| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Jin, Hao Li, Gaonian Zhao, Su Jian. Lycopsamine Exerts Protective Effects and Improves Functional Outcome After Spinal Cord Injury in Rats by Suppressing Cell Death. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-01-03. PMID:30335732. |
the lycopsamine-induced reduction in apoptosis was allied with downregulation of calpain, cleaved caspase 3 and 9, and bax. |
2019-01-03 |
2023-08-13 |
rat |
| Cheng-Yi Chang, Jian-Ri Li, Chih-Cheng Wu, Jiaan-Der Wang, Ching-Ping Yang, Wen-Ying Chen, Wen-Yi Wang, Chun-Jung Che. Indomethacin induced glioma apoptosis involving ceramide signals. Experimental cell research. vol 365. issue 1. 2019-01-02. PMID:29470962. |
we found that the induced apoptosis was accompanied by a series of biochemical events, including intracellular ceramide generation, pp2a activation, akt dephosphorylation, mcl-1 and flice inhibiting protein (flip) transcriptional downregulation, bax mitochondrial distribution, and caspase 3 activation. |
2019-01-02 |
2023-08-13 |
human |
| Baohong Jiang, Yuehua Li, Xiaofei Qu, Hongbo Zhu, Yeru Tan, Qun Fan, Yiling Jiang, Mingchu Liao, Xiaoping W. Long noncoding RNA cancer susceptibility candidate 9 promotes doxorubicin‑resistant breast cancer by binding to enhancer of zeste homolog 2. International journal of molecular medicine. vol 42. issue 5. 2019-01-02. PMID:30106089. |
the expression levels of apoptosis‑associated proteins (apoptosis regulator bcl‑2, apoptosis regulator bax, caspase‑3 and caspase‑9) were determined by western blotting. |
2019-01-02 |
2023-08-13 |
Not clear |
| Hao Huang, Han Li, Kangpei Shi, Lei Wang, Xiaotong Zhang, Xiaobo Zh. TREK‑TRAAK two‑pore domain potassium channels protect human retinal pigment epithelium cells from oxidative stress. International journal of molecular medicine. vol 42. issue 5. 2019-01-02. PMID:30106090. |
by contrast, inhibition of these channels decreased the cell survival rates and increased apoptosis enhancing factors, such as bax and cleaved‑caspase‑3. |
2019-01-02 |
2023-08-13 |
human |
| Levon M Khachigia. The Yin and Yang of YY1 in tumor growth and suppression. International journal of cancer. vol 143. issue 3. 2019-01-01. PMID:29322514. |
on the other hand, tumor suppressor roles of yy1 appear to involve yy1 stimulation of tumor suppressor brca1, increased bax transcription and apoptosis involving cytochrome c release and caspase-3/-7 cleavage, induction of heme oxygenase-1, inhibition of prb phosphorylation and p21 binding to cyclin d1 and cdk4, reduced expression of long noncoding rna of sox2 overlapping transcript, and muc4/erbb2/p38/mef2c-dependent downregulation of mmp-10. |
2019-01-01 |
2023-08-13 |
Not clear |
| Hui San Chin, Mark X Li, Iris K L Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, Ruth M Kluck, Philippe Bouillet, Marco J Herold, Daniel H D Gray, David C S Huang, Mark F van Delft, Grant Dewso. VDAC2 enables BAX to mediate apoptosis and limit tumor development. Nature communications. vol 9. issue 1. 2018-12-31. PMID:30478310. |
vdac2 enables bax to mediate apoptosis and limit tumor development. |
2018-12-31 |
2023-08-13 |
Not clear |
| Hui San Chin, Mark X Li, Iris K L Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, Ruth M Kluck, Philippe Bouillet, Marco J Herold, Daniel H D Gray, David C S Huang, Mark F van Delft, Grant Dewso. VDAC2 enables BAX to mediate apoptosis and limit tumor development. Nature communications. vol 9. issue 1. 2018-12-31. PMID:30478310. |
bax and bak, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act redundantly to drive apoptotic cell death. |
2018-12-31 |
2023-08-13 |
Not clear |
