| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chathurika D B Gamage, So-Yeon Park, Yi Yang, Rui Zhou, İsa Taş, Woo Kyun Bae, Kyung Keun Kim, Jung-Hyun Shim, Eunae Kim, Goo Yoon, Hangun Ki. Deoxypodophyllotoxin Exerts Anti-Cancer Effects on Colorectal Cancer Cells Through Induction of Apoptosis and Suppression of Tumorigenesis. International journal of molecular sciences. vol 20. issue 11. 2019-11-12. PMID:31141929. |
specifically, the compound-induced mitotic arrest in crc cells by destabilizing microtubules and activating the mitochondrial apoptotic pathway via regulation of b-cell lymphoma 2 (bcl-2) family proteins (increasing bcl-2 associated x (bax) and decreasing b-cell lymphoma-extra-large (bcl-xl)) ultimately led to caspase-mediated apoptosis. |
2019-11-12 |
2023-08-13 |
human |
| Marzieh Marzbany, Anupam Bishayee, Mahsa Rasekhia. Increased expression of ZNF 703 in breast cancer tissue: An opportunity for RNAi-NSAID combinatorial therapy. Biotechnology and applied biochemistry. vol 66. issue 5. 2019-11-11. PMID:31195426. |
ibuprofen alone or in combination with anti-znf703 rna reduced the expression of znf703, induced apoptosis, reduced mitochondrial membrane potential, and elevated bax and lc3a in mcf-7 cells. |
2019-11-11 |
2023-08-13 |
human |
| Wondossen Sime, Qiankun Niu, Yasmin Abassi, Katarzyna Chmielarska Masoumi, Reihaneh Zarrizi, Julie Bonne Køhler, Sven Kjellström, Vito Alessandro Lasorsa, Mario Capasso, Haian Fu, Ramin Massoum. BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29686263. |
the association between bap1 and 14-3-3 protein releases the apoptotic inducer protein bax from 14-3-3 and promotes cell death through the intrinsic apoptosis pathway. |
2019-11-07 |
2023-08-13 |
Not clear |
| Ying Shen, Wenling Tu, Yunqiang Liu, Xiling Yang, Qiang Dong, Bo Yang, Jinyan Xu, Yuanlong Yan, Xue Pei, Mohan Liu, Wenming Xu, Yuan Yan. TSPY1 suppresses USP7-mediated p53 function and promotes spermatogonial proliferation. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29748603. |
we demonstrated that the promotion of p53 degradation by tspy1 influenced the activity of p53 target molecules (cdk1, p21, and bax) to expedite the g2/m phase transition and decrease cell apoptosis, accelerating cell proliferation. |
2019-11-07 |
2023-08-13 |
mouse |
| Yang He, Lingyun Zhou, Zhiqiang Fan, Shikun Liu, Weijin Fan. Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N‑acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29752433. |
these effects were concomitant with blocked ers and apoptosis, as evidenced by inactivation of phosphorylated inositol-requiring enzyme-1α (ire1α)/spliced x-box binding protein 1 (xbp1), phosphorylated protein kinase-like kinase (perk)/phosphorylated eukaryotic initiation factor 2α (eif2α) and glucose-regulated protein 78 (grp78)/activating transcription factor 6 (atf6α)/c/ebp homologous protein (chop) pathways, as well as suppressed bcl-2-associated x protein (bax)/b-cell lymphoma-2 (bcl-2) and cleaved caspase 3 expressions. |
2019-11-07 |
2023-08-13 |
rat |
| Di Wu, Yana Zhao, Shengnan Fu, Jianbo Zhang, Wenhang Wang, Zhexian Yan, Heng Guo, Anjun Li. Seleno-short-chain chitosan induces apoptosis in human breast cancer cells through mitochondrial apoptosis pathway in vitro. Cell cycle (Georgetown, Tex.). vol 17. issue 13. 2019-11-07. PMID:29895197. |
sscc up-regulated the expression of bax, down-regulated the expression of bcl-2, subsequently increased the release of cytochrome c from mitochondria to cytoplasm, and activated the cleavage of caspase-9 and -3, which finally induced apoptosis in mcf-7 and bt-20 cells in vitro. |
