| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Tang, Rui Xiong, An-Guo Wu, Chong-Lin Yu, Ya Zhao, Wen-Qiao Qiu, Xiu-Ling Wang, Jin-Feng Teng, Jian Liu, Hai-Xia Chen, Jian-Ming Wu, Da-Lian Qi. Polyphenols Derived from Lychee Seed Suppress Aβ (1-42)-Induced Neuroinflammation. International journal of molecular sciences. vol 19. issue 7. 2018-10-26. PMID:30036972. |
furthermore, catechin and procyanidin a2 could inhibit aβ-induced apoptosis in bv-2 cells by upregulating bcl-2 and downregulating bax protein expression. |
2018-10-26 |
2023-08-13 |
rat |
| Dong-Ye Yi, Qing Su, Fang-Cheng Zhang, Peng Fu, Qing Zhang, Yong-Cun Cen, Hong-Yang Zhao, Wei Xian. Effect of microRNA-128 on cisplatin resistance of glioma SHG-44 cells by targeting JAG1. Journal of cellular biochemistry. vol 119. issue 4. 2018-10-25. PMID:29091297. |
in in vitro experiments, compared with the blank group, the rest groups exhibited declined mir-28 and bax expression, lowered cell inhibition rate and apoptosis rate, but elevated jag1 and bcl-2 expression with cells arrested in the s phase. |
2018-10-25 |
2023-08-13 |
Not clear |
| Chun Xie, Ai-Ping Tan. [Combined Effect of Bortezomib and Homoharringtonine on K562 Cells and their Mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 26. issue 2. 2018-10-25. PMID:29665904. |
to explore the effects of btz plus hht on proliferation and apoptosis of k562 cells, and to clarify the relationship between the mechanism inderlying the effect of btz plus hht on k562 cells and bcl-2, bax, mcl-1 proteins. |
2018-10-25 |
2023-08-13 |
Not clear |
| Hyun-Wook Ryu, Dong-Hee Shin, Dong Hoon Lee, Hye-Rim Won, So Hee Kwo. A potent hydroxamic acid-based, small-molecule inhibitor A452 preferentially inhibits HDAC6 activity and induces cytotoxicity toward cancer cells irrespective of p53 status. Carcinogenesis. vol 39. issue 1. 2018-10-24. PMID:29106445. |
a452-induced apoptosis as evidenced by activated caspase 3 and parp, increased bak and bax and decreased bcl-xl. |
2018-10-24 |
2023-08-13 |
Not clear |
| Kariyappa Vijay, Poorigali Raghavendra-Rao Sowmya, Bangalore Prabhashankar Arathi, Shivaprasad Shilpa, Hulikere Jagdish Shwetha, Marisiddaiah Raju, Vallikannan Baskaran, Rangaswamy Lakshminarayan. Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 118. 2018-10-24. PMID:29920287. |
furthermore, mitochondrial dysfunction, cell growth arrest at g0/g1 phase and caspase cascades as well as up- and down-regulated expression levels of related proteins (p21, p27, bax, p53, bcl-2, and cyclin d1) revealed the synergistic effect of carotenoid and dox treatment on ros-mediated apoptosis. |
2018-10-24 |
2023-08-13 |
Not clear |
| Hartmut Jaeschke, Luqi Duan, Jephte Y Akakpo, Anwar Farhood, Anup Ramachandra. The role of apoptosis in acetaminophen hepatotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 118. 2018-10-24. PMID:29920288. |
both qualitative and quantitative comparisons of parameters such as bax, bcl-2, caspase processing and dna fragmentation in both modes of cell death clearly show fundamental differences between apoptosis and cell death induced by apap. |
2018-10-24 |
2023-08-13 |
Not clear |
| Yoo Jin Lee, Changhee Le. Porcine deltacoronavirus induces caspase-dependent apoptosis through activation of the cytochrome c-mediated intrinsic mitochondrial pathway. Virus research. vol 253. 2018-10-23. PMID:29940190. |
altogether, our results indicate that pdcov infection stimulates momp either via bax recruitment or mptp opening to permit the release of apoptogenic cyt c into the cytoplasm, thereby leading to execution of the caspase-dependent intrinsic apoptosis pathway to facilitate viral replication in vitro. |
2018-10-23 |
2023-08-13 |
Not clear |
