| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Cheng, Y Q Feng, J Ren, D Jing, C Wan. Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line. Neoplasma. vol 63. issue 2. 2019-01-28. PMID:26774143. |
western blot analysis showed that after being treated with fengycin, bax, caspase-3, and caspase-6 expressions were increased, however, bcl-2, and cdk4/cyclin d1 expressions were decreased (p<0.05).our study suggested that fengycin may play certain inhibit roles in the development and progression of colon cancer through involving in the cell apoptosis and cell cycle processes by targeting the bax/bcl-2 pathway. |
2019-01-28 |
2023-08-13 |
human |
| Xiao-Guang Qiu, Yi-Dong Chen, Jupeng Yuan, Nasha Zhang, Tianshui Lei, Jie Liu, Ming Yan. Functional BCL-2 rs2279115 Promoter Noncoding Variant Contributes to Glioma Predisposition, Especially in Males. DNA and cell biology. vol 38. issue 1. 2019-01-28. PMID:30481055. |
as a crucial oncogene, b cell lymphoma-2 (bcl-2) could promote cancer cell survival by inhibiting apoptosis via suppressing activation of proapoptotic proteins, such as bax and bak. |
2019-01-28 |
2023-08-13 |
Not clear |
| Souvik Sinha, Atanu Maity, Shubhra Ghosh Dastida. BIM Binding Remotely Regulates BAX Activation: Insights from the Free Energy Landscapes. Journal of chemical information and modeling. vol 58. issue 2. 2019-01-24. PMID:29278499. |
activation of the pro-apoptotic bax protein, a bcl-2 family member, is known to trigger apoptosis by forming pores in the mitochondrial outer membrane (mom). |
2019-01-24 |
2023-08-13 |
Not clear |
| Min Chen, Guoping He, Qiang L. Maternal deprivation promotes hippocampal neuronal apoptosis via ERK1/2 signaling. Frontiers in bioscience (Landmark edition). vol 23. 2019-01-24. PMID:29772537. |
compared with controls, md group showed increased hippocampal neuronal apoptosis, higher mrna expressions of bax, caspase-3 and caspase-9mrnas, and lower expression of bcl-2 and bdnf. |
2019-01-24 |
2023-08-13 |
rat |
| Eun-Jung Park, Yoo-Jin Park, Sang Jin Lee, Kyuhong Lee, Cheolho Yoo. Whole cigarette smoke condensates induce ferroptosis in human bronchial epithelial cells. Toxicology letters. vol 303. 2019-01-24. PMID:30579903. |
additionally, levels of apoptosis (bax, apaf-1, and cleavage of caspase-3 and parp), autophagy (p62 and lc3b-ii), er stress (perk, ire-1a, bip, and chop), antioxidant (sod-1 and sod-2), and mapkinase activation (p-erk, p-p38, and p-jnk)-related proteins were clearly enhanced following exposure to wcsc, whereas expression of several mitochondrial dynamics-related proteins was reduced with dose. |
2019-01-24 |
2023-08-13 |
human |
| Yuchao Sun, Mengqiao Lian, Yuan Lin, Bin Xu, Yanli Li, Jin Wen, Dapeng Chen, Ming Xu, Marwan Almoiliqy, Li Wan. Role of p-MKK7 in myricetin-induced protection against intestinal ischemia/reperfusion injury. Pharmacological research. vol 129. 2019-01-22. PMID:29154988. |
myricetin significantly decreased apoptosis by selectively down-regulating the expression of p-mkk7 and p-jnk without affecting mkk7 and jnk, inhibiting bax, caspase-3 protein expression, and up-regulating bcl-2 protein expression in i/r-injured jejunum of rats. |
2019-01-22 |
2023-08-13 |
rat |
| Xinwei Guo, Chenxi Xiang, Zhiting Zhang, Feng Zhang, Tao Xi, Lufeng Zhen. Displacement of Bax by BMF Mediates STARD13 3'UTR-Induced Breast Cancer Cells Apoptosis in an miRNA-Depedent Manner. Molecular pharmaceutics. vol 15. issue 1. 2019-01-22. PMID:29179557. |
displacement of bax by bmf mediates stard13 3'utr-induced breast cancer cells apoptosis in an mirna-depedent manner. |
2019-01-22 |
2023-08-13 |
Not clear |
