| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren J Maskell, Kashif Qamar, Aram A Babakr, Thomas A Hawkins, Richard J Heads, Vishwanie S Budhram-Mahade. Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart. Cell death & disease. vol 8. issue 6. 2018-03-07. PMID:28594399. |
bax, thereby increasing apoptosis and contribute to morphological defects such as non-compaction, ventricular wall/septal thinning and increased crypts/fissures, which may cause lethality of brn-3a ko mutants soon after birth. |
2018-03-07 |
2023-08-13 |
Not clear |
| Fei Zhao, Yong-Feng Wang, Lei Song, Jia-Xin Jin, Ya-Qing Zhang, Hong-Yun Gan, Ke-Hu Yan. Synergistic Apoptotic Effect of D-Fraction From Grifola frondosa and Vitamin C on Hepatocellular Carcinoma SMMC-7721 Cells. Integrative cancer therapies. vol 16. issue 2. 2018-03-06. PMID:27151580. |
western blot analysis revealed that the upregulation of bax, downregulation of bcl-2, activation of poly-(adp-ribose)-polymerase (parp), and the release of cytochrome c were observed in cells treated with the combination of dfp/vc, which showed that the mechanism of anticancer activity in the smmc-7721 hepatocarcinoma cells involved induction of apoptosis. |
2018-03-06 |
2023-08-13 |
human |
| Liang Zhou, Ruirui Gao, Yinghui Wang, Meijuan Zhou, Zhenhua Din. Loss of BAX by miR-365 Promotes Cutaneous Squamous Cell Carcinoma Progression by Suppressing Apoptosis. International journal of molecular sciences. vol 18. issue 6. 2018-03-06. PMID:28556798. |
loss of bax by mir-365 promotes cutaneous squamous cell carcinoma progression by suppressing apoptosis. |
2018-03-06 |
2023-08-13 |
Not clear |
| Liang Zhou, Ruirui Gao, Yinghui Wang, Meijuan Zhou, Zhenhua Din. Loss of BAX by miR-365 Promotes Cutaneous Squamous Cell Carcinoma Progression by Suppressing Apoptosis. International journal of molecular sciences. vol 18. issue 6. 2018-03-06. PMID:28556798. |
loss of bax by either rna interference or highly-expressed mir-365 in cells of cutaneous squamous cell carcinoma (cscc) enhanced the tumor resistance against apoptosis, while repressing cell proliferation, migration, and invasiveness. |
2018-03-06 |
2023-08-13 |
Not clear |
| Lingling Zhang, Huanan Wang, Wei Li, Juchang Zhong, Rongcheng Yu, Xinfeng Huang, Honghui Wang, Zhikai Tan, Jiangang Wang, Yingjie Zhan. Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis. Oncotarget. vol 8. issue 2. 2018-03-05. PMID:27924057. |
after induction, puma activated bax and triggered the intrinsic mitochondrial apoptosis pathway. |
2018-03-05 |
2023-08-13 |
Not clear |
| Aditi Banerjee, Vivekjyoti Banerjee, Steven Czinn, Thomas Blanchar. Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells. Oncotarget. vol 8. issue 16. 2018-03-05. PMID:28412728. |
andrographolide-induced cell death, upr signaling, and chop, bax, and caspase 3 apoptosis elements were all inhibited in the presence of the ros scavenger nac. |
2018-03-05 |
2023-08-13 |
Not clear |
| Yao Shi, Hong Jiang, Xiaobo Yan. PPARδ activation protects H9c2 cardiomyoblasts from LPS‑induced apoptosis through the heme oxygenase‑1‑mediated suppression of NF‑κB activation. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28440451. |
the protein level of heme oxygenase‑1 (ho‑1), cleaved caspase‑3 (cc3), apoptosis regulator bcl‑2 (bcl‑2), apoptosis regulator bax (bax) and nuclear factor‑κb (nf‑κb) p65 was measured by western blot analysis. |
2018-03-05 |
2023-08-13 |
rat |
