| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Zhu, Xinyue Qi, Yuehe Liu, Wei Liao, Xiangshui Sun, Yuping Tan. The role and underlying mechanisms of microRNA‑214 in Legg‑Calvé‑Perthes disease. Molecular medicine reports. vol 20. issue 1. 2019-12-16. PMID:31180556. |
dex administration significantly suppressed cell proliferation, promoted apoptosis and decreased the bcl‑2/bax ratio in tc28 cells; overexpression of mir‑214 induced opposing effects, which were reversed by bax overexpression. |
2019-12-16 |
2023-08-13 |
Not clear |
| Hongjing Zhao, Yu Wang, Menghao Guo, Dongxue Fei, Mengyao Mu, Hongxian Yu, Mingwei Xin. Hepatoprotective effects of zinc (II) via cytochrome P-450/reactive oxygen species and canonical apoptosis pathways after arsenite waterborne exposure in common carp. Chemosphere. vol 236. 2019-12-16. PMID:31549675. |
this hypothesis was further suggested by caspase-3-executed apoptosis by death receptor pathway (fas, tnf-α and caspase-8) and mitochondrial pathway (bax, bcl-2 and caspase-9). |
2019-12-16 |
2023-08-13 |
Not clear |
| Hai Wang, Zhigang J. Inhibition of p53 alleviates prostate cell apoptosis in Escherichia coli‑induced bacterial prostatitis. Molecular medicine reports. vol 20. issue 2. 2019-12-13. PMID:31173258. |
p53, apoptosis regulator bax (bax), caspase‑9 and caspase‑3 expression were upregulated upon escherichia coli exposure (p<0.05). |
2019-12-13 |
2023-08-13 |
human |
| Hai Wang, Zhigang J. Inhibition of p53 alleviates prostate cell apoptosis in Escherichia coli‑induced bacterial prostatitis. Molecular medicine reports. vol 20. issue 2. 2019-12-13. PMID:31173258. |
following transfection with p53 sirna, the promotion of cell apoptosis induced by escherichia coli infection was decreased, and the p53 and bax protein expression were additionally decreased. |
2019-12-13 |
2023-08-13 |
human |
| Yueming Zhang, Wenrui Zhang, Lina Tao, Jinghui Zhai, Huan Gao, Yanqing Song, Xiaoyu Q. Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway. Journal of biochemical and molecular toxicology. vol 33. issue 9. 2019-12-13. PMID:31332904. |
besides, que significantly abrogated inh-induced cell apoptosis by upregulating the expression levels of bcl-2 and decreasing the levels of bax, cleaved caspase-3, and cleaved caspase-9. |
2019-12-13 |
2023-08-13 |
Not clear |
| Samuel Engelsgjerd, Selvi Kunnimalaiyaan, Emad Kandil, T Clark Gamblin, Muthusamy Kunnimalaiyaa. Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines. PloS one. vol 14. issue 3. 2019-12-12. PMID:30870485. |
inhibition of cell proliferation via apoptosis was evidenced by an increase in pro-apoptotic markers (cleaved parp, cleaved caspase-3/-7, and bax) and a decrease in an anti-apoptotic marker, bcl-2. |
2019-12-12 |
2023-08-13 |
human |
| Xin-Tong Wu, Abdur Rahman Ansari, Xin-Xin Pang, Hui-Zhen Li, Zhe-Wei Zhang, You Luo, Muhammad Arshad, Hui Son. Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice. Archivum immunologiae et therapiae experimentalis. vol 67. issue 4. 2019-12-12. PMID:31143985. |
after visfatin treatment, the expression of pro-apoptotic genes bax, bik, and p53 decreased and the expression of anti-apoptotic genes bcl-2 and bcl-xl increased, and expression of autophagy factors lc3 and beclin1 decreased, indicating that visfatin inhibits apoptosis and reduces autophagy. |
