| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Zhang, Wei Xin, Zhi Yi, Yue Li, Ying Liu, Hongyue Zhang, He Chen, Xinxin Chen, Shujie Tan, Daling Zh. Human biliverdin reductase regulates the molecular mechanism underlying cancer development. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28708313. |
in addition, the mitochondrial membrane potential and mitochondrial membrane proteins bcl-2 and bax were found to be necessary for activation of the mitochondria dependent apoptosis pathway. |
2018-10-15 |
2023-08-13 |
human |
| Maliheh Moradzadeh, Alijan Tabarraei, Hamid Reza Sadeghnia, Ahmad Ghorbani, Ashraf Mohamadkhani, Saiedeh Erfanian, Amirhossein Sahebka. Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28865123. |
furthermore, the expression levels of genes involved in apoptosis (pi3 k, akt, bcl2, bax, p53, p21, pten, casp3, casp8, and casp9), differentiation (pml-rar and hdac1), and multi-drug resistance (abcb1 and abcc1) were determined using quantitative real-time pcr. |
2018-10-15 |
2023-08-13 |
human |
| Xiang-Feng Guo, Ji-Peng Liu, Si-Quan Ma, Peng Zhang, Wen-De Su. Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29635130. |
molecular mechanism analysis indicated that al and ddp combination treatment enhanced apoptosis in sgc-7901/ddp cells, accompanied with the up-regulation of cleaved caspase-3 and parp, as well as the activation of pro-apoptotic signals, including bax and bok. |
2018-10-15 |
2023-08-13 |
human |
| Xiang-Feng Guo, Ji-Peng Liu, Si-Quan Ma, Peng Zhang, Wen-De Su. Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29635130. |
significantly, down regulation of bax or bok expressions using bax sirna or bok sirna decreased the inhibitory role of ddp in apoptosis of sgc-7901/ddp cells pretreated with al, demonstrating that al-reversed ddp resistance was associated with bax and bok expression. |
2018-10-15 |
2023-08-13 |
human |
| Linying Feng, Jianmei Gao, Yuangui Liu, Jingshan Shi, Qihai Gon. Icariside II alleviates oxygen-glucose deprivation and reoxygenation-induced PC12 cell oxidative injury by activating Nrf2/SIRT3 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29635133. |
furthermore, ogd/r accelerated neuronal oxidative injury and apoptosis along with reduced nucleus-nrf2, nqo-1, ho-1, bcl-2 protein expressions, and increased keap1, bax and cleaved caspase-3 contents, whereas ics ii significantly reversed the abovementioned changes. |
2018-10-15 |
2023-08-13 |
Not clear |
| Renbo Li, Jingbo Shang, Wei Zhou, Li Jiang, Donghui Xie, Guanjun T. Overexpression of HIPK2 attenuates spinal cord injury in rats by modulating apoptosis, oxidative stress, and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29649627. |
overexpression of hipk2 also decreased expression of bax and caspase-3 and elevated expression of bcl-2 in the sci model, indicating that hipk2 exhibited its protective activity by inhibiting sci-induced apoptosis. |
2018-10-15 |
2023-08-13 |
rat |
| Junli Shao, Chaoxi Wang, Linqiu Li, Hairong Liang, Juanxiu Dai, Xiaoxuan Ling, Huanwen Tan. Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells. International journal of molecular sciences. vol 19. issue 6. 2018-10-15. PMID:29874795. |
the study demonstrated that luteoloside could inhibit proliferation remarkably; promote apoptosis and cytochrome c release; decrease the mitochondrial membrane potential and reactive oxygen species level; upregulate the expression of fas, bax, p53, phospho-p38, phospho-jnk, and cleaved parp; downregulate the expression of bcl-2 and phospho-mtor; activate caspase-3 and caspase-8; change the nuclear morphology, and fragmentate dna in hela cells. |
2018-10-15 |
2023-08-13 |
human |
| N Reusche, A Beineke, C Urhausen, M Beyerbach, M Schmicke, S Kramer, A R Günzel-Ape. Proliferative and apoptotic changes in the healthy canine endometrium and in cystic endometrial hyperplasia. Theriogenology. vol 114. 2018-10-11. PMID:29574305. |
markers for proliferation (ki-67) and apoptosis (activated caspase-3 and tunel-method) as well as expression of bcl-2 and bax were determined in all endometrial layers. |
2018-10-11 |
2023-08-13 |
Not clear |
| N Reusche, A Beineke, C Urhausen, M Beyerbach, M Schmicke, S Kramer, A R Günzel-Ape. Proliferative and apoptotic changes in the healthy canine endometrium and in cystic endometrial hyperplasia. Theriogenology. vol 114. 2018-10-11. PMID:29574305. |
in ceh, no or limited cyclic patterns of proliferation, apoptosis, bcl-2 and bax were found. |
2018-10-11 |
2023-08-13 |
Not clear |
| N Reusche, A Beineke, C Urhausen, M Beyerbach, M Schmicke, S Kramer, A R Günzel-Ape. Proliferative and apoptotic changes in the healthy canine endometrium and in cystic endometrial hyperplasia. Theriogenology. vol 114. 2018-10-11. PMID:29574305. |
in conclusion bcl-2 and bax play a role both in the physiological regenerative processes of the cyclic canine endometrium and in deregulating proliferation and apoptosis in ceh and pyometra. |
2018-10-11 |
2023-08-13 |
Not clear |
