-11-20 |
2023-08-13 |
Not clear |
| Francesca Punzo, Iolanda Manzo, Chiara Tortora, Elvira Pota, Velia D' Angelo, Giulia Bellini, Alessandra Di Paola, Federica Verace, Fiorina Casale, Francesca Ross. Effects of CB2 and TRPV1 receptors' stimulation in pediatric acute T-lymphoblastic leukemia. Oncotarget. vol 9. issue 30. 2019-11-20. PMID:29765535. |
we analyzed the effect on apoptosis and cell cycle progression by a cytofluorimetric assays and evaluated the expression level of several target genes (caspase 3, bax, bcl-2, akt, erk, pten, notch-1, cdk2, p53) involved in cell survival and apoptosis, by real-time pcr and western blotting. |
2019-11-20 |
2023-08-13 |
Not clear |
| Kaishu Zhang, Zhengyan Ge, Longlong Fu, Qi An, Fang Zhou, Ying Guo, Xiaowei Wang, Wenhong Lu, Xiaowei Liang, Shusong Wang, Xuejun Shang, Yiqun G. Qilin pills alleviate oligoasthenospermia by inhibiting Bax-caspase-9 apoptosis pathway in the testes of model rats. Oncotarget. vol 9. issue 31. 2019-11-20. PMID:29774101. |
the improvement function of qlps on sperm and testis works mainly by suppressing mitochondrial apoptosis in the testis via modulation of b cell lymphoma (bcl)-2, bcl-2-associated x protein (bax), cytochrome c, caspase-9 and caspase-3 expression. |
2019-11-20 |
2023-08-13 |
rat |
| Weiliang Feng, Chenlu Liang, Chen Wang, Xingfei Yu, Qinglin Li, Hongjian Yan. Knockdown of ribosomal protein S15A inhibits proliferation of breast cancer cells through induction of apoptosis in vitro. Cytotechnology. vol 70. issue 5. 2019-11-20. PMID:29802490. |
mechanism analysis revealed rps15a mediated apoptosis via activating of caspase-3 and parp cleavage, upregulating of bad and bax and downregulating of bcl-2. |
2019-11-20 |
2023-08-13 |
human |
| Gyeong-Ji Kim, Hyeon-Ju Jo, Kwon-Jai Lee, Jeong Woo Choi, Jeung Hee A. Oleanolic acid induces p53-dependent apoptosis Oncotarget. vol 9. issue 41. 2019-11-20. PMID:29899865. |
this enhanced apoptosis was due to increases in p53, cytochrome c, bax, parp-1 and caspase-3 expression in du145, mcf-7 and u87 cell lines. |
2019-11-20 |
2023-08-13 |
human |
| Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Keigo Okada, Ayako Nogami, Gaku Oshikawa, Toshikage Nagao, Osamu Miur. Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2. Oncotarget. vol 9. issue 42. 2019-11-20. PMID:29928488. |
however, inhibition of bcl-xl/bcl-2 by the bh3 mimetics abt-737 and navitoclax or bcl-xl by a-1331852 induced caspase-dependent apoptosis involving activation of bak and bax synergistically with ruxolitinib in hel cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Aya Maeda, Yuki Nishida, Marla Weetall, Liangxian Cao, Arthur Branstrom, Jo Ishizawa, Takenobu Nii, Wendy D Schober, Yoshiaki Abe, Kosei Matsue, Mariko Yoshimura, Shinya Kimura, Kensuke Kojim. Targeting of BMI-1 expression by the novel small molecule PTC596 in mantle cell lymphoma. Oncotarget. vol 9. issue 47. 2019-11-20. PMID:29983879. |
ptc596 induced mitochondrial apoptosis, as evidenced by loss of mitochondrial membrane potential, caspase-3 cleavage, bax activation, and phosphatidylserine externalization. |
2019-11-20 |
2023-08-13 |
Not clear |
| Li-Na Zhang, Hui Tian, Xiu-Li Zhou, Suo-Chen Tian, Xi-Hong Zhang, Tie-Jun W. Upregulation of microRNA-351 exerts protective effects during sepsis by ameliorating skeletal muscle wasting through the Tead-4-mediated blockade of the Hippo signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019-11-20. PMID:30040486. |
up-regulation of mir-351 reduced ai; 3-mh and tyr content; positive expression of tead-4 protein; the expression levels of p38-mapk, yap, tead-4, bax, and caspase-3; apoptosis; and inflammatory responses. |
2019-11-20 |
2023-08-13 |
mouse |
| Vincenzo De Iuliis, Antonio Marino, Marika Caruso, Sabrina Capodifoglio, Vincenzo Flati, Anna Marynuk, Valeria Marricareda, Sebastiano Ursi, Paola Lanuti, Claudio Talora, Pio Conti, Stefano Martinotti, Elena Toniat. Autophagy processes are dependent on EGF receptor signaling. Oncotarget. vol 9. issue 54. 2019-11-20. PMID:30100990. |
in addition, an extended binding of p-bcl2 either with beclin-1 or with bax was observed with a decreased activation of the stress-induced jnk kinase, thus avoiding the transduction pathways that activate autophagy and apoptosis, respectively. |
2019-11-20 |
2023-08-13 |
Not clear |
| Faming Deng, Qian Xu, Juan Long, Hongfu Xi. Suppressing ROS-TFE3-dependent autophagy enhances ivermectin-induced apoptosis in human melanoma cells. Journal of cellular biochemistry. 2019-11-20. PMID:30187952. |
here, ivermectin-induced apoptosis, as evidenced by the upregulation of cleaved poly (adp-ribose) polymerase, bax expression, and caspase-3 activity and downregulation of bcl-2 expression. |
2019-11-20 |
2023-08-13 |
human |
| Raghavendra Baregundi Subbarao, Seong-Ho Ok, Soo Hee Lee, Dawon Kang, Eun-Jin Kim, Ji-Yoon Kim, Ju-Tae Soh. Lipid Emulsion Inhibits the Late Apoptosis/Cardiotoxicity Induced by Doxorubicin in Rat Cardiomyoblasts. Cells. vol 7. issue 10. 2019-11-20. PMID:30241326. |
the effects of lipid emulsion on cell viability, bax, cleaved caspase-8, cleaved capase-3, bcl-xl, apoptosis, reactive oxygen species (ros), malondialdehyde, superoxide dismutase (sod), catalase and mitochondrial membrane potential induced by doxorubicin were examined. |
2019-11-20 |
2023-08-13 |
rat |
| D Cvejic, S Selemetjev, S Savin, I Paunovic, S Tati. Changes in the balance between proliferation and apoptosis during the progression of malignancy in thyroid tumours. European journal of histochemistry : EJH. vol 53. issue 2. 2019-11-20. PMID:30256874. |
the apoptosis related molecules (bcl-2, bax) and proliferation related marker (pcna) were analysed immunohistochemically in 120 archival cases comprising pmc (n=34), ptc (n=52) and atc (n=34). |
2019-11-20 |
2023-08-13 |
Not clear |