| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Hassanin, H H Ahmed, A N Kadda. A global view of the pathophysiology of varicocele. Andrology. vol 6. issue 5. 2019-10-28. PMID:29978951. |
the genetic role should not be overlooked as a contributing factor in the induction of heat stress, excess reactive oxygen species/oxidative stress, and apoptosis; this is evidenced by the association of varicocele with decreased expression of heat-shock proteins, higher polymorphism of glutathione s transferase and nitric oxide synthase genes, and increased bax and decreased bcl2 genes and proteins. |
2019-10-28 |
2023-08-13 |
Not clear |
| Shuo-Peng Wei, Wei-Dan Jiang, Pei Wu, Yang Liu, Yun-Yun Zeng, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Yong-An Zhang, Xiao-Qiu Zhou, Lin Fen. Dietary magnesium deficiency impaired intestinal structural integrity in grass carp (Ctenopharyngodon idella). Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30139942. |
we first demonstrated that magnesium is partly involved in (1) attenuating antioxidant ability by suppressing nrf2 signalling to decrease antioxidant enzyme mrna levels and activities (except cuznsod mrna levels and activities); (2) aggravating apoptosis by activating jnk (not p38mapk) signalling to upregulate proapoptotic protein (apaf-1, bax and fasl) and caspase-2, -3, -7, -8 and -9 gene expression but downregulate antiapoptotic protein (bcl-2, iap and mcl-1b) gene expression; (3) weakening the function of tight junctional complexes (tjs) by promoting myosin light chain kinase (mlck) signalling to downregulate tj gene expression [except claudin-7, zo-2b and claudin-15 gene expression]. |
2019-10-28 |
2023-08-13 |
Not clear |
| Yasmeen M Attia, Dina M El-Kersh, Hebatallah A Wagdy, Mohamed M Elmaza. Verbascoside: Identification, Quantification, and Potential Sensitization of Colorectal Cancer Cells to 5-FU by Targeting PI3K/AKT Pathway. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30446678. |
enhanced apoptosis mainly by affecting bax and bcl-2 and to a lesser extent bcl-xl and p53 was also observed. |
2019-10-28 |
2023-08-13 |
Not clear |
| Danyang Chao, Lijun Pang, Ying Shi, Wenjing Wang, Kai Li. AZD3759 induces apoptosis in hepatoma cells by activating a p53-SMAD4 positive feedback loop. Biochemical and biophysical research communications. vol 509. issue 2. 2019-10-28. PMID:30598263. |
in this positive feedback loop, p53 induced the expression of smad4 by directly promoting its transcription as shown by p53 could bind to smad4 promoter; smad4, in turn, promoted the nuclear translocation of p53, which increased the transcription of pro-apoptotic genes, including puma and bax (two p53 target genes) and finally resulted in apoptosis. |
2019-10-28 |
2023-08-13 |
Not clear |
| Mingjie Zhang, Guoping Ding, Liangjing Zhou, Tao Shen, Xiaodong Xu, Ting Zhao, Shengnan Jia, LiPing Ca. Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 38. issue 9. 2019-10-25. PMID:30192158. |
ifn-γ treatment decreased the expression and secretion of cxcl8 in bxpc-3 pc cells, suppressed the proliferation and migration of these cells, and enhanced their apoptosis, as determined by increased levels of cleaved caspase-8 and bax together with reduced expression of bcl-2. |
2019-10-25 |
2023-08-13 |
Not clear |
| Daniel Stehle, Melanie Grimm, Stephanie Einsele-Scholz, Friederike Ladwig, Janina Johänning, Gerd Fischer, Bernhard Gillissen, Klaus Schulze-Osthoff, Frank Essman. Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax. Scientific reports. vol 8. issue 1. 2019-10-24. PMID:30127460. |
central to intrinsic apoptosis signaling is the release of cytochrome c from mitochondria, which depends on the pro-apoptotic effector proteins bax, bak or bok. |
2019-10-24 |
2023-08-13 |
Not clear |
