| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jamal Mohammadian, Mehdi Sabzichi, Ommoleila Molavi, Dariush Shanehbandi, Nasser Samad. Combined Treatment with Stattic and Docetaxel Alters the Bax/Bcl-2 Gene Expression Ratio in Human Prostate Cancer Cells Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 11. 2019-11-20. PMID:28032735. |
our results suggest that combination of a stat3 inhibitorwith doctaxel can be considered as a potent strategy for induction of apoptosis via increasing bax mrna expression. |
2019-11-20 |
2023-08-13 |
human |
| Naser Jafari, Seyed Jalal Zargar, Narguess Yassa, Mohammad Reza Delnavaz. Induction of Apoptosis and Cell Cycle Arrest by Dorema Glabrum Root Extracts in a Gastric Adenocarcinoma (AGS) Cell Line Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 12. 2019-11-20. PMID:28124886. |
quantitative real-time polymerase chain reaction (qrt-pcr) amplificationwas performed with apoptosis and cell cycle-related gene primers, for cyclin d1, c-myc, survivin, vegf, bcl-2, bax,and caspase-3 to determine alteration of gene expression. |
2019-11-20 |
2023-08-13 |
mouse |
| Nathalia da Costa Pereira Soares, Clara Lima Machado, Bruno Boquimpani Trindade, Ingridy Celestino do Canto Lima, Etel Rodrigues Pereira Gimba, Anderson Junger Teodoro, Christina Takiya, Radovan Borojevi. Lycopene Extracts from Different Tomato-Based Food Products Induce Apoptosis in Cultured Human Primary Prostate Cancer Cells and Regulate TP53, Bax and Bcl-2 Transcript Expression Asian Pacific journal of cancer prevention : APJCP. vol 18. issue 2. 2019-11-20. PMID:28345329. |
lycopene extracts from different tomato-based food products induce apoptosis in cultured human primary prostate cancer cells and regulate tp53, bax and bcl-2 transcript expression carotenoids are the main tomato components, especially lycopene. |
2019-11-20 |
2023-08-13 |
human |
| Farzaneh Sadat Hosseini, Soudeh Khanamani Falahati-Pour, Mohammad Reza Hajizadeh, Alireza Khoshdel, Mohammad Reza Mirzaei, Hadis Ahmadirad, Reza Behroozi, Nesa Jafari, Mehdi Mahmood. Persian shallot, Allium hirtifolium Boiss, induced apoptosis in human hepatocellular carcinoma cells. Cytotechnology. vol 69. issue 4. 2019-11-20. PMID:28397098. |
to explore the underlying mechanism of cell growth inhibition of persian shallot, the activity of persian shallot in inducing apoptosis was investigated through the detection of annexin v signal by flow cytometry and expression of some apoptosis related genes such p21, p53, puma, caspase-8 family-bcl-2 proteins like bid, bim, bcl-2 and bax were measured by real-time pcr in hepg2 cells. |
2019-11-20 |
2023-08-13 |
human |
| Yana Zhao, Shaojing Zhang, Pengfei Wang, Shengnan Fu, Di Wu, Anjun Li. Seleno-short-chain chitosan induces apoptosis in human non-small-cell lung cancer A549 cells through ROS-mediated mitochondrial pathway. Cytotechnology. vol 69. issue 6. 2019-11-20. PMID:28421411. |
furthermore, real-time pcr and western blot assay showed that sscc up-regulated bax and down-regulated bcl-2, subsequently incited the release of cytochrome c from mitochondria to cytoplasm, activated the increase of cleaved-caspase 3 and finally induced a549 cells apoptosis in vitro. |
2019-11-20 |
2023-08-13 |
human |
| Nadir Kocak, Filiz Ozen, Ibrahim Halil Yildirim, Yagmur Dura. Fentanyl Inhibits Tumorigenesis from Human Breast Stem Cells by Inducing Apoptosis Asian Pacific journal of cancer prevention : APJCP. vol 18. issue 3. 2019-11-20. PMID:28441707. |
gene expression analysis was performed by quantitative real-time pcr assay for the oct4,sox2 and nanog genes as stem cell markers and bax, bcl2, and p53 genes as apoptosis markers. |
2019-11-20 |
2023-08-13 |
human |
