| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Wang, Hua-Jun Sun, Rong-Gui Li, Xiao-Mei Wang, Zhi-Qiang Cheng, Nan Lo. Reprogramming factors induce proliferation and inhibit apoptosis of melanoma cells by changing the expression of particular genes. Molecular medicine reports. vol 19. issue 2. 2019-05-24. PMID:30569122. |
taken together, the results suggested that upregulated jak2 and cyclin‑b1 may be responsible for the enhanced proliferation of melanoma cells, and that bcl‑2 upregulation and bax downregulation may account for the suppressed apoptosis of these cells. |
2019-05-24 |
2023-08-13 |
mouse |
| Ruirui Yang, Jianmei Chen, Li Wang, Aijing Den. LncRNA BANCR participates in polycystic ovary syndrome by promoting cell apoptosis. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30592281. |
kgn cells were also transfected with a bancr expression vector, after which, cell proliferation, apoptosis and the expression levels of pro‑apoptotic b‑cell lymphoma 2‑associated x protein (bax) and p53 were detected by cell counting kit‑8 assay, mtt assay and western blotting, respectively. |
2019-05-24 |
2023-08-13 |
human |
| Ruirui Yang, Jianmei Chen, Li Wang, Aijing Den. LncRNA BANCR participates in polycystic ovary syndrome by promoting cell apoptosis. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30592281. |
transfection with the bancr expression vector significantly inhibited proliferation and promoted apoptosis of kgn cells, and significantly promoted the expression levels of pro‑apoptotic bax and p53. |
2019-05-24 |
2023-08-13 |
human |
| Ruirui Yang, Jianmei Chen, Li Wang, Aijing Den. LncRNA BANCR participates in polycystic ovary syndrome by promoting cell apoptosis. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30592281. |
therefore, it may be concluded that lncrna bancr participates in pcos by promoting cell apoptosis through the upregulation of bax and p53. |
2019-05-24 |
2023-08-13 |
human |
| Ziyun Gao, Junqi Shan, Bishi Wang, Luxin Qiao, Dexi Chen, Yulin Zhan. DRAM Is Involved in Regulating Nucleoside Analog-Induced Neuronal Autophagy in a p53-Independent Manner. Molecular neurobiology. vol 55. issue 3. 2019-05-23. PMID:28265856. |
the level of na-induced bcl-2 and bax expressions determined whether neuronal autophagy or apoptosis occurred. |
2019-05-23 |
2023-08-13 |
mouse |
| Simin Mirakhor Samani, Tahmineh Ezazi Bojnordi, Manijeh Zarghampour, Sobhan Merat, Daniel F Foulad. Expression of p53, Bcl-2 and Bax in endometrial carcinoma, endometrial hyperplasia and normal endometrium: a histopathological study. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. vol 38. issue 7. 2019-05-23. PMID:29560769. |
the p53, bcl-2 and bax are the three major genes that regulate apoptosis. |
2019-05-23 |
2023-08-13 |
human |
| Fang Yao, Dongjing Jiang, Fangfang Cheng, Weifeng Yao, Peidong Chen, Shuchen Guo, Yudan Cao, Li Zhan. Diterpene pekinenal from euphorbia pekinensis radix induced IEC-6 cells apoptosis mediated by mitochondria and death receptors. Toxicology in vitro : an international journal published in association with BIBRA. vol 57. 2019-05-23. PMID:30710624. |
furthermore, pekinenal up-regulated the expression level of apoptotic protein including bax, aif, apaf-1 and the expression level of mrna such as fas, fasl, tnfr1 and nf-κb, while down-regulated the expression level of bcl-2, ultimately triggering the apoptosis of caspase dependence. |
2019-05-23 |
2023-08-13 |
rat |
