| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuqin Mei, Lin Li, Qingqing Wei, Jielu Hao, Yunchao Su, Changlin Mei, Zheng Don. Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis. Scientific reports. vol 7. 2018-11-14. PMID:28317867. |
double knockout of bax and bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis. |
2018-11-14 |
2023-08-13 |
mouse |
| Shuqin Mei, Lin Li, Qingqing Wei, Jielu Hao, Yunchao Su, Changlin Mei, Zheng Don. Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis. Scientific reports. vol 7. 2018-11-14. PMID:28317867. |
to determine the associated apoptotic pathway and its role in renal interstitial fibrosis, we established a mouse model in which bax and bak, two critical genes in the intrinsic pathway of apoptosis, were deleted specifically from kidney proximal tubules and used this model to examine renal apoptosis and interstitial fibrosis following unilateral urethral obstruction (uuo). |
2018-11-14 |
2023-08-13 |
mouse |
| Shuqin Mei, Lin Li, Qingqing Wei, Jielu Hao, Yunchao Su, Changlin Mei, Zheng Don. Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis. Scientific reports. vol 7. 2018-11-14. PMID:28317867. |
it was shown that double knockout of bax and bak from proximal tubules attenuated renal tubular cell apoptosis and suppressed renal interstitial fibrosis in uuo. |
2018-11-14 |
2023-08-13 |
mouse |
| U Sh Kuzmina, L F Zainullina, S V Sadovnikov, V A Vakhitov, Yu V Vakhitov. NMDA Receptors Regulate Genes Responsible for Major Immune Functions of Mononuclears in Human Peripheral Blood. Bulletin of experimental biology and medicine. vol 165. issue 2. 2018-11-14. PMID:29923004. |
the genes, whose expression changed in response to blockade of nmda receptors in mononuclears, encode the products involved in regulation of the major functions of immune cells, such as proliferation (il4, vcam1, and cdkn2a), apoptosis (bax, myc, cdkn2a, hspb1, and cadd45a), activation (il4r, il4, vcam1, and cdkn2a), and differentiation (il4, vcam1, and bax). |
2018-11-14 |
2023-08-13 |
human |
| Zhaoyang Yan, Xiaoyong Huang, Yangzhouyun Xie, Meirong Song, Kui Zhu, Shuangyang Din. Macrolides induce severe cardiotoxicity and developmental toxicity in zebrafish embryos. The Science of the total environment. vol 649. 2018-11-14. PMID:30308910. |
lastly, apoptosis was observed in zebrafish embryos under tms treatment, with up-regulation of apoptosis associated genes such as p53, bcl 2, bax, caspase 3 and caspase 9, confirmed by increased protein expression based on western blot analysis. |
2018-11-14 |
2023-08-13 |
human |
| Guifang Wang, Weibin Ma, Jingwei D. β-Caryophyllene (BCP) ameliorates MPP+ induced cytotoxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-11-13. PMID:29710667. |
moreover, our results indicated that bcp prevented mpp+-induced apoptosis of sh-sy5y through inhibiting the up-regulation of cleaved caspase-3, bax, and restoring the expression of bcl-2. |
2018-11-13 |
2023-08-13 |
Not clear |
| Shu Zhang, Jian Huang, Xiaoqin Xie, Yun He, Fei Mo, Zhaoxun Lu. Quercetin from Polygonum capitatum Protects against Gastric Inflammation and Apoptosis Associated with Helicobacter pylori Infection by Affecting the Levels of p38MAPK, BCL-2 and BAX. Molecules (Basel, Switzerland). vol 22. issue 5. 2018-11-09. PMID:28481232. |
quercetin from polygonum capitatum protects against gastric inflammation and apoptosis associated with helicobacter pylori infection by affecting the levels of p38mapk, bcl-2 and bax. |
2018-11-09 |
2023-08-13 |
Not clear |
| Yajun Chang, Wei Huang, Qian Sun, Suli Li, Zhongkai Yan, Qiumin Wang, Xiumin Li. MicroRNA‑634 alters nerve apoptosis via the PI3K/Akt pathway in cerebral infarction. International journal of molecular medicine. vol 42. issue 4. 2018-11-08. PMID:30015915. |
