| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Mai, M Luo, J J Wu, J H Yang, L Y Hon. The combination therapy of HIF1α inhibitor LW6 and cisplatin plays an effective role on anti-tumor function in A549 cells. Neoplasma. vol 66. issue 5. 2019-08-27. PMID:31169018. |
moreover, the expression of apoptosis related protein (bcl-2, bax) and drug resistance related proteins (mdr1, mrp1) were measured by western blotting. |
2019-08-27 |
2023-08-13 |
human |
| Zhenzhen Jia, Hongyu Wang, Zeyang Feng, Shaozhi Zhang, Lining Wang, Jingwen Zhang, Qianqian Liu, Xin Zhao, Daofu Feng, Xizeng Fen. Fluorene-9-bisphenol exposure induces cytotoxicity in mouse oocytes and causes ovarian damage. Ecotoxicology and environmental safety. vol 180. 2019-08-26. PMID:31082581. |
in addition, in vivo experiments showed that bhpf exposure could induce the expression of oxidative stress genes (cat, gpx 3 and sod 2) and apoptosis genes (bax, bcl-2 and cleaved-caspase 3) and increase the number of atresia follicles in the ovaries. |
2019-08-26 |
2023-08-13 |
mouse |
| Tingting Zhang, Mengmeng Zhang, Xiaoling Fang, Fufan Zhu, Xiaomeng Xia, Xi Wang, Sixue Wan. [Effect of adipose-derived mesenchymal stem cell transplantation on cyclophosphamide-induced ovarian damage in rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 7. 2019-08-23. PMID:31413210. |
comparing with the group a, the expressions of bmp-15 and bcl-2 were increased (all p<0.01), the expressions of bax was decreased (both p<0.01), and the apoptosis rates of follicular cells were decreased in the group b and c (both p<0.01). |
2019-08-23 |
2023-08-13 |
rat |
| N Chernoff, D J Hill, I Chorus, D L Diggs, H Huang, D King, J R Lang, T-T Le, J E Schmid, G S Travlos, E M Whitley, R E Wilson, C R Woo. Cylindrospermopsin toxicity in mice following a 90-d oral exposure. Journal of toxicology and environmental health. Part A. vol 81. issue 13. 2019-08-22. PMID:29693504. |
a series of genes were differentially expressed including bax (apoptosis), rpl6 (tissue regeneration), fabp4 (fatty acid metabolism), and proc (blood coagulation). |
2019-08-22 |
2023-08-13 |
mouse |
| Chuanbo He, Shujun Cao, Zichuan Tong, Wenbin Wang, Yin Zhang, Changlei Gu. Trimetazidine ameliorates myocardial ischemia-reperfusion injury. Pakistan journal of pharmaceutical sciences. vol 31. issue 4(Special). 2019-08-22. PMID:30203764. |
trimetazidine can ameliorate rat myocardium following ischemia-reperfusion injury by effectively attenuating the injury from myocardial cell apoptosis; meanwhile, it can resist cell apoptosis through regulating bax and bcl-2 expression, which exhibits guiding significance for the treatment of myocardial ischemia and reperfusion. |
2019-08-22 |
2023-08-13 |
rat |
| Jun Zhou, Jiying Zhong, Zhenxing Huang, Meijuan Liao, Sen Lin, Jia Chen, Hongtao Che. TAK1 mediates apoptosis via p38 involve in ischemia-induced renal fibrosis. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup1. 2019-08-20. PMID:29661023. |
furthermore, inhibition of tak1 reduced p38 phosphorylation, decreased expression of bax and caspase 3 and apoptosis cells in kidneys of mice treated with ir-induced aki. |
2019-08-20 |
2023-08-13 |
mouse |
| Yei-Chen Lai, Chieh-Chin Li, Tai-Ching Sung, Chia-Wei Chang, Yu-Jing Lan, Yun-Wei Chian. The role of cardiolipin in promoting the membrane pore-forming activity of BAX oligomers. Biochimica et biophysica acta. Biomembranes. vol 1861. issue 1. 2019-08-20. PMID:29958826. |
bcl-2-associated x (bax) protein acts as a gatekeeper in regulating mitochondria-dependent apoptosis. |
2019-08-20 |
2023-08-13 |
Not clear |
