| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Albayrak, E Konac, A U Dikmen, C Y Bile. Memantine induces apoptosis and inhibits cell cycle progression in LNCaP prostate cancer cells. Human & experimental toxicology. vol 37. issue 9. 2018-12-11. PMID:29226720. |
we evaluated the effects of metformin and memantine on the protein expression levels of genes that play significant roles in apoptosis and cell cycle progression (casp3, casp9, bcl-2, survivin, bax, c-myc, hif1a, ccnd1, cdk4 and gapdh) by western blotting. |
2018-12-11 |
2023-08-13 |
Not clear |
| Feng Tong, Youhua Ying, Haihua Pan, Wei Zhao, Hongchen Li, Xiaoli Zha. MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC). Bosnian journal of basic medical sciences. vol 18. issue 3. 2018-12-11. PMID:29338680. |
mrna and protein levels of cyclin d1, apoptosis regulator bax (bax), and matrix metalloproteinase-2 (mmp-2) were analyzed by qrt-pcr and western blot, respectively, in sw-620 crc cells transfected with mir-466 mimics or negative control mirna. |
2018-12-11 |
2023-08-13 |
Not clear |
| Alaaeldin Ahmed Hamza, Gehan Hussein Heeba, Hanan Mohamed Elwy, Chandraprabha Murali, Raafat El-Awady, Amr Ami. Molecular characterization of the grape seeds extract's effect against chemically induced liver cancer: In vivo and in vitro analyses. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29352129. |
gse treatment also decreased the viability of hepg2 cells and induced early and late apoptosis through activating caspase-3 and bax. |
2018-12-11 |
2023-08-13 |
rat |
| Hui Xu, Qiushi Wang, Qian Sun, Yu Qin, Aohan Han, Ye Cao, Qianlei Yang, Ping Yang, Jiachun Lu, Qizhan Liu, Quanyong Xian. In type 2 diabetes induced by cigarette smoking, activation of p38 MAPK is involved in pancreatic β-cell apoptosis. Environmental science and pollution research international. vol 25. issue 10. 2018-12-11. PMID:29372523. |
for min6 cells, cigarette smoke extract (cse) decreased insulin secretion and content; enhanced apoptosis, as illustrated by decreases of bcl-2 levels, increases of bax and cleaved caspase-3 levels, and an increased apoptotic index; and activated the p38 mapk pathway. |
2018-12-11 |
2023-08-13 |
Not clear |
| Caimei Huang, Guohua H. Shikonin suppresses proliferation and induces apoptosis in endometrioid endometrial cancer cells via modulating Bioscience reports. vol 38. issue 2. 2018-12-11. PMID:29449346. |
moreover, shikonin-induced apoptosis was characterized by the up-regulation of the pro-apoptotic proteins cleaved-caspase-3 and bax, and the down-regulation of the anti-apoptotic protein bcl-2. |
2018-12-11 |
2023-08-13 |
human |
| Lei Xu, Xiao-Yan He, Bo-Ya Liu, Chang Xu, Shu-Lun Ai, Ren-Xi Zhuo, Si-Xue Chen. Aptamer-functionalized albumin-based nanoparticles for targeted drug delivery. Colloids and surfaces. B, Biointerfaces. vol 171. 2018-12-11. PMID:30005287. |
in addition, dox loaded aptamer-functionalized nanoparticles can induce more significant down-regulation of bcl-2 and pcna as well as up-regulation of prb, parp and bax in mcf-7 cells compared with unmodified nanoparticles, indicating the aptamer modification can induce cell apoptosis more effectively. |
2018-12-11 |
2023-08-13 |
cattle |
| Ming Li, Shuo Wang, Xianjie Li, Lulu Jiang, Xujing Wang, Ruirui Kou, Qiong Wang, Lin Xu, Ning Zhao, Keqin Xi. Diallyl sulfide protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 120. 2018-12-11. PMID:30075314. |
furthermore, das pretreatment attenuated lps/d-galn-induced hepatocyte apoptosis, as evidenced by tunel staining and protein expression of cleaved caspase3, bax and bcl-2 in liver. |
2018-12-11 |
2023-08-13 |
mouse |
| Zhanshu Liu, Tonghua Me. Immune thrombocytopenia induces autophagy and suppresses apoptosis in megakaryocytes. Molecular medicine reports. vol 18. issue 4. 2018-12-11. PMID:30106156. |
meg‑01 cell line was cultured in vitro, and morphological changes were observed by light microscopy, apoptosis was evaluated by flow cytometric analysis of annexin v‑fitc/propidium iodide staining and western blot analysis of b‑cell lymphoma (bcl)‑2, bcl‑associated x protein (bax), beclin‑1 and cleaved caspase 3. |
2018-12-11 |
2023-08-13 |
Not clear |
| Tonglin Hu, Yu Ga. β-elemene against Burkitt's lymphoma via activation of PUMA mediated apoptotic pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-11. PMID:30119230. |
the in vivo data confirmed the anti-tumor effect of β-elemene in the xenografts, suggesting that β-elemene is associated with puma activation, leading to bax and caspase induction and onset of mitochondrial apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Ya-Li Zhou, Qiang Sun, Lei Zhang, Rui L. miR-208b targets Bax to protect H9c2 cells against hypoxia-induced apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-11. PMID:30119250. |
mir-208b targets bax to protect h9c2 cells against hypoxia-induced apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Yuelai Zhou, Jinlong H. Evodiamine Induces Apoptosis, G2/M Cell Cycle Arrest, and Inhibition of Cell Migration and Invasion in Human Osteosarcoma Cells via Raf/MEK/ERK Signalling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30135419. |