the upregulated expression of mirna‑634 in an in vitro model of cerebral infarction increased cell apoptosis and the protein expression of capsase‑3/b‑cell lymphoma 2‑associated x protein (bax) via inactivation of the phosphoinositide 3‑kinase (pi3k)/akt pathway. |
2018-11-08 |
2023-08-13 |
rat |
| Fernanda DA Silva Machado, Fernanda Mosena Munari, Fernando Joel Scariot, Sergio Echeverrigaray, Cesar Aguzzoli, Claus Tröger Pich, Massuo Jorge Kato, Lydia Yamaguchi, Sidnei Moura, João Antonio Pêgas Henriques, Mariana Roesch-El. Piperlongumine Induces Apoptosis in Colorectal Cancer HCT 116 Cells Independent of Bax, p21 and p53 Status. Anticancer research. vol 38. issue 11. 2018-11-08. PMID:30396942. |
piperlongumine induces apoptosis in colorectal cancer hct 116 cells independent of bax, p21 and p53 status. |
2018-11-08 |
2023-08-13 |
Not clear |
| Xiaoyan Xia, Xiaoming Zho. Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 6. 2018-11-07. PMID:29808798. |
subsequently, we used sirt1 sirna to knockdown the expression of sirt1, and then measured cell proliferation, cell apoptosis rate, cell cycle distribution, and expression levels of bcl-2 and bax in ptx-sensitive hela cell line, ptx-resistant hela and sila-resistant cell lines. |
2018-11-07 |
2023-08-13 |
human |
| Chao Li, Li-He Che, Tie-Feng Ji, Lei Shi, Jin-Lu Y. Effects of the TLR4 signaling pathway on apoptosis of neuronal cells in diabetes mellitus complicated with cerebral infarction in a rat model. Scientific reports. vol 7. 2018-11-06. PMID:28272417. |
compared with the blank and sham groups, there was an increase in cell apoptosis, expression of bcl-2, bax, cleaved caspase-3, tnf-α, il-1β and tlr4 proteins and mda content and a decrease in sod activity in the dm + mcao and dm + mcao + tak242 groups. |
2018-11-06 |
2023-08-13 |
rat |
| Chao Li, Li-He Che, Tie-Feng Ji, Lei Shi, Jin-Lu Y. Effects of the TLR4 signaling pathway on apoptosis of neuronal cells in diabetes mellitus complicated with cerebral infarction in a rat model. Scientific reports. vol 7. 2018-11-06. PMID:28272417. |
compared with those in the dm + mcao group, rats in the dm + mcao + tak242 group exhibited an increase in sod activity and a decrease in cell apoptosis, expression of bcl-2, bax, cleaved caspase-3, tnf-α, il-1β and tlr4 proteins and mda content. |
2018-11-06 |
2023-08-13 |
rat |
| Kimita Suyama, Jiahong Yao, Huizhi Liang, Outhiriaradjou Benard, Olivier D Loudig, Dulguun Amgalan, Wendy M McKimpson, Greg R Phillips, Jeffrey Segall, Yihong Wang, Susan Fineberg, Larry Norton, Richard N Kitsis, Rachel B Haza. An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis. Cancer research. vol 78. issue 1. 2018-11-05. PMID:29038347. |
these effects were due to striking induction of apoptosis, which was mediated by bim upregulation, leading to conformational activation of bax and caspase-3 processing. |
2018-11-05 |
2023-08-13 |
Not clear |
| Pingyi Liu, Lingling Che. Inhibition of sonic hedgehog signaling blocks cell migration and growth but induces apoptosis via suppression of FOXQ1 in natural killer/T-cell lymphoma. Leukemia research. vol 64. 2018-11-05. PMID:29132010. |
additionally, snk-6 cell proliferation was greatly reduced, the cell cycle was blocked at the g0/g1 phase, and the expression of cyclind1 and cycline was markedly decreased, while an increase in cell apoptosis with elevated bcl-2-associated x protein (bax) and caspase-3 and reduced b-cell lymphoma/leukemia-2 (bcl-2) were also observed. |
2018-11-05 |
2023-08-13 |
Not clear |
| Qi-Wei Huang, Na-Na Zhai, Tao Huang, Dao-Ming L. [Hirsutine induces apoptosis of human breast cancer MDA-MB-231 cells through mitochondrial pathway]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 1. 2018-11-05. PMID:29492513. |
