| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Delphine Merino, Gemma L Kelly, Guillaume Lessene, Andrew H Wei, Andrew W Roberts, Andreas Strasse. BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines. Cancer cell. vol 34. issue 6. 2019-07-29. PMID:30537511. |
pro-survival bcl-2 proteins prevent apoptosis by keeping the cell death effectors, bax and bak, in check. |
2019-07-29 |
2023-08-13 |
Not clear |
| Xinxin Liu, Fei Liu, Shuo Zhao, Bin Guo, Peixue Ling, Guanying Han, Zan Cu. Purification of an acidic polysaccharide from Suaeda salsa plant and its anti-tumor activity by activating mitochondrial pathway in MCF-7 cells. Carbohydrate polymers. vol 215. 2019-07-29. PMID:30981376. |
the data from the western blot showed an increase in the levels of bax, cytochrome c (cyto-c), caspase-3 and caspase-9 and a decrease in the level of bcl-2 further demonstrated that ssp2-2 could induce apoptosis via a mitochondrial pathway. |
2019-07-29 |
2023-08-13 |
Not clear |
| Sunwoo Park, Whasun Lim, Seungkwon You, Gwonhwa Son. Ochratoxin A exerts neurotoxicity in human astrocytes through mitochondria-dependent apoptosis and intracellular calcium overload. Toxicology letters. vol 313. 2019-07-29. PMID:31154016. |
it induced apoptosis of nha-sv40lt cells through mitochondrial membrane potential (mmp) loss and up-regulation of bax and tp53. |
2019-07-29 |
2023-08-13 |
human |
| Bang-Qing Wang, Bin Yang, Hua-Chao Yang, Jun-Yi Wang, Sen Hu, Yu-Shuai Gao, Xing-Yao B. MicroRNA-499a decelerates glioma cell proliferation while accelerating apoptosis through the suppression of Notch1 and the MAPK signaling pathway. Brain research bulletin. vol 142. 2019-07-26. PMID:29908894. |
after the cells were treated with mir-449a mimic, sirna-notch1 or sb230580, decreased expressions of notch1, bcl-2, cyclind1, erk1/2 and p-erk1/2, cell proliferation as well as cells arrested at the s stage with elevated expressions levels of p38mapk, p-p38mapk, bax, as well as increased cell apoptosis and number of cells arrested in g0/g1 stage were assessed. |
2019-07-26 |
2023-08-13 |
Not clear |
| Ping Sun, Jun-Bo Yin, Li-Hua Liu, Jian Guo, Sheng-Hai Wang, Chun-Hui Qu, Chun-Xia Wan. Protective role of Dihydromyricetin in Alzheimer's disease rat model associated with activating AMPK/SIRT1 signaling pathway. Bioscience reports. vol 39. issue 1. 2019-07-26. PMID:30498091. |
meanwhile, the apoptosis of hippocampal cells was significantly up-regulated with decreased bcl-2 and increased bax, as compared with sham rats (all |
2019-07-26 |
2023-08-13 |
rat |
| Tahir Muhammad, Muhammad Ikram, Rahat Ullah, Shafiq Ur Rehman, Myeong Ok Ki. Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling. Nutrients. vol 11. issue 3. 2019-07-25. PMID:30884890. |
moreover, hesperetin rescued lps-induced neuronal apoptosis by reducing the expression of phosphorylated-c-jun n-terminal kinases (p-jnk), b-cell lymphoma 2 (bcl-2)-associated x protein (bax), and caspase-3 protein and promoting the bcl-2 protein level. |
2019-07-25 |
2023-08-13 |
mouse |
| Ujjal Das, Sushobhan Biswas, Sreya Chattopadhyay, Anindita Chakraborty, Rakhi Dey Sharma, Asoke Banerji, Sanjit De. Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study. Scientific reports. vol 7. issue 1. 2019-07-24. PMID:29070894. |
over expression of bax and activation of caspase 3 indicated the apoptosis of the cells. |
2019-07-24 |
2023-08-13 |
Not clear |
| Lin-Ming Luo, Li Qin, Ji-Hua Zhan, Gang Pei, Xiao-Jiang Zhou, Nai-Hong Che. [Study on effects of total saponins from Lilii Bulbus on proliferation, apoptosis, invasion and metastasis of lung cancer cells and its preliminary mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 22. 2019-07-23. PMID:30593245. |
