| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Li, Huan-Huan Wang, Xin-Tian Nie, Wan-Ru Jiang, Yuan-Shu Zhan. Sodium butyrate ameliorates lipopolysaccharide-induced cow mammary epithelial cells from oxidative stress damage and apoptosis. Journal of cellular biochemistry. 2019-11-20. PMID:30259565. |
in addition, nab decreased apoptosis by inhibiting caspase-3, caspase-9, and bax protein levels, and this action was mainly achieved via activation of the pi3k/akt signaling pathways in lps-induced mac-t cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| He Li, Hongying Chen, Ruli Li, Juanjuan Xin, Sisi Wu, Jie Lan, Kunyue Xue, Xue Li, Caili Zuo, Wei Jiang, Ling Zh. Cucurbitacin I induces cancer cell death through the endoplasmic reticulum stress pathway. Journal of cellular biochemistry. 2019-11-20. PMID:30277611. |
we confirmed that cucurbitacin-i caused cell death and stirred excessive ers levels by activating inositol requiring enzyme 1α (ire1α) and protein kinase r-like endoplasmic reticulum kinase (perk), as well as perk downstream factors, including ire1α and c/ebp homologous protein, but not activating transcription factor 6 (atf6α) pathway, which was in parallel with the increased bax and caspase-12-dependent ers-associated apoptosis, autophagy and autophagy flux levels and caspase-independent nonapoptotic cell death. |
2019-11-20 |
2023-08-13 |
Not clear |
| Zhen Yang Cui, Eunbi Jo, Hyun Jin Jang, In-Hu Hwang, Kyung-Bok Lee, Hwa-Seung Yoo, Soo Jung Park, Mi-Kyung Jung, Yeon Wol Lee, Ik-Soon Jan. Modified Ginseng Extract Induces Apoptosis in HepG2 Cancer Cells by Blocking the CXCL8-Mediated Akt/Nuclear Factor-[Formula: see text]B Signaling Pathway. The American journal of Chinese medicine. 2019-11-20. PMID:30284465. |
moreover, mrgx negatively regulated the tnf-[formula: see text]-mediated i[formula: see text]b/nf-[formula: see text]b pathway to promote bax activation, resulting in caspase-3 activation and apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Zhen Yang Cui, Eunbi Jo, Hyun Jin Jang, In-Hu Hwang, Kyung-Bok Lee, Hwa-Seung Yoo, Soo Jung Park, Mi-Kyung Jung, Yeon Wol Lee, Ik-Soon Jan. Modified Ginseng Extract Induces Apoptosis in HepG2 Cancer Cells by Blocking the CXCL8-Mediated Akt/Nuclear Factor-[Formula: see text]B Signaling Pathway. The American journal of Chinese medicine. 2019-11-20. PMID:30284465. |
taken together, these results indicated that mrgx inhibited cxcl8-mediated akt/nf-[formula: see text]b signaling, which upregulated bax activation and consequently induced apoptosis in hepg2 cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xiaolin Wang, Teng Ma, Xiaojian Wan, Yan Meng, Zhenzhen Zhao, Jinjun Bian, Rui Bao, Xiaoming Deng, Tao Yan. IGFBP7 regulates sepsis-induced acute kidney injury through ERK1/2 signaling. Journal of cellular biochemistry. 2019-11-20. PMID:30450602. |
hk-2 cells with lps induction showed cell cycle arrest at g1-g0 phases and cell apoptosis and activated erk1/2 parallel with the changes in the proteins belonging to the erk1/2 pathway, including cyclin d1, p21, bax, and bcl-2, which were inhibited by the igfbp7 knockdown. |
2019-11-20 |
2023-08-13 |
mouse |
| Peiyuan Hao, Xueming Cao, Zhongyu Zhu, Chuanyu Gao, Yan Chen, Datun Q. Effects of miR-181a targeting XIAP gene on apoptosis of cardiomyocytes induced by hypoxia/reoxygenation and its mechanism. Journal of cellular biochemistry. 2019-11-20. PMID:30485521. |
the inhibitory effect of low expression of mir-181a on myocardial apoptosis could be reversed and the inhibitory effect of low expression of mir-181a on bax protein expression and the promotion of bcl-2 protein expression could be reversed by the downregulation of xiap. |
2019-11-20 |
2023-08-13 |
Not clear |