| Li You, Ying-Ying Pan, Meng-Yao An, Wen-Hua Chen, Ying Zhang, Yan-Na Wu, Yan Li, Kai Sun, Yong-Qiang Yin, Jian-Shi Lo. The Cardioprotective Effects of Remote Ischemic Conditioning in a Rat Model of Acute Myocardial Infarction. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-05-22. PMID:30848248. |
results the ric group showed improved cardiac hemodynamics, reduced the size of the myocardial infarction, upregulated expression of bcl-2, and down-regulation of the levels of bax, caspase-3, and inos, and reduced cardiac myocyte apoptosis and inhibited the opening of the mitochondrial permeability transition pore (mptp). |
2019-05-22 |
2023-08-13 |
rat |
| Jian-Chun Lin, Zhong-Guo Liu, Bin Yu, Xian-Rong Zhan. MicroRNA-874 targeting SUFU involves in osteoblast proliferation and differentiation in osteoporosis rats through the Hedgehog signaling pathway. Biochemical and biophysical research communications. vol 506. issue 1. 2019-05-21. PMID:30342851. |
besides, elevated expression of mir-874, shh, ptch, smo, bmp2, runx2 and pcna, as well as increased cell viability, alp activity and calcium nodules but decreased expression of sufu and bax, and reduced cell apoptosis were confirmed when treated with mir-874 mimic. |
2019-05-21 |
2023-08-13 |
mouse |
| K M Ahsanul Kabir, Ruhul Amin, Imtiaj Hasan, A K M Asaduzzaman, Hamida Khatun, Syed Rashel Kabi. Geodorum densiflorum rhizome lectin inhibits Ehrlich ascites carcinoma cell growth by inducing apoptosis through the regulation of BAX, p53 and NF-κB genes expression. International journal of biological macromolecules. vol 125. 2019-05-21. PMID:30521911. |
geodorum densiflorum rhizome lectin inhibits ehrlich ascites carcinoma cell growth by inducing apoptosis through the regulation of bax, p53 and nf-κb genes expression. |
2019-05-21 |
2023-08-13 |
mouse |
| Pei Chen, Hui-Ping Liu, Hai-Hu Ji, Na-Xin Sun, Ying-Ying Fen. A cold-water soluble polysaccharide isolated from Grifola frondosa induces the apoptosis of HepG2 cells through mitochondrial passway. International journal of biological macromolecules. vol 125. 2019-05-20. PMID:30236758. |
and western blot analysis of bax, bcl-2, cytochrome c (cyto-c), caspase-3, and caspase-9 further demonstrated that the cgfp-induced apoptosis effect functioned through the mitochondrial pathway. |
2019-05-20 |
2023-08-13 |
human |
| Ling Liu, Li Yang, Hui Chang, Yan-Nan Chen, Feng Zhang, Shuo Feng, Juan Peng, Chen-Chen Ren, Xiao-An Zhan. CP‑31398 attenuates endometrial cancer cell invasion, metastasis and resistance to apoptosis by downregulating MDM2 expression. International journal of oncology. vol 54. issue 3. 2019-05-20. PMID:30628640. |
the expression of p53, p21, bad, bax, b‑cell lymphoma‑2 (bcl‑2), cytochrome c (cyt‑c), caspase‑3, cox‑2, matrix metalloproteinase (mmp)‑2 and mmp‑9 was measured to further confirm the effects of cp‑31398 on cell migration, invasion and apoptosis. |
2019-05-20 |
2023-08-13 |
Not clear |
| Ling Liu, Li Yang, Hui Chang, Yan-Nan Chen, Feng Zhang, Shuo Feng, Juan Peng, Chen-Chen Ren, Xiao-An Zhan. CP‑31398 attenuates endometrial cancer cell invasion, metastasis and resistance to apoptosis by downregulating MDM2 expression. International journal of oncology. vol 54. issue 3. 2019-05-20. PMID:30628640. |
the ec cells treated with cp‑31398 or sirna against mdm2 exhibited an increased apoptosis and a suppressed migration and invasion, corresponding to an increased expression of p53, p21, bad, bax, cyt‑c and caspase‑3, as well as to a decreased expression of bcl‑2, cox‑2, mmp‑2 and mmp‑9. |
2019-05-20 |
2023-08-13 |
Not clear |
