| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Qiang Zhou, Yin-Tao Zhao, Xiao-Yan Zhao, Cui Liang, Ya-Wei Xu, Ling Li, Yuan Liu, Hai-Bo Yan. Hyperoside Suppresses Lipopolysaccharide-induced Inflammation and Apoptosis in Human Umbilical Vein Endothelial Cells. Current medical science. vol 38. issue 2. 2018-11-02. PMID:30074179. |
furthermore, the possible pathway involved in apoptosis and inflammation by hyp was detected, and the results showed that when treated with hyp, lps-induced mitochondrial membrane instability was significantly inhibited through up-regulation of bcl-2 and down-regulation of bax. |
2018-11-02 |
2023-08-13 |
human |
| Xuanyi Che, Qingxia Zhao, Di L. [Expression of thioredoxin-2 in human lens epithelial cells with oxidative damage and its significance]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 43. issue 3. 2018-11-01. PMID:29701186. |
compared with the negative control group, the cell survival rate was increased in the trx-2 overexpression group (p<0.05), along with suppressed apoptosis, increased sod activities and cat activities, elevated gsh contents, decreased mda content, up-regulated trx-2 and bcl-2 expression and down-regulated bax and caspase-3 expression (p<0.05).
conclusion: trx-2 might be involved in the apoptosis of lens epithelial cells in patients with cataract. |
2018-11-01 |
2023-08-13 |
human |
| Jie Long, Yu Wang, Xiao-Cui Liu, Miao Yu, Yi-Lin Wang, Xia Huang, Ming Zha. [Effect of oxidative stress on myocardial apoptosis, endoplasmic reticulum stress and apoptosis factor in suckling mouse atria myocardium]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 33. issue 2. 2018-11-01. PMID:29931929. |
to investigate the relationship between oxidative stress and myocardial apoptosis, endoplasmic reticulum stress, apoptosis-inducing factors in the process of by researching the effect of oxidative stress on myocardial apoptosis, endoplasmic reticulum stress and apoptosis factor--chop, bax, bcl-2 in suckling mouse atria myocardium. |
2018-11-01 |
2023-08-13 |
mouse |
| Figen Esen, Perihan Ergin Ozcan, Erdem Tuzun, M Dustin Boon. Mechanisms of action of intravenous immunoglobulin in septic encephalopathy. Reviews in the neurosciences. vol 29. issue 4. 2018-10-31. PMID:29232196. |
iggam treatment might suppress classical complement pathway by reducing c5a activity and proapoptotic nf-κb and bax expressions, thereby, inhibiting major inflammation and apoptosis cascades. |
2018-10-31 |
2023-08-13 |
mouse |
| Tao Lin, Reza K Oqani, Jae Eun Lee, Jeong Won Kang, So Yeon Kim, Eun Seok Cho, Yong Dae Jeong, Jun Jong Baek, Dong Il Ji. α-Solanine impairs oocyte maturation and quality by inducing autophagy and apoptosis and changing histone modifications in a pig model. Reproductive toxicology (Elmsford, N.Y.). vol 75. 2018-10-31. PMID:29247839. |
α-solanine triggered autophagy and apoptosis by increasing the expressions of autophagy-related genes (lc3, atg7, and lamp2) and apoptotic related genes (bax and casp3). |
2018-10-31 |
2023-08-13 |
Not clear |
| Lin-Yan Huang, Yu-Jie Li, Peng-Peng Li, Hong-Chun Li, Ping M. Aggravated intestinal apoptosis by ClC-3 deletion is lethal to mice endotoxemia. Cell biology international. vol 42. issue 10. 2018-10-30. PMID:29972266. |
further experiments revealed that the level of bax and cleaved caspase 3 in intestinal tissue of mice with clc-3 deletion was significantly increased, while the level of bcl2 did not change, which indicated that the intestinal apoptosis was increased after lps-induced mice intestinal integrity destruction. |
2018-10-30 |
2023-08-13 |
mouse |
