| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Kang, Xiao Zheng, Ping Wang, Shanyu Gu. Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29512685. |
we further present in vitro evidence that deguelin promoted apoptosis of cancer cells by decreasing the phospho-akt signaling and affecting expression of the apoptosis-associated genes bax and bcl-2. |
2018-09-10 |
2023-08-13 |
human |
| Jianjie Zheng, Jing Li, Bo Kou, Qiuyue Yi, Tao Sh. MicroRNA-30e protects the heart against ischemia and reperfusion injury through autophagy and the Notch1/Hes1/Akt signaling pathway. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29532851. |
in h9c2 cells, silencing (si)mirna‑30e significantly inhibited cellular apoptosis, the expression of apoptosis regulator bax (bax) and caspase‑3 activity. |
2018-09-10 |
2023-08-13 |
Not clear |
| Jianjie Zheng, Jing Li, Bo Kou, Qiuyue Yi, Tao Sh. MicroRNA-30e protects the heart against ischemia and reperfusion injury through autophagy and the Notch1/Hes1/Akt signaling pathway. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29532851. |
the inhibition of autophagy following treatment with 3‑methyladenine significantly reversed the effect of si‑mirna‑30e on apoptosis, bax, caspase‑3, inos and oxidative stress in h9c2 cells. |
2018-09-10 |
2023-08-13 |
Not clear |
| Jianjie Zheng, Jing Li, Bo Kou, Qiuyue Yi, Tao Sh. MicroRNA-30e protects the heart against ischemia and reperfusion injury through autophagy and the Notch1/Hes1/Akt signaling pathway. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29532851. |
the promotion of notch1 expression increased the effect of si‑mirna‑30e on apoptosis, bax, caspase‑3, inos, notch1, hes1 and p‑akt protein expression and oxidative stress in h9c2 cells. |
2018-09-10 |
2023-08-13 |
Not clear |
| Baodong Wang, Yankun Luo, Xiaoshuang Zhou, Rongshan L. Trifluoperazine induces apoptosis through the upregulation of Bax/Bcl‑2 and downregulated phosphorylation of AKT in mesangial cells and improves renal function in lupus nephritis mice. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29568865. |
tfp promoted cell apoptosis, downregulated the expression of bcl‑2 and upregulated the expression of bax in a dose‑dependent manner at mrna and protein levels. |
2018-09-10 |
2023-08-13 |
mouse |
| Wen-Tzu Wu, Mei-Chin Mong, Ya-Chen Yang, Zhi-Hong Wang, Mei-Chin Yi. Aqueous and Ethanol Extracts of Daylily Flower (Hemerocallis fulva L.) Protect HUVE Cells Against High Glucose. Journal of food science. vol 83. issue 5. 2018-09-10. PMID:29693723. |
compared with the control groups, high glucose raised the activity of caspase-3 and caspase-8; suppressed bcl-2 mrna expression and increased bax mrna expression; and induced huve cells apoptosis. |
2018-09-10 |
2023-08-13 |
Not clear |
| Sweta Iyer, Khatira Anwari, Amber E Alsop, Wai Shan Yuen, David C S Huang, John Carroll, Nicholas A Smith, Brian J Smith, Grant Dewson, Ruth M Kluc. Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies. Nature communications. vol 7. 2018-09-07. PMID:27217060. |
during apoptosis, bak and bax are activated by bh3-only proteins binding to the α2-α5 hydrophobic groove; bax is also activated via a rear pocket. |
2018-09-07 |
2023-08-13 |
Not clear |
| Quan Yuan, Honghao Yu, Jianhua Chen, Xiaoyu Song, Li Su. Knockdown of pyruvate kinase type M2 suppresses tumor survival and invasion in osteosarcoma cells both in vitro and in vivo. Experimental cell research. vol 362. issue 1. 2018-09-07. PMID:29155364. |
