| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fangfang Hu, Zhikuan He, Chaonan Sun, Dan Ron. Knockdown of GRHL2 inhibited proliferation and induced apoptosis of colorectal cancer by suppressing the PI3K/Akt pathway. Gene. vol 700. 2019-05-13. PMID:30917932. |
knockdown of grhl2 inhibited cell viability, elevated the apoptosis rates, suppressed the expression of pcna and bcl-2, and induced the expression of bax in hct116 and ht29 cells, and these effects were reversed by activation of the pi3k/akt pathway. |
2019-05-13 |
2023-08-13 |
human |
| Z Saker, O Tsintsadze, I Jiqia, L Managadze, A Chkhotu. IMPORTANCE OF APOPTOSIS MARKERS (MDM2, BCL-2 AND Bax) IN BENIGN PROSTATIC HYPERPLASIA AND PROSTATE CANCER. Georgian medical news. issue 249. 2019-05-10. PMID:26719543. |
importance of apoptosis markers (mdm2, bcl-2 and bax) in benign prostatic hyperplasia and prostate cancer. |
2019-05-10 |
2023-08-13 |
Not clear |
| Z Saker, O Tsintsadze, I Jiqia, L Managadze, A Chkhotu. IMPORTANCE OF APOPTOSIS MARKERS (MDM2, BCL-2 AND Bax) IN BENIGN PROSTATIC HYPERPLASIA AND PROSTATE CANCER. Georgian medical news. issue 249. 2019-05-10. PMID:26719543. |
mdm2, bcl-2 and bax are well recognized markers of apoptosis. |
2019-05-10 |
2023-08-13 |
Not clear |
| Z Saker, O Tsintsadze, I Jiqia, L Managadze, A Chkhotu. IMPORTANCE OF APOPTOSIS MARKERS (MDM2, BCL-2 AND Bax) IN CONVENTIONAL RENAL CELL CARCINOMA. Georgian medical news. issue 249. 2019-05-10. PMID:26719546. |
importance of apoptosis markers (mdm2, bcl-2 and bax) in conventional renal cell carcinoma. |
2019-05-10 |
2023-08-13 |
human |
| Yao Jing, Lin Zhang, Zhiming Xu, Hao Chen, Shiming Ju, Jun Ding, Yan Guo, Hengli Tia. Phosphatase Actin Regulator-1 (PHACTR-1) Knockdown Suppresses Cell Proliferation and Migration and Promotes Cell Apoptosis in the bEnd.3 Mouse Brain Capillary Endothelial Cell Line. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-05-10. PMID:30772888. |
results phactr-1 knockdown suppressed bend.3 cell proliferation and migration, promoted cell apoptosis, and downregulated the expressions of migration-associated proteins, including matrix metalloproteinase (mmp)-2 and mmp-9 and upregulated apoptosis-associated proteins, including bax, bcl-2, cleaved caspase-3, and caspase-3. |
2019-05-10 |
2023-08-13 |
mouse |
| Wenji Wang, Jianlin Chen, Baoshan Liao, Liqun Xia, Suying Hou, Zhiwen Wang, Yishan L. Identification and functional characterization of Histone-like DNA-binding protein in Nocardia seriolae (NsHLP) involved in cell apoptosis. Journal of fish diseases. vol 42. issue 5. 2019-05-10. PMID:30854666. |
quantitative assays of mitochondrial membrane potential value, caspase-3 activity and pro-apoptotic genes mrna (bad, bid and bax) expression level demonstrated that the cell apoptosis was induced in the transfected fhm cells. |
2019-05-10 |
2023-08-13 |
Not clear |
| Zi-Yu Tian, Shu-Min Li, Hui Guo, Rong-Rong An, Wen-Jia Yuan, Yan Meng, Peng Bai, Ying Wan. [Acupuncture of intraorbital and extraorbital acupoints reduces apoptosis of retinal ganglion by down-regulating expression of Caspase-3 and ratio of Bax/Bcl-2 in rabbits with nonarteritis anterior ischemic optic neuropathy]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 4. 2019-05-09. PMID:31056882. |
to observe the effect of acupuncture of intraorbital and extraorbital acupoints on apoptosis and expression of bax, bcl-2 and caspase-3 proteins of retinal ganglion tissue in rabbits with nonarteritis anterior ischemic optic neuropathy (naion), so as to reveal its mechanism underlying improvement of naion. |
2019-05-09 |
2023-08-13 |
Not clear |
