| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Srinivasulu Cheemanapalli, Anuradha C M, Suresh Babu Pakala, Suresh Kumar Chitt. Design and screening of syringic acid analogues as BAX activators-An in silico approach to discover "BH3 mimetics". Computational biology and chemistry. vol 74. 2018-07-09. PMID:29529398. |
although bax, which is a molecular hit squad that incentive apoptosis was found to be an attractive emerging target for anticancer agents. |
2018-07-09 |
2023-08-13 |
Not clear |
| Srinivasulu Cheemanapalli, Anuradha C M, Suresh Babu Pakala, Suresh Kumar Chitt. Design and screening of syringic acid analogues as BAX activators-An in silico approach to discover "BH3 mimetics". Computational biology and chemistry. vol 74. 2018-07-09. PMID:29529398. |
the present focus of the study is to identification and development of novel molecules which are precisely activates bax mediated apoptosis. |
2018-07-09 |
2023-08-13 |
Not clear |
| Jie Deng, Yi-Fei Zhong, Yan-Ping Wu, Zhuo Luo, Yuan-Ming Sun, Guo-En Wang, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong H. Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducing oxidative DNA damage. Redox biology. vol 14. 2018-07-06. PMID:28826042. |
in addition, cell apoptosis caused by ctx was also suppressed by carnosine treatment, as assessed by decreased tunel-positive cell counts, down-regulated expressions of bax and cyt c, and reduced ratios of cleaved caspase-3/caspase-3. |
2018-07-06 |
2023-08-13 |
mouse |
| H Xi, X Fan, Z Zhang, Y Liang, Q Li, J H. Bax and Bcl-2 are involved in the apoptosis induced by local testicular heating in the boar testis. Reproduction in domestic animals = Zuchthygiene. vol 52. issue 3. 2018-07-05. PMID:28229498. |
bax and bcl-2 are involved in the apoptosis induced by local testicular heating in the boar testis. |
2018-07-05 |
2023-08-13 |
Not clear |
| H Xi, X Fan, Z Zhang, Y Liang, Q Li, J H. Bax and Bcl-2 are involved in the apoptosis induced by local testicular heating in the boar testis. Reproduction in domestic animals = Zuchthygiene. vol 52. issue 3. 2018-07-05. PMID:28229498. |
the aim of this study was to determine whether the effect of bax and bcl-2 on the apoptosis of germ cells is caused by local testicular heating (42°c, 1 hr) in boar testis. |
2018-07-05 |
2023-08-13 |
Not clear |
| H Xi, X Fan, Z Zhang, Y Liang, Q Li, J H. Bax and Bcl-2 are involved in the apoptosis induced by local testicular heating in the boar testis. Reproduction in domestic animals = Zuchthygiene. vol 52. issue 3. 2018-07-05. PMID:28229498. |
these results suggested that local testicular heating induced the apoptosis of germ cells by regulating the bax and bcl-2 protein levels. |
2018-07-05 |
2023-08-13 |
Not clear |
| Jingjing Zhang, Lu Liu, Sai Han, Yi Li, Qiuhong Qian, Qianqian Zhang, Hui Zhang, Ziyan Yang, Youzhong Zhan. B7-H3 is related to tumor progression in ovarian cancer. Oncology reports. vol 38. issue 4. 2018-07-05. PMID:28765941. |
the ability of cell invasion, migration, proliferation decreased after silencing b7-h3 whereas the apoptosis increased, which was related to the upregulation of bax, caspase-8, cleaved caspase-8 and the downregulation of bcl-2, bcl-xl, matrix metalloproteinase-2 (mmp2) by western blotting. |
2018-07-05 |
2023-08-13 |
Not clear |
| Jing Zhang, Ling Zhou, Zhaodi Nan, Qing Yuan, Jie Wen, Maolei Xu, Youjie Li, Baosheng Li, Pingyu Wang, Changmin Liu, Ying Ma, Shaoshui Chen, Shuyang Xi. Knockdown of c‑Myc activates Fas-mediated apoptosis and sensitizes A549 cells to radiation. Oncology reports. vol 38. issue 4. 2018-07-05. PMID:28849062. |
suppression of c‑myc expression by small interfering rna (sirna) displayed enhancement of fas-mediated apoptosis in a549/r cells, accompanying a significant decrease of bid, bcl‑2, pro‑caspase‑8, -9 and -3 and increase of bax. |