in vitro, shrna-mediated knockdown of pkm2 efficiently inhibited cell proliferation, and induced g1 cell cycle arrest and apoptosis in both cell lines, which was associated with decreased expressions of cyclin d1 and bcl-2 as well as increased expressions of bax, cleaved-caspase-3, and cleaved-parp. |
2018-09-07 |
2023-08-13 |
Not clear |
| Ya-Nan Jia, Hai-Peng Lu, Ya-Lin Peng, Bao-Shun Zhang, Xiao-Bao Gong, Jun Su, You Zhou, Min-Hui Pan, Li X. Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. International immunopharmacology. vol 56. 2018-09-07. PMID:29414639. |
pretreatment with oxy decreased lps/d-galn stimulated hepatocyte apoptosis by efficaciously raising the b-cell lymphoma 2 (bcl-2)/bcl-2 associated x (bax) ratio, inhibiting the expression and activation of caspases, and activating the phosphoinoside-3-kinase (pi3k)-akt pathway. |
2018-09-07 |
2023-08-13 |
mouse |
| Frank Edlic. BCL-2 proteins and apoptosis: Recent insights and unknowns. Biochemical and biophysical research communications. vol 500. issue 1. 2018-09-06. PMID:28676391. |
recent insights into bax/bak shuttling, bcl-2 protein interactions, the role of bh3-only proteins in apoptosis signaling and the active bax complex set the stage for the development of novel strategies in cancer therapy and the analysis of cellular predisposition to apoptosis. |
2018-09-06 |
2023-08-13 |
Not clear |
| A Štochmaľová, A Kádasi, R Alexa, M Bauer, A H Harrath, A V Sirotki. Direct effect of pholyphenol-rich plants, rooibos and ginkgo, on porcine ovarian cell functions. Journal of animal physiology and animal nutrition. vol 102. issue 2. 2018-09-06. PMID:29024053. |
the accumulation of markers of proliferation (pcna and cyclin b1) and apoptosis (bax) and their mrnas was analysed using immunocytochemistry and by reverse transcription-quantitative polymerase chain reaction (rt-qpcr). |
2018-09-06 |
2023-08-13 |
Not clear |
| A Štochmaľová, A Kádasi, R Alexa, M Bauer, A H Harrath, A V Sirotki. Direct effect of pholyphenol-rich plants, rooibos and ginkgo, on porcine ovarian cell functions. Journal of animal physiology and animal nutrition. vol 102. issue 2. 2018-09-06. PMID:29024053. |
it was observed that rooibos or ginkgo addition was able to inhibit proliferation (down-regulates pcna, cyclin b1 and their mrnas), to promote apoptosis (accumulation of bax) and to suppress both l and p4 release by ovarian cells. |
2018-09-06 |
2023-08-13 |
Not clear |
| Chang Liu, Guangyang Xing, Cailiang Wu, Jun Zhu, Min Wei, Dajiang Liu, Yan Ge, Yao Chen, Ting Lei, Yongxiu Yan. Inhibition of Expression of the S100A8 Gene Encoding the S100 Calcium-Binding Protein A8 Promotes Apoptosis by Suppressing the Phosphorylation of Protein Kinase B (Akt) in Endometrial Carcinoma and HEC-1A Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-06. PMID:29595187. |
s100a8 gene knockdown reduced cell proliferation in the hec-1a cells compared with control cells, induced cell apoptosis, inhibited the phosphorylation of protein kinase b (akt), and induced the expression of pro-apoptotic genes, including the cytochrome c gene, cycs, bad, bax, foxo1, foxo3, casp9, and casp3. |
2018-09-06 |
2023-08-13 |
Not clear |
| Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Yuan Zhang, Zhi-Kun Liu, Heng Song, Shu-Chai Zh. BMI-1 suppression increases the radiosensitivity of oesophageal carcinoma via the PI3K/Akt signaling pathway. Oncology reports. vol 39. issue 2. 2018-09-05. PMID:29207170. |