| Peiyuan Hao, Xueming Cao, Zhongyu Zhu, Chuanyu Gao, Yan Chen, Datun Q. Effects of miR-181a targeting XIAP gene on apoptosis of cardiomyocytes induced by hypoxia/reoxygenation and its mechanism. Journal of cellular biochemistry. 2019-11-20. PMID:30485521. |
mir-181a can inhibit the apoptosis of hypoxic-reoxygenated cardiomyocytes by targeting xiap to downregulate bax and upregulate bcl expression. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xiaonian Zhu, Li Gao, Chengmei Yan, Yonghua H. A novel role and mechanism of cystic fibrosis transmembrane conductance regulator in bisphenol A-induced prostate cancer. Journal of cellular biochemistry. 2019-11-20. PMID:30485539. |
in addition, ampkα kinase was found upregulated to promote cell apoptosis through increasing bax expression and decreasing bcl-2 expression. |
2019-11-20 |
2023-08-13 |
human |
| Tao Sun, Han Liu, Yutong Cheng, Lixiao Yan, Chayakrit Krittanawong, Shihong Li, Wang Qian, Wang Su, Xuanzu Chen, Xuejian Hou, Hongju Zhan. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside eliminates ischemia/reperfusion injury-induced H9c2 cardiomyocytes apoptosis involving in Bcl-2, Bax, caspase-3, and Akt activation. Journal of cellular biochemistry. 2019-11-20. PMID:30891810. |
2,3,5,4'-tetrahydroxystilbene-2-o-β-d-glucoside eliminates ischemia/reperfusion injury-induced h9c2 cardiomyocytes apoptosis involving in bcl-2, bax, caspase-3, and akt activation. |
2019-11-20 |
2023-08-13 |
Not clear |
| Phong Lu, Erica R Vander Mause, Katherine E Redd Bowman, Sarah M Brown, Lisa Ahne, Carol S Li. Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53. Journal of ovarian research. vol 12. issue 1. 2019-11-20. PMID:31092272. |
we have previously shown that fusing p53 (or its dna binding domain, dbd, alone) to the mitochondrial targeting signal (mts) from bak or bax can target p53 to the mitochondria and induce apoptosis in gynecological cancer cell lines including cervical cancer cells (hela; wt p53), ovarian cancer cells (skov-3; p53 267del non-expressing), and breast cancer cells (t47d; l194f p53 mutation). |
2019-11-20 |
2023-08-13 |
human |
| Yuan Zhang, Guangliang Shi, Jingzeng Cai, Jie Yang, Yingying Zheng, Dahai Yu, Qi Liu, Yafan Gong, Ziwei Zhan. Taxifolin alleviates apoptotic injury induced by DEHP exposure through cytochrome P450 homeostasis in chicken cardiomyocytes. Ecotoxicology and environmental safety. vol 183. 2019-11-19. PMID:31442803. |
the results showed that in the cardiomyocytes, dehp initiated apoptosis by increasing the expression of caspase-3, caspase-9, cyt c, and bax at both the mrna and protein levels and by decreasing the bcl-2 levels compared with that of the control group. |
2019-11-19 |
2023-08-13 |
cat |
| Dongxu Wang, Ruiwen Huo, Chuanjian Cui, Qiang Gao, Jianfa Zong, Yijun Wang, Yue Sun, Ruyan Ho. Anticancer activity and mechanism of total saponins from the residual seed cake of Camellia oleifera Abel. in hepatoma-22 tumor-bearing mice. Food & function. vol 10. issue 5. 2019-11-18. PMID:30977498. |
moreover, tssc promoted solid tumor cell apoptosis, upregulated the protein expression of bax, and downregulated the protein expression of bcl-2 in response to regulate apoptosis of cancer cells in mice bearing hepatoma 22 solid tumors. |
2019-11-18 |
2023-08-13 |
mouse |
| Y-M Ma, J-X Zheng, X Xu, Y-S Shan, Z-W Gao, W-G Che. Effects of recombinant activated coagulation factor VII on apoptosis and expressions of Bcl-2 and Bax in rats with intracerebral hemorrhage. European review for medical and pharmacological sciences. vol 22. issue 16. 2019-11-14. PMID:30178850. |
effects of recombinant activated coagulation factor vii on apoptosis and expressions of bcl-2 and bax in rats with intracerebral hemorrhage. |
2019-11-14 |
2023-08-13 |
rat |
