| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui-Fang Dong, Li-Wen Tai, Bing Zhang, Fang-Kun Shi, Hong-Mei Liu, Peng-Cang Duan, Ye Chen. Neuroprotective effect of FMS-like tyrosine kinase-3 silence on cerebral ischemia/reperfusion injury in a SH-SY5Y cell line. Gene. vol 697. 2019-04-11. PMID:30772520. |
also, we observed that flt3 silence suppressed ogd/r-induced sh-sy5y cell apoptosis, apoptosis related protein bax level and caspase-3 activity was decreased and bcl-2 expression was increased in flt3 silence sh-sy5y cell treated with ogd/r. |
2019-04-11 |
2023-08-13 |
Not clear |
| Shifu Hu, Jing Yang, Meng Rao, Yingying Wang, Fang Zhou, Guiping Cheng, Wei Xia, Changhong Zh. Copper nanoparticle-induced uterine injury in female rats. Environmental toxicology. vol 34. issue 3. 2019-04-09. PMID:30556269. |
signal transduction mechanism studies indicated that exposure to cu-nps activated caspases 3, 8, and 9 and bh3 interacting domain death agonist (tbid), reduced b cell leukemia/lymphoma 2 (bcl-2) expression, and increased the expression of apoptotic peptidase activating factor 1 (apaf-1), bcl2-associated x, apoptosis regulator (bax), and cytochrome c. a microarray analysis revealed significant alterations in the expression of 963 genes; of these, 622 were upregulated and 341 were downregulated. |
2019-04-09 |
2023-08-13 |
rat |
| Zhenyu Zhou, Yu Chen, Wei Ni, Tao Li. Upregulation of Nuclear Factor IA Suppresses Oxidized Low-Density Lipoprotein-Induced Endoplasmic Reticulum Stress and Apoptosis in Human Umbilical Vein Endothelial Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-04-09. PMID:30721172. |
overexpression of nfia remarkably inhibited ers and mitochondrial-mediated apoptosis induced by ox-ldl in huvecs by reversing the effect of ox-ldl on the expression of jnk1, p-jnk1, chop, cyt c, and bax. |
2019-04-09 |
2023-08-13 |
human |
| Yan Du, Lan-Lan Li, Hao Chen, Cong Wang, Xue-Wen Qian, Yu-Bin Feng, Lei Zhang, Fei-Hu Che. A novel all-trans retinoic acid derivative inhibits proliferation and induces apoptosis of myelodysplastic syndromes cell line SKM-1 cells via up-regulating p53. International immunopharmacology. vol 65. 2019-04-08. PMID:30415163. |
in addition, real-time quantitative rt-pcr (qrt-pcr) and western blotting were used to analyzed the expression of p53, as well as the levels of bnip3, apoptosis proteins of caspase-3, bax and bcl-2. |
2019-04-08 |
2023-08-13 |
Not clear |
| Anna Niewiarowska-Sendo, Andrzej Kozik, Ibeth Guevara-Lor. Influence of bradykinin B2 receptor and dopamine D2 receptor on the oxidative stress, inflammatory response, and apoptotic process in human endothelial cells. PloS one. vol 13. issue 11. 2019-04-08. PMID:30427893. |
in turn, endothelial cell co-stimulation with b2r and d2r agonists inhibited the release of interleukin-6 and endothelin-1 and modulated the expression of apoptosis markers, such as bcl-2, bcl-xl, bax, and caspase 3/7 activity. |
2019-04-08 |
2023-08-13 |
human |
| Abdul Ajees Abdul Salam, Upendra Nayek, Dhanya Suni. Homology Modeling and Docking Studies of Bcl-2 and Bcl-xL with Small Molecule Inhibitors: Identification and Functional Studies. Current topics in medicinal chemistry. vol 18. issue 31. 2019-04-08. PMID:30659540. |
the anti-apoptotic proteins such as bcl-2 and bcl-xl prevent apoptosis, whereas pro-apoptotic members like bax and bak, elicit the release of caspases from death antagonists inducing apoptosis. |
2019-04-08 |
2023-08-13 |
Not clear |
| Junming Fan, Hui Guang, Haizeng Zhang, Danyang Chen, Lu Ding, Xiaofang Fan, Feng Xue, Zhuohui Gan, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gon. SIRT1 Mediates Apelin-13 in Ameliorating Chronic Normobaric Hypoxia-induced Anxiety-like Behavior by Suppressing NF-κB Pathway in Mice Hippocampus. Neuroscience. vol 381. 2019-04-05. PMID:29680708. |
