| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mi Liu, Weiming Ai, Limei Sun, Fang Fang, Xuedong Wang, Shaobo Chen, Huili Wan. Triclosan-induced liver injury in zebrafish (Danio rerio) via regulating MAPK/p53 signaling pathway. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 222. 2019-07-01. PMID:31048017. |
the mrna and protein expression of anti-apoptotic protein bcl-2 decreased, while that of pro-apoptosis protein bax significantly increased, identifying that liver injury was closely related to hepatocyte apoptosis. |
2019-07-01 |
2023-08-13 |
zebrafish |
| Enping Huang, Hongyan Huang, Tianshan Guan, Chao Liu, Dong Qu, Yue Xu, Jiao Yang, Lei Yan, Yahui Xiong, Ting Liang, Qi Wang, Ling Che. Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. Toxicology letters. vol 312. 2019-07-01. PMID:31059759. |
lowering levels of parkin raised up α-syn expression, which initiated mitochondrial apoptosis by down-regulating anti-apoptotic bcl-2, followed by up-regulation of pro-apoptotic bax, resulting in translocation of cytochrome c (cyto c), an apoptogenic factor, from the mitochondria to cytoplasm and activation of caspase-dependent pathways. |
2019-07-01 |
2023-08-13 |
human |
| Yogesh Kumar, Alugoju Phaniendra, Latha Periyasam. Bixin Triggers Apoptosis of Human Hep3B Hepatocellular Carcinoma Cells: An Insight to Molecular and IN SILICO Approach. Nutrition and cancer. vol 70. issue 6. 2019-06-27. PMID:30204479. |
ros production caused dna damage and apoptosis was marked by cell cycle arrest, up-regulation of bax and fasl protein as well as cleavage of caspase-9, caspase-8 and caspase-3 protein. |
2019-06-27 |
2023-08-13 |
human |
| Ying-Yan Fang, Peng Zeng, Na Qu, Lin-Na Ning, Jiang Chu, Teng Zhang, Xin-Wen Zhou, Qing Tia. Evidence of altered depression and dementia-related proteins in the brains of young rats after ovariectomy. Journal of neurochemistry. vol 146. issue 6. 2019-06-26. PMID:29939407. |
a link between neuronal loss and apoptosis was suggested, as evidenced by increases in adenylate kinase 2 (ak2), b-cell lymphoma 2 associated x (bax), cleaved caspase 3, and phosphorylated p53 and decreases in huntingtin-interacting protein k, hexokinase, and phosphorylated b-cell lymphoma 2 (bcl-2), and apoptosis might be triggered by endoplasmic reticulum stress (probed by increased glucose-regulated protein 78 (grp78), cleaved caspase 12, phosphorylated protein kinase r (pkr)-like endoplasmic reticulum kinase, inositol-requiring enzyme-1 and activating transcription factor 6), and mitochondrial dysfunction (probed by increased cytochrome c and cleaved caspase 3 and decreased sideroflexin-1 (sfxn1) and nadh dehydrogenase (ubiquinone) 1 α subcomplex 11 (ndufa11)). |
2019-06-26 |
2023-08-13 |
rat |
| Jie-Ning Zhu, Yong-Heng Fu, Zhi-Qin Hu, Wen-Yu Li, Chun-Mei Tang, Hong-Wen Fei, Hui Yang, Qiu-Xiong Lin, De-Ming Gou, Shu-Lin Wu, Zhi-Xin Sha. Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity. Scientific reports. vol 7. issue 1. 2019-06-25. PMID:28928469. |
moreover, enforced expression of sirt1 alleviated dox-induced apoptosis of h9c2 cells, with suppressing levels of p66shc, bax, the activated caspase-3 and mir-34a-5p, and enhancing bcl-2 expression. |
2019-06-25 |
2023-08-13 |
human |
| Paul Castellano, Lisa Prevedel, Eliseo A Eugeni. HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim. Scientific reports. vol 7. issue 1. 2019-06-25. PMID:28993666. |
analysis of the pro- and anti-apoptotic pathways indicated no significant changes in bcl-2, mcl-1, bak, bax or caspase activation, suggesting that hiv blocks a very early step of apoptosis. |
2019-06-25 |
2023-08-13 |
human |