2018-07-05 |
2023-08-13 |
Not clear |
| Rui-Hua Li, Jin Li, Shi-Lian Kan, Xi-Nan Zhan. The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits. BioMed research international. vol 2017. 2018-07-05. PMID:28856161. |
six hours' reperfusion was performed in group a; reperfusion + postfasciotomy was performed in group b; and prefasciotomy + reperfusion was performed in group c. result showed that prefasciotomy and postfasciotomy could protect skeletal muscle against ischemia reperfusion injury, reduced mda (malondialdehyde) expression, mpo (myeloperoxidase) expression, and apoptosis of muscle in the reperfused areas, increased bcl-2 expression, and decreased bax expression. |
2018-07-05 |
2023-08-13 |
rabbit |
| Chen-Xin Lu, Jing-Hui Sun, Chun-Lian W. [Apoptosis mechanism of taxol combined with resveratrol on human laryngeal carcinoma Hep-2 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 3. 2018-07-05. PMID:28868867. |
after human laryngeal cancer cell hep-2 cells were processed with resveratrol (res) and taxol (tax), cck-8 assay was used to evaluate the effect of these two herbs on the proliferation of cancer cells; ao/pi staining and jc-1 were used to detect hep-1 cells apoptosis; the expression of bax, bcl-2, parp, trib3, and xiap genes was detected by real time quantitative pcr; the activity of caspase-3 and caspase-8 was determined with quantitative fluorescence method. |
2018-07-05 |
2023-08-13 |
human |
| Qi Li, Xi Chen, Xiao-Xi Kan, Yu-Jie Li, Qing Yang, Ya-Jie Wang, Ying Chen, Xiao-Gang Weng, Wei-Yan Cai, He-Fei Huang, Xiao-Xin Zh. [Protective effect and mechanism of compound Ginkgo biloba granules on oxidative stress injury of HUVEC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 4. 2018-07-05. PMID:28871700. |
besides, 80, 160, 320 640 mg•l⁻¹ compound ginkgo biloba granules can protect huvec from oxidative stress injury, recover the normal proliferation level of cells, improve their state, prohibit cell apoptosis, and can up-regulate and down-regulate the expression level of bcl-2 and bax respectively. |
2018-07-05 |
2023-08-13 |
human |
| Han Wang, Liping Zhu, Xiaodong Feng, Han Zhang, Qingqiong Luo, Fuxiang Che. Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma. European journal of pharmacology. vol 815. 2018-07-05. PMID:28935563. |
in addition, we discovered that oridonin induced oscc cell apoptosis by activating the intrinsic apoptotic pathway, which was indicated by the increased expression of cleaved-caspase 3, cleaved-caspase 9 and proapoptotic protein bax and reduced expression of caspase 9 and antiapoptotic protein bcl-xl. |
2018-07-05 |
2023-08-13 |
mouse |
| Changling Ding, Jie Zhang, Baoyuan Li, Zhaoxing Ding, Wenna Cheng, Fei Gao, Ye Zhang, Yangyang Xu, Shuping Zhan. Cornin protects SH‑SY5Y cells against oxygen and glucose deprivation‑induced autophagy through the PI3K/Akt/mTOR pathway. Molecular medicine reports. vol 17. issue 1. 2018-07-05. PMID:29115424. |
the results demonstrated that cornin was able to reduce neuronal cell loss, increase the apoptosis regulator bcl‑2/apoptosis regulator bax ratio, and decrease the protein levels of caspase‑3. |
2018-07-05 |
2023-08-13 |
Not clear |
| Subhadip Hajra, Arup Ranjan Patra, Abhishek Basu, Prosenjit Saha, Sudin Bhattachary. Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway. Chemico-biological interactions. vol 290. 2018-07-05. PMID:29775573. |
in addition, i3c sensitized tumor cells to dox-therapy by down-regulating the expression of anti-apoptotic protein bcl-2 and by up-regulating molecules like bax, cytochrome c, caspases, which led to parp cleavage and apoptosis. |
2018-07-05 |
2023-08-13 |
mouse |