moreover, bmi-1 knockdown increased cell apoptosis, downregulated mcl-1 and p-akt and upregulated bax. |
2018-09-05 |
2023-08-13 |
Not clear |
| Yao Wang, Han Li, Shu-Ping Son. β-Arrestin 1/2 Aggravates Podocyte Apoptosis of Diabetic Nephropathy via Wnt/β-Catenin Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-05. PMID:29572435. |
up-regulated β-arrestin 1/2 promoted podocyte apoptosis and p53 pathway by increasing bax, cleaved caspase-3, and p-p53 levels in high-glucose-induced podocytes. |
2018-09-05 |
2023-08-13 |
Not clear |
| Yueqi Chen, Ce Dou, Jin Yi, Ruohui Tang, Tao Yu, Lan Zhou, Wei Luo, Mengmeng Liang, Xiaolong Yin, Jianmei Li, Fei Kang, Yufeng Zhao, Shiwu Don. Inhibitory effect of vanillin on RANKL-induced osteoclast formation and function through activating mitochondrial-dependent apoptosis signaling pathway. Life sciences. vol 208. 2018-09-04. PMID:30055205. |
furthermore, vanillin could activate the mitochondrial-dependent apoptosis via inducing the expression of cytochrome c, cleaved caspease-3, bax and apaf-1 both on mrna and protein level. |
2018-09-04 |
2023-08-13 |
Not clear |
| Weronika Krzyżanowska, Bartosz Pomierny, Beata Starek-Świechowicz, Żaneta Broniowska, Beata Strach, Bogusława Budziszewsk. The effects of benzophenone-3 on apoptosis and the expression of sex hormone receptors in the frontal cortex and hippocampus of rats. Toxicology letters. vol 296. 2018-09-04. PMID:30099065. |
bp-3 in the frontal cortex induced the mitochondrial apoptosis pathway by increasing the active forms of caspase-3 and caspase-9, inducing the pro-apoptotic proteins bax and bak and increasing the number of cells with apoptotic dna fragmentation. |
2018-09-04 |
2023-08-13 |
rat |
| Bin Li, Cui-Min Ding, Yan-Xiao Li, Jing-Cui Peng, Nan Geng, Wen-Wen Qi. Over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced non-small cell lung cancer cells through PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR. Oncology reports. vol 39. issue 3. 2018-08-30. PMID:29344640. |
over-regulation of microrna-133b inhibited cell proliferation and ldh activity, induced apoptosis and caspase-3 activity, suppressed the protein expression of egfr, pi3k, p-akt, p-jak2 and p-stat3, decreased cyclin d1 and increased bax protein expression in cisplatin‑induced a549 cells. |
2018-08-30 |
2023-08-13 |
Not clear |
| Jianjun Yuan, Xueli Zhang, Rusen Zhu, Zijian Cui, Wei H. Sparstolonin B attenuates spinal cord injury‑induced inflammation in rats by modulating TLR4‑trafficking. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29436632. |
sparstolonin b attenuated the mrna expression of proinflammatory cytokines interleukin (il)‑18, il‑6, il‑1β, and il‑23, decreased the levels of tumor necrosis factor‑α and interferon‑γ, and decreased caspase‑3 activity and apoptosis regulator bax protein expression in sci rats. |
2018-08-30 |
2023-08-13 |
rat |
| Wei Zheng, Teng Liu, Rong Sun, Lei Yang, Ruifang An, Yan Xu. Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29436666. |
it has been demonstrated that daidzein [7‑hydroxy‑3‑(4‑hydroxyphenyl)‑4h‑chromen‑4‑one] may induce apoptosis in a number of cancer types via the mitochondrial apoptotic pathway by altering the b‑cell lymphoma (bcl)‑2/bcl‑2 associated x, apoptosis regulator (bax) ratio, and activating the caspase cascade. |
2018-08-30 |
2023-08-13 |
human |