| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Zhang, Xinxin Ma, Youhong Don. Effect of genistein on apoptosis of lung adenocarcinoma A549 cells and expression of apoptosis factors. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 23. issue 3. 2019-09-23. PMID:30003731. |
to investigate the effect of genistein (gen) on the apoptosis of lung adenocarcinoma cells and the expression of bcl-2 and bax, so as to screen effective antitumor drugs for the clinical treatment of lung adenocarcinoma. |
2019-09-23 |
2023-08-13 |
Not clear |
| Dong-Mei Wu, Yu-Tong Zhang, Jun Lu, Yuan-Lin Zhen. Effects of microRNA-129 and its target gene c-Fos on proliferation and apoptosis of hippocampal neurons in rats with epilepsy via the MAPK signaling pathway. Journal of cellular physiology. vol 233. issue 9. 2019-09-20. PMID:29194604. |
compared with the normal group, the other six groups showed a decreased mir-129 expression; increased expression of expression of c-fos, bax, and mapk; decreased proliferation; accelerated apoptosis; more cells arrested in the g1 phase; and fewer cells arrested in the s phase. |
2019-09-20 |
2023-08-13 |
rat |
| Dong-Mei Wu, Yu-Tong Zhang, Jun Lu, Yuan-Lin Zhen. Effects of microRNA-129 and its target gene c-Fos on proliferation and apoptosis of hippocampal neurons in rats with epilepsy via the MAPK signaling pathway. Journal of cellular physiology. vol 233. issue 9. 2019-09-20. PMID:29194604. |
compared with the blank and nc groups, the mir-129 mimic group and the sirna-c-fos group showed decreased expression of c-fos, bax, and mapk, increased cells proliferation, and decreased cell apoptosis, fewer cells arrested in the g1 phase and more cells arrested in the s phase. |
2019-09-20 |
2023-08-13 |
rat |
| Dong-Mei Wu, Yong-Jian Wang, Xin-Rui Han, Xin Wen, Shan Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu, Yuan-Lin Zhen. LncRNA LINC00880 promotes cell proliferation, migration, and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. Journal of cellular physiology. vol 233. issue 9. 2019-09-20. PMID:29215699. |
compared with the blank group, linc00880 expression was higher in the linc00880 vector and linc00880 vector + cacng5 vector groups, and lower in the si-linc00880 and si-linc00880 + si-cacng5 groups; in the linc00880 vector and si-cacng5 groups, expression of survivin, p38mapk, erk1/2, jnk1/2/3 increased and cacng5 and bax expression reduced, the proliferation, invasion and migration of tumor cells increased, and apoptosis rate decreased. |
2019-09-20 |
2023-08-13 |
Not clear |
| Krzysztof Pietruczuk, Katarzyna A Lisowska, Karol Grabowski, Jerzy Landowski, Jacek M Witkowsk. Proliferation and apoptosis of T lymphocytes in patients with bipolar disorder. Scientific reports. vol 8. issue 1. 2019-09-19. PMID:29463875. |
lymphocytes of bd patients are also more prone to apoptosis compared with healthy individuals which is related to high expression of bax, a pro-apoptotic protein. |
2019-09-19 |
2023-08-13 |
Not clear |
| Sadia Afrin, Francesca Giampieri, Tamara Y Forbes-Hernández, Massimiliano Gasparrini, Adolfo Amici, Danila Cianciosi, Josè L Quiles, Maurizio Battin. Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. Free radical biology & medicine. vol 126. 2019-09-19. PMID:30056083. |
compared to 5-fu alone, mh synergistically enhanced the chemotherapeutic effects of 5-fu, by reducing cell proliferation through the suppression of egfr, her2, p-akt and p-mtor expression, and promoting apoptosis by the modulation pro-apoptotic (p53, bax, cyto c, fasl caspase-3, -8, -9 and cleave-parp) and anti-apoptotic (bcl-2) markers. |
2019-09-19 |
2023-08-13 |
human |
| Pingan Wu, Xiaochi Chen, Inam-U-Llah, Xiaoxia Shi, Mengren Zhang, Kaixin Li, Raheel Suleman, Muhammad Shahbaz, Shahid Alam, Fengyuan Pia. Taurine Ameliorates High Glucose Induced Apoptosis in HT-22 Cells. Advances in experimental medicine and biology. vol 1155. 2019-09-19. PMID:31468455. |