| Hui San Chin, Mark X Li, Iris K L Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, Ruth M Kluck, Philippe Bouillet, Marco J Herold, Daniel H D Gray, David C S Huang, Mark F van Delft, Grant Dewso. VDAC2 enables BAX to mediate apoptosis and limit tumor development. Nature communications. vol 9. issue 1. 2018-12-31. PMID:30478310. |
together, our studies show that efficient bax-mediated apoptosis depends on vdac2, and reveal a striking difference in how bax and bak are functionally impacted by their interactions with vdac2. |
2018-12-31 |
2023-08-13 |
Not clear |
| Joanna Romanek, Jolanta Opiela, Daniel Lipiński, Zdzisław Smorą. Effect of High Hydrostatic Pressure Applied Before Cryopreservation on the Survival Rate and Quality of Porcine Mesenchymal Stem Cells After Thawing. Animal biotechnology. vol 29. issue 4. 2018-12-26. PMID:29144199. |
the aim of the present study was to examine the effects of varied high hydrostatic pressure (hhp) values on survival rate, proliferation rate, cell multipotency (transcript expression of sox2, c-myc, and rex1) and apoptosis (expression of phosphatidylserine (ps), survivin at the rna level and bax at the protein level) of porcine mesenchymal stem cells (mscs). |
2018-12-26 |
2023-08-13 |
Not clear |
| Joanna Romanek, Jolanta Opiela, Daniel Lipiński, Zdzisław Smorą. Effect of High Hydrostatic Pressure Applied Before Cryopreservation on the Survival Rate and Quality of Porcine Mesenchymal Stem Cells After Thawing. Animal biotechnology. vol 29. issue 4. 2018-12-26. PMID:29144199. |
bax protein expression was only estimated immediately after hhp to exclusively examine the impact of hhp on apoptosis of mscs. |
2018-12-26 |
2023-08-13 |
Not clear |
| Lalit P Chandravanshi, Richa Gupta, Rajendra K Shukl. Developmental Neurotoxicity of Arsenic: Involvement of Oxidative Stress and Mitochondrial Functions. Biological trace element research. vol 186. issue 1. 2018-12-24. PMID:29502250. |
further, neuronal apoptosis, as measured by changes in the expression of pro-apoptotic (bax, caspase-3), anti-apoptotic (bcl2), and stress marker proteins (p-p38, pjnk) in arsenic-exposed rats, was discussed. |
2018-12-24 |
2023-08-13 |
rat |
| Pouria Samadi, Sahar Saki, Fatemeh Karimi Dermani, Mona Pourjafar, Massoud Saidija. Emerging ways to treat breast cancer: will promises be met? Cellular oncology (Dordrecht). vol 41. issue 6. 2018-12-24. PMID:30259416. |
these components include erbb family members (her1, her2, her3 and her4), ras/mapk pathway components (ras, raf, mek and erk), vegf family members (vegfa, vegfb, vegfc, vegf and pgf), apoptosis and cell cycle regulators (bak, bax, bcl-2, bcl-x, mcl-1 and bcl-w, p53 and pi3k/akt/mtor pathway components) and dna repair pathway components such as brca1. |
2018-12-24 |
2023-08-13 |
Not clear |
| Qing-Jiu Zhang, Jie Li, Song-Yun Zhan. Effects of TRPM7/miR-34a Gene Silencing on Spatial Cognitive Function and Hippocampal Neurogenesis in Mice with Type 1 Diabetes Mellitus. Molecular neurobiology. vol 55. issue 2. 2018-12-21. PMID:28185128. |
compared to the nc group, the mice in the t1dm group had increased expressions of trpm7 and mir-34a; decreased weight and fasting insulin; increased blood glucose and levels of ica, iaa, and gad-ab; prolonged escape latency; less time spent in the target quadrant; incomplete neuronal structure; reduced neuron numbers; increased cell apoptosis and expressions of activated bax, cyt-c, and cleaved caspase-3; but reduced bcl-2 expression. |
2018-12-21 |
2023-08-13 |
mouse |
| Qing-Jiu Zhang, Jie Li, Song-Yun Zhan. Effects of TRPM7/miR-34a Gene Silencing on Spatial Cognitive Function and Hippocampal Neurogenesis in Mice with Type 1 Diabetes Mellitus. Molecular neurobiology. vol 55. issue 2. 2018-12-21. PMID:28185128. |
