| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Eun Park, Do-Hee Kim, Eunyoung Ha, Seung Mi Choi, Joon-Seok Choi, Kyung-Soo Chun, Sang Hoon Jo. Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3. Chemico-biological interactions. vol 312. 2019-10-07. PMID:31433961. |
treatment of a431 cells with tq-induced apoptosis, which was associated with the induction of p53 and bax, inhibition of mdm2, bcl-2, and bcl-xl expression, and activation of caspase-9, -7, and -3. |
2019-10-07 |
2023-08-13 |
mouse |
| Parisa Ghiasi, Saman Hosseinkhani, Hassan Ansari, Nasser Aghdami, Saeed Balalaei, Sara Pahlavan, Hossein Baharvan. Reversible permeabilization of the mitochondrial membrane promotes human cardiomyocyte differentiation from embryonic stem cells. Journal of cellular physiology. vol 234. issue 1. 2019-10-04. PMID:30071126. |
moreover, the use of apoptosis inhibitors (bcl2-associated x protein [bax] inhibitor and caspase-3/7 inhibitor) during differentiation impaired cardiomyocyte development, resulting in substantial downregulation of t, mesp1, nkx2.5, and α-mhc. |
2019-10-04 |
2023-08-13 |
human |
| Shuhu Zhou, Baojun Qiao, Xu Chu, Qingxia Kon. Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke. Journal of neuroimmunology. vol 323. 2019-10-03. PMID:30196826. |
water maze was measured; cell apoptosis was assessed by doing tunel assay and detecting the expression of p53, bax, and cleaved-caspase-3; autophagy were assessed by measuring the expression of lc3 and p62. |
2019-10-03 |
2023-08-13 |
rat |
| Anna V Sharikova, Elizabeth Quaye, Jun Yong Park, Maxwell C Maloney, Habben Desta, Ramkumar Thiyagarajan, Kenneth L Seldeen, Neil U Parikh, Parteet Sandhu, Alexander Khmaladze, Bruce R Troen, Stanley A Schwartz, Supriya D Mahaja. Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:29644532. |
meth treatment significantly increased avd, activated caspase 3/7, increased the gene expression levels of the pro- apoptosis proteins, apaf-1 and bax, and decreased mitochondrial dna content. |
2019-10-02 |
2023-08-13 |
human |
| Umamaheswari Natarajan, Thiagarajan Venkatesan, Vijayaraghavan Radhakrishnan, Shila Samuel, Appu Rathinavel. Differential Mechanisms of Cell Death Induced by HDAC Inhibitor SAHA and MDM2 Inhibitor RG7388 in MCF-7 Cells. Cells. vol 8. issue 1. 2019-10-01. PMID:30583560. |
on the other hand, the rg7388 treatment was able to induce apoptosis by elevating bax levels. |
2019-10-01 |
2023-08-13 |
Not clear |
| Xuefeng Wei, Hui Li, Guangwei Zhao, Jiameng Yang, Lihui Li, Yongzhen Huang, Xianyong Lan, Yun Ma, Linyong Hu, Huiling Zheng, Hong Che. ΔFosB regulates rosiglitazone-induced milk fat synthesis and cell survival. Journal of cellular physiology. vol 233. issue 12. 2019-09-30. PMID:29154466. |
Δfosb was found to promote the expression of bcl-2 and suppress the expression of bax, and protected gmec from apoptosis induced by rosiglitazone. |
2019-09-30 |
2023-08-13 |
Not clear |
| Vipin Mohan Dan, Balaji Muralikrishnan, Rahul Sanawar, Vinodh J S, Bhushan Bapusaheb Burkul, Kalanghad Puthankalam Srinivas, Asha Lekshmi, N S Pradeep, Syed G Dastager, B Santhakumari, Thankayyan R Santhoshkumar, R Ajay Kumar, Madhavan Radhakrishna Pilla. Streptomyces sp metabolite(s) promotes Bax mediated intrinsic apoptosis and autophagy involving inhibition of mTOR pathway in cervical cancer cell lines. Scientific reports. vol 8. issue 1. 2019-09-30. PMID:29434241. |
streptomyces sp metabolite(s) promotes bax mediated intrinsic apoptosis and autophagy involving inhibition of mtor pathway in cervical cancer cell lines. |
2019-09-30 |
2023-08-13 |
Not clear |