| Daniel R Premkumar, Esther P Jane, Swetha Thambireddy, Philip A Sutera, Jonathon M Cavaleri, Ian F Pollac. Mitochondrial dysfunction RAD51, and Ku80 proteolysis promote apoptotic effects of Dinaciclib in Bcl-xL silenced cells. Molecular carcinogenesis. vol 57. issue 4. 2019-01-22. PMID:29240261. |
our results also revealed that dinaciclib, but not ribociclib or palbociclib or seliciclib or azd5438 induced intrinsic apoptosis via upregulation of the levels of pro-apoptotic proteins (bax and bak), resulting in the activation of caspases and cleavage of parp. |
2019-01-22 |
2023-08-13 |
human |
| D M Sun, S Y Mao, W Y Zhu, J H Li. Effect of starter diet supplementation on rumen epithelial morphology and expression of genes involved in cell proliferation and metabolism in pre-weaned lambs. Animal : an international journal of animal bioscience. vol 12. issue 11. 2019-01-22. PMID:29477152. |
the mrna expression of apoptosis genes of caspase-3, caspase-8, b-cell lymphoma-2 (bcl-2) and bcl-2-associated x protein (bax) in the m+s group was decreased compared with m group, but the ratio of bcl-2 to bax were not changed between the two groups. |
2019-01-22 |
2023-08-13 |
Not clear |
| Nouf T Al-Damry, Hala A Attia, Nawal M Al-Rasheed, Nouf M Al-Rasheed, Raeesa A Mohamad, Maha A Al-Amin, Nduna Dizmiri, Muhammad Attey. Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3β and p38α/MAPK in a rat model of diabetic cardiomyopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30099338. |
cardiac protein levels of cleaved casapse-3, bax were elevated, whereas, the levels of bcl-2 and p-bad were reduced indicating cardiac apoptosis which could be attributed to the diabetes-induced reduced phosphorylation of akt and ampk with concomitant augmented activation of gsk-3β and p38mapk. |
2019-01-22 |
2023-08-13 |
rat |
| Yan Wang, Lian-Lian Liu, Yuan Tian, Yang Chen, Wen-Hui Zha, Yang Li, Fu-Ju W. Upregulation of DAPK2 ameliorates oxidative damage and apoptosis of placental cells in hypertensive disorder complicating pregnancy by suppressing human placental microvascular endothelial cell autophagy through the mTOR signaling pathway. International journal of biological macromolecules. vol 121. 2019-01-22. PMID:30243997. |
besides, dapk2 overexpression led to decreases in autophagy in hpvecs as well as apoptosis and oxidative damage in placental cells indicated by a substantial decrease in beclin-1, lc3 ii/lc3 i and bax along with an increase in bcl-2, 4ebp1 and p70s6k. |
2019-01-22 |
2023-08-13 |
human |
| Wamidh H Talib, Lina T Al Kur. Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53 - dependent apoptosis and inhibiting VEGF expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30257366. |
real time pcr assay was used to detect the change in expression of several genes associated with cell proliferation and apoptosis (casp3, casp7, casp8, casp9, p53, gadd45, bax, bim, bcl-2, topo i, and topo ii). |
2019-01-22 |
2023-08-13 |
Not clear |
| Wamidh H Talib, Lina T Al Kur. Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53 - dependent apoptosis and inhibiting VEGF expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30257366. |
the real time pcr assay demonstrated that parthenolide down-regulated the expression of bcl-2 and up-regulated the expression of e2f1, p53, gadd45, bax, bim, and casp 3,7,8,9, which indicates an activation of p53- dependent apoptosis pathway in response to parthenolide. |
2019-01-22 |
2023-08-13 |
Not clear |
| Qingyan Zhang, Danhui Huang, Zhenfei Zhang, Yuzhen Feng, Meiting Fu, Min Wei, Jueyu Zhou, Yuanjin Huang, Shuguang Liu, Rong Sh. High expression of TMEM40 contributes to progressive features of tongue squamous cell carcinoma. Oncology reports. vol 41. issue 1. 2019-01-22. PMID:30320346. |