| Ramesh Elango, Jegan Athinarayanan, Vaiyapuri Periasamy Subbarayan, David K Y Lei, Ali A Alshatw. Hesperetin induces an apoptosis-triggered extrinsic pathway and a p53- independent pathway in human lung cancer H522 cells. Journal of Asian natural products research. vol 20. issue 6. 2018-10-22. PMID:28537448. |
this study shows that hesperetin induces apoptosis in h522 cells via a pathway independentof p53 and bax but triggers the death-receptor fas-initiated fadd/ caspase-8-dependent apoptotic pathway. |
2018-10-22 |
2023-08-13 |
human |
| Yibin Lin, Jiahui Li, Shazhou Ye, Jiayi Chen, Yanru Zhang, Liu Wang, Yang Xi, Shizhong Bu, Xiaohui Qi. LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells. Gene. vol 678. 2018-10-22. PMID:30098426. |
mechanistically, gacat3 amplified stat3 expression and decreased the level of the apoptosis gene bcl-2-associated x protein (bax). |
2018-10-22 |
2023-08-13 |
Not clear |
| Venugopal Vinod Prabhu, Perumal Elangovan, Sivasithambaram Niranjali Devaraj, Kunnathur Murugesan Sakthive. Targeting apoptosis by 1,2-diazole through regulation of EGFR, Bcl-2 and CDK-2 mediated signaling pathway in human non-small cell lung carcinoma A549 cells. Gene. vol 679. 2018-10-22. PMID:30218747. |
in the present study the anti-cancer mechanism of pyrazole, was examined by the expression level of proteins epidermal growth factor receptor (egfr), bcl-2-associated x protein (bax), b-cell lymphoma-2 (bcl-2) and cyclin-dependent kinase-2 (cdk-2) which are commonly associated with the cell signaling pathways that control cell survival and apoptosis, that could facilitate to develop a novel target and effective treatment approach for patients with nsclc. |
2018-10-22 |
2023-08-13 |
human |
| Xiaowei Wang, Xiaoju Liang, Huan Liang, Bing Wan. SENP1/HIF-1α feedback loop modulates hypoxia-induced cell proliferation, invasion, and EMT in human osteosarcoma cells. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-19. PMID:28796315. |
moreover, knockdown of senp1 with sirna notably inhibited cell viability and accelerated cell apoptosis accompanied by a decrease in the expression of bcl-2 and an increase in the expression of bax in mg-63 cells following exposure to hypoxia. |
2018-10-19 |
2023-08-13 |
human |
| Tian-Hua Yao, Parekejiang Pataer, Krishna Prasad Regmi, Xi-Wen Gu, Quan-Yan Li, Jing-Ting Du, Su-Meng Ge, Jun-Bo T. Propranolol induces hemangioma endothelial cell apoptosis via a p53‑BAX mediated pathway. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29767244. |
the expression levels of downstream proteins regulated by p53 [tumour necrosis factor receptor superfamily member 6 (fas), p53‑induced death domain‑containing protein (pidd), death receptor 5 (dr5), bh3‑interacting domain death agonist (bid), apoptosis regulator bax (bax), p53 unregulated modulator of apoptosis (puma), phosphatidylinositol‑glycan biosynthesis class s protein (pigs), and insulin‑like growth factor‑binding protein 3 (igf‑bp3)] were revealed in the experimental and control groups via western blotting. |
2018-10-19 |
2023-08-13 |
Not clear |
| Shun Zhi He, Jing Li, Hong Chu Bao, Mei Mei Wang, Xin Rong Wang, Xin Huang, Feng Hua Li, Wei Zhang, An Li Xu, Hao Cui Fang, Yang Xing Shen. G protein‑coupled estrogen receptor/miR‑148a/human leukocyte antigen‑G signaling pathway mediates cell apoptosis of ovarian endometriosis. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845209. |
overexpression of mir‑148a using mir mimics significantly decreased proliferation, promoted apoptosis, increased the bcl‑2 associated x apoptosis regulator (bax)/bcl‑2 apoptosis regulator (bcl‑2) ratio and caspase3/9 activity, and suppressed hla‑g protein expression in hs 832(c).t cells. |
2018-10-19 |
2023-08-13 |
Not clear |