| Jia Lin, Hua-Shan Zhao, Lei Qin, Xue-Nan Li, Cong Zhang, Jun Xia, Jin-Long L. Atrazine Triggers Mitochondrial Dysfunction and Oxidative Stress in Quail ( Coturnix C. coturnix) Cerebrum via Activating Xenobiotic-Sensing Nuclear Receptors and Modulating Cytochrome P450 Systems. Journal of agricultural and food chemistry. vol 66. issue 25. 2018-07-05. PMID:29865786. |
atr may initiate apoptosis by activating bcl-2, bax, and caspase3 protein expression but failed to induce autophagy (lc3b has not cleaved to lc3bi/ii). |
2018-07-05 |
2023-08-13 |
Not clear |
| Wantha Jenkhetkan, Sumon Thitiorul, Chalerm Jansom, Treetip Ratanavalacha. Molecular and cytogenetic effects of Thai royal jelly: modulation through c-MYC, h-TERT, NRF2, HO-1, BCL2, BAX and cyclins in human lymphocytes in vitro. Mutagenesis. vol 32. issue 5. 2018-07-03. PMID:28992336. |
rj treatment at 0.05 mg/ml increased cyclin e, bcl2 and bax to maximum levels indicating that throughout the active cell cycle, both cell survival and cell apoptosis increased. |
2018-07-03 |
2023-08-13 |
human |
| Sin Hee Park, Moon Ho Do, Jae Hyuk Lee, Minsun Jeong, Oh Kyung Lim, Sun Yeou Ki. Inhibitory Effect of Arachis hypogaea (Peanut) and Its Phenolics against Methylglyoxal-Derived Advanced Glycation End Product Toxicity. Nutrients. vol 9. issue 11. 2018-06-29. PMID:29113063. |
peanut extracts prevented mgo-induced apoptosis by increasing bcl-2 expression and decreasing bax expression, and mgo-mediated activation of mitogen-activated protein kinases (mapks). |
2018-06-29 |
2023-08-13 |
human |
| Qi-Bing Xu, Xiang-Fan Chen, Jiao Feng, Jie-Fei Miao, Ji Liu, Feng-Tao Liu, Bi-Xi Niu, Jin-Yang Cai, Chao Huang, Yanan Zhang, Yong Lin. Design, synthesis and biological evaluation of hybrids of β-carboline and salicylic acid as potential anticancer and apoptosis inducing agents. Scientific reports. vol 6. 2018-06-28. PMID:27824091. |
8h also induced cancer cell apoptosis in an annexin v-fitc/propidium iodide flow cytometry assay, and triggered the mitochondrial/caspase apoptosis by decreasing mitochondrial membrane potential which was associated with up-regulation of bax, down-regulation of bcl-2 and activation levels of the caspase cascade in a concentration-dependent manner. |
2018-06-28 |
2023-08-13 |
human |
| Kyu Im Ahn, Eun Ok Choi, Da He Kwon, Hyun HwangBo, Min Yeong Kim, Hong Jae Kim, Seon Yeong Ji, Su-Hyun Hong, Jin-Woo Jeong, Cheol Park, Nam Deuk Kim, Wun Jae Kim, Yung Hyun Cho. Induction of apoptosis by ethanol extract of Citrus unshiu Markovich peel in human bladder cancer T24 cells through ROS-mediated inactivation of the PI3K/Akt pathway. Bioscience trends. vol 11. issue 5. 2018-06-28. PMID:29070760. |
eecu-induced apoptosis was found to correlate with an activation of caspase-8, -9, and -3 in concomitance with a decrease in the expression of the inhibitor of apoptosis family of proteins and an increase in the bax:bcl-2 ratio accompanied by the proteolytic degradation of poly(adp-ribose) polymerase. |
2018-06-28 |
2023-08-13 |
human |
| B O Yilmaz, N Yildizbayrak, Y Aydin, M Erka. Evidence of acrylamide- and glycidamide-induced oxidative stress and apoptosis in Leydig and Sertoli cells. Human & experimental toxicology. vol 36. issue 12. 2018-06-27. PMID:28067054. |
the present experiment was conducted to investigate the effect of oxidative stress on the apoptosis of mouse leydig (tm3) and sertoli (tm4) cells induced by aa and its metabolite ga. tm3 and tm4 cells were exposed to aa (10 µm and 1 mm) and ga (1 µm and 0.5 mm) for 24 h. following the exposure time, the leydig and sertoli cells were evaluated for measurement of cell viability, lactate dehydrogenase activity, lipid peroxidation and hydrogen peroxide levels, apoptosis/necrosis rate, and mrna expression levels of apoptotic genes (caspase3, bcl-2, bax, and p53). |
2018-06-27 |
2023-08-13 |
mouse |