| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kai Yu, Tingting Wang, Yujue Li, Chun Wang, Xia Wang, Mei Zhang, Yongmei Xie, Shuangqing Li, Zhenmei An, Tinghong Y. Niclosamide induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in human thyroid cancer in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28575805. |
in addition, the occurrence of tpc-1 apoptosis was correlated with activation of bax and cleaved caspases-3, and inhibition of bcl-2 and the mitochondrial membrane potential (Δym), indicating that niclosamide may induce apoptosis through a mitochondria-mediated intrinsic apoptotic pathway. |
2018-04-03 |
2023-08-13 |
human |
| Fei Wang, Hongxia Ma, Zhaoguo Liu, Wei Huang, Xiaojing Xu, Xuemei Zhan. α-Mangostin inhibits DMBA/TPA-induced skin cancer through inhibiting inflammation and promoting autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling pathway in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28582759. |
moreover, α-mangostin promoted the apoptosis of skin tumor dose-dependently by up-regulating of bax, cleaved caspase-3, cleaved parp and bad, and down-regulating of bcl-2 and bcl-xl. |
2018-04-03 |
2023-08-13 |
mouse |
| Hai-Li Lang, Guo-Wen Hu, Bo Zhang, Wei Kuang, Yong Chen, Lei Wu, Guo-Hai X. Glioma cells enhance angiogenesis and inhibit endothelial cell apoptosis through the release of exosomes that contain long non-coding RNA CCAT2. Oncology reports. vol 38. issue 2. 2018-04-03. PMID:28656228. |
finally, gain-/loss-of-function studies revealed that the overexpression of linc-ccat2 in huvecs activated vegfa and tgfβ, promoted angiogenesis, promoted bcl-2 expression and inhibited bax and caspase-3 expression, thus decreasing apoptosis. |
2018-04-03 |
2023-08-13 |
Not clear |
| Tan Ma, Xiaoqin Yin, Ruitong Han, Jie Ding, Huan Zhang, Xiaodong Han, Dongmei L. Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat. International journal of environmental research and public health. vol 14. issue 10. 2018-04-03. PMID:29064414. |
proliferation and apoptosis related proteins (ras related dexamethasone induced 1 (rasd1), mitogen-activated protein kinase kinases1/2 (mek1/2), bcl-2, and bax) were measured for mechanisms exploration. |
2018-04-03 |
2023-08-13 |
human |
| Hongjing Zhao, Ying He, Siwen Li, Xiao Sun, Yu Wang, Yizhi Shao, Zhijun Hou, Mingwei Xin. Subchronic arsenism-induced oxidative stress and inflammation contribute to apoptosis through mitochondrial and death receptor dependent pathways in chicken immune organs. Oncotarget. vol 8. issue 25. 2018-04-02. PMID:28454103. |
(4) as2o3-induced apoptosis of immune organs involved in mitochondrial pathway (decrease of b-cell lymphoma-2 (bcl-2) and increase of protein 53 (p53), bcl-2 associated x protein (bax), caspase-9, caspase-3) and death receptor pathway (increase of factor associated suicide (fas) and caspase-8). |
2018-04-02 |
2023-08-13 |
chicken |
| Huiying Zhao, Qingchun Liu, Saisai Wang, Fang Dai, Xiaofei Cheng, Xiaobin Cheng, Wenbin Chen, Min Zhang, Dong Che. In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. Cancer medicine. vol 6. issue 7. 2018-03-29. PMID:28573788. |
the induction of apoptosis is involved in the increasing of bax and cytochrome c and decreasing of bcl2 expressions. |
2018-03-29 |
2023-08-13 |
Not clear |
| Fan Yang, Yuan Li, Gege Yan, Tianyi Liu, Chao Feng, Rui Gong, Ye Yuan, Fengzhi Ding, Lai Zhang, Elina Idiiatullina, Valentin Pavlov, Zhenbo Han, Wenya Ma, Qi Huang, Ying Yu, Zhengyi Bao, Xiuxiu Wang, Bingjie Hua, Zhimin Du, Benzhi Cai, Lei Yan. Inhibition of iron overload-induced apoptosis and necrosis of bone marrow mesenchymal stem cells by melatonin. Oncotarget. vol 8. issue 19. 2018-03-26. PMID:28415572. |
taken together, melatonin protected bmscs from iron overload induced apoptosis and necrosis by regulating bcl-2, bax, cleaved caspase-3, rip1 and rip3 pathways. |
2018-03-26 |
2023-08-13 |
Not clear |
| Xiaorong Mao, Senrong Du, Zhongxia Yang, Liting Zhang, Xuebin Peng, Ni Jiang, Haiyu Zho. Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28498459. |
flow cytometry was used to detect the apoptosis of hepg2 cells, western blot analysis was used to detect the protein expression of casepase‑3, casepase‑8, b‑cell lymphoma 2 (bcl‑2)‑associated x protein (bax), bcl‑2, phosphatase and tensin homolog (pten), tissue inhibitor of metalloproteinase (timp) 3 and matrix metalloprotease (mmp) 3. |
2018-03-26 |
2023-08-13 |
Not clear |
| Zuowen Liang, Hongliang Wang, Baofeng Guo, Fubiao Li, Jinsha Liu, Zhewen Liu, Libo Xu, Wenjing Yun, Xuejian Zhao, Ling Zhan. Inhibition of prostate cancer RM1 cell growth in vitro by hydroxyapatite nanoparticle‑delivered short hairpin RNAs against Stat3. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28534932. |
stat3 mrna expression levels were measured by reverse transcription‑quantitative polymerase chain reaction and stat3, cyclin d1, b cell lymphoma 2 apoptosis regulator (bcl‑2), vascular endothelial growth factor (vegf), bcl‑2 associated x apoptosis regulator (bax) and cleaved‑caspase‑3 protein expression levels were detected using western blot analysis. |