| Mingliang Wang, Min Liu, Ting Ni, Qiliang Li. miR‑214 mediates vascular inflammation and apoptosis via PTEN expression. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29916551. |
the results demonstrated that anti‑mir‑214 mimics inhibited cell proliferation, increased apoptosis and inflammatory factors (tnf‑α, il‑1β, il‑6 and il‑18 levels), inhibited cell proliferation, and induced bax protein expression in tnf‑α‑induced vascular endothelial cells through induction of pten and nf‑κb protein expression and inhibition of akt protein expression. |
2018-10-19 |
2023-08-13 |
Not clear |
| Fan-Li Lin, Cheng-Hui Lin, Jau-Der Ho, Jing-Lun Yen, Hung-Ming Chang, George C Y Chiou, Yu-Wen Cheng, George Hsia. The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degenaration. Scientific reports. vol 7. 2018-10-18. PMID:28112220. |
furthermore, tunel assays revealed that chrysophanol attenuated mnu-induced photoreceptor cell apoptosis and inhibited the expression of the apoptosis-associated proteins parp, bax, and caspase-3. |
2018-10-18 |
2023-08-13 |
mouse |
| Yuanxin Zhang, Yakun Ge, Xie Ping, Ming Yu, Dawei Lou, Wei Sh. Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines. Molecular medicine reports. vol 18. issue 2. 2018-10-18. PMID:29901126. |
furthermore, upregulation of the ratio of apoptosis regulator bcl‑2/apoptosis regulator bax and tumor necrosis factor receptor superfamily member 6 (fas)/fas ligand indicated that the silibinin‑paclitaxel combination activated the death receptor‑mediated pathway in sgc‑7901 cells. |
2018-10-18 |
2023-08-13 |
human |
| Dandan Song, Xuelei Liu, Yugang Diao, Yingjie Sun, Guangjie Gao, Tiezheng Zhang, Keyan Chen, Ling Pe. Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats. Molecular medicine reports. vol 18. issue 2. 2018-10-18. PMID:29956781. |
the expression of apoptosis regulator bcl‑2 (bcl‑2), apoptosis regulator bax (bax), caspase 3, aqp‑1, aqp‑4, phosphorylated (p)‑akt, heme oxygenase 1 (ho‑1) and nuclear factor erythroid 2‑related factor 2 (nrf2) were investigated using western blotting and quantitative‑polymerase chain reaction of tissues and cells. |
2018-10-18 |
2023-08-13 |
rat |
| Huachang Hong, Huan Wu, Jiao Chen, Binbin Wu, Haiying Yu, Bin Yan, Yan Lian. Cytotoxicity induced by iodinated haloacetamides via ROS accumulation and apoptosis in HepG-2 cells. Environmental pollution (Barking, Essex : 1987). vol 242. issue Pt A. 2018-10-18. PMID:29980037. |
the apoptosis mechanisms were further analyzed via bax and bcl-2 gene expression and the corresponding protein expression in hepg-2 cells, that mitochondrial pathway was important in the apoptosis of hepg-2 cells induced by all i-hacams species. |
2018-10-18 |
2023-08-13 |
Not clear |
| Xintian Shao, Qixin Chen, Xixi Dou, Lei Chen, Jixu Wu, Wei Zhang, Huarong Shao, Peixue Ling, Fei Liu, Fengshan Wan. Lower range of molecular weight of xanthan gum inhibits cartilage matrix destruction via intrinsic bax-mitochondria cytochrome c-caspase pathway. Carbohydrate polymers. vol 198. 2018-10-18. PMID:30093011. |
the results showed that lrwxg could inhibit the loss of collagen in cartilage matrix, protect trabecular bone in subchondral, decrease the apoptosis of chondrocytes, down-regulate the expressions of active caspase-9, active caspase-3 and bax, and up-regulate the expression of bcl-2. |
2018-10-18 |
2023-08-13 |
rabbit |
| Song Yang, Xiuping Chen, Shengli Li, Bin Sun, Chunhua Han. Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-16. PMID:29872034. |
tunel was used to study apoptosis of neuronal cells, western-blot and immunohistochemistry detected expression of sirt3, bcl-2, superoxide dismutase 2 (sod2), bax, and cleaved caspase-3. |
2018-10-16 |
2023-08-13 |
mouse |