we also showed that resveratrol treatment decreased il-1β, il-6, tnf-ɑ, pcna, bcl-2, and acetyl-p65 levels, but increased bax and caspase 3 levels in hippocampus, suggesting a suppressive effect of resveratrol on cellular neuroinflammation and proliferation while a promotive effect on apoptosis of microglia in hippocampus. |
2019-04-05 |
2023-08-13 |
mouse |
| Haohao Liu, Shenshen Zhang, Chuanrui Liu, Jinxia Wu, Yueqin Wang, Le Yuan, Xingde Du, Rui Wang, Phelisters Wegesa Marwa, Donggang Zhuang, Xuemin Cheng, Huizhen Zhan. Resveratrol Ameliorates Microcystin-LR-Induced Testis Germ Cell Apoptosis in Rats via SIRT1 Signaling Pathway Activation. Toxins. vol 10. issue 6. 2019-04-05. PMID:29890735. |
however, res pretreatment ameliorated mc-lr-induced apoptosis and sirt1 inhibition, and downregulated the mc-lr-induced increase in p53 and ku70 acetylation, bax expression, and caspase-3 activation. |
2019-04-05 |
2023-08-13 |
rat |
| Haohao Liu, Shenshen Zhang, Chuanrui Liu, Jinxia Wu, Yueqin Wang, Le Yuan, Xingde Du, Rui Wang, Phelisters Wegesa Marwa, Donggang Zhuang, Xuemin Cheng, Huizhen Zhan. Resveratrol Ameliorates Microcystin-LR-Induced Testis Germ Cell Apoptosis in Rats via SIRT1 Signaling Pathway Activation. Toxins. vol 10. issue 6. 2019-04-05. PMID:29890735. |
the present study indicated that the administration of res could ameliorate mc-lr-induced sertoli⁻germ cell apoptosis and protect against reproductive toxicity in rats by stimulating the sirt1/p53 pathway, suppressing p53 and ku70 acetylation and enhancing the binding of ku70 to bax. |
2019-04-05 |
2023-08-13 |
rat |
| Kathryn Ondricek, Peter Thoma. Effects of hypoxia exposure on apoptosis and expression of membrane steroid receptors, ZIP9, mPRα, and GPER in Atlantic croaker ovaries. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 224. 2019-04-05. PMID:30025815. |
membrane androgen receptor (zip9) enhances apoptosis of cultured atlantic croaker ovarian follicle cells via upregulation of p53 and bax, and increased caspase 3 activity through non-classical steroid signaling. |
2019-04-05 |
2023-08-13 |
Not clear |
| Kathryn Ondricek, Peter Thoma. Effects of hypoxia exposure on apoptosis and expression of membrane steroid receptors, ZIP9, mPRα, and GPER in Atlantic croaker ovaries. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 224. 2019-04-05. PMID:30025815. |
the enhanced apoptosis in ovaries of hypoxia-exposed fish was associated with increased caspase-3/7 activity and elevated expression of the pro-apoptotic genes, bax and p53. |
2019-04-05 |
2023-08-13 |
Not clear |
| Xiao-Yun Huang, Dan Li, Zhi-Xin Chen, Yue-Hong Huang, Wen-Yu Gao, Bi-Yun Zheng, Xiao-Zhong Wan. Hepatitis B Virus X protein elevates Parkin-mediated mitophagy through Lon Peptidase in starvation. Experimental cell research. vol 368. issue 1. 2019-04-04. PMID:29689279. |
moreover, the enhanced mitophagy lowers mitochondrial apoptosis in starved hepatoma cells, and bax is implied in the machinery. |
2019-04-04 |
2023-08-13 |
Not clear |
| Fu-Shui Liu, Fan-Yuan Zhou, Yi Zhang, Chang-Qing Gu. [Effects of Acupotomy Therapy on mRNA Expressions of Bcl-2, Bax, Caspase-3 in Posterior Cervical Extensor Muscles in Cervical Spondylosis Rabbits]. Zhen ci yan jiu = Acupuncture research. vol 42. issue 6. 2019-04-03. PMID:29318858. |
to observe the effect of acupotomy therapy on mrna expressions of bcl-2, bax , caspase-3 in posterior cervical extensor muscles in cervical spondylosis rabbits, and explore its mechanisms for apoptosis of cervical muscles. |