this indicated that taurine may reduce apoptosis by controlling balance of bcl-2 and bax. |
2019-09-19 |
2023-08-13 |
Not clear |
| Pingan Wu, Xiaochi Chen, Inam-U-Llah, Xiaoxia Shi, Mengren Zhang, Kaixin Li, Raheel Suleman, Muhammad Shahbaz, Shahid Alam, Fengyuan Pia. Taurine Ameliorates High Glucose Induced Apoptosis in HT-22 Cells. Advances in experimental medicine and biology. vol 1155. 2019-09-19. PMID:31468455. |
thus, it was clear that taurine reduces apoptosis via akt/bad pathway in ht-22 cells exposed to hg which further improves downstream balance of bcl-2 and bax. |
2019-09-19 |
2023-08-13 |
Not clear |
| C Perrini, P Esposti, F Cremonesi, A Lange Consigli. Secretome derived from different cell lines in bovine embryo production in vitro. Reproduction, fertility, and development. vol 30. issue 4. 2019-09-18. PMID:28982475. |
at day 7, these data were confirmed by rt-qpcr evaluation of genes (bcl-2-associated x protein (bax) and glutathione peroxidase 1 (gpx1) involved in apoptosis and protection against reactive oxygen species. |
2019-09-18 |
2023-08-13 |
cattle |
| Adeline Y Robin, Sweta Iyer, Richard W Birkinshaw, Jarrod Sandow, Ahmad Wardak, Cindy S Luo, Melissa Shi, Andrew I Webb, Peter E Czabotar, Ruth M Kluck, Peter M Colma. Ensemble Properties of Bax Determine Its Function. Structure (London, England : 1993). vol 26. issue 10. 2019-09-18. PMID:30122452. |
bax and bak are essential mediators of intrinsic apoptosis that permeabilize the mitochondrial outer membrane. |
2019-09-18 |
2023-08-13 |
Not clear |
| Manar A Nader, Hayam Ateyya, Mohamed El-Shafey, Nagla A El-Sherbeen. Sitagliptin enhances the neuroprotective effect of pregabalin against pentylenetetrazole-induced acute epileptogenesis in mice: Implication of oxidative, inflammatory, apoptotic and autophagy pathways. Neurochemistry international. vol 115. 2019-09-17. PMID:29032011. |
also, markers for inflammation, autophagy and apoptosis were measured, nuclear factor erythroid-derived 2- like 2 (nrf2), nuclear factor kappa-b (nf-κb), phosphatidylethanolamine-conjugated form of microtubule-associated protein light chain-3 (lc3-ii), casapase-3, bcl-2-like protein 4 (bax) and glucagon like peptide-1 (glp-1) activity. |
2019-09-17 |
2023-08-13 |
mouse |
| Kazem Zibara, Asad Zeidan, Khalil Mallah, Nouhad Kassem, Ali Awad, Frédéric Mazurier, Bassam Badran, Nabil El-Zei. Signaling pathways activated by PACAP in MCF-7 breast cancer cells. Cellular signalling. vol 50. 2019-09-17. PMID:29935235. |
finally, pacap stimulation promoted apoptosis by increasing bax and decreasing bcl2 expression. |
2019-09-17 |
2023-08-13 |
human |
| Jie Li, Bing Xu, Zhi Chen, Chanjuan Zhou, Li Liao, Yinghua Qin, Chuangchuang Yang, Xiaodong Zhang, Zicheng Hu, Lin Sun, Dan Zhu, Peng Xi. PI3K/AKT/JNK/p38 signalling pathway-mediated neural apoptosis in the prefrontal cortex of mice is involved in the antidepressant-like effect of pioglitazone. Clinical and experimental pharmacology & physiology. vol 45. issue 6. 2019-09-16. PMID:29359338. |
additionally, neural apoptosis, and the expression of apoptosis-related (cleaved caspase-3, bax, bcl-2, cyt c) and signalling proteins (akt, jnk, p38) were assessed in the prefrontal cortex (pfc) of these mice. |
2019-09-16 |
2023-08-13 |
mouse |
| Li Zhang, Handong Wang, Yali Zhou, Yihao Zhu, Maoxin Fe. Fisetin alleviates oxidative stress after traumatic brain injury via the Nrf2-ARE pathway. Neurochemistry international. vol 118. 2019-09-16. PMID:29792955. |
furthermore, administration of fisetin suppressed neuron cell death and apoptosis, increased the expression of b-cell lymphoma 2 (bcl-2), while decreased the expression of bcl-2-associated x protein (bax) and caspase-3 after tbi. |