2019-11-07 |
2023-08-13 |
human |
| Mariza A Miranda, Arindam Mondal, Mandip Sachdeva, Hamilton Cabral, Youssef A A H Neto, Ikhlas Khan, Milton Groppo, James D McChesney, Jairo K Basto. Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro. Chemistry & biodiversity. vol 16. issue 10. 2019-11-06. PMID:31448497. |
down-regulation of bcl-2 and up-regulation pro-apoptotic bax and further depletion of the mitochondrial membrane potential (ΔΨm) indicates that mitochondria play a central role in the combination treatment inducing the mitochondrial signaling pathway of apoptosis in t24 cells. |
2019-11-06 |
2023-08-13 |
Not clear |
| Xi Jin, Tiantian Jia, Ruohan Liu, Shiwen X. The antagonistic effect of selenium on cadmium-induced apoptosis via PPAR-γ/PI3K/Akt pathway in chicken pancreas. Journal of hazardous materials. vol 357. 2019-11-05. PMID:29909169. |
our study revealed that cd could impact the pancreas function and induce the activation of bax and the overproduction of no via ppar-γ/pi3k/akt pathway to promote apoptosis in chicken pancreas. |
2019-11-05 |
2023-08-13 |
chicken |
| Hongge Li, Yingyu Mao, Michael Bouaziz, Honglian Yu, Xiuxia Qu, Fen Wang, Gen-Sheng Feng, Carrie Shawber, Xin Zhan. Lens differentiation is controlled by the balance between PDGF and FGF signaling. PLoS biology. vol 17. issue 2. 2019-11-05. PMID:30716082. |
activation of pi3k signaling not only prevents b-cell lymphoma 2 (bcl2)-associated x (bax)- and bcl2 antagonist/killer (bak)-mediated apoptosis but also promotes notch signaling to prevent premature cell differentiation. |
2019-11-05 |
2023-08-13 |
Not clear |
| David W Sant, Sushmita Mustafi, Christopher B Gustafson, Joshua Chen, Joyce M Slingerland, Gaofeng Wan. Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression. Scientific reports. vol 8. issue 1. 2019-11-04. PMID:29593282. |
furthermore, the apoptosis promoted by vitamin c was associated with bax and caspases activation, bcl-xl sequestration, and cytochrome c release. |
2019-11-04 |
2023-08-13 |
human |
| Liyin Li, Yanhua Qi, Xiaobo Ma, Guosheng Xiong, Lijun Wang, Cuixia Ba. TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K/Akt/mTOR signaling pathway. Cell biology international. vol 42. issue 9. 2019-11-04. PMID:29762880. |
moreover, loss of trim22 also promoted apoptosis through modulation of bcl-2, bax and active caspase 3 in k562 cell. |
2019-11-04 |
2023-08-13 |
human |
| Xiaomeng Xie, Kangdong Liu, Feifei Liu, Hanyong Chen, Xiangyu Wang, Xueyin Zu, Xiaoli Ma, Ting Wang, Qiong Wu, Yan Zheng, Ann M Bode, Zigang Dong, Dong Joon Ki. Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo. Cancer letters. vol 442. 2019-11-04. PMID:30391783. |
gossypetin caused g2 phase cell cycle arrest and induced intrinsic apoptosis by activating caspases 3 and 7 and increasing the expression of bax and cytochrome c. notably, gossypetin suppressed patient-derived esophageal xenograft tumor growth in an in vivo mouse model. |
2019-11-04 |
2023-08-13 |
mouse |
| Zofia E Madeja, Ewelina Warzych, Piotr Pawlak, Dorota Lechnia. Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications. vol 510. issue 3. 2019-11-04. PMID:30711254. |
a higher rate of apoptosis was observed in 2i blastocysts, but was not accompanied by changes in transcript content of genes controlling apoptosis (bax, bcl2, bak, bax/bcl2 ratio). |
2019-11-04 |
2023-08-13 |
cattle |
