| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Zhao, Nur-Ezan Mohamed, Su Jing Chan, Chong Teik Tan, Ran Tao, Victor C Yu, Peter T-H Won. Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of Apoptosis 1-Deficient Mice. Molecular neurobiology. vol 56. issue 3. 2019-07-17. PMID:30003515. |
modulator of apoptosis 1 (moap-1) is a bcl-2-associated x protein (bax)-associating protein that plays an important role in regulating apoptosis. |
2019-07-17 |
2023-08-13 |
mouse |
| Rituparna Roy, Debolina Pal, Subhayan Sur, Suvra Mandal, Prosenjit Saha, Chinmay Kumar Pand. Pongapin and Karanjin, furanoflavanoids of Pongamia pinnata, induce G2/M arrest and apoptosis in cervical cancer cells by differential reactive oxygen species modulation, DNA damage, and nuclear factor kappa-light-chain-enhancer of activated B cell signaling. Phytotherapy research : PTR. vol 33. issue 4. 2019-07-17. PMID:30834631. |
the compounds induced caspase-dependent apoptosis through induction of bax/bcl-2 ratio either through increased expression of bax by pongapin and plumbagin or low expression of bcl-2 by karanjin. |
2019-07-17 |
2023-08-13 |
mouse |
| Meng-Yao Sun, Dan-Dan Wang, Jian Sun, Xiao-Hua Zhao, Si Cai, Qiu-Xue Wu, Tao Jie, Zhen-Hua Ni, Jian-Yue Sun, Qing-Feng Tan. The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1. Chinese journal of natural medicines. vol 17. issue 3. 2019-07-17. PMID:30910056. |
notably, the apoptosis in gc cells was mediated by inducing cofilin-1 mitochondrial translocation, down-regulating bcl-2 and up-regulating bax expression. |
2019-07-17 |
2023-08-13 |
human |
| Loren D Walensk. Targeting BAX to drug death directly. Nature chemical biology. vol 15. issue 7. 2019-07-17. PMID:31209350. |
a series of physiologic and pharmacologic regulatory sites that mediate the activation or inhibition of bax have recently been identified, providing blueprints for the development of alternative apoptosis modulators to block pathologic cell survival or avert unwanted cell death by drugging bax directly. |
2019-07-17 |
2023-08-13 |
human |
| Jessica Neville Little, Noelle D Dwye. p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects. Human molecular genetics. vol 28. issue 3. 2019-07-15. PMID:30304535. |
by making double mutants with the pro-apoptotic genes bax and trp53 (p53), we find that p53-dependent apoptosis of cortical nscs accounts for most of the microcephaly, but that there is a significant apoptosis-independent contribution as well. |
2019-07-15 |
2023-08-13 |
mouse |
| Xiao-Yan Fan, Peng-Yu Wang, Chao Zhang, Yu-Long Zhang, Yun Fu, Cong Zhang, Qiao-Xia Li, Jie-Na Zhou, Bao-En Shan, Dong-Wei H. All-trans retinoic acid enhances cytotoxicity of CIK cells against human lung adenocarcinoma by upregulating MICA and IL-2 secretion. Scientific reports. vol 7. issue 1. 2019-07-12. PMID:29184163. |
furthermore, analysis of apoptosis markers bcl-2, bax, survivin and cleaved caspase-3 showed that bcl-2 and survivin mrna levels significantly decreased, and that bax mrna significantly increased, in the cik + atra-treated cells, with corresponding effects on their respective proteins. |
2019-07-12 |
2023-08-13 |
human |
| Qiong Wu, Xiang-Xiang Liu, Ding-Yan Lu, Yue-Ting Li, Jia Sun, Yan-Yu Lan, Ting Li. [Protective effect of Polygonum orientale flower extract on H₂O₂-induced oxidative damage of HUVEC cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 5. 2019-07-12. PMID:29676101. |