| Xuejiao Song, Tiantao Gao, Qian Lei, Lidan Zhang, Yuqin Yao, Jingyuan Xion. Piperlongumine Induces Apoptosis in Human Melanoma Cells Via Reactive Oxygen Species Mediated Mitochondria Disruption. Nutrition and cancer. vol 70. issue 3. 2019-05-17. PMID:29543494. |
in addition, piperlongumine was reported to interfere with the expression of p21, p27, cleaved caspases-3, bax, bcl-2, and p-jun n-terminal kinase (jnk), which are typical regulators associated with cell proliferation, intrinsic apoptosis, and jnks pathway. |
2019-05-17 |
2023-08-13 |
human |
| Qingmei Li, Yanqin Zhang, Qiuli Jian. MFAP5 suppression inhibits migration/invasion, regulates cell cycle and induces apoptosis via promoting ROS production in cervical cancer. Biochemical and biophysical research communications. vol 507. issue 1-4. 2019-05-17. PMID:30454902. |
moreover, apoptosis was highly induced by mfap5 silence through reducing bcl-xl and bcl-2 expressions, and promoting bax, cleaved caspase-3 and poly (adp-ribose) polymerase (parp) expressions in cervical cancer cells. |
2019-05-17 |
2023-08-13 |
human |
| Xiaowu Li, Chunhui Chen, Yu Dai, Chengzhi Huang, Qinrui Han, Linlin Jing, Ye Ma, Yihua Xu, Yawei Liu, Liang Zhao, Junjiang Wang, Xuegang Sun, Xueqing Ya. Cinobufagin suppresses colorectal cancer angiogenesis by disrupting the endothelial mammalian target of rapamycin/hypoxia-inducible factor 1α axis. Cancer science. vol 110. issue 5. 2019-05-17. PMID:30839155. |
endothelial apoptosis is triggered by cinobufagin by stimulation of bax and cascade activation of caspase 9 and caspase 3. |
2019-05-17 |
2023-08-13 |
mouse |
| Rui Wang, Boping Wen, Dong Su. miR-573 regulates cell proliferation and apoptosis by targeting Bax in nucleus pulposus cells. Cellular & molecular biology letters. vol 24. 2019-05-17. PMID:30936926. |
mir-573 regulates cell proliferation and apoptosis by targeting bax in nucleus pulposus cells. |
2019-05-17 |
2023-08-13 |
human |
| Anita Skakic, Marina Andjelkovic, Natasa Tosic, Kristel Klaassen, Maja Djordjevic, Sonja Pavlovic, Maja Stojiljkovi. CRISPR/Cas9 genome editing of SLC37A4 gene elucidates the role of molecular markers of endoplasmic reticulum stress and apoptosis in renal involvement in glycogen storage disease type Ib. Gene. vol 703. 2019-05-17. PMID:30951856. |
in this model system we used rt-qpcr analysis to investigate the expression of molecular markers of the upr response (atf4, ddit3, hspa5, and xbp1s) and apoptosis (bcl2, bax). |
2019-05-17 |
2023-08-13 |
human |
| Qun Zeng, Huilan Yi, Liqun Huang, Quan An, Hong Wan. Long-term arsenite exposure induces testicular toxicity by redox imbalance, G2/M cell arrest and apoptosis in mice. Toxicology. vol 411. 2019-05-15. PMID:30278210. |
arsenite induced testicular apoptosis with a significant increase in bax mrna and protein levels, especially the caspase-3 activation. |
2019-05-15 |
2023-08-13 |
mouse |
| Ahmad Khosravi, Iraj Sharifi, Hadi Tavakkoli, Ali Reza Keyhani, Ali Afgar, Zohreh Salari, Seyedeh Saedeh Mosallanejad, Mehdi Bamorovat, Fatemeh Sharifi, Saeid Hassanzadeh, Balal Sadeghi, Shahriar Dabiri, Abbas Mortazaeizdeh, Zahra Sheikhshoaie, Ehsan Salarki. Vascular apoptosis associated with meglumine antimoniate: In vivo investigation of a chick embryo model. Biochemical and biophysical research communications. vol 505. issue 3. 2019-05-13. PMID:30297110. |
in addition, ihc assay confirmed the low expression bcl2 and increased expression of bax, which are associated with a high rate of apoptosis. |
2019-05-13 |
2023-08-13 |
chicken |