| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zongrui Zhang, Xinyu Wang, Binbin Li, Yuanjing Hou, Jing Yang, Li Y. Development of a novel morphological paclitaxel-loaded PLGA microspheres for effective cancer therapy: in vitro and in vivo evaluations. Drug delivery. vol 25. issue 1. 2018-07-31. PMID:29299936. |
both in vitro and in vivo antitumor results demonstrated that the sustained-release ptx could induce the microtubules assembly and the over-expression of bax and cyclin b1 proteins, resulting in the microtubule dynamics disruption, g2/m phase arrest, and cell apoptosis accordingly. |
2018-07-31 |
2023-08-13 |
Not clear |
| Hailong Wang, Quan Jiang, Xinghua Fen. Effect of Icariin on apoptosis and expression of Fas, Fas ligand, B cell lymphoma, and Bcl-2-associated X protein in CD4+ T lymphocytesfrom patients with ankylosing spondylitis. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 37. issue 2. 2018-07-31. PMID:29960293. |
to investigate the effects of icariin on apoptosis and the expression of fas, fas ligand(fasl), b cell lymphoma (bcl-2), and bcl-2-associated x protein (bax) in cd4＋ t lymphocytes from patientswith ankylosing spondylitis. |
2018-07-31 |
2023-08-13 |
Not clear |
| Yong Fa Zhang, Pan Ke Su, Lun Ji Wang, Hui Qi Zheng, Xue Fei Bai, Ping Li, Xiang Ping Meng, Jian Ying Yan. T-2 toxin induces apoptosis via the Bax-dependent caspase-3 activation in mouse primary Leydig cells. Toxicology mechanisms and methods. vol 28. issue 1. 2018-07-30. PMID:28697680. |
to explore the toxic effect of t-2 toxin on mouse leydig cells and its underlying molecular mechanisms, we isolated leydig cells from mature mice, set-up leydig cells culture, treated cells with t-2 toxin, evaluated cell proliferation, detected the caspase-3 activity, mitochondrial activity and apoptosis rate, and measured the mrna levels of bcl-2, bax, parp and caspase-3. |
2018-07-30 |
2023-08-13 |
mouse |
| Pedro Faria Zeni, Disley Prates Dos Santos, Rafael Renatino Canevarolo, José Andrés Yunes, Francine Ferreira Padilha, Ricardo Luiz C de Albuquerque Júnior, Silvia Maria Egues, Maria Lucila Hernández-Maced. Photocatalytic and Cytotoxic Effects of Nitrogen-Doped TiO₂ Nanoparticles on Melanoma Cells. Journal of nanoscience and nanotechnology. vol 18. issue 5. 2018-07-30. PMID:29442890. |
gene expression analysis of this sample showed, under ultraviolet photoexcitation, an increase of pro-apoptotic bax gene expression, suggesting cell death by apoptosis. |
2018-07-30 |
2023-08-13 |
Not clear |
| Thi-Anh Pham, Imran Shair Mohammad, Van-Tuan Vu, Xiao-Long Hu, Chaurasiya Birendra, Aftab Ulah, Cui Guo, Xian-Yu Lü, Wen-Cai Ye, Hao Wan. Phloroglucinol Derivatives from the Fruits of Eucalyptus globulus and Their Cytotoxic Activities. Chemistry & biodiversity. vol 15. issue 6. 2018-07-30. PMID:29692000. |
additionally, after treatment with eucalyptin b (1), the apoptosis factor proteins (bcl2 and bax) and caspase-3 levels in a549 cells were also determined by western-blot analysis. |
2018-07-30 |
2023-08-13 |
Not clear |
| Yong Ling, Qiu-Xing Yang, Yu-Ning Teng, Shi Chen, Wei-Jie Gao, Jing Guo, Pei-Ling Hsu, Yue Liu, Susan L Morris-Natschke, Chin-Chuan Hung, Kuo-Hsiung Le. Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities. European journal of medicinal chemistry. vol 154. 2018-07-30. PMID:29803003. |
notably, compound 7d selectively inhibited cancer cells, but not non-tumor liver cell proliferation in vitro, and significantly triggered helas3 cell apoptosis by regulating apoptotic proteins of bcl-2, bax, and cleaved caspase-3 in a dose-dependent manner. |
2018-07-30 |
2023-08-13 |
Not clear |
