| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pei Wu, Xin Zheng, Xiao-Qiu Zhou, Wei-Dan Jiang, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Yong-An Zhang, Lin Fen. Deficiency of dietary pyridoxine disturbed the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella). Fish & shellfish immunology. vol 74. 2018-08-10. PMID:29339045. |
the results showed that compared with the optimal pn level, pn deficiency (1) increased the contents of reactive oxygen species (ros), malondialdehyde (mda) and protein carbonyl (pc), decreased the activities and mrna levels of antioxidant enzymes such as copper, zinc superoxide dismutase (cuznsod), catalase (cat), glutathione peroxidase (gpx), glutathione-s-transferase (gst) and glutathione reductase (gr) (p < .05); (2) up-regulated the mrna levels of cysteinyl aspartic acid-protease-3 (caspase-3), caspase-7, caspase-8, caspase-9, bcl-2 associated x protein (bax), apoptotic protease activating factor-1 (apaf-1) and fas ligand (fasl), and down-regulated the mrna levels of inhibitor of apoptosis proteins (iap), b-cell lymphoma protein-2 (bcl-2) and myeloid cell leukaemia-1 (mcl-1) (p < .05); (3) down-regulated the mrna levels of zo-1, occludin [only in middle intestine (mi)], claudin-b, claudin-c, claudin-f, claudin-3c, claudin-7a, claudin-7b and claudin-11, and up-regulated the mrna levels of claudin-12 and claudin-15a (p < .05), which might be partly linked to kelch-like-ech-associated protein 1a (keap1a)/nf-e2-related factor 2 (nrf2), p38 mitogen-activated protein kinase (p38mapk) and myosin light chain kinase (mlck) signalling in the intestines of fish. |
2018-08-10 |
2023-08-13 |
cat |
| Yuyu Xu, Lixing Wu, Aochang Chen, Chaoqi Xu, Qing Fen. Protective Effects of Olive Leaf Extract on Acrolein-Exacerbated Myocardial Infarction via an Endoplasmic Reticulum Stress Pathway. International journal of molecular sciences. vol 19. issue 2. 2018-08-10. PMID:29414845. |
the apoptosis marker, bax, was also higher while the anti-apoptosis indicator, bcl2 expression was lower both at protein and mrna levels in the combination group. |
2018-08-10 |
2023-08-13 |
rat |
| Yuyu Xu, Lixing Wu, Aochang Chen, Chaoqi Xu, Qing Fen. Protective Effects of Olive Leaf Extract on Acrolein-Exacerbated Myocardial Infarction via an Endoplasmic Reticulum Stress Pathway. International journal of molecular sciences. vol 19. issue 2. 2018-08-10. PMID:29414845. |
since hydroxytyrosol (ht) and oleuropein (op) were the main components in ole, we next investigated the effect of ht and op on cardiomyocyte h9c2 cell apoptosis induced by acrolein through er stress and bax pathway. |
2018-08-10 |
2023-08-13 |
rat |
| Hui-Xia Geng, Rui-Ping Li, Ying-Ge Li, Xiao-Qing Wang, Li Zhang, Jin-Bo Deng, Lai Wang, Jie-Xin Den. 14,15-EET Suppresses Neuronal Apoptosis in Ischemia-Reperfusion Through the Mitochondrial Pathway. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28508993. |
14,15-eet could reduce neuronal apoptosis through upregulation of the ratio of bcl-2 (anti-apoptotic protein) to bax (apoptosis protein) and inhibition of bax aggregation onto mitochondria. |
2018-08-07 |
2023-08-13 |
mouse |
| Jing-Wen Zhao, Chao-Yang Zheng, Hong Wei, Da-Wei Wang, Wei Zh. Proapoptic and immunotoxic effects of sulfur-fumigated polysaccharides from Smilax glabra Roxb. in RAW264.7 cells. Chemico-biological interactions. vol 292. 2018-08-07. PMID:30012344. |
ssgrp could also up-regulated the mrna expression of apoptosis factors including bax and caspase-8. |
2018-08-07 |
2023-08-13 |
Not clear |
| Hyun-Ju Yu, Ji-Ae Shin, In-Hyoung Yang, Dong-Hoon Won, Chi Hyun Ahn, Hye-Jeong Kwon, Jeong-Sang Lee, Nam-Pyo Cho, Eun-Cheol Kim, Hye-Jung Yoon, Jae Il Lee, Seong-Doo Hong, Sung-Dae Ch. Apoptosis induced by caffeic acid phenethyl ester in human oral cancer cell lines: Involvement of Puma and Bax activation. Archives of oral biology. vol 84. 2018-08-06. PMID:28965045. |