as compared with h₂o₂ model group, p.orientale flower extract of 50-200 mg·l⁻¹ could increase the viability of huvec cells, reduce ldh release and mda content, enhance the activities of sod and cat, down-regulate pro-apoptotic protein cleaved caspase-3 and bax, and up-regulate apoptosis inhibitory protein bcl-2. |
2019-07-12 |
2023-08-13 |
human |
| Mohamed M Zeweil, Kadry M Sadek, Nabil M Taha, Yasser El-Sayed, Sherif Menshaw. Graviola attenuates DMBA-induced breast cancer possibly through augmenting apoptosis and antioxidant pathway and downregulating estrogen receptors. Environmental science and pollution research international. vol 26. issue 15. 2019-07-11. PMID:30924043. |
nevertheless, administration of dmba and graviola especially dmba+g37 induced apoptosis through at least 1.5-fold in gene expression levels of pro-apoptotic genes: bcl2-associated x protein (bax), tumor suppressor gene (p53), and cysteinyl-aspartic acid-protease-3 (caspase-3). |
2019-07-11 |
2023-08-13 |
rat |
| Zhi-Li Jia, Juan Cen, Jia-Bo Wang, Feng Zhang, Qing Xia, Xue Wang, Xi-Qiang Chen, Rong-Chun Wang, Chung-der Hsiao, Ke-Chun Liu, Yun Zhan. Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway. Chemosphere. vol 227. 2019-07-10. PMID:31004821. |
furthermore, mrna levels of factors related to endoplasmic reticulum stress (ers) (grp78, atf6, perk, ire1, xbp1s and chop), apoptosis (bax, cyt, caspase-3, caspase-8 and caspase-9) and the nrf2 signalling pathway (nrf2, ho-1, nqo1, gclm and gclc) were significantly upregulated. |
2019-07-10 |
2023-08-13 |
cat |
| Bing Fu, Qinghong Zeng, Zhaoting Zhang, Mingyue Qian, Jiechun Chen, Wanli Dong, Min L. Epicatechin Gallate Protects HBMVECs from Ischemia/Reperfusion Injury through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization. Oxidative medicine and cellular longevity. vol 2019. 2019-07-09. PMID:30962864. |
data indicated that ecg could affect neovascularization and promote cell proliferation, tube formation, and cell migration while inhibiting apoptosis and autophagy through affecting vegf, bcl-2, bax, lc3b, caspase 3, mtor, and beclin-1 expression. |
2019-07-09 |
2023-08-13 |
human |
| Yun Xia Xu, Bo Wang, Xin Huai Zha. In vitro effects and the related molecular mechanism of galangin and quercetin on human gastric cancer cell line (SGC-7901). Pakistan journal of pharmaceutical sciences. vol 30. issue 4. 2019-07-08. PMID:29039326. |
the two flavonoids activated caspase-8, which cleaved bid into tbid; simultaneously, bax transferred from cytosol into mitochondria to decrease mmp; consequentially, cytochrome c released from mitochondria activated caspase-9, and then caspase-9 activated caspase-3, which executed the apoptosis. |
2019-07-08 |
2023-08-13 |
human |
| Yan Jia, Ruixin Lin, Hongjuan Jin, Lihui Si, Wenwen Jian, Qing Yu, Shuli Yan. MicroRNA-34 suppresses proliferation of human ovarian cancer cells by triggering autophagy and apoptosis and inhibits cell invasion by targeting Notch 1. Biochimie. vol 160. 2019-07-08. PMID:30905732. |
the mir-34 overexpression was concomitant with upsurge of apoptosis related proteins (bax) and the autophagy associated protein (lc3 ii and p62). |
2019-07-08 |
2023-08-13 |
human |
| Yuefeng He, Ruobing Zhang, Xiaoxiao Song, Li Shang, Xinan Wu, Dahai Huan. Inorganic arsenic exposure increased expression of Fas and Bax gene in vivo and vitro. Gene. vol 671. 2019-07-05. PMID:29864498. |
fas and bax genes are critical regulatory genes for apoptosis. |
2019-07-05 |
2023-08-13 |
human |
