| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Duomao Lin, Boqun Cui, Jiayue Ren, Jun M. Regulation of VDAC1 contributes to the cardioprotective effects of penehyclidine hydrochloride during myocardial ischemia/reperfusion. Experimental cell research. vol 367. issue 2. 2019-03-04. PMID:29630893. |
moreover, vdac1 overexpression with myocardial i/r further increased cytochrome c release from mitochondria to cytoplasm, elevated the levels of cleaved caspase-3 and bax, and decreased the level of bcl-2 as compared with i/r alone, and phc-mediated inhibition of mitochondria-dependent apoptosis during myocardial i/r was abolished by vdac1 overexpression. |
2019-03-04 |
2023-08-13 |
rat |
| Ioannis Gkouveris, Nikolaos G Nikitakis, Jaya Aseervatham, Kalu U E Ogburek. Interferon γ suppresses dentin sialophosphoprotein in oral squamous cell carcinoma cells resulting in antitumor effects, via modulation of the endoplasmic reticulum response. International journal of oncology. vol 53. issue 6. 2019-03-04. PMID:30320380. |
notably, treatment with ifnγ hampered osc2 migration, reduced cell viability and pcna protein expression, enhanced apoptosis, downregulated bcl‑2, and upregulated bax and cytochrome c. |
2019-03-04 |
2023-08-13 |
human |
| Xiao-Fei Song, Qi-Hua Wang, Ran Hu. Effects of microRNA-708 on Epithelial-Mesenchymal Transition, Cell Proliferation and Apoptosis in Melanoma Cells by Targeting LEF1 through the Wnt Signaling Pathway. Pathology oncology research : POR. vol 25. issue 1. 2019-02-28. PMID:29138985. |
in comparison to the blank and control groups, the mir-708, mimic, and sirna-lef1 groups had elevated expressions of bax, caspase3, and e-cadherin, while also showing enhanced cell apoptosis. |
2019-02-28 |
2023-08-13 |
mouse |
| Ulrike Heinicke, Tinka Haydn, Sarah Kehr, Meike Vogler, Simone Fuld. BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis. Oncogene. vol 37. issue 39. 2019-02-28. PMID:29858601. |
these events are required for jnj/abt-199-mediated apoptosis, since bak or bax silencing or inhibition of caspases significantly protects from jnj/abt-199-induced cell death. |
2019-02-28 |
2023-08-13 |
Not clear |
| Liuhui Chang, Xiaoming Chai, Peiming Chen, Jianfang Cao, Hong Xie, Jiang Zh. miR-181b-5p suppresses starvation-induced cardiomyocyte autophagy by targeting Hspa5. International journal of molecular medicine. vol 43. issue 1. 2019-02-28. PMID:30431062. |
bcl‑2 prevented apoptosis and autophagy by binding to bax and bcl‑2, respectively. |
2019-02-28 |
2023-08-13 |
rat |
| Francine F S Ke, Hannah K Vanyai, Angus D Cowan, Alex R D Delbridge, Lachlan Whitehead, Stephanie Grabow, Peter E Czabotar, Anne K Voss, Andreas Strasse. Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK. Cell. vol 173. issue 5. 2019-02-27. PMID:29775594. |
embryogenesis and adult life in the absence of intrinsic apoptosis effectors bax, bak, and bok. |
2019-02-27 |
2023-08-13 |
Not clear |
| Francine F S Ke, Hannah K Vanyai, Angus D Cowan, Alex R D Delbridge, Lachlan Whitehead, Stephanie Grabow, Peter E Czabotar, Anne K Voss, Andreas Strasse. Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK. Cell. vol 173. issue 5. 2019-02-27. PMID:29775594. |
intrinsic apoptosis, reliant on bax and bak, has been postulated to be fundamental for morphogenesis, but its precise contribution to this process has not been fully explored in mammals. |
2019-02-27 |
2023-08-13 |
Not clear |
| Mohamed Fizur Nagoor Meeran, Farah Laham, Sheikh Azimullah, Saeed Tariq, Shreesh Ojh. α-Bisabolol abrogates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and intrinsic pathway of apoptosis in rats. Molecular and cellular biochemistry. vol 453. issue 1-2. 2019-02-27. PMID:30159796. |
