| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dusadee Ospondpant, Suttinee Phuagkhaopong, Kran Suknuntha, Kant Sangpairoj, Thitima Kasemsuk, Chutima Srimaroeng, Pornpun Vivithanapor. Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes. Environmental toxicology and pharmacology. vol 65. 2019-02-13. PMID:30537571. |
concentrations ≥20 μm cadmium induced apoptosis and led to intracellular changes including dna fragmentation, reduced mrna expression of antioxidant enzymes (i.e., catalase and glutathione s transferase-a4), downregulation of b-cell lymphoma 2 (bcl-2), and upregulation of bcl-2-associated x protein (bax). |
2019-02-13 |
2023-08-13 |
human |
| G D A Gastal, F L N Aguiar, G M Ishak, C A Cavinder, S T Willard, P L Ryan, J M Feugang, E L Gasta. Effect of cryopreservation techniques on proliferation and apoptosis of cultured equine ovarian tissue. Theriogenology. vol 126. 2019-02-11. PMID:30543999. |
this study aimed to evaluate the effects of two cryopreservation methods (slow-freezing, sf, and vitrification, vit) on the equine ovarian tissue after 1, 3, and 7 days of ivc by assessing: (i) preantral follicle morphology and distribution of follicle classes; (ii) protein expression of markers of cell proliferation for egfr and ki-67; (iii) markers of apoptosis for bax and bcl-2; and (iv) dna fragmentation. |
2019-02-11 |
2023-08-13 |
Not clear |
| M-A Hospital, A Jacquel, F Mazed, E Saland, C Larrue, J Mondesir, R Birsen, A S Green, M Lambert, P Sujobert, E-F Gautier, V Salnot, M Le Gall, J Decroocq, L Poulain, N Jacque, M Fontenay, O Kosmider, C Récher, P Auberger, P Mayeux, D Bouscary, J-E Sarry, J Tamburin. RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia. Leukemia. vol 32. issue 3. 2019-02-08. PMID:28914261. |
we performed high-throughput transcriptomic and proteomic analyses in pim2-depleted flt3-itd aml cells and found that pim2 predominantly controlled apoptosis through bax expression and mitochondria disruption. |
2019-02-08 |
2023-08-13 |
mouse |
| Jian Zhou, Zhengzheng Li, Zhenggang Chen, Kun Yan. [Protective effect of mitochondria-targeted antioxidant SS31 on early brain injury following subarachnoid hemorrhage in rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 42. issue 9. 2019-02-08. PMID:28989143. |
the neurological scores, brain edema, blood-brain barrier (bbb) permeability, apoptosis, malondialdehyde (mda), glutathione peroxidase (gpx) activity, superoride dismutase (sod) activity, and the expression of cytosolic cytochrome c (cyt c) and bax were analyzed at 24 h after sah.
results: treatment with ss31 could significantly reduce mda levels, and restored the activities of gpx and sod in the cortex following sah when compared with the sah+v group. |
2019-02-08 |
2023-08-13 |
rat |
| Xing-He Wang, Wei Li, Xing-Hui Wang, Mei-Yu Han, Ishfaq Muhammad, Xiu-Ying Zhang, Xiao-Qi Sun, Xiao-Xu Cu. Water-soluble substances of wheat: a potential preventer of aflatoxin B1-induced liver damage in broilers. Poultry science. vol 98. issue 1. 2019-02-06. PMID:30107611. |
the results showed that (i) wsw restored afb1-induced changes in serum biochemical parameters, and ameliorated histomorphological changes in hepatocytes, (ii) wsw reduced the content of afb1 in chicken liver, (iii) wsw alleviated afb1-induced autophagy inhibition by up-regulating hepatic lc3, beclin-1, and down-regulating hepatic mtor and cytoplasmic p53 expressions, (iv) wsw alleviated afb1-induced hepatocellular apoptosis via inhibiting pro-apoptotic gene expression (nuclear p53, caspase3, bax), and promoting anti-apoptotic gene expression (bcl-2), (v) wsw feeding ameliorated afb1-induced liver inflammation via impeding tlr4/nf-${{f \kappa }}$b and il-1/nf-${{f \kappa }}$b signaling pathways, down-regulating pro-inflammatory cytokines (il-1${{f eta }}$, il-6, and il-8), and markedly up-regulating anti-inflammatory genes (il-10 and ho-1). |
2019-02-06 |
2023-08-13 |
chicken |
| Nasim Rahmani Kukia, Yousef Rasmi, Ardeshir Abbasi, Nana Koshoridze, Alireza Shirpoor, George Burjanadze, Ehsan Saboor. Bio-Effects of TiO2 Nanoparticles on Human Colorectal Cancer and Umbilical Vein Endothelial Cell Lines Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 10. 2019-02-06. PMID:30361551. |