| Y-M Ma, J-X Zheng, X Xu, Y-S Shan, Z-W Gao, W-G Che. Effects of recombinant activated coagulation factor VII on apoptosis and expressions of Bcl-2 and Bax in rats with intracerebral hemorrhage. European review for medical and pharmacological sciences. vol 22. issue 16. 2019-11-14. PMID:30178850. |
to investigate the effects of recombinant activated coagulation factor vii (rfviia) on apoptosis and the expressions of b-cell lymphoma 2 (bcl-2) and bcl-2-associated x protein (bax) in rats with intracerebral hemorrhage (ich). |
2019-11-14 |
2023-08-13 |
rat |
| Jingfei Chen, Juchang Zhong, Yeying Liu, Yuan Huang, Fei Luo, Yingjun Zhou, Xi Pan, Shousong Cao, Lingling Zhang, Yingjie Zhang, Jiangang Wan. Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA-dependent apoptosis in colorectal cancer. Cancer medicine. vol 7. issue 12. 2019-11-14. PMID:30402948. |
here, we demonstrated that vb1 promoted apoptosis via p53-dependent induction of p53 upregulated modulator of apoptosis (puma) and further to induce bax (bcl-2-associated x protein) activation and mitochondrial dysfunction in colon cancer hct-116 and lovo cells. |
2019-11-14 |
2023-08-13 |
Not clear |
| Jingfei Chen, Juchang Zhong, Yeying Liu, Yuan Huang, Fei Luo, Yingjun Zhou, Xi Pan, Shousong Cao, Lingling Zhang, Yingjie Zhang, Jiangang Wan. Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA-dependent apoptosis in colorectal cancer. Cancer medicine. vol 7. issue 12. 2019-11-14. PMID:30402948. |
deficiency in p53, puma, or bax abrogated vb1-induced apoptosis and promoted cell survival in hct-116 cells. |
2019-11-14 |
2023-08-13 |
Not clear |
| Xuhui Hou, Songbai Yang, Jian Yi. Blocking the REDD1/TXNIP axis ameliorates LPS-induced vascular endothelial cell injury through repressing oxidative stress and apoptosis. American journal of physiology. Cell physiology. vol 316. issue 1. 2019-11-14. PMID:30485138. |
meanwhile, depletion of redd1 effectively restricted lps-induced huvec apoptosis, as exemplified by reduced dna fragmentation, and it also elevated antiapoptotic bcl-2 protein, concomitant with reduced levels of proapoptotic proteins bax and cleaved caspase-3. |
2019-11-14 |
2023-08-13 |
human |
| Qi Liu, Jie Yang, Yafan Gong, Jingzeng Cai, Ziwei Zhan. Role of miR-731 and miR-2188-3p in mediating chlorpyrifos induced head kidney injury in common carp via targeting TLR and apoptosis pathways. Aquatic toxicology (Amsterdam, Netherlands). vol 215. 2019-11-14. PMID:31479757. |
during cpf exposure, mrna expression of tlr pathway genes and its downstream genes involved in autophagy and apoptosis pathway including tlr1, tlr2, tlr7, tlr9, myd88, irak1, irak4, irf7, pi3k, akt, mtor, caspase3, caspase8 and bax were differentially increased under cpf exposure, along with atg13 and bcl2 decreased at the same time. |
2019-11-14 |
2023-08-13 |
Not clear |
| Yuanyuan Chen, Fengxia Xue, Cha Han, Huiyun Yang, Lulu Han, Ke Li, Jie Li, Qian Xu, Zengyan Li, Bibo Yuan, Limin Yu, Xiaoli Gao, Ye Ya. Ferulic acid ameliorated placental inflammation and apoptosis in rat with preeclampsia. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 41. issue 6. 2019-11-12. PMID:30183401. |
fa also ameliorated placental apoptosis in l-name induced rats by increasing bcl-2 whereas decreasing bax expression in placenta. |
2019-11-12 |
2023-08-13 |
rat |
| Cheng-Yu Ye, Cui-Ping Zheng, Wei-Wei Ying, Shan-Shan Wen. Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1. Cell cycle (Georgetown, Tex.). vol 17. issue 24. 2019-11-12. PMID:30382763. |
retored mir-497 and si-raf-1 resulted in increases in the bax expression and cell apoptosis and decreases in the expressions of raf-1, mek-2, survivin, bcl-2, along with the extent of erk1/2 phosphorylation. |
2019-11-12 |
2023-08-13 |
human |