| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaojun Cui, Zhangyou He, Zihao Liang, Zhenyi Chen, Haifeng Wang, Jiankai Zhan. Exosomes From Adipose-derived Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Wnt/β-Catenin Signaling Pathway. Journal of cardiovascular pharmacology. vol 70. issue 4. 2018-06-04. PMID:28582278. |
simultaneously, admscs-ex dramatically antagonized i/r-induced myocardial apoptosis, along with the upregulation of bcl-2 and downregulation of bax, and inhibition of caspase 3 activity in rat myocardium. |
2018-06-04 |
2023-08-13 |
rat |
| Xiaojun Cui, Zhangyou He, Zihao Liang, Zhenyi Chen, Haifeng Wang, Jiankai Zhan. Exosomes From Adipose-derived Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Wnt/β-Catenin Signaling Pathway. Journal of cardiovascular pharmacology. vol 70. issue 4. 2018-06-04. PMID:28582278. |
similarly, admscs-ex significantly reduced cell apoptosis and the expression of bax, but markedly increased cell viability and the expression of bcl-2 and cyclin d1 under h/r. |
2018-06-04 |
2023-08-13 |
rat |
| Min Jia, Zai-Bo Li, Lin Li, Hong-Tao Chu, Zhuang-Zhuang L. Role of matrix metalloproteinase‑7 and apoptosis‑associated gene expression levels in the pathogenesis of atrial fibrosis in a Beagle dog model. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901395. |
the aim of the present study was to investigate the potential role of matrix metalloproteinase‑7 (mmp‑7) and apoptosis‑associated genes [timp metallopeptidase inhibitor 2(timp‑2), bcl2 associated x, apoptosis regulator (bax) and bcl2, apoptosis regulator (bcl‑2)] in the pathogenesis of atrial fibrillation (af) in a beagle dog model. |
2018-06-04 |
2023-08-13 |
dog |
| Kun Wang, Wei-Jie Bei, Yuan-Hui Liu, Hua-Long Li, Shi-Qun Chen, Kai-Yang Lin, Zhi-Ling Zhou, Ji-Yan Chen, Yong Liu, Ning Ta. miR‑21 attenuates contrast‑induced renal cell apoptosis by targeting PDCD4. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901491. |
the expression level of the apoptosis regulator protein, b‑cell lymphoma 2 (bcl‑2) was upregulated, whereas that of the apoptosis regulator, bcl‑2‑associated x protein (bax) was downregulated upon transfection of mir‑21 mimics; mir‑21 overexpression additionally directly inhibited the expression of programmed cell death protein 4 (pdcd4), as determined by a dual luciferase reporter assay, and pdcd4 silencing reduced the rate of hk‑2 cell apoptosis. |
2018-06-04 |
2023-08-13 |
human |
| Yuyong Liu, Ke Liu, Nian Wang, Huali Zhan. N‑acetylcysteine induces apoptosis via the mitochondria‑dependent pathway but not via endoplasmic reticulum stress in H9c2 cells. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901511. |
the dissipation of mitochondrial transmembrane potential, release of cytochrome c, translocation of b cell lymphoma‑2 (bcl‑2)‑associated x protein (bax) to the mitochondria, and the increased ratio of bax/bcl‑2 mrna indicated that nac treatment‑induced apoptosis occurred mainly through the mitochondria‑dependent pathway. |
2018-06-04 |
2023-08-13 |
Not clear |
| Yuxin Chen, Ling Zhu, Xi Yang, Cheng Wei, Chuanrong Chen, Yang He, Zhaoning J. Ailanthone induces G2/M cell cycle arrest and apoptosis of SGC‑7901 human gastric cancer cells. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901518. |
cell cycle progression and apoptosis were measured by flow cytometry, and the protein and mrna expression levels of bcl‑2 and bax were analyzed by western blot analysis and reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) respectively, in sgc‑7901 cells. |
2018-06-04 |
2023-08-13 |
human |
| Yuxin Chen, Ling Zhu, Xi Yang, Cheng Wei, Chuanrong Chen, Yang He, Zhaoning J. Ailanthone induces G2/M cell cycle arrest and apoptosis of SGC‑7901 human gastric cancer cells. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901518. |