| Pratiksha Jadaun, Dhananjay Yadav, Prakash Singh Bise. Spirulina platensis prevents high glucose-induced oxidative stress mitochondrial damage mediated apoptosis in cardiomyoblasts. Cytotechnology. vol 70. issue 2. 2019-11-20. PMID:28702859. |
spirulina extract (1 μg/ml), considerably inhibited increased ros and rns levels, reduction in cytochrome c release, raise in mitochondrial membrane potential, decreased the over expression of proapoptotic protein bax and suppressed the bax/bcl2 ratio with induced apoptosis without affecting cell viability. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ye Li, Xu Zhang, Jian Yang, Yi Zhang, Dongming Zhu, Lifeng Zhang, Yanbo Zhu, Dechun Li, Jian Zho. Methylation of BNIP3 in pancreatic cancer inhibits the induction of mitochondrial-mediated tumor cell apoptosis. Oncotarget. vol 8. issue 38. 2019-11-20. PMID:28968982. |
the expression of bnip3 correlated positively to the proapoptotic protein bax and negatively to the antiapoptotic protein bcl-2, whereas the induction of apoptosis by bnip3 was independent of caspase 3 and 9 activation. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ana P Pinto, Alisson L da Rocha, Luciana da C Oliveira, Gustavo P Morais, Larissa G de Vicente, Dennys E Cintra, José R Pauli, Leandro P Moura, Eduardo R Ropelle, Adelino S R da Silv. Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training. Frontiers in endocrinology. vol 8. 2019-11-20. PMID:29018408. |
as the disruption of endoplasmic reticulum (er) homeostasis is linked to animal models of fatty liver disease, we investigated the effects of these ot models on the proteins related to er stress (i.e., bip, inositol-requiring enzyme 1, protein kinase rna-like endoplasmic reticulum kinase, eif2alpha, atf6beta, and glucose-regulated protein 94) and apoptosis (c/ebp-homologous protein, caspase-3, 4, and 12, bax, and tumor necrosis factor receptor-associated factor 2) in livers of c57bl/6 mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Arni Amir, Yanwirasti, Asmarinah, Fadil Oenzi. Alteration Expression of Bax, Bcl-2 and VDAC1 Genes in Oligozoospermic and Fertile Subjects. Pakistan journal of biological sciences : PJBS. vol 19. issue 2. 2019-11-20. PMID:29023042. |
it was suggested that oligozoospermia may be occurred by inducing the increase of bax pro-apoptotic and vdac1 genes expression and decreasing of bcl-2 expression to lead the excessive of apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| Yu-Hao Zhao, Tie-Feng Ji, Qi Luo, Jin-Lu Y. Long non-coding RNA H19 induces hippocampal neuronal apoptosis Oncotarget. vol 8. issue 39. 2019-11-20. PMID:29029394. |
lncrna h19 over-expression also increased hippocampal neuronal apoptosis and expression of wnt3, β-catenin, tcf-1, bax, caspase-8 and caspase-3. |
2019-11-20 |
2023-08-13 |
rat |
| Chen Zhu, Yi Wang, Hua Liu, Haiman Mu, Yue Lu, Jiayi Zhang, Jianhua Huan. Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis. Oncotarget. vol 8. issue 48. 2019-11-20. PMID:29137383. |
the underlying mechanisms include increased phosphorylation of akt and erk by rg1, increased ratio of bcl-2 and bax, and decreased release of cytochrome c from mitochondria, thereby protecting the heart from doxorubicin-induced apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| Kunihiro Suzuki, Toyoshi Yanagihara, Tetsuya Yokoyama, Takashige Maeyama, Saiko Ogata-Suetsugu, Masako Arimura-Omori, Hironori Mikumo, Naoki Hamada, Eiji Harada, Kazuyoshi Kuwano, Taishi Harada, Yoichi Nakanish. Bax-inhibiting peptide attenuates bleomycin-induced lung injury in mice. Biology open. vol 6. issue 12. 2019-11-20. PMID:29138212. |
