| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junjun Liang, Nina Liu, Haibin Xi. Knockdown long non-coding RNA PEG10 inhibits proliferation, migration and invasion of glioma cell line U251 by regulating miR-506. General physiology and biophysics. vol 38. issue 4. 2019-09-11. PMID:31241046. |
the cell proliferation and apoptosis related p16, p53, bcl-2, bax, and pro-/cleaved-caspase-3/9, migration and invasion related-protein: matrix metalloproteinases mmp-2, mmp-9 and vimentin, and raf/mek/erk and jak1/stat3 pathways-related proteins were accessed by western blot. |
2019-09-11 |
2023-08-13 |
human |
| James N Tsoporis, Anastasia Fazio, Ioannis K Rizos, Shehla Izhar, Gerald Proteau, Vasileos Salpeas, Angelos Rigopoulos, Eleftherios Sakadakis, Ioannis K Toumpoulis, Thomas G Parke. Increased right atrial appendage apoptosis is associated with differential regulation of candidate MicroRNAs 1 and 133A in patients who developed atrial fibrillation after cardiac surgery. Journal of molecular and cellular cardiology. vol 121. 2019-09-10. PMID:29885959. |
we examined the levels of the muscle-specific mirs 1 and 133a and markers of apoptosis including tunel staining, caspase-3 activation, bcl2 and bax mrnas in right atrial appendage (raa) biopsies and blood plasma taken before aortic cross-clamping and after reperfusion. |
2019-09-10 |
2023-08-13 |
rat |
| Haiyan Wen, Siqi Zhou, Jinchun Son. Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells. Biochemical and biophysical research communications. vol 508. issue 4. 2019-09-10. PMID:30573364. |
further analyses suggested that magnolol-induced apoptosis was related to the abnormal expression of p53, bax, bcl-2, cytochrome c and caspase activation. |
2019-09-10 |
2023-08-13 |
human |
| Trey Farmer, Katelyn L O'Neill, Naava Naslavsky, Xu Luo, Steve Capla. Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane. Molecular biology of the cell. vol 30. issue 10. 2019-09-10. PMID:30840537. |
in addition, retromer-depleted cells displayed more rapid bax activation and apoptosis. |
2019-09-10 |
2023-08-13 |
Not clear |
| Guoqing Luo, Jingjing Zhou, Guanjie Li, Ningdong Hu, Xu Xia, Haibo Zho. Ferruginol Diterpenoid Selectively Inhibits Human Thyroid Cancer Growth by Inducing Mitochondrial Dependent Apoptosis, Endogenous Reactive Oxygen Species (ROS) Production, Mitochondrial Membrane Potential Loss and Suppression of Mitogen-Activated Protein Kinase (MAPK) and PI3K/AKT Signaling Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:31005958. |
the anticancer effects of ferruginol were likely due to the induction of apoptosis which was also associated with upregulation of bax and downregulation of bcl-2. |
2019-09-10 |
2023-08-13 |
human |
| Xiaoli Shi, Jinmiao Zha, Bei Wen, Shuzhen Zhan. Diastereoisomer-specific neurotoxicity of hexabromocyclododecane in human SH-SY5Y neuroblastoma cells. The Science of the total environment. vol 686. 2019-09-10. PMID:31200309. |
the expression levels of several cell apoptosis-related genes and proteins, including bax, caspase-3, caspase-9, cytochrome c, bcl-2, and x-linked inhibitor of apoptosis (xiap), as well as the cell cycle arrest, dna damage, adenosine triphosphate (atp) consumption, reactive oxygen species (ros) levels, and intracellular calcium ion (ca |
2019-09-10 |
2023-08-13 |
human |
| Jingjing Wang, Mengmeng Li, Wei Zhang, Aixin Gu, Jiawen Dong, Jianping Li, Anshan Sha. Protective Effect of N-Acetylcysteine against Oxidative Stress Induced by Zearalenone via Mitochondrial Apoptosis Pathway in SIEC02 Cells. Toxins. vol 10. issue 10. 2019-09-09. PMID:30304829. |
moreover, these activities increased apoptosis and mitochondrial membrane potential (ΔΨm), and regulated the messenger rna (mrna) expression of bax, bcl-2, caspase-3, caspase-9, and cytochrome c (cyto c). |
2019-09-09 |