| Sara Alves, Leire Neiri, Susana Rodrigues Chaves, Selma Vieira, Dário Trindade, Stephen Manon, Veronica Dominguez, Belen Pintado, Veronique Jonckheere, Petra Van Damme, Rui Duarte Silva, Rafael Aldabe, Manuela Côrte-Rea. N-terminal acetylation modulates Bax targeting to mitochondria. The international journal of biochemistry & cell biology. vol 95. 2018-10-29. PMID:29233735. |
the pro-apoptotic bax protein is the main effector of mitochondrial permeabilization during apoptosis. |
2018-10-29 |
2023-08-13 |
mouse |
| Haiyang Zhang, Yong Zhao, Peng Sun, Miaoqing Zhao, Zhenhui Su, Xunbo Jin, Wei Son. p53β: a new prognostic marker for patients with clear-cell renal cell carcinoma from 5.3 years of median follow-up. Carcinogenesis. vol 39. issue 3. 2018-10-29. PMID:29346503. |
p53β transfected 786-o and caki-1 cells were cultured to examine expressions of b-cell lymphoma 2-associated x protein (bax) and caspase-3, and ratios of apoptosis. |
2018-10-29 |
2023-08-13 |
Not clear |
| Haiyang Zhang, Yong Zhao, Peng Sun, Miaoqing Zhao, Zhenhui Su, Xunbo Jin, Wei Son. p53β: a new prognostic marker for patients with clear-cell renal cell carcinoma from 5.3 years of median follow-up. Carcinogenesis. vol 39. issue 3. 2018-10-29. PMID:29346503. |
p53β transfected 786-o and caki-1 cells expressed significantly higher level of bax and caspase-3, and had higher ratios of apoptosis than untransfected cells. |
2018-10-29 |
2023-08-13 |
Not clear |
| J-R Tenório, T Santana, S-I-M-L Queiroz, D-H-I-P de Oliveira, L-M-G Queiro. Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax. Medicina oral, patologia oral y cirugia bucal. vol 23. issue 2. 2018-10-29. PMID:29476674. |
apoptosis and cell cycle aberrations in epithelial odontogenic lesions: an evidence by the expression of p53, bcl-2 and bax. |
2018-10-29 |
2023-08-13 |
Not clear |
| J-R Tenório, T Santana, S-I-M-L Queiroz, D-H-I-P de Oliveira, L-M-G Queiro. Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax. Medicina oral, patologia oral y cirugia bucal. vol 23. issue 2. 2018-10-29. PMID:29476674. |
defects in regulation of apoptosis and cell cycle may be involved in the development and progression of those lesions, therefore we aimed to investigate the expression of bcl-2, bax and p53 to better understand the possible role of these proteins in ambs, okcs and aots. |
2018-10-29 |
2023-08-13 |
Not clear |
| Wei Duan, Yan Chen, Xiao-Rong Wan. MicroRNA‑155 contributes to the occurrence of epilepsy through the PI3K/Akt/mTOR signaling pathway. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29901097. |
overexpression of mirna‑155 resulted in decreased brain‑derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) protein expression, increased caspase‑3 activity, tumor protein p53 (p53) and apoptosis regulator bax (bax) protein expression, and inhibited phosphoinositide 3‑kinase (pi3k), phosphorylated (p‑)protein kinase b (akt) and p‑mechanistic target of rapamycin (mtor) protein expression in epilepsy cells. |
2018-10-29 |
2023-08-13 |
human |
| Sara Salucci, Sabrina Burattini, Francesca Buontempo, Ester Orsini, Lucia Furiassi, Michele Mari, Simone Lucarini, Alberto M Martelli, Elisabetta Falcier. Marine bisindole alkaloid: A potential apoptotic inducer in human cancer cells. European journal of histochemistry : EJH. vol 62. issue 2. 2018-10-29. PMID:29943949. |
in particular, the bisindole alkaloid induces a mitochondrial involvement in apoptosis machinery activation with blc-2/bcl-x down-regulation and bax up-regulation. |
2018-10-29 |
2023-08-13 |
human |