| Ye Feng, Xianglei Chen, Yi Zheng, Qiao Liu, Haiwen Chen, Yuanhua Cai, Lixia Cao, Xiaolin Lai, Lili Pan, Yang Li, Shao-Yuan Wan. Prognostic value and susceptibility of BAX rs4645878 polymorphism in cancer: A systematic review and meta-analysis. Medicine. vol 97. issue 29. 2018-07-30. PMID:30024563. |
bcl-2 associated x (bax) is an important modulator of apoptosis. |
2018-07-30 |
2023-08-13 |
Not clear |
| Silvia Sancilio, Marialucia Gallorini, Amelia Cataldi, Laura Sancillo, Rosa Alba Rana, Viviana di Giacom. Modifications in Human Oral Fibroblast Ultrastructure, Collagen Production, and Lysosomal Compartment in Response to Electronic Cigarette Fluids. Journal of periodontology. vol 88. issue 7. 2018-07-27. PMID:28338391. |
in a previous study by the authors, the increase of reactive oxygen production and bax expression, followed by the occurrence of apoptosis, was demonstrated in human gingival fibroblasts (hgfs). |
2018-07-27 |
2023-08-13 |
human |
| Ruirui Lu, Jie Zhou, Bihao Liu, Ning Liang, Yu He, Lixia Bai, Peichun Zhang, Yanchun Zhong, Yuan Zhou, Jiuyao Zho. Paeoniflorin ameliorates Adriamycin-induced nephrotic syndrome through the PPARγ/ANGPTL4 pathway in vivo and vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:28972886. |
in vitro study, pf reduced caspase3 and bax and increased bcl-2, indicating that the apoptosis rate of podocytes induced by adr was reduced by pf. |
2018-07-26 |
2023-08-13 |
rat |
| Zi-Zhou Yao, Ai-Xin Hu, Xiang-Sheng Li. DUSP19 regulates IL-1β-induced apoptosis and MMPs expression in rat chondrocytes through JAK2/STAT3 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:29174854. |
ag490 inhibited jak2/stat3 activation as well as apoptosis in chondrocytes induced by il-1β or dusp19 down-regulation, evidenced by decreased expression of bax, caspase-3 and increased bcl-2 expression as well as mmp-3, -9 and -13 expressions. |
2018-07-26 |
2023-08-13 |
rat |
| Yating Zhang, Guoliang Li, Yizhou Zhong, Manqi Huang, Jiejiao Wu, Jiewei Zheng, Weifeng Rong, Lihai Zeng, Xiao Yin, Fengrong Lu, Zhiwei Xie, Dandan Xu, Qiming Fan, Xiaohui Jia, Ting Wang, Qiansheng Hu, Wen Chen, Qing Wang, Zhenlie Huan. 1,2-Dichloroethane Induces Reproductive Toxicity Mediated by the CREM/CREB Signaling Pathway in Male NIH Swiss Mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 160. issue 2. 2018-07-25. PMID:28973639. |
moreover, the activation of p53 and bax with the inhibition of bcl-2 might be the reason for the upregulation of caspase-3 in the apoptosis, as detected by tdt-mediated dutp nick-end labeling assay in the testes induced by 1,2-dce. |
2018-07-25 |
2023-08-13 |
mouse |
| Mei Xue, Xu Chen, Zhija Guo, Xiaoqian Liu, Yanping Bi, Jie Yin, Haiyan Hu, Ping Zhu, Jian Zhuang, Courtney Cates, Thomas Rousselle, Ji L. L-Carnitine Attenuates Cardiac Dysfunction by Ischemic Insults Through Akt Signaling Pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 160. issue 2. 2018-07-25. PMID:28973678. |
the immunoblotting results showed that lc administration restrained myocardial apoptosis as evidenced by decreasing the level of bax expression, increasing the levels of phosphorylation of akt, pi3k, and bcl-2 protein expression, but these were blocked by lyc94002. |
2018-07-25 |
2023-08-13 |
mouse |
| Shanshan Cui, Wen Li, Pengyan Wang, Xin Lv, Yuxia Gao, Guowei Huan. Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells. Molecular and cellular biochemistry. vol 444. issue 1-2. 2018-07-25. PMID:29250709. |
to further investigate how folic acid influenced cell apoptosis, we also analyzed the activities of caspase-3/7 and the mrna and protein expressions of bcl2, bax, tp53, casp3, and casp8 in human umbilical vein endothelial cells. |