| Vipin Mohan Dan, Balaji Muralikrishnan, Rahul Sanawar, Vinodh J S, Bhushan Bapusaheb Burkul, Kalanghad Puthankalam Srinivas, Asha Lekshmi, N S Pradeep, Syed G Dastager, B Santhakumari, Thankayyan R Santhoshkumar, R Ajay Kumar, Madhavan Radhakrishna Pilla. Streptomyces sp metabolite(s) promotes Bax mediated intrinsic apoptosis and autophagy involving inhibition of mTOR pathway in cervical cancer cell lines. Scientific reports. vol 8. issue 1. 2019-09-30. PMID:29434241. |
the active fraction induced autophagy and bax mediated apoptosis suggesting that mtor inhibition resulted in programmed cell death of cancer cells. |
2019-09-30 |
2023-08-13 |
Not clear |
| Ning Ding, Chuan Liu, Li Yao, Yun Bai, Peng Cheng, Zhilin Li, Keyu Luo, Tieniu Mei, Jianhua Li, Junchao Xing, Xiaoliang Gao, Qinyu Ma, Jianzhong Xu, Fei Luo, Ce Do. Alendronate induces osteoclast precursor apoptosis via peroxisomal dysfunction mediated ER stress. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29600563. |
peroxisomal dysfunction further induced endoplasmic reticulum (er) stress in pocs and finally resulted in cell apoptosis marked by reduced expression of b-cell lymphoma 2 (bcl-2) and increased expressions of ccaat/enhancer binding protein homologous protein (chop), bcl2 associated x (bax), and cleaved caspase-3. |
2019-09-30 |
2023-08-13 |
mouse |
| Saba Shahin, Surya P Singh, Chandra M Chaturved. 1800 MHz mobile phone irradiation induced oxidative and nitrosative stress leads to p53 dependent Bax mediated testicular apoptosis in mice, Mus musculus. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29637556. |
1800 mhz mobile phone irradiation induced oxidative and nitrosative stress leads to p53 dependent bax mediated testicular apoptosis in mice, mus musculus. |
2019-09-30 |
2023-08-13 |
mouse |
| Ning Ren, Ming Wan. microRNA-212-induced protection of the heart against myocardial infarction occurs via the interplay between AQP9 and PI3K/Akt signaling pathway. Experimental cell research. vol 370. issue 2. 2019-09-30. PMID:30017933. |
the expression of mir-212, aqp9, pi3k, akt, vegf, bax, and b cell lymphoma 2 (bcl-2), along with cell apoptosis were determined using reverse transcription quantitative polymerase chain reaction (rt-qpcr), western blot analysis and flow cytometry. |
2019-09-30 |
2023-08-13 |
rat |
| Qing-Ling Zhou, Fei Teng, Yong-Shan Zhang, Qiang Sun, Yan-Xia Cao, Guo-Wei Men. FPR1 gene silencing suppresses cardiomyocyte apoptosis and ventricular remodeling in rats with ischemia/reperfusion injury through the inhibition of MAPK signaling pathway. Experimental cell research. vol 370. issue 2. 2019-09-30. PMID:30031130. |
frp1 gene silencing decreased cvf value, infarct area, apoptotic index, positive expression rates of fpr1 and mapk, decreased fpr1, p38, erk, jnk, mmp-2, timp-2, nf-kb, bax, p-p38, p-erk, and p-jnk levels, increased bcl-2 level, promoted cell proliferation and cell cycle progression, and inhibited cell apoptosis rate. |
2019-09-30 |
2023-08-13 |
rat |
| Joel S Riley, Giovanni Quarato, Catherine Cloix, Jonathan Lopez, Jim O'Prey, Matthew Pearson, James Chapman, Hiromi Sesaki, Leo M Carlin, João F Passos, Ann P Wheeler, Andrew Oberst, Kevin M Ryan, Stephen Wg Tai. Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. The EMBO journal. vol 37. issue 17. 2019-09-30. PMID:30049712. |
during apoptosis, pro-apoptotic bax and bak are activated, causing mitochondrial outer membrane permeabilisation (momp), caspase activation and cell death. |
2019-09-30 |
2023-08-13 |
Not clear |
| Tao Li, Weilin Xu, Liansheng Gao, Guoping Guan, Zhongyuan Zhang, Pingyou He, Hangzhe Xu, Linfeng Fan, Feng Yan, Gao Che. Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood-brain barrier integrity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 2. 2019-09-30. PMID:30211660. |