| Yanping Feng, Fang Liu, Zhixiang Du, Dongjie Zhao, Jianxin Cheng, Wei Gu. Wip1 regulates SKOV3 cell apoptosis through the p38 MAPK signaling pathway. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28440479. |
western blot analysis was performed to determine expression of tumor protein 53 (p53), cleaved caspase‑3, caspase‑3, bcl2 associated x (bax), bcl2 apoptosis regulator (bcl‑2), p38 mitogen‑activated protein kinase (p38 mapk) and phosphorylated (p)‑p38 mapk. |
2018-03-05 |
2023-08-13 |
human |
| Yanli Liu, Hongxu Yang, Yi Wen, Bingyi Li, Yinhua Zhao, Jing Xing, Min Zhang, Yongjin Che. Nrf2 Inhibits Periodontal Ligament Stem Cell Apoptosis under Excessive Oxidative Stress. International journal of molecular sciences. vol 18. issue 5. 2018-03-05. PMID:28513573. |
additionally, the apoptosis levels gradually increased with oxidative stress by the upregulation of caspase-9, caspase-3, bax and c-fos levels in addition to the downregulation of bcl-2. |
2018-03-05 |
2023-08-13 |
Not clear |
| Lili Li, Xiaoheng Li, Xianwu Chen, Yong Chen, Jianpeng Liu, Fenfen Chen, Fei Ge, Leping Ye, Qingquan Lian, Ren-Shan G. Perfluorooctane sulfonate impairs rat Leydig cell development during puberty. Chemosphere. vol 190. 2018-03-05. PMID:28985536. |
at ≥ 500 nm, pfos downregulated lhcgr, inhibited bcl-2 and increased bax levels to cause leydig cell apoptosis. |
2018-03-05 |
2023-08-13 |
rat |
| Chao Wu, Jie Xu, Yanna Hao, Ying Zhao, Yang Qiu, Jie Jiang, Tong Yu, Peng Ji, Ying Li. Application of a lipid-coated hollow calcium phosphate nanoparticle in synergistic co-delivery of doxorubicin and paclitaxel for the treatment of human lung cancer A549 cells. International journal of nanomedicine. vol 12. 2018-03-05. PMID:29184399. |
furthermore, in vitro cytotoxicity experiment, apoptosis analysis, in vivo anti-tumor efficacy and protein expression analysis of bax, bcl-2, and caspase-3 demonstrated that the co-delivery system based on lcp had significant synergistic anti-tumor activity. |
2018-03-05 |
2023-08-13 |
human |
| JinFeng Zhang, Le Su, Qing Ye, ShangLi Zhang, HsiangFu Kung, Fan Jiang, GuoSheng Jiang, JunYing Miao, BaoXiang Zha. Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells. Oncotarget. vol 8. issue 5. 2018-03-02. PMID:28032588. |
treatment with 4f reduced both b-cell lymphoma-2 (bcl-2) expression and bcl-2/bcl-2-associated x protein (bax) ratio, which indicated that 4f induced apoptosis, at least in part, via mitochondrial-dependent signaling. |
2018-03-02 |
2023-08-13 |
human |
| Kapil Suchal, Salma Malik, Sana Irfan Khan, Rajiv Kumar Malhotra, Sameer N Goyal, Jagriti Bhatia, Shreesh Ojha, Dharamvir Singh Ary. Molecular Pathways Involved in the Amelioration of Myocardial Injury in Diabetic Rats by Kaempferol. International journal of molecular sciences. vol 18. issue 5. 2018-03-02. PMID:28505121. |
furthermore, it also attenuated apoptosis by reducing the expression of pro-apoptotic proteins (bax and caspase-3), terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) positive cells, and increasing the level of anti-apoptotic protein (bcl-2). |
2018-03-02 |
2023-08-13 |
rat |
| Zu-Zhuang Wei, Qi-Pin Qin, Ting Meng, Cai-Xing Deng, Hong Liang, Zhen-Feng Che. 5-Bromo-oxoisoaporphine platinum(II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and mitochondrial functions. European journal of medicinal chemistry. vol 145. 2018-03-02. PMID:29335202. |