| Mohammed A El-Missiry, Magda A ElKomy, Azza I Othman, Ali M AbouEl-Ez. Punicalagin ameliorates the elevation of plasma homocysteine, amyloid-β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 102. 2018-10-11. PMID:29579708. |
compared with methionine-treated animals, mice that treated with methionine and punicalagin remarkably displayed less apoptosis, indicated by the lower level of proapoptotic protein (bax, caspases- 3, 9 and p53) and higher levels of antiapoptotic bcl-2 protein than those in hyperhomocysteinemic mice. |
2018-10-11 |
2023-08-13 |
mouse |
| Zhiren Zhang, Yunqing Cao, Yanhui Zhai, Xiaoling Ma, Xinglan An, Sheng Zhang, Ziyi L. MicroRNA-29b regulates DNA methylation by targeting Dnmt3a/3b and Tet1/2/3 in porcine early embryo development. Development, growth & differentiation. vol 60. issue 4. 2018-10-11. PMID:29878317. |
in addition, the pluripotency genes nanog and sox2 were significantly downregulated, and the apoptosis genes bax and casp3 were upregulated, but anti-apoptosis gene bcl-2 was downregulated in blastocysts. |
2018-10-11 |
2023-08-13 |
Not clear |
| Saman Sizdahkhani, Michael J Feldman, Martin G Piazza, Alexander Ksendzovsky, Nancy A Edwards, Abhik Ray-Chaudhury, Dragan Maric, Marsha J Merrill, Karel Pacak, Zhengping Zhuang, Prashant Chittiboin. Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target. Scientific reports. vol 7. 2018-10-10. PMID:28094316. |
we found that somatostatin analogue octreotide induces apoptosis in vhl-hb stromal cells in a dose-dependent fashion by bax - caspase-3 pathway unrelated to canonical vhl pathway. |
2018-10-10 |
2023-08-13 |
Not clear |
| Weilan Kong, Kai Kang, Yang Gao, Haitao Liu, Xianglin Meng, Yanhui Cao, Songliu Yang, Wen Liu, Jiannan Zhang, Kaijiang Yu, Mingyan Zha. GTS-21 Protected Against LPS-Induced Sepsis Myocardial Injury in Mice Through α7nAChR. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29680908. |
the pathological results of myocardial tissue were detected by the he method; the apoptosis rate was detected by the tunel method; the relative expressions of nf-κb p65, caspase-3, caspase-8, bcl-2, bax, p53, and a7nachr were detected by real-time quantitative pcr (rt-pcr); and the protein expressions of il-6, il-1 β, tnf-α, and pstat3 were detected by western blot. |
2018-10-10 |
2023-08-13 |
mouse |
| Fen Zhou, Xin Huang, Yun Pan, Di Cao, Chuan Liu, Yiyi Liu, Aijun Che. Resveratrol protects HaCaT cells from ultraviolet B-induced photoaging via upregulation of HSP27 and modulation of mitochondrial caspase-dependent apoptotic pathway. Biochemical and biophysical research communications. vol 499. issue 3. 2018-10-09. PMID:29604279. |
resveratrol inhibited uvb-induced apoptosis by upregulating the expression of hsp27, reducing the production of proapoptotic proteins such as p65, bax, and cleaved caspase-3, and promoting the expression of anti-apoptotic protein bcl-2. |
2018-10-09 |
2023-08-13 |
Not clear |
| Yong Zhang, Xiaoming Lei, Wei Li, Xiaoying Ding, Jie Bai, Jin Wang, Gang W. TNIP1 alleviates hepatic ischemia/reperfusion injury via the TLR2-Myd88 pathway. Biochemical and biophysical research communications. vol 501. issue 1. 2018-10-09. PMID:29709475. |
cell apoptosis also was inhibited after ad-tnip1 transfection, as shown by the caspase-3 and caspase-9 levels and bcl-2 and bax values. |
2018-10-09 |
2023-08-13 |
mouse |
| Wendong Ruan, Guangzhi Ning, Shiqing Feng, Shijie Gao, Yan Ha. MicroRNA‑381/Hes1 is a potential therapeutic target for spinal cord injury. International journal of molecular medicine. vol 42. issue 2. 2018-10-09. PMID:29750292. |
overexpression of microrna‑381 promoted cell proliferation, and inhibited apoptosis and caspase‑3 and apoptosis regulator bax (bax) protein expression in neurocytes. |
2018-10-09 |
2023-08-13 |
rat |
| Wendong Ruan, Guangzhi Ning, Shiqing Feng, Shijie Gao, Yan Ha. MicroRNA‑381/Hes1 is a potential therapeutic target for spinal cord injury. International journal of molecular medicine. vol 42. issue 2. 2018-10-09. PMID:29750292. |
wnt inhibitor, wnt‑c59 (1 µmol/l), inhibited cell proliferation, promoted apoptosis and caspase‑3 and bax protein expression, suppressed β‑catenin protein expression and induced hes1 protein expression in neurocytes following microrna‑381 overexpression. |
2018-10-09 |
2023-08-13 |
rat |
| Wendong Ruan, Guangzhi Ning, Shiqing Feng, Shijie Gao, Yan Ha. MicroRNA‑381/Hes1 is a potential therapeutic target for spinal cord injury. International journal of molecular medicine. vol 42. issue 2. 2018-10-09. PMID:29750292. |
notch inhibitor, fli‑06 (1 µmol/l), promoted cell proliferation, inhibited apoptosis and caspase‑3 and bax protein expression, and suppressed nicd and hes1 protein expression in neurocytes following microrna‑381 overexpression. |
2018-10-09 |
2023-08-13 |
rat |
| Ze-Wei Ma, Dong-Xiang Li. Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins. Acta pharmacologica Sinica. vol 39. issue 6. 2018-10-05. PMID:29265109. |
in this way, hn inhibits bax pore formation in mitochondrial outer membrane and suppresses cytochrome c release and mitochondria-dependent apoptosis. |
2018-10-05 |
2023-08-13 |
Not clear |