2019-04-03 |
2023-08-13 |
Not clear |
| Juanjuan Zhu, Mingyu Zhou, Xueke Zhao, Mao Mu, Mingliang Chen. Blueberry, combined with probiotics, alleviates non-alcoholic fatty liver disease via IL-22-mediated JAK1/STAT3/BAX signaling. Food & function. vol 9. issue 12. 2019-04-03. PMID:30411754. |
we conclude that il-22 is vital for the therapeutic effect of bp, and acts via activation of jak1/stat3 signaling and inhibition of the apoptosis factor bax, which makes il-22 a promising target for therapy of nafld. |
2019-04-03 |
2023-08-13 |
rat |
| Yutian Zhang, Diying Li, Zhuo Wang, Wanting Zang, Pan Rao, Yunxiang Liang, Yuxia Me. Alpha-terpineol affects synthesis and antitumor activity of triterpenoids from Antrodia cinnamomea mycelia in solid-state culture. Food & function. vol 9. issue 12. 2019-04-03. PMID:30474680. |
several related proteins involved in the mitochondrial pathway of apoptosis (p53, bax, caspase-3) did not show expression upregulation by acts-e, suggesting that apoptosis induction occurred through a p53-independent process. |
2019-04-03 |
2023-08-13 |
Not clear |
| Muhammad Sohail Khan, Tahir Ali, Min Woo Kim, Myeung Hoon Jo, Jong Il Chung, Myeong Ok Ki. Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29779175. |
both histological and immunoblot analysis indicated that anthocyanins reversed the activation of jnk, prevented neuroinflammation by lowering the levels of inflammatory markers (p-nf-kb, tnf-α, and il-1β), and reduced neuronal apoptosis by reducing the expression of bax, cytochrome c, cleaved caspase-3, and cleaved parp-1, while increasing the level of survival proteins p-akt, p-gsk3β, and anti-apoptotic bcl-2 protein. |
2019-04-01 |
2023-08-13 |
mouse |
| Weikang Wang, Peng Luo, Weijun Guo, Yulong Shi, Ding Xu, Hong Zheng, Liyun Ji. LncRNA SNHG20 knockdown suppresses the osteosarcoma tumorigenesis through the mitochondrial apoptosis pathway by miR-139/RUNX2 axis. Biochemical and biophysical research communications. vol 503. issue 3. 2019-04-01. PMID:30072099. |
specifically, snhg20 knockdown up-regulated the expression levels of caspase-9, caspase-3 and bax, indicating that snhg20 knockdown accelerated the apoptosis of osteosarcoma cells via mitochondrial apoptosis pathway. |
2019-04-01 |
2023-08-13 |
human |
| Yan-Dan Zhou, Jin-Gang Hou, Ge Yang, Shuang Jiang, Chen Chen, Zi Wang, Ying-Ying Liu, Shen Ren, Wei L. Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-04-01. PMID:30551489. |
moreover, icariin pretreatment significantly reduced cellular apoptosis via reduced levels of bax, cleaved caspase-3/9, and increased anti-apoptotic protein bcl-2 in the cells. |
2019-04-01 |
2023-08-13 |
human |
| Mengjie Sun, Hui Song, Yuting Ye, Qianqian Yang, Xiaodong Xu, Xiaodong Zhu, Jiong Zhang, Shaolin Shi, Jinquan Wang, Zhihong Li. Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-04-01. PMID:30551497. |
we found that treatment of tp at 10 ng/ml, a concentration that is routinely used for podocyte protection, was sufficient to activate pro-apoptotic signaling of mapk p38, p53 and bax and induced apoptosis in cultured podocytes; and higher concentrations of tp exacerbated the p38, p53 and bax activations and apoptosis. |
2019-04-01 |
2023-08-13 |
mouse |
| Lei Fang, Wei Xu, Dedi Kon. Icariin inhibits cell proliferation, migration and invasion by down-regulation of microRNA-625-3p in thyroid cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-04-01. PMID:30551506. |
ica significantly suppressed cell viability in a dose-dependent manner and induced apoptosis by regulating bcl-2, bax and cleaced-caspase-3/-9 expression in sw579 and tpc1 cells (p < 0.001). |
2019-04-01 |
2023-08-13 |
Not clear |