significantly increased ros level, loss of Δψ, decrease of bcl-2 level, and increase of some of the mitochondria-initiated apoptosis protein levels (including bax, cyt c, caspase-3, caspase-9, and apaf-1) were observed in hep-g2 cells. |
2018-03-02 |
2023-08-13 |
Not clear |
| Li-Qun Yuan, Yan-Ming Chen, Chao Sun, Zhong-Yong Wang, De-Lin Wang, Qing La. Actein inhibits glioma growth via a mitochondria-mediated pathway. Cancer biomarkers : section A of Disease markers. vol 18. issue 4. 2018-03-01. PMID:28128733. |
administration of actein also induced mitochondria-related apoptosis by increasing expression of pro-apoptotic factors bax, cleaved caspase-3, cleaved caspase-9 and cleaved poly (adp-ribose) polymerase 1 (parp1) as well as decreasing anti-apoptotic bcl-2 expression in u87 cells and u251 cells. |
2018-03-01 |
2023-08-13 |
human |
| Hui Wang, Xiaomin Zhang, Pujiao Yu, Qiulian Zhou, Jialiang Zhang, Haifeng Zhang, Hongsheng Zhu, Chenlin Zhang, Wenming Yao, Lin Che, Jiahong Xu, Yihua Bei, Xinli L. Traditional Chinese Medication Qiliqiangxin Protects Against Cardiac Remodeling and Dysfunction in Spontaneously Hypertensive Rats. International journal of medical sciences. vol 14. issue 5. 2018-03-01. PMID:28539827. |
qlqx also attenuated cardiac fibrosis and apoptosis in shrs as evidenced by downregulation of α-sma, collagen i, collagen iii, and tgf-β expressions and reduction of bax to bcl-2 ratio. |
2018-03-01 |
2023-08-13 |
rat |
| E González-Burgos, Carlos Fernández-Moriano, R Lozano, I Iglesias, M P Gómez-Serranillo. Ginsenosides Rd and Re co-treatments improve rotenone-induced oxidative stress and mitochondrial impairment in SH-SY5Y neuroblastoma cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 109. issue Pt 1. 2018-02-26. PMID:28843595. |
furthermore, these compounds prevented apoptosis by modulating bax and bcl-2 proteins and inhibiting cytochrome c release and caspase-3 activation. |
2018-02-26 |
2023-08-13 |
human |
| Na Zhang, Chongwen Bi, Lu Liu, Yueying Dou, Sheng Tang, Weiqiang Pang, Hongbin Deng, Danqing Son. IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1α and PERK signaling. Oncotarget. vol 7. issue 17. 2018-02-23. PMID:27009865. |
importantly, interruption of chop rendered hcc cells sensitive to imb-6g-induced apoptosis via inactivation of bim, puma and bax. |
2018-02-23 |
2023-08-13 |
human |
| Shibin Yuan, Bangyuan Wu, Zhengqiang Yu, Jing Fang, Na Liang, Mingqiang Zhou, Cheng Huang, Xi Pen. The mitochondrial and endoplasmic reticulum pathways involved in the apoptosis of bursa of Fabricius cells in broilers exposed to dietary aflatoxin B1. Oncotarget. vol 7. issue 40. 2018-02-23. PMID:27542244. |
(3) afb1-induced apoptosis of bursal cells involved mitochondrial pathway (increase of bax, bak, cytc, caspase-9, apaf-1, caspase-3 and decrease of bcl-2 and bcl-xl) and er pathway (increase of grp78/bip, grp94 and cam). |
2018-02-23 |
2023-08-13 |
chicken |
| Min Yao, Feng Gao, Xiaomeng Wang, Yonghong Shi, Shuxia Liu, Huijun Dua. Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway. Molecular medicine reports. vol 15. issue 6. 2018-02-23. PMID:28487945. |
the protein levels of nox4, notch1, notch intracellular domain 1 (nicd1), phosphorylated (p) ras‑related c3 botulinum toxin substrate 1 (rac1), rac1, b‑cell lymphoma 2 apoptosis regulator (bcl‑2), bcl‑2 associated protein x apoptosis regulator (bax) and cleaved caspase‑3 were determined by western blotting. |
2018-02-23 |
2023-08-13 |
Not clear |