| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Imran Khan, Ashutosh Bahuguna, Manigandan Krishnan, Shruti Shukla, Hoomin Lee, Sang-Hyun Min, Dong Kyu Choi, Youngjin Cho, Vivek K Bajpai, Yun Suk Huh, Sun Chul Kan. The effect of biogenic manufactured silver nanoparticles on human endothelial cells and zebrafish model. The Science of the total environment. vol 679. 2019-08-13. PMID:31085416. |
as a result, ru-agnps potentiated the formation of reactive oxygen species (ros) in huvecs as confirmed by the results of immunoblotting analysis using apoptotic markers, such as bax, bcl2, and cytochrome c. moreover, the induction of apoptosis in huvecs was also authenticated in a dose-dependent manner after the treatment with ru-agnps by the incucyte analysis. |
2019-08-13 |
2023-08-13 |
human |
| Hongming Teng, Dayu Wang, Jiali Lu, Ying Zhou, Yue Pang, Qingwei L. Novel insights into the evolution of the caveolin superfamily and mechanisms of antiapoptotic effects and cell proliferation in lamprey. Developmental and comparative immunology. vol 95. 2019-08-12. PMID:30742851. |
the overexpression of pegfp-n1-l-caveolin-like led to the altered expression of factors related to apoptosis, such as decreased caspase-9, caspase-3, p53, and bax expression and increased bcl-2 expression. |
2019-08-12 |
2023-08-13 |
human |
| Wei Wei, Xiao-Bing Lan, Ning Liu, Jia-Mei Yang, Juan Du, Lin Ma, Wen-Jin Zhang, Jian-Guo Niu, Tao Sun, Jian-Qiang Y. Echinacoside Alleviates Hypoxic-Ischemic Brain Injury in Neonatal Rat by Enhancing Antioxidant Capacity and Inhibiting Apoptosis. Neurochemical research. vol 44. issue 7. 2019-08-12. PMID:30911982. |
tunel staining and western blot analysis was performed to respectively estimate the extent of brain cell apoptosis and the expression level of the apoptosis-related proteins caspase-3, bax, and bcl-2. |
2019-08-12 |
2023-08-13 |
rat |
| Matthew A Taylor, Firas Khathayer, Swapan K Ra. Quercetin and Sodium Butyrate Synergistically Increase Apoptosis in Rat C6 and Human T98G Glioblastoma Cells Through Inhibition of Autophagy. Neurochemical research. vol 44. issue 7. 2019-08-12. PMID:31011879. |
western blotting results showed that combination of qct and nab increased apoptosis by decreasing anti-apoptotic bcl-2 and increasing pro-apoptotic bax, decreasing survivin, activating caspase-3, and degrading poly (adp-ribose) polymerase (parp). |
2019-08-12 |
2023-08-13 |
human |
| Ahmed H Eid, Amany M Gad, Ebtehal Mohammad Fikry, Hany H Ara. Venlafaxine and carvedilol ameliorate testicular impairment and disrupted spermatogenesis in rheumatoid arthritis by targeting AMPK/ERK and PI3K/AKT/mTOR pathways. Toxicology and applied pharmacology. vol 364. 2019-08-08. PMID:30578887. |
with regard to apoptosis, the two agents lowered the protein expression of caspase-3, cleaved caspase-3, cleaved parp, bax and p53, promoting germ cell survival. |
2019-08-08 |
2023-08-13 |
rat |
| Guiqiang Miao, Xuehui Zang, Huige Hou, Hui Sun, Lihui Wang, Ting Zhang, Yongtao Tan, Wenzhou Liu, Pei Ye, Lihua Gao, Zhengang Zh. Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis. BioMed research international. vol 2019. 2019-08-07. PMID:30993110. |
bax targeted by mir-29a regulates chondrocyte apoptosis in osteoarthritis. |
2019-08-07 |
2023-08-13 |
human |
| Guiqiang Miao, Xuehui Zang, Huige Hou, Hui Sun, Lihui Wang, Ting Zhang, Yongtao Tan, Wenzhou Liu, Pei Ye, Lihua Gao, Zhengang Zh. Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis. BioMed research international. vol 2019. 2019-08-07. PMID:30993110. |