furthermore, experiments revealed that tmem40 knockdown resulted in increased levels of p53 and bax, and decreased levels of mmp‑9, which indicated that tmem40 regulated cell apoptosis and migration via involvement of p53, bax and mmp‑9 in tscc cells. |
2019-01-22 |
2023-08-13 |
Not clear |
| Jeong-Geon Mun, Ji-Ye Kee, Yo-Han Han, Sullim Lee, Seong-Hwan Park, Hee Dong Jeon, Seung-Heon Hon. Galla Rhois water extract inhibits lung metastasis by inducing AMPK‑mediated apoptosis and suppressing metastatic properties of colorectal cancer cells. Oncology reports. vol 41. issue 1. 2019-01-22. PMID:30365120. |
grwe suppressed viability of ct26 cells by inducing apoptosis through the cleavage of caspase‑3 and parp, downregulation of caspase‑8, caspase‑9, bcl‑2 and bcl‑xl, and upregulation of bax. |
2019-01-22 |
2023-08-13 |
Not clear |
| Yang Zhang, Lu Wang, Peng Gao, Zhiguo Sun, Ning Li, Yanqin Lu, Jianglun Shen, Jian Sun, Yiming Yang, Hao Dai, Haifeng Ca. ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple-negative breast cancer cells. International journal of molecular medicine. vol 42. issue 5. 2019-01-21. PMID:30226569. |
the present study revealed that isl1 overexpression reversed the protein expression profile of p‑akt, bcl‑2 and bax, while isl1 knockdown promoted cell apoptosis. |
2019-01-21 |
2023-08-13 |
Not clear |
| Rui Lin, Jialin Duan, Fei Mu, Haixu Bian, Meina Zhao, Min Zhou, Yao Li, Aidong Wen, Yong Yang, Miaomiao X. Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model. International journal of molecular medicine. vol 42. issue 5. 2019-01-21. PMID:30226574. |
furthermore, the results of an apoptosis assay revealed that the apoptosis rate was decreased, the expression of bax decreased and bcl‑2 increased, and the ratio of bcl‑2/bax was increased. |
2019-01-21 |
2023-08-13 |
Not clear |
| Yan-Rou Tsai, Cheng-Fu Chang, Jing-Huei Lai, John Chung-Che Wu, Yen-Hua Chen, Shuo-Jhen Kang, Barry J Hoffer, David Tweedie, Weiming Luo, Nigel H Greig, Yung-Hsiao Chiang, Kai-Yun Che. Pomalidomide Ameliorates H₂O₂-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects. International journal of molecular sciences. vol 19. issue 10. 2019-01-21. PMID:30347766. |
pom also suppressed nuclear factor kappa-light-chain-enhancer (nf-κb) levels and significantly mitigated cortical neuronal apoptosis by regulating bax, cytochrome c and poly (adp-ribose) polymerase. |
2019-01-21 |
2023-08-13 |
rat |
| Robert J Ellis, David M Small, Keng Lim Ng, David A Vesey, Luis Vitetta, Ross S Francis, Glenda C Gobe, Christudas Morai. Indoxyl Sulfate Induces Apoptosis and Hypertrophy in Human Kidney Proximal Tubular Cells. Toxicologic pathology. vol 46. issue 4. 2019-01-18. PMID:29683083. |
pathologically relevant concentrations of is induced apoptosis and increased the expression of the proapoptotic molecule bax in both cell types. |
2019-01-18 |
2023-08-13 |
human |
| Eric Alejandro Rhon-Calderón, Carlos Alejandro Toro, Alejandro Lomniczi, Rocío Alejandra Galarza, Alicia Graciela Falett. Changes in the expression of genes involved in the ovarian function of rats caused by daily exposure to 3-methylcholanthrene and their prevention by α-naphthoflavone. Archives of toxicology. vol 92. issue 2. 2019-01-17. PMID:29094188. |
3mc increased ahr binding to promoter regions of genes involved in notch signaling (hes1, jag1), activation of primordial follicles (cdk2), cell adhesion (icam1), stress and tumor progression (dnajb6), apoptosis (bax, caspase-9) and expression of growth and transcription factors (igf2, sp1). |
2019-01-17 |
2023-08-13 |
rat |