| Daniel Stehle, Melanie Grimm, Stephanie Einsele-Scholz, Friederike Ladwig, Janina Johänning, Gerd Fischer, Bernhard Gillissen, Klaus Schulze-Osthoff, Frank Essman. Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax. Scientific reports. vol 8. issue 1. 2019-10-24. PMID:30127460. |
to elucidate the molecular basis of bok-mediated apoptosis we analyzed apoptosis induction by transmembrane-domain deficient bokΔtm compared to the respective bax and bak proteins and proteins in which the first leucine in the bh3-stretch was mutated to glutamic acid. |
2019-10-24 |
2023-08-13 |
Not clear |
| Daniel Stehle, Melanie Grimm, Stephanie Einsele-Scholz, Friederike Ladwig, Janina Johänning, Gerd Fischer, Bernhard Gillissen, Klaus Schulze-Osthoff, Frank Essman. Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax. Scientific reports. vol 8. issue 1. 2019-10-24. PMID:30127460. |
mutation of the first leucine in the bh3-domain (l78e) blocks activity of bak, while mutation of the homologue residues in bax or bok (l63e and l70e respectively) does not affect apoptosis induction. |
2019-10-24 |
2023-08-13 |
Not clear |
| Yiming Bi, Yan Fu, Shuyan Wang, Xingxiu Chen, Xiaoping Ca. Schizandrin A exerts anti-tumor effects on A375 cells by down-regulating H19. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 10. 2019-10-22. PMID:31618367. |
scha increased cell apoptosis along with the up-regulation of pro-apoptotic proteins (cleaved-caspase-3, cleaved-caspase-9, and bax) and the down-regulation of anti-apoptotic protein (bcl-2). |
2019-10-22 |
2023-08-13 |
Not clear |
| Yuan-Fang Fan, Ying Xu, Xiao-Hui Su, Li-Ling Liu, Ya-Ge Tian, Yuan Zhao, Xiang-Ying Kong, Na Li. [Effect of Tripterygium Glycosides Tablets on reproductive toxicity in female rats with Ⅱ type collagen induced arthritis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 16. 2019-10-21. PMID:31602913. |
immunohistochemistry was used to observe the expression of bax and bcl-2 related proteins in the apoptosis pathway of uterus and ovary. |
2019-10-21 |
2023-08-13 |
rat |
| Ding-Yan Lu, Jing Li, Jia Sun, Wei-Na Xue, Bin He, Yong-Jun Li, Yong-Lin Wang, Chang-Hu Lin, Ting Li. [Shenxiong Glucose Injection inhibits H_2O_2-induced apoptosis of H9c2 cells by activating PI3K/AKT pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 17. 2019-10-21. PMID:31602952. |
cell viability was detected by mts assay,morphological changes of apoptosis were observed by ao/eb fluorescence staining,apoptosis rate was detected by annexin/pi method,cell expression profile was detected by gene chip technology,the mrna of pik3 ca,bcl-2,bax,caspase-3 and gapdh were detected by qrt-pcr,the protein expression levels of pik3 ca,akt,p-akt,bcl-2,bax and caspase-3 were detected by western blot,and the contents of ldh and mda were detected by kit. |
2019-10-21 |
2023-08-13 |
Not clear |
| Judong Kim, Edward Pajarillo, Asha Rizor, Deok-Soo Son, Jayden Lee, Michael Aschner, Eunsook Le. LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PloS one. vol 14. issue 1. 2019-10-18. PMID:30645642. |
lrrk2 deletion and its pharmacological inhibition attenuated mn-induced apoptosis in macrophages and microglia, along with concomitant decreases in the pro-apoptotic bcl-2-associated x (bax) protein. |
2019-10-18 |
2023-08-13 |
human |
| Maryam Hormozi, Shadi Ghoreishi, Parasto Baharvan. Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-10-17. PMID:30873887. |
the results showed that astaxanthin increases the expression of bax and caspase3 genes and decreases that of bcl2, thereby, inducing apoptosis and inhibiting growth and proliferation of the cells. |
2019-10-17 |
2023-08-13 |
Not clear |
