| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Yao, Feng Gao, Xiaomeng Wang, Yonghong Shi, Shuxia Liu, Huijun Dua. Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway. Molecular medicine reports. vol 15. issue 6. 2018-02-23. PMID:28487945. |
inhibition of the notch pathway via dapt increased bcl‑2 expression, decreased bax and cleaved caspase‑3 levels and prevented hkc cell apoptosis. |
2018-02-23 |
2023-08-13 |
Not clear |
| Valentina Pagliara, Assunta Saide, Emma Mitidieri, Roberta d'Emmanuele di Villa Bianca, Raffaella Sorrentino, Giulia Russo, Annapina Russ. 5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53. Oncotarget. vol 7. issue 31. 2018-02-22. PMID:27385096. |
consequently apoptosis will be induced through the mitochondrial apoptotic cell death pathway characterized by an increased ratio of bax to bcl-2, cytochrome c release and subsequent caspase activation. |
2018-02-22 |
2023-08-13 |
Not clear |
| Yong-Cheng Ma, Yu Ke, Xiaolin Zi, Fei Zhao, Lin Yuan, Ying-Li Zhu, Xia-Xia Fan, Ning-Min Zhao, Qiao-Yan Li, Yu-Hua Qin, Hong-Min Li. Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species. Oncotarget. vol 7. issue 52. 2018-02-22. PMID:27863415. |
induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by ds2, a newly synthetic diterpenoid analog, is regulated by bax and caused by generation of reactive oxygen species. |
2018-02-22 |
2023-08-13 |
human |
| Yong-Cheng Ma, Yu Ke, Xiaolin Zi, Fei Zhao, Lin Yuan, Ying-Li Zhu, Xia-Xia Fan, Ning-Min Zhao, Qiao-Yan Li, Yu-Hua Qin, Hong-Min Li. Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species. Oncotarget. vol 7. issue 52. 2018-02-22. PMID:27863415. |
the ds2-induced apoptosis was significantly attenuated by knockdown of bax proteins. |
2018-02-22 |
2023-08-13 |
human |
| Yong-Cheng Ma, Yu Ke, Xiaolin Zi, Fei Zhao, Lin Yuan, Ying-Li Zhu, Xia-Xia Fan, Ning-Min Zhao, Qiao-Yan Li, Yu-Hua Qin, Hong-Min Li. Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species. Oncotarget. vol 7. issue 52. 2018-02-22. PMID:27863415. |
more interestingly, the antioxidants pretreatment completely attenuated ds2 mediated loss of the mmp and apoptosis, as well as bax expression and growth inhibition. |
2018-02-22 |
2023-08-13 |
human |
| Huang Ruihua, Zhang Mengyi, Zhao Chong, Qiu Meng, Ma Xin, Tang Qiulin, Bi Feng, Liu Min. RhoA regulates resistance to irinotecan by regulating membrane transporter and apoptosis signaling in colorectal cancer. Oncotarget. vol 7. issue 52. 2018-02-22. PMID:27888624. |
furthermore, inhibition of rhoa in drug resistant cells, at least partially, rescues the resistance against irinotecan and increases the sensitivity to other chemotherapeutic drug by inhibiting expression of mdr1, mrp1and gstp1, promotes apoptosis by suppressing the expression of bcl-xl and bcl-2 and increasing bax expression, and significantly decreases side population cells. |
2018-02-22 |
2023-08-13 |
Not clear |
| Li Xiong, Zhipeng Liu, Guoqing Ouyang, Liangwu Lin, He Huang, Hongxiang Kang, Wei Chen, Xiongying Miao, Yu We. Autophagy inhibition enhances photocytotoxicity of Photosan-II in human colorectal cancer cells. Oncotarget. vol 8. issue 4. 2018-02-22. PMID:28031534. |
ps-pdt-treated sw620 cells exhibited nuclear condensation and increased levels of cleaved caspase-3, parp and bax, which is reminiscent of apoptosis. |
2018-02-22 |
2023-08-13 |
mouse |
| Kan Yin, Rongjia Zhu, Shihua Wang, Robert Chunhua Zha. Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells. Stem cells and development. vol 26. issue 10. 2018-02-22. PMID:28178868. |
