| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai-Feng Liu, Wei-Wen Liu, Dian-Chun Fang, Rong-Pu Me. Expression and significance of proapoptotic gene Bax in gastric carcinoma. World journal of gastroenterology. vol 5. issue 1. 2019-11-20. PMID:11819375. |
it was significantly higher in intestinal type and well or moderately differentiated gastric carcinoma than in diffuse type and poorly differentiated gastric carcinoma (p < 0.05 and p <0.01).conclusion:the proapoptotic gene bax is differently expressed in most of gastric carcinoma and may take part in the modulation of apoptosis in gastric carcinoma. |
2019-11-20 |
2023-08-12 |
human |
| Hong-Yu Xu, You-Lin Yang, Yuan-Yuan Gao, Qiao- Li Wu, Guang-Qiang Ga. Effect of arsenic trioxide on human hepatoma cell line BEL-7402 cultured in vitro. World journal of gastroenterology. vol 6. issue 5. 2019-11-20. PMID:11819674. |
arsenic trioxide treatment at 0.5&mgr;mol/l resulted in a higher expression level of bcl-2 and lower expression level of bax,which were 8.81% and 3.83% respectively, as compared with that of the control group (15.33%) (p(1)<0.01, p(2)<0.01).conclusion:arsenic trioxide not only inhibited proliferation but also induced apoptosis of human hepatoma cell line bel-7402. |
2019-11-20 |
2023-08-12 |
human |
| Wei-Dan Peng, Jie Zhang, Hong-Xiang Hui, Yan-Ming Xu, Feng Zhu, An-Gang Yang, Cheng-Ji Wan. Upregulation of bax Gene Expression Promotes Paclitaxel-induced Apoptosis in Esophageal Carcinoma Cells. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. vol 32. issue 4. 2019-11-20. PMID:12075422. |
upregulation of bax gene expression promotes paclitaxel-induced apoptosis in esophageal carcinoma cells. |
2019-11-20 |
2023-08-12 |
human |
| Wei-Dan Peng, Jie Zhang, Hong-Xiang Hui, Yan-Ming Xu, Feng Zhu, An-Gang Yang, Cheng-Ji Wan. Upregulation of bax Gene Expression Promotes Paclitaxel-induced Apoptosis in Esophageal Carcinoma Cells. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. vol 32. issue 4. 2019-11-20. PMID:12075422. |
these results implied that bax protein may play an important role in paclitaxel-induced apoptosis. |
2019-11-20 |
2023-08-12 |
human |
| Xiao-Ling Guo, Zuo-Ren Dong, Fu-Xu Wang, Xing-Yan Du, Feng-Ru Lin, Er-Gu Ya. [Clinic Significance of Expression of bcl-2 and bax Gene in Patients with Acute Leukemia and its Relationship with mdr-1 Gene Expression] Zhongguo shi yan xue ye xue za zhi. vol 9. issue 4. 2019-11-20. PMID:12578566. |
[clinic significance of expression of bcl-2 and bax gene in patients with acute leukemia and its relationship with mdr-1 gene expression] it is generally accepted that the inhibition of apoptosis is one of the mechanism of drug resistance to tumor. |
2019-11-20 |
2023-08-12 |
Not clear |
| Xuemin Zhang, Meiru Hu, Yu Lan, Ming Yu, Ben D-M Che. Cleavage of Bcl-2 Protein by Activated Caspase-3 Is Associated with Inactivation of Lyn(p53/56) Kinase Activity in Human M-07e Leukemic Cells during Apoptosis. Zhongguo shi yan xue ye xue za zhi. vol 8. issue 3. 2019-11-20. PMID:12578676. |
apoptosis of m-07e cells was accompanied with a massive cleavage of bcl-2 and bax proteins into shortened fragments with molecular mass of 22 kd and 18 kd, respectively. |
2019-11-20 |
2023-08-12 |
human |
| Xuemin Zhang, Meiru Hu, Yu Lan, Ming Yu, Ben D-M Che. Cleavage of Bcl-2 Protein by Activated Caspase-3 Is Associated with Inactivation of Lyn(p53/56) Kinase Activity in Human M-07e Leukemic Cells during Apoptosis. Zhongguo shi yan xue ye xue za zhi. vol 8. issue 3. 2019-11-20. PMID:12578676. |