in comparison to the t1dm group, the t1dm + si-trpm7, t1dm + si-mir-34a, and t1dm + si-trpm7 + si-mir-34a groups showed increased weight and fasting insulin; reduced blood glucose and levels of ica, iaa, and gad-ab; shortened escape latency; prolonged time spent in the target quadrant platform; intact neuronal structure; increased neuron numbers; repaired neurons; reduced cell apoptosis and expressions of activated bax, cyt-c, and cleaved caspase-3; but increased bcl-2 expression. |
2018-12-21 |
2023-08-13 |
mouse |
| Pan-Pan Tan, Bian-Hua Zhou, Wen-Peng Zhao, Liu-Shu Jia, Jing Liu, Hong-Wei Wan. Mitochondria-Mediated Pathway Regulates C2C12 Cell Apoptosis Induced by Fluoride. Biological trace element research. vol 185. issue 2. 2018-12-20. PMID:29594946. |
the protein expression levels of apoptosis factors, including bax, bcl-2, cytochrome c (cyt c), caspase-3, and caspase-9, were measured using real-time polymerase chain reaction (real-time pcr) and immunocytofluorescence. |
2018-12-20 |
2023-08-13 |
Not clear |
| Wenjing Shao, Yuying Li, Feng Chen, Haiyan Jia, Jia Jia, Yan F. Long non-coding RNA DLEU1 contributes to the development of endometrial cancer by sponging miR-490 to regulate SP1 expression. Die Pharmazie. vol 73. issue 7. 2018-12-20. PMID:30001771. |
suppression of dleu1 significantly inhibited ishikawa cell viability, promoted cell apoptosis, decreased bcl-2 expression and increased the expression of bax, cleaved-caspase-3 and cleaved-caspase-3, suppressed cell migration and invasion, and inhibited emt via increasing the expression of e-cadherin and decreasing the expression of n-cadherin, snail and vimentin. |
2018-12-20 |
2023-08-13 |
Not clear |
| Eusondia Arnett, Ashlee M Weaver, Kiersten C Woodyard, Maria J Montoya, Michael Li, Ky V Hoang, Andrew Hayhurst, Abul K Azad, Larry S Schlesinge. PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis. PLoS pathogens. vol 14. issue 6. 2018-12-19. PMID:29928066. |
this suggested that m.tb differentially regulates mcl-1 and bax expression through pparγ to limit apoptosis. |
2018-12-19 |
2023-08-13 |
human |
| Aya M Zaki, Dalia M El-Tanbouly, Rania M Abdelsalam, Hala F Zak. Plumbagin ameliorates hepatic ischemia-reperfusion injury in rats: Role of high mobility group box 1 in inflammation, oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:29990872. |
simultaneously, plumbagin significantly ameliorated apoptosis by amending the mrna expressions of both anti-apoptotic (bcl-2) and pro-apoptotic (bax). |
2018-12-18 |
2023-08-13 |
rat |
| Yong-Qiang Zhang, Zhong-Hang Wen, Ke Wan, Dongbo Yuan, Xiaoping Zeng, Guangyi Liang, Jianguo Zhu, Bixue Xu, Heng Lu. A novel synthesized 3', 5'-diprenylated chalcone mediates the proliferation of human leukemia cells by regulating apoptosis and autophagy pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:29990873. |
the results showed that c10 regulated the expression of bax, c-myc, bcl-2, p38/ampk and erk 1/2, activated the expression of caspase-3, -8, and parp at the protein level in the apoptosis pathway of the two leukemia cell types, and inhibited the expression of erythroleukemia carcinogene fli-1 in the human erythroleukemia cell line hel. |
2018-12-18 |
2023-08-13 |
human |
| Tao-Li Wang, Chen-Sheng Ouyang, Li-Zhu Li. β-Asarone suppresses Wnt/β-catenin signaling to reduce viability, inhibit migration/invasion/adhesion and induce mitochondria-related apoptosis in lung cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:29990876. |
moreover, β-asarone induces apoptosis associated with the activation of caspase-9 and caspase-3, the upregulation of xaf1, puma, bax (ser184) and bad (ser112), the downregulation of xiap, bcl-2 and survivin, the translocation of bax, bad, phospho-bax (ser184), phospho-bad (ser112) and cytochrome c and the reduction of the mitochondrial membrane potential. |
2018-12-18 |
2023-08-13 |
Not clear |