| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jung Min Kim, In-Hu Hwang, Ik-Soon Jang, Min Kim, In Seok Bang, Soo Jung Park, Yun-Jo Chung, Jong-Cheon Joo, Min-Goo Le. Houttuynia cordata Thunb Promotes Activation of HIF-1A-FOXO3 and MEF2A Pathways to Induce Apoptosis in Human HepG2 Hepatocellular Carcinoma Cells. Integrative cancer therapies. vol 16. issue 3. 2018-05-03. PMID:27698266. |
taken together, our results demonstrate that h cordata enhances hif-1a/foxo3 signaling, leading to mef2a upregulation in hepg2 cells, and in parallel, it disturbs the expression of bcl-2 family proteins (bax, bcl-2, and bcl-xl), which results in apoptosis. |
2018-05-03 |
2023-08-13 |
mouse |
| Xuebin Wan, Dan Wang, Qi Xiong, Hong Xiang, Huanan Li, Hongshuai Wang, Zezhang Liu, Hongdan Niu, Jian Peng, Siwen Jiang, Jin Cha. Elucidating a molecular mechanism that the deterioration of porcine meat quality responds to increased cortisol based on transcriptome sequencing. Scientific reports. vol 6. 2018-05-03. PMID:27833113. |
our results showed that when serum cortisol level was significantly increased, the meat color at 1 h postmortem, muscle bundle ratio, apoptosis rate, and gene expression levels of calcium channel and cell apoptosis including serca1, ip3r1, bax, bcl-2, and caspase-3, were notably increased. |
2018-05-03 |
2023-08-13 |
Not clear |
| Hui Liu, Huihan Wang, Bin Wu, Kun Yao, Aijun Liao, Miao Miao, Yang Li, Wei Yan. Down-regulation of long non-coding RNA MALAT1 by RNA interference inhibits proliferation and induces apoptosis in multiple myeloma. Clinical and experimental pharmacology & physiology. vol 44. issue 10. 2018-05-03. PMID:28664617. |
moreover, knockdown of malat1 induced apoptosis, which was closely associated with the activation of caspase-3/-9, down-regulation of bcl-2 and up-regulation of bax. |
2018-05-03 |
2023-08-13 |
mouse |
| Chien Tai Hong, Kai-Yin Chau, Anthony H V Schapir. The Cytomegalovirus protein pUL37×1 targets mitochondria to mediate neuroprotection. Scientific reports. vol 6. 2018-05-01. PMID:27562039. |
human cytomegalovirus immediate-early protein pul37 × 1 induces bax mitochondrial translocation and inactivation to prevent apoptosis. |
2018-05-01 |
2023-08-13 |
human |
| Frank Reichenbach, Cornelius Wiedenmann, Enrico Schalk, Diana Becker, Kathrin Funk, Peter Scholz-Kreisel, Franziska Todt, Denise Wolleschak, Konstanze Döhner, Jens U Marquardt, Florian Heidel, Frank Edlic. Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 23. issue 16. 2018-04-30. PMID:28420723. |
mitochondrial bax determines the predisposition to apoptosis in human aml. |
2018-04-30 |
2023-08-13 |
human |
| Elham Bakhtiari, Azar Hosseini, Seyed Hadi Mousav. The role of ROS and NF-κB pathway in olmesartan induced-toxicity in HeLa and mcf-7 cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-30. PMID:28666209. |
apoptosis results showed that olmesartan and bay 11-7082 increased expression of apoptotic proteins such as bax, caspase3 and iκb. |
2018-04-30 |
2023-08-13 |
Not clear |
| Dong Li, Jiumin Liu, Wei Du, Huang Liu, Weilin Xiao, Xiaosong Song, Zhaoying Fan, Chuangbo Ke, Qiangguo Yu, Weibing Qin, Yunge Tang, Xiaoyong P. Carnitine/organic cation transporter 2 (OCTN2) contributes to rat epididymal epithelial cell growth and proliferation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-30. PMID:28666211. |
moreover, forced expression of octn2 inhibited the cell apoptosis process, and at the same time increased expression of the pro-apoptosis factor bax, and decreased expression of the anti-apoptosis factors bcl-2 and survivin. |