however, the regulation mechanisms of bax underlying chondrocyte apoptosis in oa remain unknown. |
2019-08-07 |
2023-08-13 |
human |
| Guiqiang Miao, Xuehui Zang, Huige Hou, Hui Sun, Lihui Wang, Ting Zhang, Yongtao Tan, Wenzhou Liu, Pei Ye, Lihua Gao, Zhengang Zh. Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis. BioMed research international. vol 2019. 2019-08-07. PMID:30993110. |
in the present study, we determined the role of bax in human oa and chondrocyte apoptosis. |
2019-08-07 |
2023-08-13 |
human |
| Pyone Myat Thu, Zu-Guo Zheng, Ya-Ping Zhou, Yan-Yan Wang, Xin Zhang, Dan Jing, Hui-Min Cheng, Ji Li, Ping Li, Xiaojun X. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. European journal of pharmacology. vol 850. 2019-08-06. PMID:30716311. |
pc treatment caused increased bax and decreased bcl-2 expression, along with the activation of cleaved caspase-3, 7, 9 and cleaved-parp, thus induced mitochondrial apoptosis. |
2019-08-06 |
2023-08-13 |
Not clear |
| Fei Xu, Yingchun Song, Ai Gu. Anti-Apoptotic Effects of Docosahexaenoic Acid in IL-1β-Induced Human Chondrosarcoma Cell Death through Involvement of the MAPK Signaling Pathway. Cytogenetic and genome research. vol 158. issue 1. 2019-08-05. PMID:31261155. |
our results show that il-1β promotes the apoptosis of sw1353 cells, increases the expression of bax and cleaved caspase-3, and activates the mapk signaling pathway. |
2019-08-05 |
2023-08-13 |
human |
| Zhongyang Xu, Kefeng Zhang, Qian Wang, Yanping Zhen. MicroRNA‑124 improves functional recovery and suppresses Bax‑dependent apoptosis in rats following spinal cord injury. Molecular medicine reports. vol 19. issue 4. 2019-08-01. PMID:30720072. |
luciferase reporter assay demonstrated that mir‑124 inhibited apoptosis regulator bax (bax) expression, a key molecule in the activation of the mitochondrial apoptotic pathway, by targeting its 3'‑untranslated region in bv‑2 cells. |
2019-08-01 |
2023-08-13 |
rat |
| Xiao-Hua Sun, Ming-Fen Song, Hai-Dong Song, Yu-Wen Wang, Ming-Jin Luo, Li-Ming Yi. miR‑155 mediates inflammatory injury of hippocampal neuronal cells via the activation of microglia. Molecular medicine reports. vol 19. issue 4. 2019-08-01. PMID:30720115. |
mir‑155‑treated microglia increased the apoptosis of neuronal hippocampal cells by modulating the expression levels of apoptosis regulator bax, apoptosis regulator bcl‑2, pro‑caspase‑3 and cleaved‑caspase‑3. |
2019-08-01 |
2023-08-13 |
Not clear |
| Yingying Hu, Xi Chen, Xina Li, Zhange Li, Hongtao Diao, Lu Liu, Jia Zhang, Jin Ju, Lin Wen, Xin Liu, Zhenwei Pan, Chaoqian Xu, Xin Hai, Yong Zhan. MicroRNA‑1 downregulation induced by carvedilol protects cardiomyocytes against apoptosis by targeting heat shock protein 60. Molecular medicine reports. vol 19. issue 5. 2019-08-01. PMID:30896796. |
the expression of heat shock protein 60 (hsp60), a direct target of mir‑1, was identified to be decreased in mi and h2o2‑induced apoptosis, which was associated with a decrease in bcl‑2 and an increase in bax; expression was restored following treatment with carvedilol. |
2019-08-01 |
2023-08-13 |
rat |
| Shanshan Zhu, Tao Wang, Fei Luo, Huawen Li, Qing Jia, Taiping He, Hongfu Wu, Tangbin Zo. Astaxanthin inhibits proliferation and induces apoptosis of LX‑2 cells by regulating the miR‑29b/Bcl‑2 pathway. Molecular medicine reports. vol 19. issue 5. 2019-08-01. PMID:30896849. |
rt‑qpcr and western blotting demonstrated that ast induced lx‑2 cells apoptosis which may be by regulating mir‑29b, as indicated by inhibited bcl‑2 expression levels and elevated bax and caspase‑3 expression levels. |