2018-03-26 |
2023-08-13 |
Not clear |
| Xiaoou Xu, Satoru Yokoyama, Yoshihiro Hayakawa, Ikuo Saik. Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma. Oncology reports. vol 38. issue 1. 2018-03-26. PMID:28560413. |
coptidis rhizoma induces intrinsic apoptosis through bax and bak activation in human melanoma. |
2018-03-26 |
2023-08-13 |
human |
| Xiaoou Xu, Satoru Yokoyama, Yoshihiro Hayakawa, Ikuo Saik. Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma. Oncology reports. vol 38. issue 1. 2018-03-26. PMID:28560413. |
furthermore, multi-domain pro-apoptotic proteins bax and bak were activated by cr treatment and were also required for the cr-induced apoptosis. |
2018-03-26 |
2023-08-13 |
human |
| Dong-Sheng He, Xiao-Jian Hu, Yi-Qi Yan, Hui Li. Underlying mechanism of Sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586000. |
in conclusion, upregulation of sirt1 expression may inhibit oa chondrocyte apoptosis and extracellular matrix degradation by increasing bcl‑2 expression and decreasing bax, mmp1 and mmp13 expression, via downregulation of p38, jnk and erk phosphorylation. |
2018-03-26 |
2023-08-13 |
Not clear |
| Yaoqun Wu, Pei Zhang, Hongyun Yang, Yong Ge, Yong Xi. Effects of demethoxycurcumin on the viability and apoptosis of skin cancer cells. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586041. |
the effects of dmc treatment on cell viability were analyzed using the cell counting kit‑8 (cck‑8) assay; cell cycle distribution was analyzed by flow cytometry; apoptosis was assessed by flow cytometry and hoechst 33258 staining; and the protein expression levels of cytochrome c, b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein (bax), caspase‑9 and caspase‑3 were evaluated by western blotting. |
2018-03-26 |
2023-08-13 |
human |
| Begoña Ugarte-Uribe, Ana J García-Sáe. Apoptotic foci at mitochondria: in and around Bax pores. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 372. issue 1726. 2018-03-26. PMID:28630156. |
the permeabilization of the mitochondrial outer membrane by bax and bak during apoptosis is considered a key step and a point of no return in the signalling pathway. |
2018-03-26 |
2023-08-13 |
Not clear |
| Rachel T Uren, Sweta Iyer, Ruth M Kluc. Pore formation by dimeric Bak and Bax: an unusual pore? Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 372. issue 1726. 2018-03-26. PMID:28630157. |
two bcl-2 protein family members, bak and bax, form these pores during apoptosis, and how they do so has been investigated for the last two decades. |
2018-03-26 |
2023-08-13 |
Not clear |
| Y Huang, S-H Liang, L-B Xiang, X-T Han, W Zhang, J Tang, X-H Wu, M-Q Zhan. [miR-218 Promoted the Apoptosis of Human Ovarian Carcinoma Cells via Suppression of the WNT/β-Catenin Signaling Pathway]. Molekuliarnaia biologiia. vol 51. issue 4. 2018-03-23. PMID:28900081. |
after over-expressing mir-218 in human ovarian carcinoma (ovcar3) cells, cell viability was determined by mtt method, cell apoptosis was observed by flow cytometry (fcm), mrna expression of mir-218, bcl2, bax was measured by rt-pcr and protein expression levels of wnt, tankyrase and β-catenin were quantified by western blots. |
2018-03-23 |
2023-08-13 |
human |
| Qin Zhang, Xin-Wei Dong, Jia-Ying Xia, Ke-Ying Xu, Zhe-Rong X. Obestatin Plays Beneficial Role in Cardiomyocyte Injury Induced by Ischemia-Reperfusion In Vivo and In Vitro. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-22. PMID:28472020. |
finally, we assessed cells apoptosis using flow cytometry and detected the concentrations of caspase-3, bax, and bcl-2 using western blot analysis. |
2018-03-22 |
2023-08-13 |
rat |
| Shangfei He, Xianbao Wang, Yongkang Zhong, Lu Tang, Ya Zhang, Yuanna Ling, Zhipeng Tan, Pingzhen Yang, Aihua Che. Hesperetin post-treatment prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating PI3K/Akt signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-22. PMID:28531921. |
our results showed that hpt post-treatment significantly inhibited apoptosis by elevating the expression of bcl-2, decreasing the expression of bax and cleaved caspase-3, and diminished the apoptotic cardiomyocytes ratio. |
2018-03-22 |
2023-08-13 |
rat |
| Sheng-Xiang Lv, Xiao Qia. Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-22. PMID:29355527. |
mechanistic studies indicated that iv induced apoptosis by the mitochondrial apoptotic pathway, as evidenced by the increase of bax, cleaved caspase-3, poly (adp-ribose) polymerase (parp), and cytoplasm cyto-c released from mitochondria. |
2018-03-22 |
2023-08-13 |
Not clear |
| Ji Ae Kim, Jin Chul Kim, Jung Sun Min, Inho Kang, Jeongho Oh, Jeong Keun Ah. HSV-1 ICP27 induces apoptosis by promoting Bax translocation to mitochondria through interacting with 14-3-3θ. BMB reports. vol 50. issue 5. 2018-03-21. PMID:28256197. |
hsv-1 icp27 induces apoptosis by promoting bax translocation to mitochondria through interacting with 14-3-3θ. |
2018-03-21 |
2023-08-13 |
Not clear |