| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Yang, Gaopeng Guan, Lanjie Lei, Qizhuang Lv, Shengyuan Liu, Xiuwen Zhan, Zhenzhen Jiang, Xiang G. Palmitic acid induces human osteoblast-like Saos-2 cell apoptosis via endoplasmic reticulum stress and autophagy. Cell stress & chaperones. vol 23. issue 6. 2019-06-14. PMID:30194633. |
inhibiting autophagy with 3-ma attenuated the pa and er stress-induced cell apoptosis and the apoptosis-related gene expression (caspase 3 and bax), but seemed to have no obvious effects on er stress, although the chop expression was downregulated. |
2019-06-14 |
2023-08-13 |
human |
| Mohamed Rahmani, Jewel Nkwocha, Elisa Hawkins, Xinyan Pei, Rebecca E Parker, Maciej Kmieciak, Joel D Leverson, Deepak Sampath, Andrea Ferreira-Gonzalez, Steven Gran. Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells. Cancer research. vol 78. issue 11. 2019-06-13. PMID:29559471. |
venetoclax/gdc-0980 coadministration induced rapid and pronounced bax mitochondrial translocation, cytochrome c release, and apoptosis in various aml cell lines in association with akt/mtor inactivation and mcl-1 downregulation; ectopic expression of mcl-1 significantly protected cells from this regimen. |
2019-06-13 |
2023-08-13 |
Not clear |
| Haifa A S ALHaithloul, Mohammed F Alotaibi, May Bin-Jumah, Hassan Elgebaly, Ayman M Mahmou. Olea europaea leaf extract up-regulates Nrf2/ARE/HO-1 signaling and attenuates cyclophosphamide-induced oxidative stress, inflammation and apoptosis in rat kidney. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-13. PMID:30611992. |
in addition, ole significantly prevented oxidative stress, inflammation and apoptosis by enhancing the antioxidant defenses and bcl-2 expression, and suppressing the pro-inflammatory and pro-apoptotic markers nf-κb, bax, cytochrome c and caspase-3. |
2019-06-13 |
2023-08-13 |
rat |
| Haisen Yin, Risheng Que, Chunying Liu, Weidan Ji, Bin Sun, Xuejing Lin, Qin Zhang, Xinying Zhao, Zhangxiao Peng, Xiaofeng Zhang, Haihua Qian, Lei Chen, Yonggang Yao, Changqing S. Survivin-targeted drug screening platform identifies a matrine derivative WM-127 as a potential therapeutics against hepatocellular carcinoma. Cancer letters. vol 425. 2019-06-11. PMID:29608986. |
mechanistic studies showed that wm-127 suppressed the activity of survivin/β-catenin pathway and the expression of bax to induce cell cycle arrest and apoptosis. |
2019-06-11 |
2023-08-13 |
mouse |
| Edyta Wysokińska, Jakub Cichos, Agnieszka Kowalczyk, Mirosław Karbowiak, Leon Strządała, Artur Bednarkiewicz, Wojciech Kała. Toxicity Mechanism of Low Doses of NaGdF₄:Yb Biomolecules. vol 9. issue 1. 2019-06-10. PMID:30609856. |
at the molecular level, this led to upregulation of proapoptotic bax and downregulation of anti-apoptotic bcl-2, which triggered the apoptosis with phosphatidylserine externalization, caspase-3 activation and dna fragmentation. |
2019-06-10 |
2023-08-13 |
Not clear |
| Debarshi Sarkar, Deepanshu Joshi, Shio Kumar Sing. Maternal BDE-209 exposure during lactation causes testicular and epididymal toxicity through increased oxidative stress in peripubertal mice offspring. Toxicology letters. vol 311. 2019-06-10. PMID:31039416. |
maternal bde-209 exposure during lactation increased apoptosis and oxidative status with altered expressions of various cell survival (bcl-2), apoptotic (bax and caspase-3) and oxidative stress (nrf2 and ho-1) markers in testes and epididymis of peripubertal mice offspring. |
2019-06-10 |
2023-08-13 |
mouse |