2018-04-30 |
2023-08-13 |
rat |
| Zeynep Cakir, Kathrin Funk, Joachim Lauterwasser, Franziska Todt, Ralf M Zerbes, Aline Oelgeklaus, Atsushi Tanaka, Martin van der Laan, Frank Edlic. Parkin promotes proteasomal degradation of misregulated BAX. Journal of cell science. vol 130. issue 17. 2018-04-30. PMID:28760928. |
the pro-apoptotic bcl-2 protein bax commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. |
2018-04-30 |
2023-08-13 |
human |
| Kai-Hong Zhao, Can Zhang, Yue Bai, Yan Li, Xun Kang, Jian-Xin Chen, Kun Yao, Tao Jiang, Xiao-Song Zhong, Wen-Bin L. Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway. Drug design, development and therapy. vol 11. 2018-04-26. PMID:28721010. |
the present study confirmed that cytarabine inhibits proliferation and promotes apoptosis of u87 cells, and molecular analysis of this effect showed that cytarabine significantly reduces expression of phosphatidylinositol 3-kinase/serine/threonine kinase also known as the protein kinase b/mechanistic target of rapamycin (pi3k/akt/mtor) pathway, ki-67, bcl2, and 4-1bb, and upregulates bax and cleaved caspase-3. |
2018-04-26 |
2023-08-13 |
human |
| Abhishek Basu, Arin Bhattacharjee, Prosenjit Ghosh, Amalesh Samanta, Sudin Bhattachary. Sensitizing effects of an organovanadium compound during adjuvant therapy with cyclophosphamide in a murine tumor model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-25. PMID:28711021. |
further studies revealed that vc-iv sensitized tumor cells to cyclophosphamide therapy by down-regulating the anti-apoptotic protein bcl-2 and by up-regulating molecules like p53, bax, cytochrome c, caspases, which led to parp cleavage and apoptosis. |
2018-04-25 |
2023-08-13 |
Not clear |
| Yansheng Wang, Changqing Liu, Jianchun Wang, Yang Zhang, Linlin Che. Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway. Oncology reports. vol 38. issue 3. 2018-04-25. PMID:28714021. |
we found that iodine-131 reduced cell proliferation, induced apoptosis, induced p53, pidd, t-bid (mitochondria) protein expression, suppressed cytochrome c (mitochondria) protein expression, and increased bax protein expression, and promoted caspase-2, -3 and -9 expression levels in human cardiac muscle cells. |
2018-04-25 |
2023-08-13 |
human |
| Fanjun Meng, Yuxia Zhang, Xing Li, Juan Wang, Zhiyu Wan. Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K/AKT autophagy signaling pathway. Oncology reports. vol 38. issue 3. 2018-04-25. PMID:28731179. |
overexpression of mir-138 in the human melanoma cell line a2058 inhibited cell proliferation and induced cell apoptosis, and increased caspase-3 and bax protein expression when compared with a negative control group. |
2018-04-25 |
2023-08-13 |
human |
| Fanjun Meng, Yuxia Zhang, Xing Li, Juan Wang, Zhiyu Wan. Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K/AKT autophagy signaling pathway. Oncology reports. vol 38. issue 3. 2018-04-25. PMID:28731179. |
ly294002, an inhibitor of pi3k, suppressed pi3k/akt/mtor signaling, induced apoptosis, inhibited cell proliferation, increased caspase-3 and bax protein expression, and decreased pdk1 protein expression in a2058 cells following mir-138 overexpression. |
2018-04-25 |
2023-08-13 |
human |
| Xueqin Wang, Xuemei He, Xian Deng, Yanzheng He, Xiangyu Zho. Roles of miR‑4463 in H2O2‑induced oxidative stress in human umbilical vein endothelial cells. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28713907. |