tgf-beta 1 inhibited rhgm-csf-stimulated cell growth and promoted apoptosis in m-07e cells with a pattern identical to that induced by rhgm-csf depletion, which included massive cleavage of both bcl-2 and bax proteins and inactivation of lyn kinase activity. |
2019-11-20 |
2023-08-12 |
human |
| Xin Duan, Bingyang Ji, Kun Yu, Jinping Liu, Feilong Hei, Cun Lon. Acidic buffer or plus cyclosporine a postconditioning protects isolated rat hearts against ischemia-reperfusion injury. Perfusion. 2019-11-20. PMID:21310770. |
results: compared with the control group, acidic buffer or plus cyclosporine a post-conditioning significantly improved myocardial performance, decreased cytochrome c release into the cytosol, increased bcl-2 expression and decreased bax expression, decreased sensitivity of mptp-opening to [ca2+] and the rate of apoptosis after reperfusion. |
2019-11-20 |
2023-08-12 |
rat |
| Fang Huang, Jing Huang, Qing Lv, Yang Yang, Gang Wu, Caimin X. WITHDRAWN: Selenite induces apoptosis in colorectal cancer cells through interaction with thioredoxin reductase. BMB reports. 2019-11-20. PMID:24286309. |
moreover, we showed that trxr ablation sensitized apoptosis induced by selenite, and the synergistic effect was related to bax activation and mitochondrial apoptotic pathway. |
2019-11-20 |
2023-08-12 |
Not clear |
| Y Qu, X Zhang, R W. Knockdown of NF-κB p65 subunit expression suppresses growth of nude mouse lung tumor cell xenografts by activation of Bax apoptotic pathway. Neoplasma. vol 62. issue 1. 2019-11-20. PMID:25563365. |
knockdown of nf-κb p65 subunit expression significantly inhibited the growth of nude mouse lewis tumor cell xenografts by induction of tumor cell apoptosis and significantly up-regulation of pro-apoptotic protein bax expression. |
2019-11-20 |
2023-08-13 |
mouse |
| San-Qiang Li, Zhi-Hong Hu, Sha Zhu, Dong-Mei Wang, Hong-Mei Han, Hua-Jie L. The Effect of ADAM8 on the Proliferation and Apoptosis of Hepatocytes and Hepatoma Carcinoma Cells. Journal of biochemical and molecular toxicology. vol 29. issue 9. 2019-11-20. PMID:26293243. |
apoptosis experiment in vitro showed that recombinant adam8 did not induce or inhibit the expression of apoptosis-related factors bcl2, bax, and caspase3 in l02 cells, but significantly induced the expression of bcl2, inhibited the expression of bax and caspase3 in hepg2 cells. |
2019-11-20 |
2023-08-13 |
mouse |
| Shixiu Feng, Min Zhang, Jing Xu, Yinming H. Prisconnatanones A, a cytotoxic naphthoquinone from Prismatomeris connata, suppresses the proliferation of human laryngocarcinoma HEp-2 cells in vitro. Natural product research. vol 30. issue 24. 2019-11-20. PMID:26983581. |
and, western blot analysis revealed that the levels of the apoptosis protein, cleaved caspase-3, parp, p21 and bax protein increased, while the level of anti-apoptosis protein bcl-2 decreased.. |
2019-11-20 |
2023-08-13 |
human |
| Michinari Nakamura, Peiyong Zhai, Dominic P Del Re, Yasuhiro Maejima, Junichi Sadoshim. Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI insight. vol 1. issue 5. 2019-11-20. PMID:27218122. |