| Danyal Smani, Sumit Sarkar, James Raymick, Jyotshna Kanungo, Merle G Paule, Qiang G. Downregulation of 14-3-3 Proteins in a Kainic Acid-Induced Neurotoxicity Model. Molecular neurobiology. vol 55. issue 1. 2019-05-08. PMID:28840498. |
this could lead to subsequent upregulation of 14-3-3-binding proteins such as bax and phospho-erk that contribute to further downstream apoptosis processes, eventually leading to cell death. |
2019-05-08 |
2023-08-13 |
rat |
| Ya-Nan Song, Ding Yuan, Chang-Cheng Zhang, Luo-Pei Wang, Yu-Min He, Ting Wang, Zhi-Yong Zho. [Effect of saponins extracted from Panax japonicus on inhibiting cardiomyocyte apoptosis by AMPK/Sirt1/NF-κB signaling pathway in aging rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 23. 2019-05-08. PMID:29376267. |
their myocardial morphology changes were observed by using haematoxylin-eoin(he) staining; cardiomyocyte apoptosis was tested by using tunel assays; and the protein expression levels of bcl-2, bax, il-1β, tnf-α, ampk, p-ampk, sirt1, and ac-nf-κb p65 in myocardial tissues of rats were detected by western blot. |
2019-05-08 |
2023-08-13 |
rat |
| Yasheen Gao, Caroline Y Um, Veronika Fedirko, Robin E Rutherford, March E Seabrook, Elizabeth L Barry, John A Baron, Roberd M Bostic. Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients. PloS one. vol 13. issue 12. 2019-05-07. PMID:30557404. |
to clarify the roles of vitamin d and calcium as potential chemopreventive agents against colorectal cancer in humans, and to develop "treatable", pre-neoplastic, phenotypic biomarkers of risk for colorectal neoplasms, we estimated the effects of supplemental vitamin d3 (1,000 iu/day [25 μg/day]) and calcium (1,200 mg/day), alone and in combination, on biomarkers of proliferation (mib-1), differentiation (p21), and apoptosis (bax [apoptosis-promoting] and bcl-2 [apoptosis-inhibiting]), in the normal-appearing rectal mucosa in a subsample of participants (n = 104) in a larger randomized, double-blind, placebo-controlled clinical trial among colorectal adenoma patients. |
2019-05-07 |
2023-08-13 |
human |
| Yasheen Gao, Caroline Y Um, Veronika Fedirko, Robin E Rutherford, March E Seabrook, Elizabeth L Barry, John A Baron, Roberd M Bostic. Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients. PloS one. vol 13. issue 12. 2019-05-07. PMID:30557404. |
these pilot study results support further investigation of whether 1) vitamin d and calcium promote colorectal epithelial cell differentiation, reduce proliferation, and promote apoptosis in the normal-appearing human colorectal mucosa, 2) vitamin d and calcium act as chemopreventive agents against colorectal neoplasms, and 3) mib-1, p21, and bax are potential "treatable", pre-neoplastic, biomarkers of risk for colorectal neoplasms. |
2019-05-07 |
2023-08-13 |
human |
| Kai Jin, Lunliang Ruan, Jiujun Pu, Ailing Zhong, Fuchao Wang, Song Tan, Hua Huang, Jiamin Mu, Gang Yan. Metformin suppresses growth and adrenocorticotrophic hormone secretion in mouse pituitary corticotroph tumor AtT20 cells. Molecular and cellular endocrinology. vol 478. 2019-05-06. PMID:30025915. |
meanwhile, metformin down-regulated the anti-apoptotic protein b cell lymphoma 2 (bcl-2) but up-regulated the pro-apoptotic protein bcl2-associated x (bax), which suggests the involvement of the mitochondrial-mediated apoptosis pathway. |
2019-05-06 |
2023-08-13 |
mouse |
| S Subhapriya, P Gomathipriy. Zeolite X from coal fly ash inhibits proliferation of human breast cancer cell lines (MCF-7) via induction of S phase arrest and apoptosis. Molecular biology reports. vol 45. issue 6. 2019-05-03. PMID:30206739. |