and the apoptosis induction of tsll on lung cancer cells is associated with the regulation of bcl-2 and bax proteins expression. |
2019-07-23 |
2023-08-13 |
human |
| Tongsen Zhang, Si Chen, Lei Chen, Lixiao Zhang, Fanqi Meng, Shuang Sha, Chunlong Ai, Jiandong Ta. Chlorogenic Acid Ameliorates Lead-Induced Renal Damage in Mice. Biological trace element research. vol 189. issue 1. 2019-07-22. PMID:30196488. |
the expression of bax and bcl-2 associated with apoptosis was also significantly regulated by cga. |
2019-07-22 |
2023-08-13 |
mouse |
| Jiangtao Pu, Xiaojun Tang, Xiang Zhuang, Zhi Hu, Kaiming He, Yunfei Wu, Tianyang Da. Matrine induces apoptosis via targeting CCR7 and enhances the effect of anticancer drugs in non-small cell lung cancer in vitro. Innate immunity. vol 24. issue 7. 2019-07-22. PMID:30236029. |
the results showed that matrine (≥10 μm) caused a significant inhibition on cell viability and 10 and 100 μm matrine induced cell apoptosis via influencing p53, bax, casp3, and bcl-2 expressions in a549 cells. |
2019-07-22 |
2023-08-13 |
Not clear |
| Feng Xu, Qi Li, Zhiyu Wang, Xiangming Ca. Sinomenine inhibits proliferation, migration, invasion and promotes apoptosis of prostate cancer cells by regulation of miR-23a. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 112. 2019-07-22. PMID:30784907. |
results sinomenine significantly suppressed cell proliferation, promoted apoptosis and inhibited migration and invasion, as well as down-regulated cyclin d1, cdk4, bcl-2, mmp-2, mmp-9, vimentin protein levels and up-regulated p16 and bax protein levels in pc3 cells. |
2019-07-22 |
2023-08-13 |
Not clear |
| Yudi Xiong, Tianqi Li, Ganiou Assani, Huan Ling, Qian Zhou, Yangyang Zeng, Fuxiang Zhou, Yunfeng Zho. Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 112. 2019-07-22. PMID:30784916. |
moreover, ribociclib induced cell cycle arrest in g0-g1 phase and cell apoptosis, and inhibited c33a cell proliferation in dose - dependent manner following by decreased expression of certain related genes such as cdk4, cdk6, e2f1, p-rb, and increased bax expression. |
2019-07-22 |
2023-08-13 |
human |
| Alexander V Sirotkin, Andrej Benčo, Milos Mlynček, Abdel H Harrath, Saleh Alwasel, Jan Kotwic. The involvement of the phosphorylatable and nonphosphorylatable transcription factor CREB-1 in the control of human ovarian cell functions. Comptes rendus biologies. vol 342. issue 3-4. 2019-07-22. PMID:31028003. |
the expression of total and phosphorylated creb-1, markers of proliferation (pcna) and apoptosis (bax), as well as the release of progesterone, oxytocin, prostaglandin f2 alpha (pgf2), prostaglandin e2 (pge2), and insulin-like growth factor i (igf-i) were compared by immunocytochemistry, enzyme immunoassay (eia), and immunoradiometric assay (irma). |
2019-07-22 |
2023-08-13 |
human |
| Arokia Vijaya Anand Mariadoss, Ramachandran Vinayagam, Baojun Xu, Karthikkumar Venkatachalam, Vijayalakshmi Sankaran, Shalini Vijayakumar, Sandya Rani Bakthavatsalam, Sadiq A Mohamed, Ernest Davi. Phloretin loaded chitosan nanoparticles enhance the antioxidants and apoptotic mechanisms in DMBA induced experimental carcinogenesis. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31071336. |
in addition, immunoblot analyses of phcsnps treatment enhanced the release of bcl-2 associated x protein (bax), cytochrome c, caspase-3, 9 and suppressed the b-cell lymphoma 2 (bcl-2) expression, which the use of phcsnps for mitochondrial-mediated apoptosis. |
2019-07-22 |
2023-08-13 |
Not clear |
