| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ninggao Dai, Ruifan Ye, Qikuan He, Pengyi Guo, Hao Chen, Qiyu Zhan. Capsaicin and sorafenib combination treatment exerts synergistic anti‑hepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272354. |
in lm3 cells, capsaicin and sorafenib combination treatment achieved a markedly stronger induction of apoptosis by increasing caspase‑3, bax and poly(adp‑ribose) polymerase activity and inhibiting bcl‑2, and induction of autophagy by upregulating the levels of beclin‑1 and lc3a/b ii, enhancing p62 degradation. |
2018-12-11 |
2023-08-13 |
Not clear |
| Weiguo Liao, Jie Liu, Bin Liu, Xiaojie Huang, Yongxin Yin, De Cai, Mingyi Li, Runzhi Zh. JIB‑04 induces cell apoptosis via activation of the p53/Bcl‑2/caspase pathway in MHCC97H and HepG2 cells. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272369. |
annexin v/pi staining, a cck‑8 assay and western blot analysis demonstrated that jib‑04 induced apoptosis in mhcc97h and hepg2 cells, which was evidenced by the expression of proapoptotic and apoptotic proteins including p53, bak, bax, caspase‑3 and caspase‑9. |
2018-12-11 |
2023-08-13 |
human |
| Nadir Koçak, Hüseyin Dönmez, İbrahim Halil Yildiri. Effects of melatonin on apoptosis and cell differentiation in MCF-7 derived cancer stem cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 12. 2018-12-11. PMID:30301504. |
expression of genes related to apoptosis (bax and bcl2) and self-renewal and differentiation (oct4, sox2, and nanog) analyzed after the sorting of cancer stem cells from mcf-7 cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Jian Wu, An-Quan Shang, Chu Chen, Wei-Wei Wang, Cun-Quan Xiong, Nai-Zhou Gu. Serum‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2. Oncology reports. vol 40. issue 5. 2018-11-27. PMID:30132563. |
the detection of apoptosis‑associated proteins by western blotting revealed that the expression of apoptosis regulator bax and caspase‑3 in the vc and supernatant groups was decreased. |
2018-11-27 |
2023-08-13 |
Not clear |
| Hyeri Shin, Aryung Nam, Kun-Ho Song, Kupil Lee, Robert B Rebhun, Kyoung-Won Se. Anticancer effects of high-dose ascorbate on canine melanoma cell lines. Veterinary and comparative oncology. vol 16. issue 4. 2018-11-27. PMID:30188000. |
further investigation demonstrated that high-dose ascorbate induced apoptosis via the activation of bax. |
2018-11-27 |
2023-08-13 |
human |
| D Y Zhao, W X Zhang, Q Q Qi, X Long, X Li, Y B Yu, X L Zu. Brain-derived neurotrophic factor modulates intestinal barrier by inhibiting intestinal epithelial cells apoptosis in mice. Physiological research. vol 67. issue 3. 2018-11-26. PMID:29527912. |
apoptosis involvement was determined with tunel staining, active caspase-3 immunostaining and western blotting for the protein expression of active caspase-3, bax and bcl-2. |
2018-11-26 |
2023-08-13 |
mouse |
| Xin-Yi Fang, Hai Zhang, Lin Zhao, Shuai Tan, Qing-Cuo Ren, Lun Wang, Xiao-Fei She. A new xanthatin analogue 1β-hydroxyl-5α-chloro-8-epi-xanthatin induces apoptosis through ROS-mediated ERK/p38 MAPK activation and JAK2/STAT3 inhibition in human hepatocellular carcinoma. Biochimie. vol 152. 2018-11-26. PMID:29960031. |
firstly, xtt inhibited the cell growth and induced apoptosis in human hcc cells, which was associated with the induction of bax and cleaved-caspase-3, inhibition of bcl-2 and survivin expression. |
2018-11-26 |
2023-08-13 |
human |
| Wenzhe Song, Parth Thakor, David A Vesey, Glenda C Gobe, Christudas Morai. Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-11-26. PMID:29966967. |
mφcm induced a markedly vacuolated phenotype in mcf-7 increased apoptosis in mcf-7 cells, but correlative changes in bcl-2 or bax were absent. |
2018-11-26 |
2023-08-13 |
Not clear |
| Farina Hanif, Kahkashan Perveen, Saima M Malhi, Huma Jawed, Shabana U Simje. Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicology in vitro : an international journal published in association with BIBRA. vol 52. 2018-11-26. PMID:30003979. |
combination of tmz and vp increased the ratio of bax to bcl-2 expression and thus shifted the equilibrium of cells towards apoptosis. |
2018-11-26 |
2023-08-13 |
Not clear |
| Huaying Dong, Wei Wang, Ru Chen, Yu Zhang, Kejian Zou, Mulin Ye, Xionghui He, Fan Zhang, Jing Ha. Exosome-mediated transfer of lncRNA‑SNHG14 promotes trastuzumab chemoresistance in breast cancer. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:30015837. |
the signal transduction reporter array indicated that lncrna‑snhg14 may promote the effect of trastuzumab by targeting the apoptosis regulator bcl‑2 (bcl‑2)/apoptosis regulator bax (bax) signaling pathway. |
2018-11-26 |
2023-08-13 |
human |