furthermore, iso triggers calcium overload and atp depletion in the rat's heart mitochondria followed by the mitochondrial cytochrome-c release and the activation of intrinsic pathway of apoptosis by upregulating the myocardial pro-apoptotic bax, p |
2019-02-27 |
2023-08-13 |
rat |
| Aree Khamchan, Tatdao Paseephol, Wanthanee Hanchan. Protective effect of wax apple (Syzygium samarangense (Blume) Merr. & L.M. Perry) against streptozotocin-induced pancreatic ß-cell damage in diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-02-27. PMID:30245463. |
pancreatic apoptosis was noted in diabetic rats and indicated by enhancing the expression of cleaved caspase-3 and bax proteins and downregulating the expression of bcl-2 and bcl-xl proteins. |
2019-02-27 |
2023-08-13 |
rat |
| Aree Khamchan, Tatdao Paseephol, Wanthanee Hanchan. Protective effect of wax apple (Syzygium samarangense (Blume) Merr. & L.M. Perry) against streptozotocin-induced pancreatic ß-cell damage in diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-02-27. PMID:30245463. |
moreover, pancreatic ß-cell apoptosis was alleviated with significantly down-regulated cleaved caspase-3 and bax protein expression, and upregulated bcl-2 and bcl-xl protein expression in wax apple treated diabetic rats. |
2019-02-27 |
2023-08-13 |
rat |
| Zhengrong Xu, Tao Li, Man Li, Lei Yang, Rudan Xiao, Li Liu, Xin Chi, Dianwu Li. eRF3b-37 inhibits the TGF-β1-induced activation of hepatic stellate cells by regulating cell proliferation, G0/G1 arrest, apoptosis and migration. International journal of molecular medicine. vol 42. issue 6. 2019-02-25. PMID:30272252. |
the increased mrna and protein expression of the pro‑fibrogenic factors collagen i, connective tissue growth factor and α‑smooth muscle actin (sma) stimulated by tgf‑β1 were reduced by erf3b‑37 via the following mechanisms: i) inhibiting lx‑2 cell proliferation, leading to g0/g1 cell cycle arrest and inhibition of dna synthesis by downregulating the mrna expressions of cyclin d1 and cyclin dependent kinase‑4, and upregulating the levels of p21; ii) increasing cell apoptosis by upregulating the mrna level of b‑cell lymphoma-2 (bcl‑2)‑associated x protein (bax) and fas, and downregulating the expression of bcl‑2; and iii) reducing cell migration by downregulating the mrna and protein expression of α‑sma. |
2019-02-25 |
2023-08-13 |
mouse |
| Xiaojing Li, Hongmin Wang, Jie Ding, Shaozhen Nie, Li Wang, Lili Zhang, Shaoda Re. Celastrol strongly inhibits proliferation, migration and cancer stem cell properties through suppression of Pin1 in ovarian cancer cells. European journal of pharmacology. vol 842. 2019-02-25. PMID:30389635. |
celastrol induced apoptosis primarily via up-regulation of caspase-3, caspase-8, and bax, and down-regulation of bcl-2. |
2019-02-25 |
2023-08-13 |
human |
| Zhi-Chuan Zhu, Ji-Wei Liu, Kui Li, Jing Zheng, Zhi-Qi Xion. KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells. Oncogene. vol 37. issue 22. 2019-02-22. PMID:29520102. |
kpnb1 inhibition upregulated puma and noxa and freed mcl-1-sequestered bax and bak, leading to mitochondrial outer membrane permeabilization (momp) and apoptosis. |
2019-02-22 |
2023-08-13 |
Not clear |
| Jung Yoon Jang, Yong Jung Kang, Bokyung Sung, Min Jeong Kim, Chaeun Park, Dongwan Kang, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Ki. MHY440, a Novel Topoisomerase Ι Inhibitor, Induces Cell Cycle Arrest and Apoptosis via a ROS-Dependent DNA Damage Signaling Pathway in AGS Human Gastric Cancer Cells. Molecules (Basel, Switzerland). vol 24. issue 1. 2019-02-21. PMID:30597845. |
mhy440 induced ags cell apoptosis through the upregulation of fas-l, fas, and bax as well as the proteolysis of bh3 interacting-domain death agonist and poly(adp-ribose) polymerase. |