| Yuanhang Ren, Yangping Mu, Ying Yue, Hong Jin, Ke Tao, Taiping Ho. Neochamaejasmin A extracted from Stellera chamaejasme L. induces apoptosis involving mitochondrial dysfunction and oxidative stress in Sf9 cells. Pesticide biochemistry and physiology. vol 157. 2019-06-10. PMID:31153465. |
we also observed that nca induced apoptosis via mitochondrial-dependent intrinsic apoptotic pathway by upregulating cytochrome c and proapoptotic protein (bax) and downregulating the mitochondrial membrane potential (mmp) and antiapoptotic protein (bcl-2). |
2019-06-10 |
2023-08-13 |
Not clear |
| M Shokoohi, H Shoorei, M Soltani, S-H Abtahi-Eivari, R Salimnejad, M Moghimia. Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion in adult rats. Andrologia. vol 50. issue 7. 2019-06-06. PMID:29770471. |
this study was designed to determine the effects of daily oral administration (250 mg/kg) of the hydroalcoholic extract of fumaria parviflora (fp) for 14 days on the sperm parameters, oxidative stress parameters, serum testosterone levels, expression of bax and bcl-2 genes, and apoptosis index of germ cells after testicular torsion-detorsion (ischaemia-reperfusion, ir) injury model in rats. |
2019-06-06 |
2023-08-13 |
rat |
| M Shokoohi, H Shoorei, M Soltani, S-H Abtahi-Eivari, R Salimnejad, M Moghimia. Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion in adult rats. Andrologia. vol 50. issue 7. 2019-06-06. PMID:29770471. |
the index of apoptosis, the gene expression of bax and the level of mda were significantly higher in td group than tdfp and fp groups. |
2019-06-06 |
2023-08-13 |
rat |
| Justin Kale, Ozgur Kutuk, Glauber Costa Brito, Tallulah S Andrews, Brian Leber, Anthony Letai, David W Andrew. Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance. EMBO reports. vol 19. issue 9. 2019-06-04. PMID:29987135. |
phosphorylation switches bax from promoting to inhibiting apoptosis thereby increasing drug resistance. |
2019-06-04 |
2023-08-13 |
human |
| Justin Kale, Ozgur Kutuk, Glauber Costa Brito, Tallulah S Andrews, Brian Leber, Anthony Letai, David W Andrew. Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance. EMBO reports. vol 19. issue 9. 2019-06-04. PMID:29987135. |
here, we connect akt pathway activation to reduced sensitivity to chemotherapy via akt phosphorylation of bax at residue s184, one of the pro-apoptotic bcl-2 family proteins required for cells to undergo apoptosis. |
2019-06-04 |
2023-08-13 |
human |
| Sweta Iyer, Rachel T Uren, Ruth M Kluc. Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage. Methods in molecular biology (Clifton, N.J.). vol 1877. 2019-05-31. PMID:30536008. |
mitochondrial permeabilization is a key event in the intrinsic pathway of apoptosis, and is mediated by either of the bcl-2 family members bak or bax. |
2019-05-31 |
2023-08-13 |
Not clear |
| Zeng Qi, Lixue Chen, Zhuo Li, Zijun Shao, Yuli Qi, Kun Gao, Songxin Liu, Yinshi Sun, Pingya Li, Jinping Li. Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study. International journal of molecular sciences. vol 20. issue 4. 2019-05-29. PMID:30769948. |
treatment with r-phq and s-phq clearly induced the apoptosis of tumor cells, significantly increased the expression of bax, and remarkably inhibited the expression of bcl-2 and vascular endothelial growth factor (vegf) in h22 tumor tissues. |
2019-05-29 |
2023-08-13 |
mouse |
| Bahram Rasoulian, Zahra Hajializadeh, Saeed Esmaeili-Mahani, Marzieh Rashidipour, Iman Fatemi, Ayat Kaeid. Neuroprotective and antinociceptive effects of rosemary (Rosmarinus officinalis L.) extract in rats with painful diabetic neuropathy. The journal of physiological sciences : JPS. vol 69. issue 1. 2019-05-28. PMID:29754274. |