2019-12-12 |
2023-08-13 |
mouse |
| Yi Wen, Ruohong Liu, Ning Lin, Hao Luo, Jiajia Tang, Qilin Huang, Hongyu Sun, Lijun Tan. NADPH Oxidase Hyperactivity Contributes to Cardiac Dysfunction and Apoptosis in Rats with Severe Experimental Pancreatitis through ROS-Mediated MAPK Signaling Pathway. Oxidative medicine and cellular longevity. vol 2019. 2019-12-11. PMID:31210840. |
sap rats exhibited significant cardiac impairment along with increased nox activity and protein expression, ros production, cell apoptosis, and proapoptotic bax and cleaved caspase-3 protein levels. |
2019-12-11 |
2023-08-13 |
rat |
| Shaolong Ma, Chao Zhang, Ziyan Zhang, Yuxuan Dai, Rui Gu, Rui Jian. Geniposide protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via up-regulation of miR-145-5p. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-10. PMID:31307231. |
meanwhile, apoptosis driven by lps was mitigated by geniposide, which accompanied with p53, bax and cleaved caspase-3 down-regulation, and bcl-2 up-regulation. |
2019-12-10 |
2023-08-13 |
Not clear |
| Asma Derf, Ankita Sharma, Sandip B Bharate, Bhabatosh Chaudhur. Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Bioorganic & medicinal chemistry letters. vol 29. issue 3. 2019-12-09. PMID:30579794. |
the antioxidant aegeline, an alkaloid-amide occurring in the leaves of the plant aegle marmelos correa, was the only molecule that overcame apoptosis induced by both α-synuclein and bax in yeast. |
2019-12-09 |
2023-08-13 |
human |
| Xueyin Zu, Xiaomeng Xie, Yuanyuan Zhang, Kangdong Liu, Ann M Bode, Zigang Dong, Dong Joon Ki. Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells. Phytotherapy research : PTR. vol 33. issue 9. 2019-12-09. PMID:31225674. |
we also found that lapachol induces mitochondria-mediated cellular apoptosis by activating caspases-3, -7, and parp, inducing the expression of cytochrome c and bax by inhibiting downstream molecules of rsk2. |
2019-12-09 |
2023-08-13 |
Not clear |
| Sirinapha Klungsaeng, Veerapol Kukongviriyapan, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunpra. Cucurbitacin B induces mitochondrial-mediated apoptosis pathway in cholangiocarcinoma cells via suppressing focal adhesion kinase signaling. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 3. 2019-12-06. PMID:30470919. |
increased apoptotic cell death following cucurbitacin b treatment was correlated with caspase-9 and caspase-3 activations, bax upregulation, increased cytochrome c, apoptosis-inducing factor release, and decreased bcl-2 and bcl-xl levels, suggesting activation of the mitochondrial-mediated apoptosis pathway. |
2019-12-06 |
2023-08-13 |
Not clear |
| Marwa El Sheikh, Ayman Mesalam, Ahmed Atef Mesalam, Muhammad Idrees, Kyeong-Lim Lee, Il-Keun Kon. Melatonin Abrogates the Anti-Developmental Effect of the AKT Inhibitor SH6 in Bovine Oocytes and Embryos. International journal of molecular sciences. vol 20. issue 12. 2019-12-06. PMID:31212969. |
the rt-qpcr results showed up-regulation of the mrna of maturation-, mitochondrial-, and cumulus expansion-related genes including gdf-9, bmp-15, marf1, atpase, atp5f1e, polg2, has2, tnfaip6, and ptgs2 and down-regulation of bcl-2 associated x apoptosis regulator (bax), caspase 3, and p21 involved in apoptosis and cell cycle arrest in melatonin-sh6 co-treated group compared to sh6 sole treatment. |