| Wei Zhang, Yangyang Zhang, Keke Ding, Hengbing Zhang, Qian Zhao, Zheng Liu, Yawei X. Involvement of JNK1/2-NF-κBp65 in the regulation of HMGB2 in myocardial ischemia/reperfusion-induced apoptosis in human AC16 cardiomyocytes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-11-26. PMID:30119172. |
hmgb2 silencing significantly inhibited i/r-induced the cell proliferation reduction, cell apoptosis, activation of erk1/2, jnk1/2 and nf-κbp65, increased bax, cleaved parp and caspase-3 and decreased bcl-2 expression. |
2018-11-26 |
2023-08-13 |
human |
| Wei Zhang, Yangyang Zhang, Keke Ding, Hengbing Zhang, Qian Zhao, Zheng Liu, Yawei X. Involvement of JNK1/2-NF-κBp65 in the regulation of HMGB2 in myocardial ischemia/reperfusion-induced apoptosis in human AC16 cardiomyocytes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-11-26. PMID:30119172. |
moreover, pdtc treatment in rats following i/r injury also showed decreases in the cell apoptosis, hmgb2, cleaved parp and caspase-3 and bax expression, and jnk1/2 activation. |
2018-11-26 |
2023-08-13 |
human |
| Fang Chen, Zhiqiang Sun, Xiaoguang Zhu, Yali M. Astilbin inhibits high glucose-induced autophagy and apoptosis through the PI3K/Akt pathway in human proximal tubular epithelial cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-11-26. PMID:30119185. |
the cell apoptosis was evaluated by detecting the apoptosis rate, caspase-3 activity, and the expression of bcl-2 and bax. |
2018-11-26 |
2023-08-13 |
human |
| Jin Li, Hui Li, Qixiong Li, Ying Xu. Repaglinide inhibits cyclosporine A-induced renal tubular toxicityby affecting apoptosis and Bax and Bcl-2 expression Turkish journal of medical sciences. vol 48. issue 4. 2018-11-26. PMID:30121055. |
repaglinide inhibits cyclosporine a-induced renal tubular toxicityby affecting apoptosis and bax and bcl-2 expression repaglinide (rg) is a prandial glucose regulator used for the treatment of type 2 diabetes. |
2018-11-26 |
2023-08-13 |
rat |
| Nair Anupama, M R Preetha Rani, G L Shyni, K G Ragh. Glucotoxicity results in apoptosis in H9c2 cells via alteration in redox homeostasis linked mitochondrial dynamics and polyol pathway and possible reversal with cinnamic acid. Toxicology in vitro : an international journal published in association with BIBRA. vol 53. 2018-11-26. PMID:30144576. |
finally, apoptosis was observed with upregulation of bax, activation of caspase-3 and downregulation of bcl-2. |
2018-11-26 |
2023-08-13 |
Not clear |
| Yao Yuan, Jiewei Wu, Bailin Li, Jia Niu, Haibo Tan, Shengxiang Qi. Regulation of Signaling Pathways Involved in the Anti-proliferative and Apoptosis-inducing Effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells. Scientific reports. vol 8. issue 1. 2018-11-23. PMID:29343765. |
furthermore, m22 caused induction of apoptosis that downregulated the anti-apoptotic bcl-2 gene and increased expression of bax, casp3 and casp9 as well as the apaf1 gene. |
2018-11-23 |
2023-08-13 |
human |
| Yifeng Gao, Trygve O Tollefsbo. Combinational Proanthocyanidins and Resveratrol Synergistically Inhibit Human Breast Cancer Cells and Impact Epigenetic⁻Mediating Machinery. International journal of molecular sciences. vol 19. issue 8. 2018-11-21. PMID:30060527. |
additional analyses show that treatments with gsps and res in combination synergistically induced apoptosis in mda-mb-231 cells by upregulating bax expression and down-regulating bcl-2 expression. |
2018-11-21 |
2023-08-13 |
human |
| Shi-Chen Qin, Zhong Zhao, Jin-Xin Sheng, Xiang-Hui Xu, Jie Yao, Jin-Jun Lu, Bin Chen, Guo-Dong Zhao, Xiao-Yong Wang, Yan-Dong Yan. Dowregulation of OTX1 attenuates gastric cancer cell proliferation, migration and invasion. Oncology reports. vol 40. issue 4. 2018-11-20. PMID:30066897. |
in addition, the inhibition of otx1 led to increased gc cell apoptosis by upregulating cleaved parp, cleaved caspase‑3 and bax. |
2018-11-20 |
2023-08-13 |
human |
| Hiroaki Fujiwara, Keisuke Tateishi, Hiroyuki Kato, Takuma Nakatsuka, Keisuke Yamamoto, Yasuo Tanaka, Hideaki Ijichi, Naminatsu Takahara, Suguru Mizuno, Hirofumi Kogure, Saburo Matsubara, Yousuke Nakai, Kazuhiko Koik. Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma to the BET inhibitor JQ1. Cancer science. vol 109. issue 11. 2018-11-19. PMID:30156013. |
jq1 induced apoptosis only in rbe cells through the upregulation of proapoptotic genes bax and bim. |
2018-11-19 |
2023-08-13 |
Not clear |
| Imran Khan, Ashutosh Bahuguna, Pradeep Kumar, Vivek K Bajpai, Sun Chul Kan. In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis. Scientific reports. vol 8. issue 1. 2018-11-16. PMID:29317755. |
the cane induced reactive oxygen species (ros) production in a549 cells, leading to activation of key regulators of apoptosis such as p-jnk, bax and bcl2 as well as release of cytochrome c, and activation of the caspase cascade. |
2018-11-16 |
2023-08-13 |
mouse |