2019-09-16 |
2023-08-13 |
mouse |
| Ali Khames, Marwa M Khalaf, Amany M Gad, Ola M Abd El-Raouf, Mohamed Ahmed Kandei. Nicorandil combats doxorubicin-induced nephrotoxicity via amendment of TLR4/P38 MAPK/NFκ-B signaling pathway. Chemico-biological interactions. vol 311. 2019-09-16. PMID:31376360. |
nephrotoxicity was assessed by biochemical tests through measuring kidney function biomarkers such as [serum levels of urea, creatinine, albumin and total protein] besides renal kidney injury molecule-1 (kim-1) and cystatin c], oxidative stress parameters such as [renal tissue malondialdehyde (mda), reduced glutathione (gsh), sod, catalase and nrf-2], mediators of inflammation such as [toll like receptor 4 (tlr-4), nuclear factor kappa-light-chain-enhancer of activated b cells (nf-kb), p38 mapk, interleukin 1 beta (il-1 β), and tumor necrosis factor alpha (tnf-α)] and markers of apoptosis [bax and bcl-2 in renal tissue]. |
2019-09-16 |
2023-08-13 |
rat |
| Ali Khames, Marwa M Khalaf, Amany M Gad, Ola M Abd El-Raouf, Mohamed Ahmed Kandei. Nicorandil combats doxorubicin-induced nephrotoxicity via amendment of TLR4/P38 MAPK/NFκ-B signaling pathway. Chemico-biological interactions. vol 311. 2019-09-16. PMID:31376360. |
nicorandil pretreatment resulted in a significant decrease in nephrotoxicity biomarkers, oxidative stress markers, inflammatory mediators and prevented apoptosis through decreasing bax and increasing bcl-2 in renal tissues. |
2019-09-16 |
2023-08-13 |
rat |
| Ye Tian, Si-Xun Jia, Jie Shi, Guan-Yu Gong, Jia-Wen Yu, Yan Niu, Chen-Meng Yang, Xiao-Chi Ma, Mei-Yun Fan. Polyphyllin I induces apoptosis and autophagy via modulating JNK and mTOR pathways in human acute myeloid leukemia cells. Chemico-biological interactions. vol 311. 2019-09-16. PMID:31421117. |
ppi induced apoptosis via activating jnk pathway, as evidenced by the decreased bcl-2 levels and increased bax, cleaved-caspase-3 and phosphorylated-jnk expressions. |
2019-09-16 |
2023-08-13 |
human |
| Y Gao, H Zhu, Q Ma. Effects of neuroblastoma breakpoint family member 1 (NBPF1) gene on growth and Akt-p53-Cyclin D pathway in cutaneous squamous carcinoma cells. Neoplasma. vol 66. issue 4. 2019-09-12. PMID:31058534. |
overexpression of nbpf1 not only arrested a431 cells in g1 phase and promoted apoptosis, but also up-regulated the expressions of bax and p53 mrna and protein and down-regulated the expressions of bcl-2, survivin and cyclin d1. |
2019-09-12 |
2023-08-13 |
Not clear |
| A V Sirotkin, A Ben O, A Tandlmajerová, M Lauková, D Vaší Ek, J Laurin Ik, J Kornhauser, S Alwasel, A H Harrat. cAMP response element-binding protein 1 controls porcine ovarian cell proliferation, apoptosis, and FSH and insulin-like growth factor 1 response. Reproduction, fertility, and development. vol 30. issue 8. 2019-09-11. PMID:29448973. |
levels of total and phosphorylated (p-) creb1, proliferating cell nuclear antigen (pcna), a marker of proliferation, and bax, a marker of apoptosis, were evaluated by western immunoblotting and immunocytochemical analysis. |
2019-09-11 |
2023-08-13 |
Not clear |
| Qing Li, Huachong Ma, Shuya Sun, Liying Sh. Anticancer effect of inactivated Sendai virus strain Tianjin on human osteosarcoma HOS cells. General physiology and biophysics. vol 38. issue 4. 2019-09-11. PMID:31219428. |
uv-tianjin-induced apoptosis was mediated by the mitochondrial pathway, which was confirmed by mitochondrial dysfunction, downregulation of b-cell lymphoma 2 (bcl-2), b-cell lymphoma-xl (bcl-xl) and myeloid cell leukemia-1 (mcl-1), upregulation of b-cell lymphoma 2 associated x protein (bax) and bcl-2 homologous antagonist/killer (bak), as well as the cleavage of caspase-9 and -3. |
2019-09-11 |
2023-08-13 |
human |