results: exposure to increasing concentrations of tio2 nps enhanced overall cell survivalof hct116 cells and reduced the bcl-2 and caspase 3 expression while the ratio of bax/bcl-2 was down-regulated.tio2 nps at 400 and 50 μg/ml concentrations suppressed cell proliferation and induced apoptosis of ht29 cells andalso up-regulated p53 and bax at the mrna level, enhanced the bax/bcl-2 ratio and eventually up-regulated caspase3 mrna. |
2019-02-06 |
2023-08-13 |
human |
| Lu Kong, Wangcheng Hu, Chuncheng Lu, Keping Cheng, Meng Tan. Mechanisms underlying nickel nanoparticle induced reproductive toxicity and chemo-protective effects of vitamin C in male rats. Chemosphere. vol 218. 2019-02-06. PMID:30472609. |
protein expression of bcl-2-associated x protein (bax) and apoptosis inducing factor (aif) was significantly unregulated. |
2019-02-06 |
2023-08-13 |
rat |
| Lu Kong, Wangcheng Hu, Chuncheng Lu, Keping Cheng, Meng Tan. Mechanisms underlying nickel nanoparticle induced reproductive toxicity and chemo-protective effects of vitamin C in male rats. Chemosphere. vol 218. 2019-02-06. PMID:30472609. |
the cellular apoptosis might be induced by caspase family proteinases, but the regulator factor (factor associated suicide (fas), b-cell lymphoma-2 (bcl-2), bax, bh3-interacting domain death agonist (bid) and aif protein) might not be involved in this process. |
2019-02-06 |
2023-08-13 |
rat |
| Qianqian Zheng, Biao Wang, Jian Gao, Na Xin, Wei Wang, Xiaowen Song, Yue Shao, Chenghai Zha. CD155 knockdown promotes apoptosis via AKT/Bcl-2/Bax in colon cancer cells. Journal of cellular and molecular medicine. vol 22. issue 1. 2019-02-04. PMID:28816021. |
finally, cd155 knockdown increased the expression ratio between bax and bcl-2, resulting in a significant increase in colon cancer cell apoptosis. |
2019-02-04 |
2023-08-13 |
human |
| Guoqing Ouyang, Zhipeng Liu, Li Xiong, Xiang Chen, Qinglong Li, He Huang, Liangwu Lin, Xiongying Miao, Lun Ma, Wei Chen, Yu We. [Role of PpIX-based photodynamic therapy in promoting the damage and apoptosis of colorectal cancer cell and its mechanisms]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 42. issue 8. 2019-02-04. PMID:28872077. |
compared to the other 3 groups, ros production, the number of apoptotic cells and the protein expressions of bax and caspase-3 in pdt group increased, while bcl-2 expression was decreased (p<0.05).
conclusion: ppix-mediated pdt can enhance the apoptosis in hct116 cell, which may be related to mitochondrial apoptosis pathway. |
2019-02-04 |
2023-08-13 |
Not clear |
| Mahmut Sözmen, Alparslan K Devrim, Yonca B Kabak, Tuba Devrim, Mert Sudagida. The Effects of Periostin in a Rat Model of Isoproterenol: Mediated Cardiotoxicity. Cardiovascular toxicology. vol 18. issue 2. 2019-02-04. PMID:28895052. |
growth factors (vegf, angpt, fgf-2, tgfβ), mitosis and apoptosis (bcl-2, bax, pcna, ki-67, phospho-histone h3), cell cycle activators and inhibitors (cyclin d1, d2, a2, cdc2), the origin of regenerating cells (ckit and cd45) mrna were detected using quantitative real-time polymerase chain reaction (pcr) and pcr array. |
2019-02-04 |
2023-08-13 |
rat |
| Qing Tang, Ming-Yue Li, Yu-Fei Su, Jia Fu, Zong-Yi Zou, Yi Wang, Shao-Ning L. Absence of miR-223-3p ameliorates hypoxia-induced injury through repressing cardiomyocyte apoptosis and oxidative stress by targeting KLF15. European journal of pharmacology. vol 841. 2019-02-04. PMID:30336138. |
additionally, absence of mir-223-3p manifestly dampened hypoxia-induced cardiomyocyte injury in h9c2 cells, including improving cell viability, attenuating the ldh leakage and preventing cardiomyocyte apoptosis accompanied by an increase in the expression of bcl-2 and a decrease in the expression of bax and c-caspase 3 in the setting of hypoxia. |
2019-02-04 |
2023-08-13 |
Not clear |
| Limei Zhang, Huihui Ji, Yi Huang, Haochang Hu, Bin Li, Yong Yang, Hang Yu, Xiaoying Chen, Wenxia Li, Fang Liu, Shi Wang, Chunming Wang, Ke Chen, Yingchun Bao, Haibo Liu, Shiwei Dua. Association of BAX hypermethylation with coronary heart disease is specific to individuals aged over 70. Medicine. vol 98. issue 4. 2019-02-04. PMID:30681575. |