apoptosis induced by caffeic acid phenethyl ester in human oral cancer cell lines: involvement of puma and bax activation. |
2018-08-06 |
2023-08-13 |
human |
| Yuting Wu, Zhiqiang Qian, Shu Fu, Yun Yue, Yeli Li, Ruimin Sun, Bo Huang, Danli Yan. IcarisideII improves left ventricular remodeling in spontaneously hypertensive rats by inhibiting the ASK1-JNK/p38 signaling pathway. European journal of pharmacology. vol 819. 2018-08-06. PMID:29175071. |
icarisideii down-regulated the activation of the oxidative stress associated proteins ask1, p38 and jnk; inhibited the expression of p53, bax and cleaved-caspase3 in the mitochondrial apoptosis pathway; and up-regulated the expression of bcl-2. |
2018-08-06 |
2023-08-13 |
rat |
| Jiyi Huang, Zhantu Liu, Ping Xu, Zeyu Zhang, Dong Yin, Jichun Liu, Huan He, Ming H. Capsaicin prevents mitochondrial damage, protects cardiomyocytes subjected to anoxia/reoxygenation injury mediated by 14-3-3η/Bcl-2. European journal of pharmacology. vol 819. 2018-08-06. PMID:29175072. |
cap pretreatment significantly attenuated generation of reactive oxygen species, inhibited mptp opening and caspase-3 activation, downregulated bax, upregulated 14-3-3η and bcl-2, and ultimately reduced apoptosis in h9c2 cells that underwent a/r. |
2018-08-06 |
2023-08-13 |
Not clear |
| Mei-Lin Cui, Huan-Yi Yang, Guo-Qing H. Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum. Journal of Zhejiang University. Science. B. vol 18. issue 12. 2018-08-06. PMID:29204990. |
for htl-9 cells, western-blot and reverse-transcriptase polymerase chain reaction (rt-pcr) analysis showed that tsi (100 μg/ml) can up-regulate the expression of bax, caspase-3, caspase-8, and cytochrome c (cyto-c), indicating that tsi could induce cell apoptosis mainly through the mitochondrial pathway. |
2018-08-06 |
2023-08-13 |
human |
| Vinay Kumar Tripathi, Allur Subramaniyan Sivakumar, Anupam Dhasmana, Inho Hwan. Crosstalk Between Co-Cultured 3T3-L1 and C2C12 Cells After the Exposure of Nano-Titanium Dioxide. Journal of nanoscience and nanotechnology. vol 18. issue 6. 2018-08-06. PMID:29442721. |
additionally, real-time pcr data analysis shown an increased in the expression of p53, bax, caspase-9, caspase-3 and decreased the level of bcl-2, by this means specifying that apoptosis induced by tio2 nps occurs via the caspase-dependent pathway. |
2018-08-06 |
2023-08-13 |
Not clear |
| Tianbao Lu, Ming Zong, Shasha Fan, Ying Lu, Shanhan Yu, Lieying Fa. Thioredoxin 1 is associated with the proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes. Clinical rheumatology. vol 37. issue 1. 2018-08-03. PMID:28914370. |
in hypoxia, downregulation of trx1 significantly suppressed fls proliferation, and the expression of pi3kp85, phospho-akt, and bcl-2, while notably increased fls apoptosis and the expression of active caspase3 and bax. |
2018-08-03 |
2023-08-13 |
Not clear |
| Tianbao Lu, Ming Zong, Shasha Fan, Ying Lu, Shanhan Yu, Lieying Fa. Thioredoxin 1 is associated with the proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes. Clinical rheumatology. vol 37. issue 1. 2018-08-03. PMID:28914370. |
in normoxia, trx1 overexpression promoted the fls proliferation and the expression of pi3kp85, phospho-akt, and bcl-2, but inhibited fls apoptosis and the expression of active caspase3 and bax in flss. |
2018-08-03 |
2023-08-13 |
Not clear |
| Shao Chen, Zhicheng Jin, Li Dai, Hongqiang Wu, Jieke Wang, Long Wang, Zongwei Zhou, Lianghui Yang, Weiyang Ga. Aloperine induces apoptosis and inhibits invasion in MG-63 and U2OS human osteosarcoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-03. PMID:29080457. |
data of morphologic changes, dapi assays and flow cytometry showed that alo induced apoptosis of os cells, and the results of western blotting and qrt-pcr indicated that alo upregulated protein and mrna of bax and cleaved caspase-3, while downregulated bcl-2. |
2018-08-03 |
2023-08-13 |
human |