in conclusion, ailanthone may inhibit the proliferation of sgc‑7901 cells by inducing g2/m phase cell cycle arrest and apoptosis via altering the protein and mrna expression levels of bcl‑2 and bax in sgc‑7901 cells. |
2018-06-04 |
2023-08-13 |
human |
| Tian Feng, Libin Wang, Nan Zhou, Chang Liu, Jiahui Cui, Rangxin Wu, Juan Jing, Shengyong Zhang, Hui Chen, Siwang Wan. Salidroside, a scavenger of ROS, enhances the radioprotective effect of Ex-RAD® via a p53-dependent apoptotic pathway. Oncology reports. vol 38. issue 5. 2018-06-04. PMID:28901519. |
sal downregulated the expression of bax and p53 and increased the ratio of bcl-2/bax, which indicated that sal inhibited the radiation-induced apoptosis through p53-dependent pathways. |
2018-06-04 |
2023-08-13 |
mouse |
| Juan Wang, Huiling Li, Shuangfa Qiu, Zheng Dong, Xudong Xiang, Dongshan Zhan. MBD2 upregulates miR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI. Cell death & disease. vol 8. issue 10. 2018-06-04. PMID:29022913. |
here, in cultured human kidney tubular epithelial cells (hk-2), we show that knockdown of mbd2 by sirna attenuated van-induced apoptosis, caspase activity, and the expression of bax and cleaved caspase 3. |
2018-06-04 |
2023-08-13 |
mouse |
| Shibao Li, Zhiyuan Wu, Ping Ma, Yinhai Xu, Yuming Chen, Hua Wang, Ping He, Zhihua Kang, Lingyu Yin, Yao Zhao, Xinju Zhang, Xiao Xu, Xiaochao Ma, Ming Gua. Ligand-dependent EphA7 signaling inhibits prostate tumor growth and progression. Cell death & disease. vol 8. issue 10. 2018-06-04. PMID:29022918. |
this protein can also induce pca cell apoptosis that correlated with increasing the protein expression levels of bax, elevating the caspase-3 activities, reducing the protein expression levels of bcl-2 and facilitating the dephosphorylation of akt, which is further increased by the stimulation of ephrina5-fc. |
2018-06-04 |
2023-08-13 |
human |
| M M R Chowdhury, Byung-Hyun Choi, Imran Khan, Kyeong-Lim Lee, Ayman Mesalam, Seok-Hwan Song, Lianguang Xu, Myeong-Don Joo, Fahmida Afrin, Il-Keun Kon. Supplementation of lycopene in maturation media improves bovine embryo quality in vitro. Theriogenology. vol 103. 2018-05-31. PMID:28800556. |
the percentages of mii-stage oocytes, the presumptive zygotes that underwent cleavage and developed into blastocysts were significantly (p < 0.05) higher, the intracellular ros concentrations reduced significantly (p < 0.05) in oocytes/blastocysts, tunel assay demonstrates reduced apoptosis and increased total cell number per blastocyst (p < 0.05), immunocytochemistry confirmed that diminished protein expression of nuclear factor kappa b (nfκb), cyclooxygenase-2 (cox2), and 8-oxoguanine (indicated by ros) and relative mrna expression of the caspase-3, nfκb, cox2, inos and bcl2-associated x (bax) was significantly (p < 0.05) lower whereas the anti-apoptotic gene bcl2 was significantly (p < 0.05) higher in the 0.2 μm lycopene-supplemented group than the control. |
2018-05-31 |
2023-08-13 |
cattle |
| Sohair M Salem, Ahmed R Hamed, Rehab M Mosaa. MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-31. PMID:28802228. |
herein, we aimed to explore whether mir-375, mir-145, and mir-224 are involved in induction of apoptosis of crc cells by regulating apoptosis-mediating genes mtdh, map3k1, pdk1, bax, and bcl-xl. |
2018-05-31 |
2023-08-13 |
Not clear |
| Sohair M Salem, Ahmed R Hamed, Rehab M Mosaa. MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-31. PMID:28802228. |
the study concluded that the expression modulation of tumor suppressors mir-375 and mir-145, and oncomir mir-224 have the ability to induce apoptosis of crc cells through regulation of apoptosis mediating genes mtdh, map3k1, pdk1, bcl-xl and bax. |