manf was mainly expressed in rat neurons, and its expression increased significantly at 3 h after sah induction and peaked at 24 h. stereotactic injection of rh-manf into the cerebroventricle significantly increased the level of manf, p-akt, p-mouse double minute 2 homolog (p-mdm2), and b-cell lymphoma 2 (bcl-2) in brain tissue, whereas it down-regulated the expression of p53, bcl-2-associated x protein (bax), and cleaved caspase-3, which indicated that neuronal apoptosis was remarkably suppressed. |
2019-09-30 |
2023-08-13 |
human |
| Yi-Xuan Li, Zi-He Ye, Tong Chen, Xiao-Feng Jia, Ling H. The effects of donepezil on phencyclidine-induced cognitive deficits in a mouse model of schizophrenia. Pharmacology, biochemistry, and behavior. vol 175. 2019-09-30. PMID:30218672. |
moreover, donepezil can also improve pcp-induced schizophrenia-like cognitive deficits by inhibiting neuronal apoptosis and regulating synaptic plasticity, which was possible through the up-regulation of p-akt, p-gsk-3β, bcl-2 and the down-regulation of bax, caspase-3. |
2019-09-30 |
2023-08-13 |
mouse |
| Jiabing Shen, Tingting Zhou, Haizhen Li, Wanyan Li, Shuyao Wang, Yan Song, Kaifu Ke, Maohong Ca. Cab45s inhibits neuronal apoptosis following intracerebral hemorrhage in adult rats. Brain research bulletin. vol 143. 2019-09-30. PMID:30266588. |
depletion of cab45s attenuated the expression of grp78, but increased the expressions of bax and caspase-3 in pc12 cells treated with hemin, which finally promoted apoptosis. |
2019-09-30 |
2023-08-13 |
rat |
| Shunji Gao, Yanyan Yu, Lu Liu, Jun Meng, Guifang L. Circular RNA hsa_circ_0007059 restrains proliferation and epithelial-mesenchymal transition in lung cancer cells via inhibiting microRNA-378. Life sciences. vol 233. 2019-09-30. PMID:31351967. |
after overexpressing hsa_circ_0007059, cell viability, apoptosis, p53/cyclind1, bax and pro/cleaved-caspase-3 and emt-correlative factors (e-cadherin, vimetin, twist1 and zeb1) were tested in a549 and h1975 cells. |
2019-09-30 |
2023-08-13 |
Not clear |
| Shunji Gao, Yanyan Yu, Lu Liu, Jun Meng, Guifang L. Circular RNA hsa_circ_0007059 restrains proliferation and epithelial-mesenchymal transition in lung cancer cells via inhibiting microRNA-378. Life sciences. vol 233. 2019-09-30. PMID:31351967. |
overexpressed hsa_circ_0007059 evidently restrained cell proliferation, elevated p53 and repressed cyclind1 expression, meanwhile triggered apoptosis and enhanced bax and cleaved-caspase-3 expression. |
2019-09-30 |
2023-08-13 |
Not clear |
| Jing-Kang Wang, Li-Chao Wang, Yong Jiang, Peng-Fei Tu, Ke-Wu Zen. [Neuroprotective effects and mechanism of ethanol extract of Cistanche tubulosa against oxygen-glucose deprivation/reperfusion]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 13. 2019-09-24. PMID:31359678. |
5,25,50 mg·l-1) by detecting cell viability with mtt assay,apoptosis with ao/eb and hoechst 33258,mitochondrial membrane potential changes with jc-1 staining,mitochondrial oxidative stress with mitosox staining,as well as the apoptosis-related protein expression( parp,cleaved parp,caspase-3,cleaved caspase-3,bax,bcl-2) with western blot. |
2019-09-24 |
2023-08-13 |
Not clear |
| Jing-Kang Wang, Li-Chao Wang, Yong Jiang, Peng-Fei Tu, Ke-Wu Zen. [Neuroprotective effects and mechanism of ethanol extract of Cistanche tubulosa against oxygen-glucose deprivation/reperfusion]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 13. 2019-09-24. PMID:31359678. |
meanwhile,ctee could obviously suppress the activation of key proteins in mitochondrial apoptosis pathway such as caspase-3 and parp,and significantly inhibit the rise of bax and down-regulation of bcl-2. |
2019-09-24 |
2023-08-13 |
Not clear |