2019-02-21 |
2023-08-13 |
human |
| Lin Bai, Aihua Wang, Yali Zhang, Xiaofeng Xu, Xiao Zhan. Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway. Experimental cell research. vol 366. issue 2. 2019-02-20. PMID:29548748. |
malat1 knockdown enhanced cddp-induced apoptosis in vivo, as indicated by upregulation of bax protein expression and downregulation of bcl-2 protein expression. |
2019-02-20 |
2023-08-13 |
Not clear |
| Dalin Sun, Weihang Dong, Baofang Jin, Guanghui Chen, Bin Cai, Weimin Deng, Yugui Cui, Yihan Ji. Mechanisms of Yangjing Capsule in Leydig Cell Apoptosis and Testosterone Synthesis via Promoting StAR Expression. Biological & pharmaceutical bulletin. vol 41. issue 9. 2019-02-20. PMID:29984732. |
leydig tumor cells (mltc-1) were cultured and treated with yc, and immunofluorescence assay was performed to examine the expression of star; furthermore, luciferase reporter assay was conducted to evaluate the impact of yc on star promoter; next, mltc-1 cells were treated with star small interfering rna (sirna), and flow cytometry was carried out to examine the effect of star sirna on the apoptosis of the cells; furthermore, quantitative (q)rt-pcr and western blot methods was used to determine the expression of star and apoptosis related molecules bcl-2, bax and caspase-3 on both mrna and protein levels in different groups; finally the secretion of testosterone in different groups was examined by radioimmunoassay. |
2019-02-20 |
2023-08-13 |
Not clear |
| Yi-Ru Wang, Yi-Hui Zhang, Zhi-Yu Chen, Dong-Mei Xu, Xiang Chen, Xiao-Yan Zhang, Hai-Yan H. [Effect of Active Ingredients of Qingxin Kaiqiao Recipe on Spatial Learning and Memory Capacities, and Expressions of Bax, Bcl-2, Caspase-3, and PAPP in Hippocampus of AD Model Rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 37. issue 2. 2019-02-18. PMID:30650272. |
conclusion three active ingredients (spaonins, benzene, and polysaccharides) of qkr could improve spatial memory and learning capacities to different degrees, which might be possibly achieved by decreasing expressions of bax, caspase-3, papp in hippocampal ca1 region, elevating bcl-2 expression, and inhibiting apoptosis in hippocampus. |
2019-02-18 |
2023-08-13 |
rat |
| Chun-Gu Wang, Wei-Na Yao, Bin Zhang, Jing Hua, Dong Liang, Heng-Shan Wan. Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration. Bioorganic & medicinal chemistry letters. vol 28. issue 14. 2019-02-13. PMID:29921475. |
the antitumor activity of compound 10 was possibly due to the induction of cell apoptosis through intrinsic apoptosis pathways, accompanied by increasing the expression of bax and caspase-3 in a dose-dependent manner. |
2019-02-13 |
2023-08-13 |
Not clear |
| b' Iva Vukeli\\xc4\\x87, Dijana Detel, Lara Bati\\xc4\\x8di\\xc4\\x87 Pu\\xc4\\x8dar, Iva Poto\\xc4\\x8dnjak, Sun\\xc4\\x8dica Buljevi\\xc4\\x87, Robert Domitrovi\\xc4\\x8. Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 121. 2019-02-13. PMID:30165128.' |
induction of apoptosis and oxidative stress was attenuated in a dose-dependent manner by suppressing bax, caspase-8, caspase-9 and heme oxygenase-1 (ho-1) protein expression in mice administrated with cha. |
2019-02-13 |
2023-08-13 |
mouse |
| Shu-Meng J. Overexpression of SLC25A15 is involved in the proliferation of cutaneous melanoma and leads to poor prognosis. Medecine sciences : M/S. vol 34 Focus issue F1. 2019-02-13. PMID:30403179. |
furthermore, slc25a15 sirna was able to promote apoptosis of a375 cells, which exhibited decreased expression levels of the anti-apoptotic protein bcl-2 while showing increased pro-apoptotic protein bax and cleaved caspase-3. |
2019-02-13 |
2023-08-13 |
Not clear |