2018-05-31 |
2023-08-13 |
Not clear |
| Annapina Russo, Assunta Saide, Roberta Cagliani, Monica Cantile, Gerardo Botti, Giulia Russ. rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment. Scientific reports. vol 6. 2018-05-30. PMID:27924828. |
furthermore, we demonstrate that rpl3 significantly enhances the apoptosis of 5-fu treated calu-6 cells promoting the overexpression of the pro-apoptotic proteins bax and the inhibition of the anti-apoptotic protein bcl-2. |
2018-05-30 |
2023-08-13 |
human |
| Jinhee Kim, Sanjukta Chakraborty, G K Jayaprakasha, Mariappan Muthuchamy, Bhimanagouda S Pati. Citrus nomilin down-regulates TNF-α-induced proliferation of aortic smooth muscle cells via apoptosis and inhibition of IκB. European journal of pharmacology. vol 811. 2018-05-30. PMID:28551013. |
additionally, results showed a decreased ratio of anti-apoptotic bcl-2 protein to pro-apoptotic bax (bcl2/bax), indicating mitochondrial dysfunction consistent with apoptosis. |
2018-05-30 |
2023-08-13 |
human |
| Min Cong, Weihua Zhao, Tianhui Liu, Ping Wang, Xu Fan, Qingling Zhai, Xiaoli Bao, Dong Zhang, Hong You, Tatiana Kisseleva, David A Brenner, Jidong Jia, Hui Zhuan. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. International journal of molecular medicine. vol 40. issue 2. 2018-05-30. PMID:28627620. |
the number of hepatocytes in early apoptosis stained with annexin v was significantly reduced by 28-30% in the hsap treatment group compared with the ccl4 group, and the expression of bcl-2 was increased, whereas the expression of bax and cleaved caspase-3 were significantly inhibited in the hsap pre-treatment group compared with the ccl4 group. |
2018-05-30 |
2023-08-13 |
mouse |
| Qiao-Li Lv, Hong Du, Yan-Ling Liu, Yuang-Tao Huang, Gui-Hua Wang, Xue Zhang, Shu-Hui Chen, Hong-Hao Zho. Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma. Oncology reports. vol 38. issue 2. 2018-05-30. PMID:28656255. |
additionally, upregulation of mir‑320b could markedly promote apoptosis by increasing the level of bax and reducing bcl-2 expression in glioma. |
2018-05-30 |
2023-08-13 |
human |
| Juanjuan Yi, Cuilin Cheng, Xiaoyu Li, Haitian Zhao, Hang Qu, Zhenyu Wang, Lu Wan. Protective mechanisms of purified polyphenols from pinecones of Pinus koraiensis on spleen tissues in tumor-bearing S180 mice in vivo. Food & function. vol 8. issue 1. 2018-05-29. PMID:27924972. |
the results indicated that the protective multi-mechanisms of action also were associated with the inhibition of apoptosis through down-regulation protein expressions of bax, caspase-9, caspase-8 caspase-3, fas and up-regulation of the expressions of bcl-2. |
2018-05-29 |
2023-08-13 |
mouse |
| Ping Chen, Shina Xu, Jinlong Q. Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway. Journal of cellular biochemistry. vol 119. issue 1. 2018-05-29. PMID:28585698. |
transfection with foxo3a sirna inhibited the lycopene-induced increase in cell apoptosis, bax and cleaved parp expression. |
2018-05-29 |
2023-08-13 |
mouse |
| Junqin Liang, Xuewen Zeng, Yilinuer Halifu, Wenjing Chen, Fengxia Hu, Peng Wang, Huan Zhang, Xiaojing Kan. Blocking RhoA/ROCK inhibits the pathogenesis of pemphigus vulgaris by suppressing oxidative stress and apoptosis through TAK1/NOD2-mediated NF-κB pathway. Molecular and cellular biochemistry. vol 436. issue 1-2. 2018-05-29. PMID:28608226. |
additionally, inhibition of rhoa/rock signaling reduced uvb-induced apoptosis, as exemplified by a reduction in dna fragmentation, and also elevated anti-apoptotic bcl-2 protein, concomitant with reduced levels of pro-apoptotic protein bax, caspase-3 cleavage and decreased parp-1 protein. |
2018-05-29 |
2023-08-13 |
human |