these results suggest that hirsutine may induce apoptosis of human breast cancer mda-mb-231 cells through decreasing the ratio of bcl-2 to bax, opening mptp, releasing cyt c from mitochondria, and activating caspase 9 and caspase 3. |
2018-11-05 |
2023-08-13 |
human |
| Zhen-Dong Zhu, Ji-Yun Ye, Hua Niu, Yu-Mei Ma, Xue-Mei Fu, Zhong-Hua Xia, Xuan Zhan. Effects of microRNA-292-5p on myocardial ischemia-reperfusion injury through the peroxisome proliferator-activated receptor-α/-γ signaling pathway. Gene therapy. vol 25. issue 3. 2018-11-05. PMID:29670247. |
compared with the model group and the t0070907 + mir-292-5p inhibitor, the mir-292-5p inhibitor group exhibited decreased incidence and duration time of ventricular tachycardia and ventricular fibrillation, serum myocardial enzymes, tnf-α, il-6, il-1β, mda, cardiomyocyte apoptosis, expressions of bax and p53 in addition to increased sod and gsh-px activity, and increased expressions of bcl-2, pparα, pparγ, plin5, aqp7, and pck1. |
2018-11-05 |
2023-08-13 |
mouse |
| Songtao Fan, Xiaojun Huang, Sunan Wang, Chang Li, Zhihong Zhang, Mingyong Xie, Shaoping Ni. Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 119. 2018-11-05. PMID:29753871. |
relatively, through activation of peroxisome proliferator-activated receptor α (pparα), psg increased hepatic glutathione peroxidase and glutathione content depleted by ctx, as well as prevented mitochondria-dependent apoptosis with regulation on bcl-2 family proteins (bad, bax and bcl-2). |
2018-11-05 |
2023-08-13 |
mouse |
| Zhi-Lei Zhang, Guang-Chao Liu, Li Peng, Chong Zhang, Yu-Ming Jia, Wu-Han Yang, Lei Ma. Effect of PAK1 gene silencing on proliferation and apoptosis in hepatocellular carcinoma cell lines MHCC97-H and HepG2 and cells in xenograft tumor. Gene therapy. vol 25. issue 4. 2018-11-05. PMID:29802374. |
cell proliferation, the cells at s phase, the mrna and protein expressions of pak1, pcna, ki67, cyclin e, cdk2 and bcl-2 of mhcc97-h and hepg2 cells and cells in xenograft tumor were decreased, while the cells at g1 phase, apoptosis rate, the mrna and protein expressions of p21, p53 and bax of mhcc97-h and hepg2 cells and cells in xenograft tumor were increased in the pak1 shrna group. |
2018-11-05 |
2023-08-13 |
mouse |
| Sajad Hassanzadeh, Seyed Behnamedin Jameie, Maryam Soleimani, Mona Farhadi, Mahdieh Kerdari, Navid Danae. Coenzyme Q10 Influences on the Levels of TNF-α and IL-10 and the Ratio of Bax/Bcl2 in a Menopausal Rat Model Following Lumbar Spinal Cord Injury. Journal of molecular neuroscience : MN. vol 65. issue 2. 2018-11-05. PMID:29948851. |
we hypothesized that in the absence of female gonadal steroids, which provide protection following an sci, coq10 could modulate the expression of cytokines, such as tumor necrosis factor (tnf)-α and interleukin (il)-10, besides aquaporin-4 (aqp4) water channels in the cns, which participate in neuroinflammation, as well as the bax and bcl2 proteins that are involved in apoptosis at the site of injury. |
2018-11-05 |
2023-08-13 |
rat |
| Manisha Kumari, Mahaveer Prasad Purohit, Satyakam Patnaik, Yogeshwer Shukla, Pradeep Kumar, Kailash Chand Gupt. Curcumin loaded selenium nanoparticles synergize the anticancer potential of doxorubicin contained in self-assembled, cell receptor targeted nanoparticles. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 130. 2018-11-05. PMID:29969665. |
this combination decreased the expressions of nfκb, phospho-nfκb, emt-metastasis-associated proteins (snail, vimentin, n-cadherin, cd44, mmp-2 and mmp-9), autophagy-associated proteins (beclin-1 and lc-3bii), as well as anti-apoptotic protein bcl-2, increased the expression of pro-apoptotic protein bax, and increased cyt c release, which indicated decrease in inflammation, metastasis, and autophagy with increase in apoptosis. |
2018-11-05 |
2023-08-13 |
mouse |