the mechanism of the effects included proliferation rate increase mediated by increased s phase proportion; mitochondrial biogenesis and function alteration mediated by fusion (mfn1, mfn2, and opa-1) and fission (fis1, drp-1, and mtp18)-related proteins, nrf1, tfam, pgc-1a, and upregulated intracellular ros and no concentration; migration acceleration through the erk1/2 and fak pathway and upregulation of growth factors such as hgf and pdgf; and resistance to apoptosis with increased bcl-2 and decreased bax, or through tunneling nanotube formation between lll-treated mscs and 5-fluorouracil-induced apoptotic mscs. |
2018-02-22 |
2023-08-13 |
human |
| Alireza Ebrahimzadeh Bideskan, Abbas Mohammadipour, Alireza Fazel, Hossein Haghir, Houshang Rafatpanah, Mahmoud Hosseini, Aliakbar Rajabzade. Maternal exposure to titanium dioxide nanoparticles during pregnancy and lactation alters offspring hippocampal mRNA BAX and Bcl-2 levels, induces apoptosis and decreases neurogenesis. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 69. issue 6. 2018-02-22. PMID:28254502. |
maternal exposure to titanium dioxide nanoparticles during pregnancy and lactation alters offspring hippocampal mrna bax and bcl-2 levels, induces apoptosis and decreases neurogenesis. |
2018-02-22 |
2023-08-13 |
Not clear |
| Xiaojie Wang, Qing Peng, Feng Jiang, Li Xue, Jiafu Li, Zhongcai Fan, Pan Chen, Guo Chen, Yihua Ca. Secreted frizzled-related protein 5 protects against oxidative stress-induced apoptosis in human aortic endothelial cells via downregulation of Bax. Journal of biochemical and molecular toxicology. vol 31. issue 12. 2018-02-22. PMID:28834606. |
secreted frizzled-related protein 5 protects against oxidative stress-induced apoptosis in human aortic endothelial cells via downregulation of bax. |
2018-02-22 |
2023-08-13 |
human |
| Xiaojie Wang, Qing Peng, Feng Jiang, Li Xue, Jiafu Li, Zhongcai Fan, Pan Chen, Guo Chen, Yihua Ca. Secreted frizzled-related protein 5 protects against oxidative stress-induced apoptosis in human aortic endothelial cells via downregulation of Bax. Journal of biochemical and molecular toxicology. vol 31. issue 12. 2018-02-22. PMID:28834606. |
co-expression of bax significantly reversed the anti-apoptotic effect of sfrp5 overexpression, whereas knockdown of bax restrained ang ii- and oxldl-induced apoptosis in haecs. |
2018-02-22 |
2023-08-13 |
human |
| Xiaojie Wang, Qing Peng, Feng Jiang, Li Xue, Jiafu Li, Zhongcai Fan, Pan Chen, Guo Chen, Yihua Ca. Secreted frizzled-related protein 5 protects against oxidative stress-induced apoptosis in human aortic endothelial cells via downregulation of Bax. Journal of biochemical and molecular toxicology. vol 31. issue 12. 2018-02-22. PMID:28834606. |
taken together, sfrp5 confers protection against oxidative stress-induced apoptosis through inhibition of β-catenin activation and downregulation of bax. |
2018-02-22 |
2023-08-13 |
human |
| Xiao-Xin Chen, Kar Ho Lam, Qing-Xi Chen, George Pak-Heng Leung, Sydney Chi Wai Tang, Stephen Cho-Wing Sze, Jian-Bo Xiao, Feng Feng, Ying Wang, Kalin Yan-Bo Zhang, Zhang-Jin Zhan. Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 110. 2018-02-22. PMID:29030256. |
moreover, spas induced apoptosis in both cell lines which were accompanied with an increase in loss of mitochondrial membrane potential, production of reactive oxygen species, bax to bcl-2 protein expression ratio, and activated caspase 3. |
2018-02-22 |
2023-08-13 |
rat |
| Ying Xu, Cheng-Cheng Gao, Zhen-Guo Pan, Chuan-Wen Zho. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Biochemical and biophysical research communications. vol 496. issue 3. 2018-02-22. PMID:29305260. |