2019-08-01 |
2023-08-13 |
human |
| Dingyun Li, Tao Zhang, Jiajun Lai, Jian Zhang, Ting Wang, Yafei Ling, Shengquan He, Zhiwei H. MicroRNA‑25/ATXN3 interaction regulates human colon cancer cell growth and migration. Molecular medicine reports. vol 19. issue 5. 2019-08-01. PMID:30942397. |
cell viability and cell migration were analyzed using mtt and wound healing assays, respectively, apoptosis was analyzed using flow cytometry, and western blot analysis was conducted to determine the protein expression of ataxin‑3 (atxn3), apoptosis regulator bax (bax) and cyclin d1. |
2019-08-01 |
2023-08-13 |
human |
| Dingyun Li, Tao Zhang, Jiajun Lai, Jian Zhang, Ting Wang, Yafei Ling, Shengquan He, Zhiwei H. MicroRNA‑25/ATXN3 interaction regulates human colon cancer cell growth and migration. Molecular medicine reports. vol 19. issue 5. 2019-08-01. PMID:30942397. |
overexpression of mir‑25 increased cell viability and migration, decreased apoptosis, decreased caspase‑3/9 activity level in addition to decreased bax protein expression, and increased cyclin d1 protein expression in colon cancer cells. |
2019-08-01 |
2023-08-13 |
human |
| Lu Xu, Ling Ding, Yuanqi Su, Ruyue Shao, Jie Liu, Yan Huan. Neuroprotective effects of curcumin against rats with focal cerebral ischemia-reperfusion injury. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30816425. |
curcumin was demonstrated to improve nerve damage symptoms and infarct volume, reduce brain water content, relieve neuronal apoptosis and also increase the expression of p‑mek, p‑erk, p‑creb, bcl‑2 and reduce bax levels in vivo and in vitro. |
2019-07-30 |
2023-08-13 |
rat |
| Xiaoyuan Wang, Zhijian Li, Jie Bai, Wuqi Song, Fengmin Zhan. miR‑17‑5p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting phosphatase and tensin homolog. Molecular medicine reports. vol 19. issue 4. 2019-07-30. PMID:30816540. |
furthermore, transient overexpression of mir‑17‑5p induced a significant increase in the proliferation and a significant decrease in the apoptosis of htmcs by affecting the expression of pten, and the apoptosis‑related proteins b‑cell lymphoma‑associated x protein (bax), b‑cell lymphoma‑extra large (bcl‑xl) and b‑cell lymphoma‑2 (bcl‑2). |
2019-07-30 |
2023-08-13 |
human |
| Liang Zhang, Zhenyu Wang, Jie Zhang, Xiaomao Luo, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang, Dewen Ton. Porcine parvovirus infection impairs progesterone production in luteal cells through mitogen-activated protein kinases, p53, and mitochondria-mediated apoptosis. Biology of reproduction. vol 98. issue 4. 2019-07-29. PMID:29360968. |
using the p53-specific pharmacological inhibitor (pifithrin-α) and sirna could partially attenuate ppv-induced bax upregulation, caspase-3 activation, apoptosis, and the reduction of progesterone production in primary porcine slcs. |
2019-07-29 |
2023-08-13 |
Not clear |
| Alfiya G Iksanova, Raylya R Gabbasova, Tatyana V Kupriyanova, Almaz A Akhunzyanov, Michail V Pugachev, Ruzalia M Vafiva, Nikita V Shtyrlin, Konstantin V Balakin, Yurii G Shtyrli. In-vitro antitumor activity of new quaternary phosphonium salts, derivatives of 3-hydroxypyridine. Anti-cancer drugs. vol 29. issue 7. 2019-07-29. PMID:29738336. |
3-hydroxypyridine derivatives induced apoptosis by hyperexpression of bax and caspase-3, whereas 4-deoxypyridoxine derivative induced cell death partly by reactive oxygen species generation and caspase-3 hyperexpression. |
2019-07-29 |
2023-08-13 |
Not clear |