| Li-Ya Dong, Li-Ping Yao, Jing Zhao, Ke-Ke Jin, Xiao-Xiao Qi. Captopril inhibits calpain‑mediated apoptosis of myocardial cells in diabetic rats and improves cardiac function. Molecular medicine reports. vol 18. issue 2. 2018-10-29. PMID:29956776. |
therefore, captopril improved myocardial structure and ventricular function, by inhibiting calpain‑1 and calpain‑2 activation, increasing bcl‑2 expression, reducing bax expression and subsequently inhibiting caspase‑3‑dependent apoptosis. |
2018-10-29 |
2023-08-13 |
rat |
| Ye Ji Jeong, Yeonghoon Son, Na-Kyung Han, Hyung-Do Choi, Jeong-Ki Pack, Nam Kim, Yun-Sil Lee, Hae-June Le. Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice. International journal of molecular sciences. vol 19. issue 7. 2018-10-29. PMID:30029554. |
in addition, levels of markers for dna damage (8-hydroxy-2'-deoxyguanosine, p53, p21, γh2ax, and bax), apoptosis (cleaved caspase-3 and cleaved poly(adp-ribose) polymerase 1 (parp-1)), astrocyte (gfap), and microglia (iba-1) were significantly elevated in the brains of aged mice. |
2018-10-29 |
2023-08-13 |
mouse |
| Osama A Elkashty, Ramy Ashry, Ghada Abu Elghanam, Hieu M Pham, Xinyun Su, Camille Stegen, Simon D Tra. Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas. Medical oncology (Northwood, London, England). vol 35. issue 9. 2018-10-29. PMID:30078069. |
sf increased scchn apoptosis and this mechanism was due to a down-regulation of bcl2 and up-regulation of bax, leading to an up-regulation of caspase3. |
2018-10-29 |
2023-08-13 |
human |
| A Sudha, P Srinivasan, V Kanimozhi, K Palanivel, B Kadalman. Antiproliferative and apoptosis-induction studies of 5-hydroxy 3',4',7-trimethoxyflavone in human breast cancer cells MCF-7: an in vitro and in silico approach. Journal of receptor and signal transduction research. vol 38. issue 3. 2018-10-26. PMID:29734849. |
the treatment of mcf-7 cells with htmf encouraged apoptosis through the modulation of apoptotic markers, such as p53, bcl-2, bax, and cleaved parp. |
2018-10-26 |
2023-08-13 |
human |
| Guang Li, Yanping Song, Gangcan Li, Jingjing Ren, Jia Xie, Yunjie Zhang, Fei Gao, Jiao Mu, Jinqian Da. Downregulation of microRNA‑21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM‑1 cells. Molecular medicine reports. vol 18. issue 3. 2018-10-26. PMID:30015844. |
in addition, the expression levels of apoptosis regulator bcl‑2 (bcl2), cyclind1 and phosphorylated‑protein kinase b (akt) were significantly decreased in skm‑1 cells transfected with the mir‑21 inhibitor, whilst the expression levels of phosphatase and tensin homolog (pten), bcl‑associated protein x (bax) and cleaved caspase 3 were significantly elevated. |
2018-10-26 |
2023-08-13 |
Not clear |
| Jing Li, Zhongjun Ding, Yue Yang, Baohong Mao, Yanxia Wang, Xiaoying X. Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis. Molecular medicine reports. vol 18. issue 3. 2018-10-26. PMID:30015960. |
reverse transcription‑quantitative polymerase chain reaction and western blot analysis were performed to detect the expression of apoptosis‑associated factors, including survivin, hypoxia inducible factor 1‑α (hif1‑α), bcl‑2 apoptosis regulator (bcl‑2), bcl‑2 associated x apoptosis regulator (bax). |
2018-10-26 |
2023-08-13 |
human |
| Jing Li, Zhongjun Ding, Yue Yang, Baohong Mao, Yanxia Wang, Xiaoying X. Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis. Molecular medicine reports. vol 18. issue 3. 2018-10-26. PMID:30015960. |
additionally, lbp decreased mmp disruption and cell apoptosis induced by h2o2, by increasing the mrna and protein expression of survivin, hif1‑α and bcl‑2 and decreasing bax expression. |
2018-10-26 |
2023-08-13 |
human |