and suppressing fadd, dr5 and bax by si rna significantly reduced the apoptosis and enhanced the cell viability induced by the co-application of iri and trail. |
2018-02-22 |
2023-08-13 |
Not clear |
| Jui-Chieh Chen, Ming-Ju Hsieh, Chih-Jung Chen, Jen-Tsun Lin, Yu-Sheng Lo, Yi-Ching Chuang, Su-Yu Chien, Mu-Kuan Che. Polyphyllin G induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of AKT and mitogen-activated protein kinase pathways in vitro and in vivo. Oncotarget. vol 7. issue 43. 2018-02-21. PMID:27602962. |
in this study, polyphyllin g can potently induced apoptosis dependent on the activations of caspase-8, -3, and -9 and the changes of bcl-2, bcl-xl and bax protein expression in different human npc cell lines (hone-1 and npc-039). |
2018-02-21 |
2023-08-13 |
human |
| Binlong Chen, Diyan Li, Miao Li, Sichen Li, Kenan Peng, Xian Shi, Lanyun Zhou, Pu Zhang, Zhongxian Xu, Huadong Yin, Yan Wang, Xiaoling Zhao, Qing Zh. Induction of mitochondria-mediated apoptosis and PI3K/Akt/ mTOR-mediated autophagy by aflatoxin B2 in hepatocytes of broilers. Oncotarget. vol 7. issue 51. 2018-02-21. PMID:27863407. |
afb2 induced mitochondria-mediated apoptosis via the production of reactive oxygen species (ros) and promotion of the translocation of bax and cytochrome c (cyt c) between mitochondria and the cytosol, triggering the formation of apoptosomes. |
2018-02-21 |
2023-08-13 |
Not clear |
| Zhimin Zhang, Lianyou Zhao, Yanfen Zhou, Xuanhao Lu, Zhengqiang Wang, Jipeng Wang, Wei L. Taurine ameliorated homocysteine-induced H9C2 cardiomyocyte apoptosis by modulating endoplasmic reticulum stress. Apoptosis : an international journal on programmed cell death. vol 22. issue 5. 2018-02-21. PMID:28229251. |
furthermore, blocking the perk pathway partly alleviated hcy-induced er stress-modulated cardiomyocyte apoptosis, and down-regulated the levels of bax and cleaved caspase-3. |
2018-02-21 |
2023-08-13 |
Not clear |
| Gabriele Catyana Krause, Kelly Goulart Lima, Gabriela Viegas Haute, Aline Daniele Schuster, Henrique Bregolin Dias, Fernanda Cristina Mesquita, Leonardo Pedrazza, Elisa Simon Marczak, Bruno Souza Basso, Anderson Catarina Velasque, Bianca Andrade Martha, Fernanda Bordignon Nunes, Márcio Vinícius Donadio, Jarbas Rodrigues de Oliveir. Fructose-1,6-bisphosphate decreases IL-8 levels and increases the activity of pro-apoptotic proteins in HepG2 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-20. PMID:28242545. |
then, we found, by rt-pcr, a high expression level of pro-apoptotic protein, such as bax and p53, and decreased the expression levels of anti-apoptotic proteins, like bcl-2 suggesting apoptosis. |
2018-02-20 |
2023-08-13 |
Not clear |
| Dan Wu, Mulin Liang, Hongxing Dang, Fang Fang, Feng Xu, Chengjun Li. Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway. Biochemical and biophysical research communications. vol 495. issue 2. 2018-02-20. PMID:29198702. |
hyperoxic conditions increased levels of bim, bax, and foxo3a, which induced proliferation restriction and apoptosis of aeciis. |
2018-02-20 |
2023-08-13 |
Not clear |
| Dong Chen, Shaopeng Sun, Dawei Cai, Guangqi Kon. Induction of mitochondrial-dependent apoptosis in T24 cells by a selenium (Se)-containing polysaccharide from Ginkgo biloba L. leaves. International journal of biological macromolecules. vol 101. 2018-02-19. PMID:28283461. |
this se-gblp-induced apoptosis is associated with an increased protein expression of pro-apoptotic bax, decreased expression of anti-apoptotic bcl-2, loss of mitochondrial membrane potential, and cleavage of caspase-9, caspase-3 and parp, suggesting that se-gblp-induced apoptosis occurs through the mitochondria-dependent pathway. |
2018-02-19 |
2023-08-13 |
human |