the results of western blotting revealed that the expression of several apoptosis (cytochrome c, bax, bid, caspase 3, 9, 8, and parp) and cell cycle-related proteins (cyclin b1, cdc25c, and cdc2) was significantly altered. |
2018-12-11 |
2023-08-13 |
human |
| Hilda Merino, Dinender K Singl. Secreted Frizzled-Related Protein-2 Inhibits Doxorubicin-Induced Apoptosis Mediated through the Akt-mTOR Pathway in Soleus Muscle. Oxidative medicine and cellular longevity. vol 2018. 2018-12-11. PMID:30151071. |
our data shows that with dox treatment, there is a significant increase in oxidative stress, apoptosis, proapoptotic protein bax, ppten levels, and wnt3a and |
2018-12-11 |
2023-08-13 |
Not clear |
| A Roshini, Srikanth Jagadeesan, Lakshmi Arivazhagan, Young-Jae Cho, Jong-Hwan Lim, Yang-Hoi Doh, Sang-Jae Kim, Jinhee Na, Kyung Hyun Cho. pH-sensitive tangeretin-ZnO quantum dots exert apoptotic and anti-metastatic effects in metastatic lung cancer cell line. Materials science & engineering. C, Materials for biological applications. vol 92. 2018-12-11. PMID:30184773. |
we also confirmed regulation of apoptosis via expression levels of bax and bcl-2 proteins; g2/m phase cell cycle arrest was observed. |
2018-12-11 |
2023-08-13 |
human |
| Shengchen Wang, Shufang Zheng, Qiaojian Zhang, Zijiang Yang, Kai Yin, Shiwen X. Atrazine hinders PMA-induced neutrophil extracellular traps in carp via the promotion of apoptosis and inhibition of ROS burst, autophagy and glycolysis. Environmental pollution (Barking, Essex : 1987). vol 243. issue Pt A. 2018-12-11. PMID:30193222. |
moreover, we found that in the nets process, atr downregulated the expression of the anti-apoptosis gene b-cell lymphoma-2 (bcl-2), increased the expression of the pro-apoptosis factors bcl-2-associated x (bax), cysteinyl aspartate specific proteinases (caspase3, 9), and anti-autophagy factor mammalian target of rapamycin (mtor), decreased the expression of autophagy-related protein light chain 3b (lc3b) and glucose transport proteins (glut1, 4), disturbed the activities of phosphofructokinase (pfk), pyruvate kinase (pkm), and hexokinase (hk) and limited reactive oxygen species (ros) levels, indicating that the reduced nets release was a consequence of increased apoptosis and diminished ros burst, autophagy and down-regulated glycolysis under atr treatment. |
2018-12-11 |
2023-08-13 |
human |
| Biao Gu, Qi Wang, Weijie Dai, Gang Ma, Yaqi Song, Qingquan W. Effect of GDF11 on proliferation and apoptosis of esophageal cancer cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 11. 2018-12-11. PMID:30213293. |
in order to investigate the effect of recombinant gdf11 on the proliferation and apoptosis of esophageal cancer cells, the expression of apoptosis-promoting protein bax and proliferative-associated protein bcl-2 in esophageal cancer cells were determined using western blot. |
2018-12-11 |
2023-08-13 |
Not clear |
| Wenyang Li, Ying Li, Xiangyuan Jiang, Xiaohui Li, Zugong Y. Compound Ammonium Glycyrrhizin Protects Hepatocytes from Injury Induced by Lipopolysaccharide/Florfenicol through a Mitochondrial Pathway. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-12-11. PMID:30227687. |
furthermore, with the up-regulation of apoptosis genes bax, cytochrome c and the down-regulation of bcl-2, caspase-3 and caspase-9 are activated at the gene level. |
2018-12-11 |
2023-08-13 |
chicken |
| Yanwei Su, Chao Quan, Xiandong Li, Yuqin Shi, Peng Duan, Kedi Yan. Mutual promotion of apoptosis and autophagy in prepubertal rat testes induced by joint exposure of bisphenol A and nonylphenol. Environmental pollution (Barking, Essex : 1987). vol 243. issue Pt A. 2018-12-11. PMID:30228064. |
apoptosis was mediated by the mitochondrial apoptosis pathway, since the bax and caspase-3 gene expressions significantly increased with a prominent decrease of bcl-2. |
2018-12-11 |
2023-08-13 |
rat |
| Feifei Li, Jianni Qi, Chengyong Qin, Zhaoqing Fu, Wanhua Re. Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272302. |
furthermore, following grim‑19 knockdown, the effects of trd on the viability and apoptosis of hepg2 cells, and the expression of downstream target genes (including cyclin d1, stat3, p‑stat3, bcl‑2 and bax) were reversed. |
2018-12-11 |
2023-08-13 |
human |
| Shanshan Wei, Taoli Sun, Jie Du, Bikui Zhang, Daxiong Xiang, Wenqun L. Xanthohumol, a prenylated flavonoid from Hops, exerts anticancer effects against gastric cancer in vitro. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272303. |
xn treatment increased the number of apoptotic cells, downregulated the expression of bcl‑2 and upregulated the expression of bax, suggesting induction of apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Jun Wang, Weiwei Feng, Yuanqiang Dong, Xiang Mao, Fenghua Guo, Fen Lu. MicroRNA‑495 regulates human gastric cancer cell apoptosis and migration through Akt and mTOR signaling. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272336. |
the pi3k inhibitor, was used to suppress the pi3k/akt/mtor pathway, inhibit cell proliferation, promote cell apoptosis, promote caspase‑3/‑9 and bax protein expression, and suppress cyclin d1 protein expression of gastric cancer cells through mir‑495 inhibition. |
2018-12-11 |
2023-08-13 |
human |