| Li-Hong Mei, Gao Yang, Fang Fan. Hyperbaric Oxygen Combined with 5-Aminolevulinic Acid Photodynamic Therapy Inhibited Human Squamous Cell Proliferation. Biological & pharmaceutical bulletin. vol 42. issue 3. 2019-07-03. PMID:30587670. |
in addition, we found that hbo significantly enhanced pdt-induced cell apoptosis via increasing the active caspase-3, active caspase-9, apaf-1 and bax levels and down-regulating bcl-2. |
2019-07-03 |
2023-08-13 |
human |
| Qing Xie, Shuai Wang, Yue Zhao, Zhenchao Zhang, Chuan Qin, Xianjun Yan. MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway. Oncology reports. vol 41. issue 5. 2019-07-03. PMID:30864744. |
microrna-216a overexpression led to a decrease in cell proliferation and migration, as well as increases in apoptosis, caspase-3/8 activities, bax expression and p53 protein expression in mcf-7 cells. |
2019-07-03 |
2023-08-13 |
human |
| F Guo, D Jiao, G Q Sui, L N Sun, Y J Gao, Q F Fu, C X Ji. Anticancer effect of YWHAZ silencing via inducing apoptosis and autophagy in gastric cancer cells. Neoplasma. vol 65. issue 5. 2019-07-01. PMID:29940752. |
further, ywhaz-silenced bgc-823 cells acquired increased apoptosis rate, which was confirmed by increased levels of cleaved caspase-3, cleaved parp, and bax, and decreased level of bcl-2. |
2019-07-01 |
2023-08-13 |
Not clear |
| S Q Feng, X Y Zhang, H T Fan, Q J Sun, M Zhan. Up-regulation of LncRNA MEG3 inhibits cell migration and invasion and enhances cisplatin chemosensitivity in bladder cancer cells. Neoplasma. vol 65. issue 6. 2019-07-01. PMID:29940769. |
ddp treatment significantly induced cell apoptosis, down-regulated bcl2 expression, and up-regulated cleaved-caspase-3 and bax expression in bc cells with meg3 over-expression. |
2019-07-01 |
2023-08-13 |
Not clear |
| T Jiang, J Chen, X B Huang, Y X Li, L Zhon. miR-451a induced apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells by targeting IL-6R. Neoplasma. vol 65. issue 6. 2019-07-01. PMID:30334451. |
ph+ all cell line sup-b15 and ph- all cell line nalm-6 were treated with mir-451a mimic and inhibitor, respectively; proliferation rate was assessed by cck-8, apoptosis rate was tested by annexin/pi and the expression levels of bcl-xl, bax, cyclin d2 and c-myc were examined by qpcr and western blot (wb). |
2019-07-01 |
2023-08-13 |
Not clear |
| Guangyu Zhou, Xiaofei Zhang, Wanning Wang, Wenlong Zhang, Huaying Wang, Guangda Xi. Both Peripheral Blood and Urinary miR-195-5p, miR-192-3p, miR-328-5p and Their Target Genes PPM1A, RAB1A and BRSK1 May Be Potential Biomarkers for Membranous Nephropathy. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-07-01. PMID:30865617. |
results a total of 1246 degs were identified from pbmcs samples, among them upregulated ccl5 was found to be involved in the chemokine signaling pathway, and bax was found to be apoptosis related; while downregulated ppm1a and cdk1 were associated with the mapk signaling pathway and the p53 signaling pathway, respectively. |
2019-07-01 |
2023-08-13 |
Not clear |
| Yingyuan Guo, Yanru Hao, Guofang Guan, Shuaishuai Ma, Zhiling Zhu, Fang Guo, Jie Ba. Mukonal Inhibits Cell Proliferation, Alters Mitochondrial Membrane Potential and Induces Apoptosis and Autophagy in Human CNE1 Nasopharyngeal Carcinoma Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-07-01. PMID:30877718. |
mukonal activated autophagy and apoptosis in cne1 cells, which was also associated with upregulation of the autophagy-related proteins, lc3 ii and beclin-1, as well as apoptosis-associated proteins, bax, cleaved caspase-3 and -9. |
2019-07-01 |
2023-08-13 |
human |