| Wen-Shuang Sheng, He-Lin Xu, Lei Zheng, Yuan-Di Zhuang, Li-Zhuo Jiao, Jia-Feng Zhou, De-Li ZhuGe, Ting-Ting Chi, Ying-Zheng Zhao, Li La. Intrarenal delivery of bFGF-loaded liposome under guiding of ultrasound-targeted microbubble destruction prevent diabetic nephropathy through inhibition of inflammation. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup2. 2019-06-24. PMID:29653493. |
in addition, inflammation-induced cellular apoptosis of renal tubular cells was also significantly inhibited by detecting bax, caspase-3 and bcl-2. |
2019-06-24 |
2023-08-13 |
rat |
| Chengjun Li, Xing Zhou, Chang Sun, Xiaozhou Liu, Xin Shi, Sujia W. Isoliquiritigenin inhibits the proliferation, apoptosis and migration of osteosarcoma cells. Oncology reports. vol 41. issue 4. 2019-06-24. PMID:30720124. |
increased tumor cell apoptosis triggered by isl was associated with downregulation of apoptosis regulator bcl‑2, upregulation of apoptosis regulator bax and damaged mitochondrial function evidenced by a low level of atp‑synthesis. |
2019-06-24 |
2023-08-13 |
Not clear |
| Zhaohai Pan, Chuanjun Qu, Ying Chen, Xiaoyu Chen, Xiaona Liu, Wenjin Hao, Wenjuan Xu, Lei Ye, Peng Lu, Defang Li, Qiusheng Zhen. Bufotalin induces cell cycle arrest and cell apoptosis in human malignant melanoma A375 cells. Oncology reports. vol 41. issue 4. 2019-06-24. PMID:30816542. |
furthermore, bufotalin significantly increased bax expression levels, decreased bcl‑2 expression, and then upregulated apoptosis‑related proteins, caspase‑3/-9, followed by a375 cell apoptosis. |
2019-06-24 |
2023-08-13 |
human |
| Enkhtaivan Gansukh, Khine Khine Mya, Mina Jung, Young-Soo Keum, Doo Hwan Kim, Ramesh Kumar Sain. Lutein derived from marigold (Tagetes erecta) petals triggers ROS generation and activates Bax and caspase-3 mediated apoptosis of human cervical carcinoma (HeLa) cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 127. 2019-06-24. PMID:30826408. |
lutein derived from marigold (tagetes erecta) petals triggers ros generation and activates bax and caspase-3 mediated apoptosis of human cervical carcinoma (hela) cells. |
2019-06-24 |
2023-08-13 |
human |
| Min Quan, Shunai Liu, Li Zhou, Shenghu Feng, Yu Zhang, Jun Chen. Hepatitis C virus nonstructural 5A protein inhibits the starvation‑induced apoptosis of hepatoblastoma cells by increasing Beclin 1 expression. Oncology reports. vol 41. issue 5. 2019-06-24. PMID:30896822. |
furthermore, it was confirmed that beclin 1 expression by ns5a was involved in the negative regulation of starvation‑induced liver cancer apoptosis, which was accompanied by reduced p53 and apoptosis regulator bax expression, as well as decreased caspase‑3/-7 activation. |
2019-06-24 |
2023-08-13 |
Not clear |
| Ajaz Ahmad, Atif Zafar, Masood Ahma. Mitigating effects of apigenin on edifenphos-induced oxidative stress, DNA damage and apoptotic cell death in human peripheral blood lymphocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 127. 2019-06-24. PMID:30910686. |
in addition, results indicate that edf induced apoptosis in lymphocytes concurrent with ros generation, loss of mitochondrial membrane potential, up-regulation of bax and caspase-9/-3 activation. |
2019-06-24 |
2023-08-13 |
human |
| Keywan Mortezaee, Masoud Najafi, Bagher Farhood, Amirhossein Ahmadi, Yaiza Potes, Dheyauldeen Shabeeb, Ahmed Eleojo Mus. Modulation of apoptosis by melatonin for improving cancer treatment efficiency: An updated review. Life sciences. vol 228. 2019-06-24. PMID:31077716. |
melatonin through modulation of several apoptosis mediators such as mitochondria, bax, bcl-2, endogenous ros, and apoptosis receptors facilitate apoptosis. |
2019-06-24 |
2023-08-13 |
Not clear |