2018-07-25 |
2023-08-13 |
human |
| Richard W Birkinshaw, Peter E Czabota. The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation. Seminars in cell & developmental biology. vol 72. 2018-07-24. PMID:28396106. |
we focus on the structural details of these interactions, how they promote or prevent apoptosis and recent developments towards understanding the conformational changes of bak and bax that lead to mom permeabilisation. |
2018-07-24 |
2023-08-13 |
Not clear |
| Mohamed A Lebda, Kadry M Sadek, Yasser S El-Saye. Aspartame and Soft Drink-Mediated Neurotoxicity in Rats: Implication of Oxidative Stress, Apoptotic Signaling Pathways, Electrolytes and Hormonal Levels. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28660358. |
brain mrna transcripts of target genes showed that aspartame and soft drink induced upregulation of bax, casp3, p27 and mdm2 (1.5-fold) and down-regulation of bcl2, suggesting an activation of cellular apoptosis. |
2018-07-23 |
2023-08-13 |
rat |
| Mingze Chang, Lin Qiao, Bin Li, Juanhong Wang, Gejuan Zhang, Wenzhen Shi, Zhiqin Liu, Naibing Gu, Zhengli Di, Xinlai Wang, Ye Tia. Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance. Oncology reports. vol 38. issue 2. 2018-07-23. PMID:28677777. |
in addition, sirt6 restoration led to apoptosis with alterative expression of bax, bcl-2, cleaved caspase-8, and inhibition of janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway in glioma. |
2018-07-23 |
2023-08-13 |
human |
| Meiling Xu, Qiuhong Fan, Junjun Zhang, Yanfang Chen, Ruizhe Xu, Liesong Chen, Peifeng Zhao, Ye Tia. NFAT3/c4-mediated excitotoxicity in hippocampal apoptosis during radiation-induced brain injury. Journal of radiation research. vol 58. issue 6. 2018-07-23. PMID:28992110. |
once treated with the nfat3/c4 inhibitor 11r-vivit peptide pre-irradiation, hippocampal proliferation and neuron survival (dentate gyrus cells in particular) were protected from radiation-induced injury, resulting in inhibition of the apoptosis marker bax. |
2018-07-23 |
2023-08-13 |
rat |
| Kang Li, Kun Na, Tingting Sang, Kaikai Wu, Ying Wang, Xingya Wan. The ethanol extracts of sporoderm-broken spores of Ganoderma lucidum inhibit colorectal cancer in vitro and in vivo. Oncology reports. vol 38. issue 5. 2018-07-23. PMID:29048673. |
flow cytometric analysis demonstrated that bsglee induces apoptosis and cell cycle arrest at g0/g1 phase, which are associated with deregulation of the expression of key genes and proteins (p21, p16, cyclin d1, bcl-2, bax, nag-1, parp and caspase-3) that regulate apoptosis and cell cycle cascades. |
2018-07-23 |
2023-08-13 |
mouse |
| E Matías Belotti, Antonela F Stassi, Melisa M L Velázquez, Pablo U Díaz, Belkis E Marelli, Florencia Rey, Ulises S Notaro, Hugo H Ortega, Natalia R Salvett. Changes in the Proliferation/Apoptosis Balance in the Bovine Ovary: A Key Early Event in Follicular Persistence. Cells, tissues, organs. vol 204. issue 5-6. 2018-07-23. PMID:29130964. |
we analyzed cell proliferation by evaluating the expression of ki-67 and apoptosis by evaluating caspase-3, bax, and bcl2 expression. |
2018-07-23 |
2023-08-13 |
cattle |
| Jike Song, Dadong Guo, Hongsheng B. Chlorogenic acid attenuates hydrogen peroxide‑induced oxidative stress in lens epithelial cells. International journal of molecular medicine. vol 41. issue 2. 2018-07-23. PMID:29207051. |
using mtt assay, reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) and elisa techniques, cell viability, and protein/mrna levels of bcl2 apoptosis regulator (bcl‑2) and bcl2 associated x apoptosis regulator (bax) were investigated. |
2018-07-23 |
2023-08-13 |
human |