activated caspase-3 and the bax:bcl-2 ratio, both biochemical indicators of apoptosis, were assessed in the dorsal half of the lumbar spinal cord tissue by western blotting. |
2019-05-28 |
2023-08-13 |
rat |
| Chuiming Jia, Dejuan Kong, Yiwei Guo, Lianqiao Li, Lina Qua. Enhanced antitumor effect of combination of annexin A1 knockdown and bortezomib treatment in multiple myeloma in vitro and in vivo. Biochemical and biophysical research communications. vol 505. issue 3. 2019-05-28. PMID:30292410. |
cell apoptosis was dramatically promoted in mm cells following silencing of anxa1 and btz administration versus that in anxa1-silenced alone or btz-treated alone cells, as evidenced by decreased expression of phosphorylated signal transducers and activators of transcription 3 and bcl2, and increased expression of bax. |
2019-05-28 |
2023-08-13 |
Not clear |
| Qing Zhang, Xiao-Feng Zhan. Hyperoside decreases the apoptosis and autophagy rates of osteoblast MC3T3‑E1 cells by regulating TNF‑like weak inducer of apoptosis and the p38mitogen activated protein kinase pathway. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30387825. |
expression levels of apoptosis‑associated genes, including caspase‑3, apoptosis regulator bax, apoptosis regulator bcl‑2 and cellular tumor antigen p53, in addition to autophagy‑associated genes, including beclin1 and microtubule‑associated protein light chain 3 conversion lc3‑ii/i, were measured using reverse transcription‑quantitative polymerase chain reaction and western blotting. |
2019-05-28 |
2023-08-13 |
Not clear |
| Jin-Xing Lv, Jian Zhou, Rui-Qing Tong, Bin Wang, Xue-Lei Chen, Yan-Yan Zhuang, Fei Xia, Xue-Dong We. Hypoxia‑induced miR‑210 contributes to apoptosis of mouse spermatocyte GC‑2 cells by targeting Kruppel‑like factor 7. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30431115. |
hypoxia‑inducible factor‑1α (hif‑1α), caspase‑3, b‑cell lymphoma 2, apoptosis regulator bax and kruppel‑like factor 7 (klf7) protein expression levels were detected by western blotting. |
2019-05-28 |
2023-08-13 |
mouse |
| Wen-Bin Jiang, Wei Zhao, Hao Chen, You-Yang Wu, Yi Wang, Guo-Sheng Fu, Xiang-Jun Yan. Baicalin protects H9c2 cardiomyocytes against hypoxia/reoxygenation-induced apoptosis and oxidative stress through activation of mitochondrial aldehyde dehydrogenase 2. Clinical and experimental pharmacology & physiology. vol 45. issue 3. 2019-05-24. PMID:29047162. |
however, we found that daidzin, an aldh2 antagonist, remarkably attenuated baicalin-elicited inhibitory action on h/r-induced the downregulation of cells viability and bcl-2 protein expression, and the upregulations of caspase-3 activity, apoptosis rate, cytochrome c and bax proteins expressions in h9c2 cells. |
2019-05-24 |
2023-08-13 |
Not clear |
| Fang Liu, Lei Yang, Yanqian Zheng, Wenhui Zhang, Jianming Zh. Effects and molecular mechanisms of AT1-AA in retinopathy of preeclampsia. Acta biochimica et biophysica Sinica. vol 51. issue 1. 2019-05-24. PMID:30566576. |
cell apoptosis and cytokines including reactive oxygen species (ros), as well as apoptosis-related proteins such as bcl-2, bax, and caspase-3 were detected. |
2019-05-24 |
2023-08-13 |
rat |
| Yang Wang, Hua-Jun Sun, Rong-Gui Li, Xiao-Mei Wang, Zhi-Qiang Cheng, Nan Lo. Reprogramming factors induce proliferation and inhibit apoptosis of melanoma cells by changing the expression of particular genes. Molecular medicine reports. vol 19. issue 2. 2019-05-24. PMID:30569122. |
induced expression of these factors also decreased the apoptosis, as well as upregulated b‑cell lymphoma 2 (bcl‑2) and downregulated bcl‑2‑associated x (bax) mrna expression levels. |
2019-05-24 |
2023-08-13 |
mouse |