| M Kajta, A Wnuk, J Rzemieniec, W Lason, M Mackowiak, E Chwastek, M Staniszewska, I Nehring, A K Wojtowic. Triclocarban Disrupts the Epigenetic Status of Neuronal Cells and Induces AHR/CAR-Mediated Apoptosis. Molecular neurobiology. vol 56. issue 5. 2019-08-20. PMID:30097849. |
this study demonstrated that triclocarban that was used at environmentally relevant concentrations induced apoptosis in mouse embryonic neurons, inhibited sumoylation, and changed the epigenetic status, as evidenced by impaired activities of hdac, sirtuins, and dnmt, global dna hypomethylation, and alterations of methylation levels of bax, bcl2, ahr, and car genes. |
2019-08-20 |
2023-08-13 |
mouse |
| Patrice N Wagner, Qiong Shi, Christi T Salisbury-Ruf, Jing Zou, Michael R Savona, Yuri Fedoriw, Sandra S Zinke. Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice. Blood. vol 133. issue 2. 2019-08-20. PMID:30413413. |
deletion of the proapoptotic bcl-2 family members bax and bak inhibits bone marrow apoptosis. |
2019-08-20 |
2023-08-13 |
mouse |
| Min Zhao, Xiao Wan Li, De Z Chen, Fang Hao, Shu X Tao, Hai Yan Yu, Rui Cheng, Hong Li. Neuro-Protective Role of Metformin in Patients with Acute Stroke and Type 2 Diabetes Mellitus via AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Pathway and Oxidative Stress. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-08-20. PMID:30905926. |
cell viability, cell apoptosis rate, and the expression of bax, bcl-2, ampk, pampk and mtor were detected; mda content and sod activity were also detected. |
2019-08-20 |
2023-08-13 |
rat |
| Pei-Bin Lin, Juan Shen, Pei-Yu Ou, Ling-Yan Liu, Zhi-Yu Chen, Fu-Jiang Chu, Jie Wang, Xiao-Bao Ji. Prodigiosin isolated from Serratia marcescens in the Periplaneta americana gut and its apoptosis‑inducing activity in HeLa cells. Oncology reports. vol 41. issue 6. 2019-08-20. PMID:30942457. |
flow cytometry (fcm) was utilized to measure the apoptotic rate with annexin v staining and the expression levels of proteins involved in apoptosis, including b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x (bax) and caspase‑3 were determined by western blot analysis and reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr). |
2019-08-20 |
2023-08-13 |
Not clear |
| Pei-Bin Lin, Juan Shen, Pei-Yu Ou, Ling-Yan Liu, Zhi-Yu Chen, Fu-Jiang Chu, Jie Wang, Xiao-Bao Ji. Prodigiosin isolated from Serratia marcescens in the Periplaneta americana gut and its apoptosis‑inducing activity in HeLa cells. Oncology reports. vol 41. issue 6. 2019-08-20. PMID:30942457. |
therefore, the results of the present study demonstrated that the prodigiosin could induce apoptosis in hela cells, which may be associated with the upregulation of bax and caspase‑3, the concomitant downregulation of bcl‑2 levels and also triggering the extrinsic apoptotic signaling pathway. |
2019-08-20 |
2023-08-13 |
Not clear |
| Xiang Li, Baoyue Zhang, Ning Li, Xiuna Ji, Kechun Liu, Meng Ji. Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level. Chemosphere. vol 231. 2019-08-19. PMID:31132538. |
herein, we reported that exposure to pb at environmentally relevant concentration level (1 μg/l, 10 μg/l and 100 μg/l), disturbed the courtship behavior of adult male zebrafish and further altered the transcriptional patterns of key genes involved in testicular steroidogenesis (igf3, amh, piwil1, lhcgr, fshr, cyp11c1, star, cyp19a1a, cyp19a1b) and apoptosis (bax, cytoc, caspase 9, caspase 3, puma). |
2019-08-19 |
2023-08-13 |
human |
| Sarathbabu Subbarayan, Selvi Subramanian, Nachimuthu Senthil Kuma. Recombinant Pierisin-5 Induces Apoptosis and Differential Expression of Bcl-2, Bax, and p53 in Human Cancer Cells. DNA and cell biology. vol 38. issue 8. 2019-08-19. PMID:31339741. |