flow cytometry was used to evaluate the percentage of apoptotic cells, and the protein expression levels of the apoptotic markers cleaved (c)‑caspase3, poly (adenosine diphosphate‑ribose) polymerase 1 (parp1), b cell lymphoma‑2 (bcl‑2), bcl‑2‑associated x protein (bax) and x‑linked inhibitor of apoptosis protein (xiap) were determined using western blot analysis. |
2018-04-24 |
2023-08-13 |
human |
| Luo-Cheng Li, Zhi-Wei Wang, Xiao-Ping Hu, Zhi-Yong Wu, Zhi-Peng Hu, Yong-Le Rua. MDG‑1 inhibits H2O2‑induced apoptosis and inflammation in human umbilical vein endothelial cells. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28713956. |
in addition, pretreatment with mdg‑1 decreased the expression levels of proapoptotic proteins bcl2 associated x (bax) and caspase‑3, while it increased the expression levels of the antiapoptotic protein bcl2 apoptosis regulator (bcl‑2), compared with h2o2 treatment alone. |
2018-04-24 |
2023-08-13 |
human |
| Lijian Cui, Ruixia Liu, Chunyun Li, Xiaozheng Yu, Xiaoya Liu, Fei Hou, Cheng Chi, Chenghong Yin, Chao Wan. Angiotensin‑(1‑7) attenuates caerulein‑induced pancreatic acinar cell apoptosis. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28713987. |
the ratio of the pro‑apoptotic protein bax to the anti‑apoptotic protein bcl‑2 dropped notably, which demonstrated a tendency towards curbing apoptosis. |
2018-04-24 |
2023-08-13 |
mouse |
| Arvinder Kapur, Mildred Felder, Lucas Fass, Justanjot Kaur, Austin Czarnecki, Kavya Rathi, San Zeng, Kathryn Kalady Osowski, Colin Howell, May P Xiong, Rebecca J Whelan, Manish S Patanka. Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation. Scientific reports. vol 6. 2018-04-23. PMID:27270209. |
in p53 expressing ecc-1 and ovcar-3 but not in p53-deficient skov-3 cells, citral induces g1/s cell cycle arrest and apoptosis as determined by annexin v staining and increased cleaved caspase3 and bax and decreased bcl-2. |
2018-04-23 |
2023-08-13 |
human |
| Florian Engert, Michal Kovac, Daniel Baumhoer, Michaela Nathrath, Simone Fuld. Osteosarcoma cells with genetic signatures of BRCAness are susceptible to the PARP inhibitor talazoparib alone or in combination with chemotherapeutics. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:27447864. |
genetic silencing of bax and bak or pharmacological inhibition of caspases by zvad.fmk significantly rescued os cells from talazoparib/tmz-induced apoptosis. |
2018-04-23 |
2023-08-13 |
Not clear |
| Hongbin Chen, Wei Lin, Yixian Zhang, Longzai Lin, Jianhao Chen, Yongping Zeng, Mouwei Zheng, Zezhong Zhuang, Houwei Du, Ronghua Chen, Nan Li. IL-10 Promotes Neurite Outgrowth and Synapse Formation in Cultured Cortical Neurons after the Oxygen-Glucose Deprivation via JAK1/STAT3 Pathway. Scientific reports. vol 6. 2018-04-23. PMID:27456198. |
moreover, il-10 attenuated ogd-induced neuronal apoptosis by down-regulating the bax expression and up-regulating the bcl-2 expression, facilitated neurite outgrowth by increasing the expression of netrin-1, and promoted synapse formation in cultured primary cortical neurons after ogd injury. |
2018-04-23 |
2023-08-13 |
rat |
| Huan Shen, Li Liu, Yongjin Yang, Wenxing Xun, Kewen Wei, Guang Zen. Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling. Oncology research. vol 25. issue 7. 2018-04-23. PMID:28109089. |
in addition, ba significantly promoted mitochondrial apoptosis, as reflected by an increase in tunel+ cells and the activities of caspases 3 and 9, an increase in bax expression, and a decrease in bcl-2 expression and the mitochondrial oxygen consumption rate. |
2018-04-23 |
2023-08-13 |
human |