2023-08-13 |
Not clear |
| Yonggang Wang, Fangshi Hao, Yonghao Nan, Licheng Qu, Wanli Na, Chunshu Jia, Xiaoliang Che. PKM2 Inhibitor Shikonin Overcomes the Cisplatin Resistance in Bladder Cancer by Inducing Necroptosis. International journal of biological sciences. vol 14. issue 13. 2019-09-09. PMID:30443191. |
we further investigate the underlying mechanism, and found that the dysregulation of bcl-2 family proteins, including bcl-2, puma, bax, play an important role in deciding that shikonin kills the bc cells by necroptosis or apoptosis. |
2019-09-09 |
2023-08-13 |
Not clear |
| Yonggang Wang, Fangshi Hao, Yonghao Nan, Licheng Qu, Wanli Na, Chunshu Jia, Xiaoliang Che. PKM2 Inhibitor Shikonin Overcomes the Cisplatin Resistance in Bladder Cancer by Inducing Necroptosis. International journal of biological sciences. vol 14. issue 13. 2019-09-09. PMID:30443191. |
collectively, our results suggested that inducing necroptosis is an alternative way to overcome the apoptosis resistant in bc therapy, and orchestrating the regulation of bcl-2, puma, and bax in bc cisplatin resistant cells may improve the therapy effect of cisplatin in bc tumor. |
2019-09-09 |
2023-08-13 |
Not clear |
| Bo Zhu, Yongzhe Li, Tao Hu, Yan Zhan. The hepatoprotective effect of polysaccharides from Pleurotus ostreatus on carbon tetrachloride-induced acute liver injury rats. International journal of biological macromolecules. vol 131. 2019-09-09. PMID:30851331. |
tunel and immunohistochemistry analyses showed that tunel apoptosis cell rate and bax, cytochrome c, caspase-3, caspase-9, and apoptosis-inducing factor expression levels were obviously decreased, whereas bcl-2 expression levels obviously increased after pop treatment. |
2019-09-09 |
2023-08-13 |
rat |
| Wencheng Xu, Xiaoqin Wang, Yuanchao Tu, Hiroshi Masaki, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hiran. Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells. Chemico-biological interactions. vol 310. 2019-09-09. PMID:31255635. |
as the important markers of apoptosis, p53 and bax were both upregulated by the treatment of tet and cep. |
2019-09-09 |
2023-08-13 |
human |
| Stephanie Bleicken, Tufa E Assafa, Carolin Stegmueller, Alice Wittig, Ana J Garcia-Saez, Enrica Bordigno. Topology of active, membrane-embedded Bax in the context of a toroidal pore. Cell death and differentiation. vol 25. issue 10. 2019-09-06. PMID:30185826. |
bax is a bcl-2 protein critical for apoptosis induction. |
2019-09-06 |
2023-08-13 |
Not clear |
| Stephanie Bleicken, Tufa E Assafa, Carolin Stegmueller, Alice Wittig, Ana J Garcia-Saez, Enrica Bordigno. Topology of active, membrane-embedded Bax in the context of a toroidal pore. Cell death and differentiation. vol 25. issue 10. 2019-09-06. PMID:30185826. |
in healthy cells, bax is mostly a monomeric, cytosolic protein, while upon apoptosis initiation it inserts into the outer mitochondrial membrane, oligomerizes, and forms pores that release proapoptotic factors like cytochrome c into the cytosol. |
2019-09-06 |
2023-08-13 |
Not clear |
| Aneta Štochmal'ová, Abdel Halim Harrath, Saleh Alwasel, Alexander V Sirotki. Direct inhibitory effect of flaxseed on porcine ovarian granulosa cell functions. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 44. issue 5. 2019-09-05. PMID:30286297. |
first, we examined the effect of flaxseed extract on the accumulation of proliferation (pcna) and apoptosis (bax) markers and on leptin release in cultured porcine ovarian granulosa cells. |
2019-09-05 |
2023-08-13 |
Not clear |
| Fatihah N Othman, Sangu Muthuraju, Siti Suraiya M Noor, Sarimah Abdullah, Abdul Aziz Mohd Yusoff, John Tharakan, Shalini Bhaskar, Mohd Shah Mahmood, Fauziah Kassim, Hanip Rafia, Mohd Saffari Mohd Haspani, Azmi Alias, Rogelio H Pando, Jafri M Abdullah, Hasnan Jaafa. Human tuberculosis brain promotes neuronal apoptosis but not in astrocytes with high expression of vascular endothelial growth factor. Tuberculosis (Edinburgh, Scotland). vol 112. 2019-09-03. PMID:30205968. |