mechanistically, our data support the induction of apoptosis through the activation of mitochondrial dependent pathway as indicated by an up-regulation of bax and downregulation of bcl-2 ratio, the expulsion of cytochrome c from the mitochondria to the cytosol and cleavage of pro-caspase-3 into activation of caspase-3 in mcf-7 cells. |
2019-05-03 |
2023-08-13 |
human |
| María P Turiello, Andrea L Cristofolini, Mariana R Fiorimanti, Tomás Diaz, Lilia R Cavaglieri, Cecilia I Merki. Effect of prepubertal nutrition on cellular apoptosis and proliferation in at term placenta of Anglo-Nubian goats. Reproduction in domestic animals = Zuchthygiene. vol 54. issue 3. 2019-05-02. PMID:30575133. |
to evaluate the induction of apoptosis through the intrinsic pathway, proteins bax and bcl-2 were determinated. |
2019-05-02 |
2023-08-13 |
Not clear |
| Adam Tarko, Aneta Štochmalova, Sandra Hrabovszka, Adriana Vachanova, Abdel Halim Harrath, Saleh Alwasel, Roland Grossman, Alexander V Sirotki. Can xylene and quercetin directly affect basic ovarian cell functions? Research in veterinary science. vol 119. 2019-04-30. PMID:30086515. |
proliferation and apoptosis were assessed via immunocytochemistry using pcna and bax markers. |
2019-04-30 |
2023-08-13 |
cattle |
| Olga Fedorova, Alexey Petukhov, Alexandra Daks, Oleg Shuvalov, Tatyana Leonova, Elena Vasileva, Nikolai Aksenov, Gerry Melino, Nikolai A Barle. Orphan receptor NR4A3 is a novel target of p53 that contributes to apoptosis. Oncogene. vol 38. issue 12. 2019-04-30. PMID:30455429. |
functionally, over-expression of nr4a3 attenuated proliferation of cancer cells and promoted apoptosis by augmenting the expression of pro-apoptotic genes, puma and bax. |
2019-04-30 |
2023-08-13 |
Not clear |
| Xiaolu Zhang, Jing Liu, Yufeng Gu, Chengming Sun, Fuzheng Q. Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs. Cell biology international. vol 43. issue 2. 2019-04-30. PMID:30536541. |
the intrinsic apoptosis pathway was activated in lncrna ogfrp1 silenced cells, including increased bax and active-caspase 3 and decreased bcl2. |
2019-04-30 |
2023-08-13 |
human |
| C Wang, Z P Mao, L Wang, F H Zhang, G H Wu, D Y Wang, J L Sh. Cordycepin inhibits cell growth and induces apoptosis in human cholangiocarcinoma. Neoplasma. vol 64. issue 6. 2019-04-29. PMID:28895407. |
in the present study, colony formation assay, cell-counting kit-8 (cck-8) assay and tumor xenograft experiment were performed to evaluate the effect of cordycepin on human cca cell growth in vitro and in vivo; flow cytometric analysis was performed to evaluate the effect of cordycepin on cell apoptosis; quantitative real-time reverse transcription pcr (qrt-pcr) and western blot assays were performed to evaluate the expression levels of caspase-3, bcl-2 and bax. |
2019-04-29 |
2023-08-13 |
human |
| C Wang, Z P Mao, L Wang, F H Zhang, G H Wu, D Y Wang, J L Sh. Cordycepin inhibits cell growth and induces apoptosis in human cholangiocarcinoma. Neoplasma. vol 64. issue 6. 2019-04-29. PMID:28895407. |
furthermore, the flow cytometric analysis, qrt-pcr and western blot assays showed that cordycepin could trigger qbc939 and rbe cells apoptosis by regulating the expression levels of caspase-3, bcl-2 and bax. |
2019-04-29 |
2023-08-13 |
human |
| Wen-Ying Wei, Zhen-Guo Ma, Ning Zhang, Si-Chi Xu, Yu-Pei Yuan, Xiao-Feng Zeng, Qi-Zhu Tan. Overexpression of CTRP3 protects against sepsis-induced myocardial dysfunction in mice. Molecular and cellular endocrinology. vol 476. 2019-04-29. PMID:29655602. |
additionally, ctrp3 suppressed cardiac apoptosis induced by lps in mice as indicated by terminal deoxynucleotidyl transferase nick-end labeling (tunel) staining and western blot for cleaved-caspase3, bax and bcl-2. |
2019-04-29 |
2023-08-13 |
mouse |