bax is a pro-apoptotic member of the bcl-2 family of proteins, and plays a central role in mitochondria-dependent apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| Kunihiro Suzuki, Toyoshi Yanagihara, Tetsuya Yokoyama, Takashige Maeyama, Saiko Ogata-Suetsugu, Masako Arimura-Omori, Hironori Mikumo, Naoki Hamada, Eiji Harada, Kazuyoshi Kuwano, Taishi Harada, Yoichi Nakanish. Bax-inhibiting peptide attenuates bleomycin-induced lung injury in mice. Biology open. vol 6. issue 12. 2019-11-20. PMID:29138212. |
several lines of evidence have implied that bax is involved in both epithelial apoptosis and fibroblast proliferation in idiopathic pulmonary fibrosis; however, the mechanisms remain unknown. |
2019-11-20 |
2023-08-13 |
mouse |
| Kunihiro Suzuki, Toyoshi Yanagihara, Tetsuya Yokoyama, Takashige Maeyama, Saiko Ogata-Suetsugu, Masako Arimura-Omori, Hironori Mikumo, Naoki Hamada, Eiji Harada, Kazuyoshi Kuwano, Taishi Harada, Yoichi Nakanish. Bax-inhibiting peptide attenuates bleomycin-induced lung injury in mice. Biology open. vol 6. issue 12. 2019-11-20. PMID:29138212. |
bip-v5 treatment decreased bleomycin-induced apoptosis of alveolar epithelial cell lines (a549 cells and la-4 cells) by suppressing bax activation. |
2019-11-20 |
2023-08-13 |
mouse |
| Xiaoshuang Tang, Jing Jia, Feng Li, Wei Liu, Chao Yang, Bin Jin, Qi Shi, Xinyang Wang, Dalin He, Peng Gu. Salen-Mn compounds induces cell apoptosis in human prostate cancer cells through promoting AMPK activity and cell autophagy. Oncotarget. vol 8. issue 49. 2019-11-20. PMID:29156794. |
moreover, salen-mn induced cell apoptosis, and increased the expression of apoptotic proteins, such as cleaved caspase-3, cleaved parp, and bax, in pc-3 and du145 prostate cancer cells. |
2019-11-20 |
2023-08-13 |
mouse |
| Yan-Fang Zou, Wei-Tang Liao, Zong-Jie Fu, Qian Zhao, Yong-Xi Chen, Wen Zhan. MicroRNA-30c-5p ameliorates hypoxia-reoxygenation-induced tubular epithelial cell injury via HIF1α stabilization by targeting SOCS3. Oncotarget. vol 8. issue 54. 2019-11-20. PMID:29190957. |
down-regulating mir-30c-5p increased the levels of apoptosis and c-casp3 and bax expression; additionally, cell proliferation was inhibited. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hui-Min Liang, Li-Jiao Geng, Xiao-Yan Shi, Chao-Gang Zhang, Shu-Yan Wang, Guang-Ming Zhan. By up-regulating μ- and δ-opioid receptors, neuron-restrictive silencer factor knockdown promotes neurological recovery after ischemia. Oncotarget. vol 8. issue 60. 2019-11-20. PMID:29254142. |
nerve function scores, step-down reaction periods, error times and apoptosis rates, as well as levels of b-cell cll/lymphoma 2 (bcl-2), bcl2-associated x protein (bax), and nrsf expression were lower in the nrsf shrna group than in the model and nc groups. |
2019-11-20 |
2023-08-13 |
rat |
| Huan Liu, Guizhi Zhou, Xin Fu, Haiyan Cui, Guangrui Pu, Yao Xiao, Wei Sun, Xinhua Dong, Libin Zhang, Sijia Cao, Guiqin Li, Xiaowei Wu, Xu Yan. Long noncoding RNA TUG1 is a diagnostic factor in lung adenocarcinoma and suppresses apoptosis via epigenetic silencing of BAX. Oncotarget. vol 8. issue 60. 2019-11-20. PMID:29254212. |
long noncoding rna tug1 is a diagnostic factor in lung adenocarcinoma and suppresses apoptosis via epigenetic silencing of bax. |
2019-11-20 |
2023-08-13 |
Not clear |
| Huan Liu, Guizhi Zhou, Xin Fu, Haiyan Cui, Guangrui Pu, Yao Xiao, Wei Sun, Xinhua Dong, Libin Zhang, Sijia Cao, Guiqin Li, Xiaowei Wu, Xu Yan. Long noncoding RNA TUG1 is a diagnostic factor in lung adenocarcinoma and suppresses apoptosis via epigenetic silencing of BAX. Oncotarget. vol 8. issue 60. 2019-11-20. PMID:29254212. |
gain and loss functional assays showed that inhibition of bax reversed the induced apoptosis by tug1 knockdown. |
2019-11-20 |
2023-08-13 |
Not clear |