we have shown previously that, in cardiomyocytes, oxidative stress activates mst1 at mitochondria, where mst1 phosphorylates bcl-xl at ser14, inducing dissociation of bcl-xl from bax and thereby promoting apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| Y Sun, Z Wang, L Wang, L-Z Wang, C Zang, L-R Su. The Effect and Mechanisms of Proliferative Inhibition of Crocin on Human Leukaemia Jurkat Cells. The West Indian medical journal. vol 64. issue 5. 2019-11-20. PMID:27398676. |
by cell count, growth curve, mtt method for the detection of cell proliferation, annexin v/propidium iodide (pi) method for the apoptosis rates, and reverse transcription-polymerase chain reaction (rt-pcr) for bcl-2 and bax gene expression, the effect and mechanisms of proliferative inhibition of crocin on jurkat cells were further explored. |
2019-11-20 |
2023-08-13 |
human |
| Ming Zhang, Tiansheng Zheng, Min Zong, Dechao Kong, Xiang Li, Cheng Xue, Peng Fu, Jiahu Fan. Sustained static stress-induced chondrocyte apoptosis in the rat cervical vertebral growth plate and its signal transduction mechanisms. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie. vol 24. issue Suppl 1. 2019-11-20. PMID:27439006. |
a sustained static load of ≥0.2 mpa over at least 12 h was observed to induce chondrocyte apoptosis, up-regulation of bax and caspase-3 expression, and down-regulation of bcl-2 expression. |
2019-11-20 |
2023-08-13 |
rat |
| Stephanie Einsele-Scholz, Silke Malmsheimer, Katrin Bertram, Daniel Stehle, Janina Johänning, Marianne Manz, Peter T Daniel, Bernhard F Gillissen, Klaus Schulze-Osthoff, Frank Essman. Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak. Journal of cell science. vol 129. issue 15. 2019-11-20. PMID:27505430. |
bok is a genuine multi-bh-domain protein that triggers apoptosis in the absence of bax and bak. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jianfeng Wang, Yunze Xu, Yun Zou, Liangsong Zhu, Baijun Dong, Jiwei Huang, Yonghui Chen, Wei Xue, Yiran Huang, Wen Kong, Jin Zhan. Overexpression of cannabinoid receptor 1 promotes renal cell carcinoma progression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2019-11-20. PMID:27757850. |
am251 significantly decreased tumor cell proliferation and induced cell apoptosis by upregulating the expression of the pro-apoptotic protein bax and decreasing the expression of the anti-apoptotic proteins survivin and bcl-2. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jorge L Rosas-Triguero. The importance of evolutionarily conserved C-terminal basic residues for the stability of proapoptotic Bax protein. FEBS open bio. vol 6. issue 10. 2019-11-20. PMID:27761357. |
bax is a protein that promotes apoptosis (a form of cell death). |
2019-11-20 |
2023-08-13 |
human |
| Jorge L Rosas-Triguero. The importance of evolutionarily conserved C-terminal basic residues for the stability of proapoptotic Bax protein. FEBS open bio. vol 6. issue 10. 2019-11-20. PMID:27761357. |
the atomistic details of the mechanism by which bax is activated during apoptosis remain a subject of debate. |
2019-11-20 |
2023-08-13 |
human |
| Pianpian Chen, Yongmei Shen, Hongxue Shi, Xiuying Ma, Beibei Lin, Tong Xiao, Fenzan Wu, Jingjing Zhu, Zhengmao Li, Jian Xiao, Xiaokun Li, Hongyu Zhang, Funeng Gen. Gastroprotective effects of Kangfuxin-against ethanol-induced gastric ulcer via attenuating oxidative stress and ER stress in mice. Chemico-biological interactions. 2019-11-20. PMID:27983966. |
moreover, increased cell apoptosis and pro-apoptotic protein bax and caspase 3 were observed in ethanol treated mice, while the anti-apoptotic protein bcl 2 was inhibited. |
2019-11-20 |
2023-08-13 |
mouse |