the neurons expressed strong bax expression in the infected brain tissues compared to the control tissues (p < 0.001), which indicated more apoptosis in neurons. |
2019-09-03 |
2023-08-13 |
human |
| Alexander V Sirotkin, Sandra Hrabovszká, Aneta Štochmaľová, Roland Grossmann, Saleh Alwasel, Abdel Halim Harrat. Effect of quercetin on ovarian cells of pigs and cattle. Animal reproduction science. vol 205. 2019-09-03. PMID:30981564. |
proliferation (pcna) and apoptosis (bax) markers and release of progesterone (p4), testosterone (t), estradiol (e2), and igf-i were quantified using quantitative immunocytochemistry, enzyme immunoassay, or radioimmunoassay. |
2019-09-03 |
2023-08-13 |
cattle |
| Yingying Shi, Luping Wang, Pijun Yu, Yi Liu, Wei Che. MicroRNA‑486‑5p inhibits the growth of human hypertrophic scar fibroblasts by regulating Smad2 expression. Molecular medicine reports. vol 19. issue 6. 2019-09-03. PMID:31059039. |
furthermore, the expression of cyclin‑dependent kinase (cdk)2, cdk4 and apoptosis regulator bcl‑2 was repressed, while apoptosis regulator bax expression was enhanced by mir‑486‑5p mimic transfection. |
2019-09-03 |
2023-08-13 |
human |
| Jorge R de Sousa, Raimunda S S Azevedo, Arnaldo J Martins Filho, Marialva T F Araujo, Ermelinda R C Moutinho, Barbara C Baldez Vasconcelos, Ana C R Cruz, Consuelo S Oliveira, Lívia C Martins, Beatriz H Baldez Vasconcelos, Livia M N Casseb, Jannifer O Chiang, Juarez A S Quaresma, Pedro F C Vasconcelo. Correlation between Apoptosis and in Situ Immune Response in Fatal Cases of Microcephaly Caused by Zika Virus. The American journal of pathology. vol 188. issue 11. 2019-08-30. PMID:30121258. |
the expression of various apoptosis markers in the neural parenchyma, including fasl, fas, bax, bcl2, and caspase 3 differed between zikv-positive cases and controls. |
2019-08-30 |
2023-08-13 |
Not clear |
| Mohammed A El-Magd, Yasser Mohamed, Eman S El-Shetry, Shafika A Elsayed, Maha Abo Gazia, Ghada A Abdel-Aleem, Noha M Shafik, Walied S Abdo, Nabila I El-Desouki, Mohamed A Basyon. Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 114. 2019-08-29. PMID:30925457. |
the obtained data revealed that administration of mel before mscs treatment without preconditioning yielded a better ameliorative effect against den-induced hepatocellular carcinoma (hcc) as evidenced by: 1) reduced serum levels of alpha fetoprotein and gamma-glutamyl transferase; 2) decreased number and area of glutathione s-transferase placental positive foci; 3) induced apoptosis (as indicated by increased cleaved caspase-3 activity, upregulated expression of proapoptotic genes bax and caspase 3 and downregulated expression of anti-apoptotic genes bcl2, survivin); 4) decreased malondialdehyde level and increased activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes; and 5) reduced inflammation, angiogenesis and metastasis as indicated by downregulated expression of interleukin 1 beta, nuclear factor kappa b, vascular endothelial growth factor, and matrix metallopeptidase 9 genes and upregulated expression of metalloproteinase inhibitor 1 gene. |
2019-08-29 |
2023-08-13 |
rat |
| Cheng Tian, Meimei Wang, Shanshan Liu, Hang Ma, Kai He, Deqi Zhou, Yanlin Li, Xiaoli Ye, Xuegang L. A new glycoprotein SPG-8700 isolated from sweet potato with potential anti-cancer activity against colon cancer. Natural product research. vol 33. issue 16. 2019-08-27. PMID:29527942. |
further results indicated that spg-8700 promoted apoptosis in hct-116 cells through regulating the expression of bcl-2 and bax and had no effect on the growth of normal cells. |
2019-08-27 |
2023-08-13 |
Not clear |