| Shuo Yu, Lian-Sheng Gong, Nian-Feng Li, Yi-Feng Pan, Lun Zhan. Galangin (GG) combined with cisplatin (DDP) to suppress human lung cancer by inhibition of STAT3-regulated NF-κB and Bcl-2/Bax signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-03. PMID:29091869. |
the pro-apoptotic proteins of bax and bid were up-regulated, accompanied with caspases cleavage, leading to apoptosis. |
2018-08-03 |
2023-08-13 |
mouse |
| Florian Simon, Alexander Oberhuber, Nikolaos Floros, Albert Busch, Markus Udo Wagenhäuser, Hubert Schelzig, Mansur Dura. Acute Limb Ischemia-Much More Than Just a Lack of Oxygen. International journal of molecular sciences. vol 19. issue 2. 2018-08-01. PMID:29373539. |
due to the lack of atp, individual cell organelles can no longer sustain their activity, thus initiating the cascade pathways of apoptosis via the release of cytokines such as the bcl2 associated x protein (bax). |
2018-08-01 |
2023-08-13 |
Not clear |
| Bao-Ju Yao, Xiao-Qing He, Yu-Hui Lin, Wen-Jun Da. Cardioprotective effects of anisodamine against myocardial ischemia/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis. Molecular medicine reports. vol 17. issue 1. 2018-07-31. PMID:29115503. |
in addition, anisodamine was revealed to suppress oxidative stress, inflammatory factor production and myocardial cell apoptosis, as demonstrated by the downregulation of caspase‑3 and apoptosis regulator bax protein expression. |
2018-07-31 |
2023-08-13 |
rat |
| Zongrui Zhang, Xinyu Wang, Binbin Li, Yuanjing Hou, Jing Yang, Li Y. Development of a novel morphological paclitaxel-loaded PLGA microspheres for effective cancer therapy: in vitro and in vivo evaluations. Drug delivery. vol 25. issue 1. 2018-07-31. PMID:29299936. |
both in vitro and in vivo antitumor results demonstrated that the sustained-release ptx could induce the microtubules assembly and the over-expression of bax and cyclin b1 proteins, resulting in the microtubule dynamics disruption, g2/m phase arrest, and cell apoptosis accordingly. |
2018-07-31 |
2023-08-13 |
Not clear |
| Hailong Wang, Quan Jiang, Xinghua Fen. Effect of Icariin on apoptosis and expression of Fas, Fas ligand, B cell lymphoma, and Bcl-2-associated X protein in CD4+ T lymphocytesfrom patients with ankylosing spondylitis. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 37. issue 2. 2018-07-31. PMID:29960293. |
to investigate the effects of icariin on apoptosis and the expression of fas, fas ligand(fasl), b cell lymphoma (bcl-2), and bcl-2-associated x protein (bax) in cd4＋ t lymphocytes from patientswith ankylosing spondylitis. |
2018-07-31 |
2023-08-13 |
Not clear |
| Yong Fa Zhang, Pan Ke Su, Lun Ji Wang, Hui Qi Zheng, Xue Fei Bai, Ping Li, Xiang Ping Meng, Jian Ying Yan. T-2 toxin induces apoptosis via the Bax-dependent caspase-3 activation in mouse primary Leydig cells. Toxicology mechanisms and methods. vol 28. issue 1. 2018-07-30. PMID:28697680. |
to explore the toxic effect of t-2 toxin on mouse leydig cells and its underlying molecular mechanisms, we isolated leydig cells from mature mice, set-up leydig cells culture, treated cells with t-2 toxin, evaluated cell proliferation, detected the caspase-3 activity, mitochondrial activity and apoptosis rate, and measured the mrna levels of bcl-2, bax, parp and caspase-3. |
2018-07-30 |
2023-08-13 |
mouse |
| Pedro Faria Zeni, Disley Prates Dos Santos, Rafael Renatino Canevarolo, José Andrés Yunes, Francine Ferreira Padilha, Ricardo Luiz C de Albuquerque Júnior, Silvia Maria Egues, Maria Lucila Hernández-Maced. Photocatalytic and Cytotoxic Effects of Nitrogen-Doped TiO₂ Nanoparticles on Melanoma Cells. Journal of nanoscience and nanotechnology. vol 18. issue 5. 2018-07-30. PMID:29442890. |
gene expression analysis of this sample showed, under ultraviolet photoexcitation, an increase of pro-apoptotic bax gene expression, suggesting cell death by apoptosis. |
2018-07-30 |
2023-08-13 |
Not clear |