| Yan Tang, Zuocheng Wang, JungWoo Yang, Wang Zheng, Di Chen, Guanqing Wu, Richard Sandford, Jingfeng Tang, Xing-Zhen Che. Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway. Scientific reports. vol 7. issue 1. 2019-06-21. PMID:28904368. |
our tunel experiments using tunicamycin, an apoptosis inducer, and gadd34, an inhibitor of eif2α phosphorylation, demonstrated that pc1-5tmc inhibits apoptosis of hek293t cells in a pkr-eif2α-dependent manner, with concurrent up- and down-regulation of bcl-2 and bax, respectively, revealed by western blotting. |
2019-06-21 |
2023-08-13 |
mouse |
| Tao Wu, Xi Duan, Chunyan Hu, Changqiang Wu, Xiaobin Chen, Jing Huang, Junbo Liu, Shu Cu. Synthesis and characterization of gold nanoparticles from Abies spectabilis extract and its anticancer activity on bladder cancer T24 cells. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-06-20. PMID:30810403. |
condensation and dna fragmentation are characteristic of apoptosis by dapi, tunel staining, and the significant up regulations of beclin-1, bax and caspase 3, whereas the expressions of anti-apoptotic bcl-2 and bid were down regulated. |
2019-06-20 |
2023-08-13 |
Not clear |
| Maowei He, Zimin Xiang, Libin Xu, Yanting Duan, Fangqin Li, Jianmei Che. Lipopolysaccharide induces human olfactory ensheathing glial apoptosis by promoting mitochondrial dysfunction and activating the JNK-Bnip3-Bax pathway. Cell stress & chaperones. vol 24. issue 1. 2019-06-18. PMID:30374881. |
furthermore, we verified that lps modulated mitochondrial apoptosis by promoting bax upregulation, and this process was regulated by the jnk-bnip3 pathway. |
2019-06-18 |
2023-08-13 |
human |
| Maowei He, Zimin Xiang, Libin Xu, Yanting Duan, Fangqin Li, Jianmei Che. Lipopolysaccharide induces human olfactory ensheathing glial apoptosis by promoting mitochondrial dysfunction and activating the JNK-Bnip3-Bax pathway. Cell stress & chaperones. vol 24. issue 1. 2019-06-18. PMID:30374881. |
inhibition of the jnk-bnip3 pathway prevented lps-mediated bax activation, thus attenuating oeg apoptosis. |
2019-06-18 |
2023-08-13 |
human |
| Mahnoosh Abbaszade Dibavar, Masoud Soleimani, Amir Atashi, Neda Rassaei, Shahin Amir. The effect of simultaneous administration of arsenic trioxide and microvesicles derived from human bone marrow mesenchymal stem cells on cell proliferation and apoptosis of acute myeloid leukemia cell line. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup3. 2019-06-18. PMID:30600718. |
the results showed lower cell viability rate, higher apoptosis ratio, higher bax gene, and lower ki67 and bcl-2 genes' expression in cells exposed to mvs in combination with ato compared to cells treated with each agent alone and non-treated control. |
2019-06-18 |
2023-08-13 |
human |
| Jiaying Zhang, Mengqi Li, Qunli Yu, Ling Han, Zuolin M. Effects of Lysosomal-Mitochondrial Apoptotic Pathway on Tenderness in Post-Mortem Bovine Longissimus Muscle. Journal of agricultural and food chemistry. vol 67. issue 16. 2019-06-17. PMID:30933511. |
activated bid and bax triggered mitochondrial membrane permeability ( p < 0.05) and further activated caspase-9 and caspase-3 ( p < 0.05), leading to apoptosis. |
2019-06-17 |
2023-08-13 |
cattle |
| Lei Yang, Gaopeng Guan, Lanjie Lei, Qizhuang Lv, Shengyuan Liu, Xiuwen Zhan, Zhenzhen Jiang, Xiang G. Palmitic acid induces human osteoblast-like Saos-2 cell apoptosis via endoplasmic reticulum stress and autophagy. Cell stress & chaperones. vol 23. issue 6. 2019-06-14. PMID:30194633. |
inhibiting er stress with 4-pba diminished the pa-induced cell apoptosis, activated autophagy, and increased the expression of caspase 3 and bax. |
2019-06-14 |
2023-08-13 |
human |