as a member of b-cell lymphoma-2 (bcl-2) gene family, bcl-2 associated x (bax) is important for cell apoptosis. |
2019-02-04 |
2023-08-13 |
Not clear |
| Fábio Henrique Fernandes, Mrio Otvio Botasso-Nasciutti, Andr Luiz Ventura Svio, Leonardo da Cunha Menezes Souza, Jhennifer Rebecca Fernandes-Cal, Fbio Florena Cardoso, Marcos Roberto de Mattos Fontes, Anjana Fernandes Albuquerque, Carla C Munari, Fbio Kummrow, Gisela de Aragão Umbuzeiro, Daisy Maria Fvero Salvador. In Vivo genotoxicity of a commercial C.I. Disperse Red 1 dye. Environmental and molecular mutagenesis. vol 59. issue 9. 2019-01-31. PMID:30152043. |
additionally, upregulation of genes involved in the inflammatory process (il1b) (0.0005 and 0.005 mg/kg bw) and cell-cycle control (cdkn1a) in liver cells, and apoptosis (bcl2 and bax) in leukocytes (0.005 mg/kg bw) were also detected. |
2019-01-31 |
2023-08-13 |
mouse |
| Jia Zhang, Yanyan Guo, Wanyu Ge, Xia Zhou, Minglin Pa. High glucose induces the apoptosis of HUVECs in mitochondria dependent manner by enhancing VDAC1 expression. Die Pharmazie. vol 73. issue 12. 2019-01-31. PMID:30522557. |
as high glucose-induced apoptosis is caused by elevated mitochondrial permeability-mediated release of mitochondrial cytochrome c, voltage-dependent anion channel (vdac1), the controller of mitochondrial permeability, and its regulator bax were investigated. |
2019-01-31 |
2023-08-13 |
Not clear |
| Jia Zhang, Yanyan Guo, Wanyu Ge, Xia Zhou, Minglin Pa. High glucose induces the apoptosis of HUVECs in mitochondria dependent manner by enhancing VDAC1 expression. Die Pharmazie. vol 73. issue 12. 2019-01-31. PMID:30522557. |
our results suggest that upregulation of vdac1 is the central event in high glucose-induced cell apoptosis, since silencing vdac1 reduced high glucose-induced upregulation of mitochondrial/cellular bax; thus silencing vdac1 recovered the high glucose-reduced binding of bax to vdac1, which finally reduced the high mitochondrial permeability. |
2019-01-31 |
2023-08-13 |
Not clear |
| Ali Mohammad Alizadeh, Zahra Heydari, Mostafa Rahimi, Behzad Bazgir, Hossein Shirvani, Sadaf Alipour, Yassaman Heidarian, Solmaz Khalighfard, Amin Isaneja. Oxytocin mediates the beneficial effects of the exercise training on breast cancer. Experimental physiology. vol 103. issue 2. 2019-01-30. PMID:29143998. |
furthermore, the expression of genes involved in cell apoptosis, such as caspase-3 and bax, was significantly increased in the tumour tissues. |
2019-01-30 |
2023-08-13 |
mouse |
| K X Zhou, L H Xie, X Peng, Q M Guo, Q Y Wu, W H Wang, G L Zhang, J F Wu, G J Zhang, C W D. CXCR4 antagonist AMD3100 enhances the response of MDA-MB-231 triple-negative breast cancer cells to ionizing radiation. Cancer letters. vol 418. 2019-01-30. PMID:29317253. |
the combined effect of ionizing radiation and amd3100 was determined in vitro by surviving fraction, cell cycle distribution, bax and bcl-2 expression, and apoptosis assays in a tnbc cell line (mda-mb-231). |
2019-01-30 |
2023-08-13 |
mouse |
| K X Zhou, L H Xie, X Peng, Q M Guo, Q Y Wu, W H Wang, G L Zhang, J F Wu, G J Zhang, C W D. CXCR4 antagonist AMD3100 enhances the response of MDA-MB-231 triple-negative breast cancer cells to ionizing radiation. Cancer letters. vol 418. 2019-01-30. PMID:29317253. |
radiosensitivity was enhanced specifically through increased bax expression, reduced bcl-2 expression, prolonged g2-m arrest, and increased apoptosis. |
2019-01-30 |
2023-08-13 |
mouse |
| Xi-Bin Hu, Shu-Hua Fu, Q I Luo, Jian-Zhong He, Yan-Fei Qiu, Wei Lai, Min Zhon. Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury Journal of biosciences. vol 43. issue 5. 2019-01-29. PMID:30541958. |
compared with the blank and nc groups, the mir-216a mimic and sirna-gdnf groups had higher mrna and protein levels of c-fos, vegf and bax, cell number in the g1 phase and increased cell apoptosis but reduced bdnf, gdnf, gfrα1, ret and bcl-2 expression, cell proliferation and cell numbers in the s phase, while the opposite trend was observed in the mir-216a inhibitor group. |
2019-01-29 |
2023-08-13 |
rat |