| Hyo In Kim, Se Hyang Hong, Jin Mo Ku, Ye Seul Lim, Sol Ji Lee, Jungbin Song, Tai Young Kim, Chunhoo Cheon, Seong-Gyu K. Scutellaria Radix Promotes Apoptosis in Non-Small Cell Lung Cancer Cells via Induction of AMPK-Dependent Autophagy. The American journal of Chinese medicine. vol 47. issue 3. 2019-10-17. PMID:30974965. |
western blot assays showed increased expressions of bcl-2-associated x protein (bax), cleaved-caspase 3 and cleaved-poly adp ribose polymerase (parp), key factors of apoptosis. |
2019-10-17 |
2023-08-13 |
Not clear |
| Xianwu Chen, Chao Li, Yong Chen, Chaobo Ni, Xiuxiu Chen, Linlei Zhang, Xuni Xu, Min Chen, Xinyi Ma, Huilu Zhan, Aoyu Xu, Renshan Ge, Xiaoling Gu. Aflatoxin B1 impairs leydig cells through inhibiting AMPK/mTOR-mediated autophagy flux pathway. Chemosphere. vol 233. 2019-10-16. PMID:31176127. |
moreover, afb1 induced leydig cell apoptosis through lowering pampk/ampk ratio and increasing pmtor/mtor ratio, and then further up-regulating autophagy and apoptosis proteins, lc3, beclin 1, and bax, as well as down-regulating autophagy flux protein p62 and anti-apoptosis protein bcl-2. |
2019-10-16 |
2023-08-13 |
Not clear |
| Wen-Hu Liu, Jiang-Bei Yuan, Fan Zhang, Jin-Xia Chan. [Curcumin inhibits proliferation,migration and invasion of gastric cancer cells via Wnt3a/β-catenin/EMT signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 14. 2019-10-16. PMID:31602860. |
the migration and invasiveness of cells were determined by wound healing and transwell assays,the apoptosis rate was assessed by flow cytometry,the expression of n-cadherin,e-cadherin,snail1,wnt3 a,p-β-catenin,p-lrp6,bcl-2 and bax were detected by western blot,and the enzymatic activity of caspase-3,caspase-8 and caspase-9 was evaluated via caspase kit. |
2019-10-16 |
2023-08-13 |
human |
| Wen-Hu Liu, Jiang-Bei Yuan, Fan Zhang, Jin-Xia Chan. [Curcumin inhibits proliferation,migration and invasion of gastric cancer cells via Wnt3a/β-catenin/EMT signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 14. 2019-10-16. PMID:31602860. |
moreover,curcumin could inhibit the migration and invasion of mkn45 cells,downregulate the expression of n-cadherin,snail1,wnt3 a,p-β-catenin,p-lrp6 and bcl-2,and upregulate the expression of e-cadherin and bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well. |
2019-10-16 |
2023-08-13 |
human |
| Yiping Yang, Shuyan Ma, Fu Wei, Guiqiang Liang, Xiaobo Yang, Yuman Huang, Jian Wang, Yunfeng Zo. Pivotal role of cAMP-PKA-CREB signaling pathway in manganese-induced neurotoxicity in PC12 cells. Environmental toxicology. vol 34. issue 9. 2019-10-15. PMID:31161640. |
we found that mn exposure significantly inhibited camp signaling and protein expression of bcl-2, while increasing apoptosis rate, protein levels of pde4, bax, activated caspase-3, and activated caspase-8 in pc12 cells. |
2019-10-15 |
2023-08-13 |
Not clear |
| Wei Yu, Xiaofeng Cui, Zhongyi Wan, Yanhui Yu, Xiumin Liu, Lifang Ji. Silencing forkhead box M1 promotes apoptosis and autophagy through SIRT7/mTOR/IGF2 pathway in gastric cancer cells. Journal of cellular biochemistry. vol 119. issue 11. 2019-10-10. PMID:29953672. |
foxm1 silence markedly inhibits ags and sgc-7901 cell survival and proliferation, increases their apoptosis, and modulates apoptosis-related protein expression, including reduced bcl-2 level and increased bax and caspase-3 levels. |
2019-10-10 |
2023-08-13 |
human |
| Mingli Han, Yimeng Wang, Guangcheng Guo, Lin Li, Dongwei Dou, Xin Ge, Pengwei Lv, Fang Wang, Yuanting G. microRNA-30d mediated breast cancer invasion, migration, and EMT by targeting KLF11 and activating STAT3 pathway. Journal of cellular biochemistry. vol 119. issue 10. 2019-10-09. PMID:29923255. |
furthermore, the mir-30d mimic increased bt474 and mda-mb-231 breast cancer cell survival, inhibited apoptosis and increased bcl-2 expression, whilst inhibited bax protein levels. |
2019-10-09 |
2023-08-13 |
Not clear |