| Hong Li, Hai-Lin Zhuang, Jun-Jin Lin, Yue-Fen Zhang, Hui Huang, Ting Luo, Wen-Tao Yu, Feng N. [Effect of rosmarinic acid from Sarcandra glabra in inhibiting proliferation and migration and inducing apoptosis of MDA-MB-231 cells via regulation of expressions of Bcl-2 and Bax]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 16. 2019-07-19. PMID:30200738. |
[effect of rosmarinic acid from sarcandra glabra in inhibiting proliferation and migration and inducing apoptosis of mda-mb-231 cells via regulation of expressions of bcl-2 and bax]. |
2019-07-19 |
2023-08-13 |
Not clear |
| Hong Li, Hai-Lin Zhuang, Jun-Jin Lin, Yue-Fen Zhang, Hui Huang, Ting Luo, Wen-Tao Yu, Feng N. [Effect of rosmarinic acid from Sarcandra glabra in inhibiting proliferation and migration and inducing apoptosis of MDA-MB-231 cells via regulation of expressions of Bcl-2 and Bax]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 16. 2019-07-19. PMID:30200738. |
the results suggested that rosmarinicacid can inhibit the proliferation and migration, and induce the apoptosis of mda-mb-231 cells, which may be correlated with the down-regulation of bcl-2 gene and the up-regulation of bax gene. |
2019-07-19 |
2023-08-13 |
Not clear |
| Lijiang Wang, Liyue Wang, Xiaoxia Zhou, Guoran Ruan, Guangyong Yan. Qishen Yiqi Dropping Pills Ameliorates Doxorubicin-induced Cardiotoxicity in Mice via Enhancement of Cardiac Angiogenesis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-07-19. PMID:30943187. |
moreover, tunel staining and western blot analysis of bax protein, bcl-2 protein, and cleaved caspase-3 protein expression levels were conducted to explore whether qydp exerted effect on cardiac apoptosis. |
2019-07-19 |
2023-08-13 |
mouse |
| Biao Cai, Shu Ye, Yan Wang, Ting-Ting Wang, Liang Wang, Ai-Juan Jiang, Zheng-Qing Fang, Guo-Ming Shen, Dao-Jun Xi. [Effects of Huangpu Tongqiao capsule on apoptosis of Alzheimer's disease cell model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 11. 2019-07-18. PMID:29945394. |
after primary cultured hippocampal neurons ad cell model was induced by aβ₂₅₋₃₅, cell survival rate was detected by mtt, cell apoptosis rate was assayed by flow cytometry, and protein expressions of bax, cyt c and caspase-3 were determined by western blot analysis. |
2019-07-18 |
2023-08-13 |
Not clear |
| Biao Cai, Shu Ye, Yan Wang, Ting-Ting Wang, Liang Wang, Ai-Juan Jiang, Zheng-Qing Fang, Guo-Ming Shen, Dao-Jun Xi. [Effects of Huangpu Tongqiao capsule on apoptosis of Alzheimer's disease cell model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 11. 2019-07-18. PMID:29945394. |
the results showed that the primary cultured hippocampal neurons were cultured successfully, and cells grew mature at seventh days; compared with normal group, the survival rate of hippocampal neurons in ad cell model group was decreased, the apoptosis rate of hippocampal neurons was increased, and the protein expressions of bax, cyt c and caspase-3 were increased ( |
2019-07-18 |
2023-08-13 |
Not clear |
| Zheng Lou, Qing-Qing Wei, Da-Wei Wang, Huan-Peng G. [Effect of allicin on proliferation and apoptosis of KG-1 cells and its molecular mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 12. 2019-07-18. PMID:29950084. |
the above results suggest that allicin inhibited the proliferation of kg-1 cells primarily by inducing late apoptosis; the execution of apoptosis involved cleaved caspase 3; the induction of apoptosis involved the protein expression, the decrease of erk1/2andexpression of survivin and the dose-dependent decrease of p-erk1/2; the mrna expression involved the increase of bax, and the down-regulation of survivin, bcl-2 and erk1/2. |
2019-07-18 |
2023-08-13 |
Not clear |