recombinant pierisin-5 induces apoptosis and differential expression of bcl-2, bax, and p53 in human cancer cells. |
2019-08-19 |
2023-08-13 |
human |
| Yi Luo, Hongxia Qin, Lin Zhao, Long Jin, Anan Jiang, Xuewei Li, Mingzhou Li, Xun Wan. Report-Ouabain inhibits RAW264.7 cells proliferation and induces apoptosis via Bcl-2 and bax expression. Pakistan journal of pharmaceutical sciences. vol 31. issue 5. 2019-08-16. PMID:30150200. |
report-ouabain inhibits raw264.7 cells proliferation and induces apoptosis via bcl-2 and bax expression. |
2019-08-16 |
2023-08-13 |
Not clear |
| Y N Hua, J L Song, Z L Ma, L Wu, Z Zhang, L Zhang, N Li, S B Cong, L Ho. Effect of RRS1 gene knockdown on BT549 cell line proliferation and apoptosis in breast cancer. Neoplasma. vol 66. issue 1. 2019-08-15. PMID:30509086. |
wb detected the expression of bcl-2 and bax genes related to apoptosis at the protein level, and mtt assay confirmed that rrs1 knockdown significantly decreased cell viability (p<0.05) and induced apoptosis which was rescued by shrna-rrs1 expression. |
2019-08-15 |
2023-08-13 |
Not clear |
| Y N Hua, J L Song, Z L Ma, L Wu, Z Zhang, L Zhang, N Li, S B Cong, L Ho. Effect of RRS1 gene knockdown on BT549 cell line proliferation and apoptosis in breast cancer. Neoplasma. vol 66. issue 1. 2019-08-15. PMID:30509086. |
the apoptotic cells amount analyzed by fcm was significantly increased and rrs1 knockdown also decreased the expression of apoptosis related protein bcl-2 and simultaneously increased the expression of bax (p<0.05). |
2019-08-15 |
2023-08-13 |
Not clear |
| Yudan Chen, Hong Zhou, Chao He, Ting Wang, Guiting Zhang, Peng Zhang, Ren Wang, Qianqian Wu, Yuye Ya. [The oxLDL/β2GPI/anti-β2GPI antibody complex induces apoptosis of human umbilical vein endothelial cells by promoting the production of reactive oxygen species]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 3. 2019-08-15. PMID:31030715. |
results the oxldl/β2gpi/aβ2gpiab complex significantly reduced the viability of huvecs, increased the expression of bax and cleaved caspase-3 protein, decreased the level of bcl2 protein, and promoted the apoptosis of huvecs. |
2019-08-15 |
2023-08-13 |
human |
| Alexander V Sirotkin, Juraj Petrak, Saleh Alwasel, Abdel Halim Harrat. Apoptosis signal-regulating kinase (ASK1) and transcription factor tumor suppressor protein TP53 suppress rabbit ovarian granulosa cell functions. Animal reproduction science. vol 204. 2019-08-14. PMID:30948244. |
the accumulation of ask1, the cytoplasmic apoptosis regulators bax and bcl2, and proliferating cell nuclear antigen (pcna, a cell proliferation marker), as well as progesterone release, were evaluated by quantitative immunocytochemistry and radioimmunoassay. |
2019-08-14 |
2023-08-13 |
rabbit |
| Yan Yuan, Jinlong Yang, Jie Chen, Shiwen Zhao, Tao Wang, Hui Zou, Yi Wang, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Li. Alpha-lipoic acid protects against cadmium-induced neuronal injury by inhibiting the endoplasmic reticulum stress eIF2α-ATF4 pathway in rat cortical neurons in vitro and in vivo. Toxicology. vol 414. 2019-08-13. PMID:30605698. |
furthermore, the er-stress inhibitor salubrinal blocked the dephosphorylation of eukaryotic translation initiation factor 2α (eif2α) and significantly reduced the induction of er stress marker chop, the increase of the b-cell lymphoma-2 associate x protein (bax)/b-cell lymphoma-2 (bcl-2) ratio, and apoptosis induced by cd. |
2019-08-13 |
2023-08-13 |
rat |