2019-12-06 |
2023-08-13 |
cattle |
| Daisen Hou, Zhihui Che, Ping Chen, Wenli Zhang, Yiwei Chu, Dongqin Yang, Jie Li. Suppression of AURKA alleviates p27 inhibition on Bax cleavage and induces more intensive apoptosis in gastric cancer. Cell death & disease. vol 9. issue 8. 2019-12-03. PMID:30013101. |
suppression of aurka alleviates p27 inhibition on bax cleavage and induces more intensive apoptosis in gastric cancer. |
2019-12-03 |
2023-08-13 |
Not clear |
| Daisen Hou, Zhihui Che, Ping Chen, Wenli Zhang, Yiwei Chu, Dongqin Yang, Jie Li. Suppression of AURKA alleviates p27 inhibition on Bax cleavage and induces more intensive apoptosis in gastric cancer. Cell death & disease. vol 9. issue 8. 2019-12-03. PMID:30013101. |
bax is a key molecule in mitochondria-apoptosis pathway, however it is not always an efficient apoptosis inducer in chemotherapeutic agents-treated cancer cells. |
2019-12-03 |
2023-08-13 |
Not clear |
| Daisen Hou, Zhihui Che, Ping Chen, Wenli Zhang, Yiwei Chu, Dongqin Yang, Jie Li. Suppression of AURKA alleviates p27 inhibition on Bax cleavage and induces more intensive apoptosis in gastric cancer. Cell death & disease. vol 9. issue 8. 2019-12-03. PMID:30013101. |
here, we found that specific inhibition of aurka by mln8237-induced calpain-mediated bax cleavage at n-terminal 33th asparagine (c-bax) to promote apoptosis. |
2019-12-03 |
2023-08-13 |
Not clear |
| Daisen Hou, Zhihui Che, Ping Chen, Wenli Zhang, Yiwei Chu, Dongqin Yang, Jie Li. Suppression of AURKA alleviates p27 inhibition on Bax cleavage and induces more intensive apoptosis in gastric cancer. Cell death & disease. vol 9. issue 8. 2019-12-03. PMID:30013101. |
the c-bax, as bax, could also efficiently located to mitochondria but c-bax is a stronger apoptosis inducer than bax. |
2019-12-03 |
2023-08-13 |
Not clear |
| Daisen Hou, Zhihui Che, Ping Chen, Wenli Zhang, Yiwei Chu, Dongqin Yang, Jie Li. Suppression of AURKA alleviates p27 inhibition on Bax cleavage and induces more intensive apoptosis in gastric cancer. Cell death & disease. vol 9. issue 8. 2019-12-03. PMID:30013101. |
morever, c-bax-induced apoptosis could not be blocked by the canonical bax inhibitor, bcl-2. |
2019-12-03 |
2023-08-13 |
Not clear |
| Daisen Hou, Zhihui Che, Ping Chen, Wenli Zhang, Yiwei Chu, Dongqin Yang, Jie Li. Suppression of AURKA alleviates p27 inhibition on Bax cleavage and induces more intensive apoptosis in gastric cancer. Cell death & disease. vol 9. issue 8. 2019-12-03. PMID:30013101. |
also, p27 efficiently inhibited bax cleavage and p27 knockdown sensitized apoptosis through bax cleavage when cancer cells were treated with mln8237. |
2019-12-03 |
2023-08-13 |
Not clear |
| Zhijie Zhang, Xue Wang, Chengzhou Ma, Zhiwang Li, Huayong Chen, Zhiming Zhang, Tao L. Genipin protects rats against lipopolysaccharide-induced acute lung injury by reinforcing autophagy. International immunopharmacology. vol 72. 2019-12-03. PMID:30959368. |
genipin treatment also alleviated lps-induced cell apoptosis (down-regulation of bax, up-regulation of bcl-2, and decreased number of terminal deoxynucleotidyl transferase dutp nick end label-positive cells) and oxidative stress (increased sod and decreased mda content) in the lung. |
2019-12-03 |
2023-08-13 |
rat |