| Jian Zhang, Xiaolin Wang, Hui Liu, Zemin Li, Fan Chen, Hua Wang, Zhaomin Zheng, Jianru Wan. TNF-α enhances apoptosis by promoting chop expression in nucleus pulposus cells: role of the MAPK and NF-κB pathways. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 37. issue 3. 2019-10-31. PMID:30561076. |
pharmacological sirna knockdown of chop promoted bax, decreased bcl-2, and attenuated tnf-α-mediated cell apoptosis. |
2019-10-31 |
2023-08-13 |
rat |
| Jian Zhang, Xiaolin Wang, Hui Liu, Zemin Li, Fan Chen, Hua Wang, Zhaomin Zheng, Jianru Wan. TNF-α enhances apoptosis by promoting chop expression in nucleus pulposus cells: role of the MAPK and NF-κB pathways. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 37. issue 3. 2019-10-31. PMID:30561076. |
this change up-regulates the pro-apoptotic protein bax and down-regulates the anti-apoptosis protein bcl-2, inducing cell apoptosis. |
2019-10-31 |
2023-08-13 |
rat |
| Hong-Qiang Chen, Ji Zhao, Yan Li, Yu-Jing Huang, Dong-Jiao Chen, Li-Xiong He, Ling-Qiao Wang, Chuan-Fen Zheng, Jia Wang, Jia Cao, Wei-Qun Shu, Jin-Yi Liu, Wen-Bin Li. Epigenetic inactivation of LHX6 mediated microcystin-LR induced hepatocarcinogenesis via the Wnt/β-catenin and P53 signaling pathways. Environmental pollution (Barking, Essex : 1987). vol 252. issue Pt A. 2019-10-31. PMID:31151060. |
in addition, we found that up-regulation of p53 and bax resulted in apoptosis, and that down-regulation of ctnnb1 and mmp7 led to migration of mc-lr treated l02 cells. |
2019-10-31 |
2023-08-13 |
human |
| Heaji Lee, Yunsook Li. Tocotrienol-rich fraction supplementation reduces hyperglycemia-induced skeletal muscle damage through regulation of insulin signaling and oxidative stress in type 2 diabetic mice. The Journal of nutritional biochemistry. vol 57. 2019-10-29. PMID:29679925. |
these changes were in part mechanistically explained by reduced levels of skeletal muscle proteins related to oxidative stress (4-hydroxynonenal, protein carbonyls, nrf2 and ho-1), inflammation (nfkb, mcp-1, il-6 and tnf-α), and apoptosis (bax, bcl₂ and caspase-3) in diabetic mice. |
2019-10-29 |
2023-08-13 |
mouse |
| Lijun Hao, Qian Li, Xin Zhao, Yanli Li, Ce Zhan. A long noncoding RNA LOC103690121 promotes hippocampus neuronal apoptosis in streptozotocin-induced type 1 diabetes. Neuroscience letters. vol 703. 2019-10-29. PMID:30851305. |
western blot analysis showed that the expression profiles of apoptosis related proteins (cleaved-caspase-3, -8, -9, and bax) were in line with loc103690121 expression, while the profiles of bcl-2 and pi3k/akt signaling pathway was contrast to loc103690121 expression. |
2019-10-29 |
2023-08-13 |
rat |
| Anja Müller, Bernd Gillissen, Antje Richter, Anja Richter, Cindrilla Chumduri, Peter T Daniel, Christian W Schol. Pan-class I PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53. Cell death & disease. vol 9. issue 3. 2019-10-28. PMID:29515122. |
in bax and bak deficient b-nhl, which are resistant to bkm120-induced apoptosis, bkm120-induced mitotic catastrophe results in polyploidy. |
2019-10-28 |
2023-08-13 |
Not clear |
| Zhiyu Ma, Ying Zhang, Juan Su, Sheng Yang, Wenna Qiao, Xiang Li, Zhihai Lei, Ling Cheng, Na An, Wenshao Wang, Yanyan Feng, Jinlong Zhan. Effects of neuromedin B on steroidogenesis, cell proliferation and apoptosis in porcine Leydig cells. Journal of molecular endocrinology. vol 61. issue 1. 2019-10-28. PMID:29632025. |
in addition, specific doses of nmb promoted the proliferation of leydig cells and increased the expression of proliferating cell nuclear antigen and cyclin b1 proteins, while suppressing leydig cell apoptosis and decreasing bax and caspase-3 protein expression. |
2019-10-28 |
2023-08-13 |
Not clear |