| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Ae Kim, Jin Chul Kim, Jung Sun Min, Inho Kang, Jeongho Oh, Jeong Keun Ah. HSV-1 ICP27 induces apoptosis by promoting Bax translocation to mitochondria through interacting with 14-3-3θ. BMB reports. vol 50. issue 5. 2018-03-21. PMID:28256197. |
the subcellular localization of bax plays a crucial role during apoptosis. |
2018-03-21 |
2023-08-13 |
Not clear |
| Jianhua Li, Caiyan Bai, Junxia Guo, Wanqian Liang, Jingning Lon. NDUFA4L2 protects against ischaemia/reperfusion-induced cardiomyocyte apoptosis and mitochondrial dysfunction by inhibiting complex I. Clinical and experimental pharmacology & physiology. vol 44. issue 7. 2018-03-21. PMID:28429857. |
the apoptosis of h9c2 cells was evaluated by flow cytometry and the expression of bax and bcl-2 was detected by western blot. |
2018-03-21 |
2023-08-13 |
Not clear |
| Jianhua Li, Caiyan Bai, Junxia Guo, Wanqian Liang, Jingning Lon. NDUFA4L2 protects against ischaemia/reperfusion-induced cardiomyocyte apoptosis and mitochondrial dysfunction by inhibiting complex I. Clinical and experimental pharmacology & physiology. vol 44. issue 7. 2018-03-21. PMID:28429857. |
overexpression of ndufa4l2 led to a dramatic prevention of h/r-induced apoptosis accompanied by a decrease in the expression of bax and an increase in the expression of bcl-2. |
2018-03-21 |
2023-08-13 |
Not clear |
| Yu Zhang, Shiguo Chen, Chaoyang Wei, Gary O Rankin, Xingqian Ye, Yi Charlie Che. Flavonoids from Chinese bayberry leaves induced apoptosis and G1 cell cycle arrest via Erk pathway in ovarian cancer cells. European journal of medicinal chemistry. vol 147. 2018-03-21. PMID:29438890. |
blf treatment increased the expression of cleaved caspase-3 and -7 and induced apoptosis via a erk-dependent caspase-9 activation intrinsic apoptotic pathway by up-regulating the pro-apoptotic proteins (bad and bax) and down-regulating the anti-apoptotic proteins (bcl-xl and bcl-2), which were also in consistency with the results from hoechst 33342 staining and flow cytometry analysis. |
2018-03-21 |
2023-08-13 |
Not clear |
| Przemysław Sitarek, Ewa Skała, Monika Toma, Marzena Wielanek, Janusz Szemraj, Tomasz Skorski, Adam J Białas, Tomasz Sakowicz, Tomasz Kowalczyk, Maciej Radek, Halina Wysokińska, Tomasz Śliwińsk. Transformed Root Extract of Leonurus sibiricus Induces Apoptosis through Intrinsic and Extrinsic Pathways in Various Grades of Human Glioma Cells. Pathology oncology research : POR. vol 23. issue 3. 2018-03-20. PMID:28032310. |
tr root extract induces apoptosis on various grades (i-iii) of human glioma cells by the generation of reactive oxygen species (ros) along with concurrent loss of mitochondrial membrane potential, enhanced s and g2/m phases of the cell cycle, and altered mrna levels of bax, bcl-2, p53, cas-3, cas-8 and cas-9 factors involved in apoptosis. |
2018-03-20 |
2023-08-13 |
human |
| Ling Zhu, Yuxin Chen, Cheng Wei, Xi Yang, Jing Cheng, Zhimin Yang, Chuanrong Chen, Zhaoning J. Anti-proliferative and pro-apoptotic effects of cinobufagin on human breast cancer MCF-7 cells and its molecular mechanism. Natural product research. vol 32. issue 4. 2018-03-19. PMID:28412840. |
taken together, our data confirm that cbf inhibits growth and triggers apoptosis of mcf-7 cells by affecting the expression of bax and bcl-2 in vitro. |
2018-03-19 |
2023-08-13 |
human |
| Attila Kádasi, Nora Maruniaková, Aneta Štochmaľová, Miroslav Bauer, Roland Grossmann, Abdel Halim Harrath, Adriana Kolesárová, Alexander V Sirotki. Direct effect of curcumin on porcine ovarian cell functions. Animal reproduction science. vol 182. 2018-03-19. PMID:28528022. |
markers of proliferation (accumulation of pcna) and apoptosis (accumulation of bax) were analyzed by immunocytochemistry. |
2018-03-19 |
2023-08-13 |
Not clear |
| Attila Kádasi, Nora Maruniaková, Aneta Štochmaľová, Miroslav Bauer, Roland Grossmann, Abdel Halim Harrath, Adriana Kolesárová, Alexander V Sirotki. Direct effect of curcumin on porcine ovarian cell functions. Animal reproduction science. vol 182. 2018-03-19. PMID:28528022. |
it was observed that addition of curcumin reduced ovarian cell proliferation (expression of both pcna and its mrna), promoted apoptosis (accumulation of both bax and its mrna), reduced cell viability, and stimulated both progesterone and testosterone release. |
2018-03-19 |
2023-08-13 |
Not clear |
| Juhyun Song, Oh Yoen Ki. Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition. Nutrients. vol 9. issue 6. 2018-03-19. PMID:28604593. |
apoptosis cell death signaling markers (cleaved poly [adp-ribose] polymerase 1 (parp), p53, and bax) and er stress markers (phosphorylated eif2α (p-eif2α), atf4, chop, |
2018-03-19 |
2023-08-13 |
Not clear |
| Lalitha Devi, Himesh Makala, Lavanya Pothana, Khemlal Nirmalkar, Sandeep Goe. Comparative efficacies of six different media for cryopreservation of immature buffalo (Bubalus bubalis) calf testis. Reproduction, fertility, and development. vol 28. issue 7. 2018-03-15. PMID:25482277. |
similarity in expression of pro-apoptosis proteins transcription factor tumour protein p53 (tp53) and bcl2-associated x protein (bax) in d20s20 cryopreserved tissues to that of fcc (p>0.05) suggested lower apoptosis and dna damage as key reasons for superior cryopreservation. |
2018-03-15 |
2023-08-13 |
cattle |
| Young-Min Han, Migyeung Jeong, Jong-Min Park, Mi-Young Kim, Eun-Jin Go, Ji Young Cha, Kyung Jo Kim, Ki Baik Hah. The ω-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of β-catenin complex, inhibiting COX-2 through repressing NF-κB, and inducing 15-prostaglandin dehydrogenase. Oncotarget. vol 7. issue 39. 2018-03-15. PMID:27566583. |
through in vitro cell models involving docosahexaenoic acid (dha) administration, down-regulation of survivin and bcl-2, and up-regulation of bax, accompanied by blockage of β-catenin complex dissociation, the main mechanisms responsible for dha-induced apoptosis in hct116 cells were determined. |
2018-03-15 |
2023-08-13 |
mouse |
| Cai-Ping Wang, Yun-Wei Shi, Miao Tang, Xiao-Chuan Zhang, Yun Gu, Xin-Miao Liang, Zhi-Wei Wang, Fei Din. Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats. Molecular neurobiology. vol 54. issue 3. 2018-03-14. PMID:26924319. |
in addition, isoquercetin also effectively alleviated hippocampus neuron apoptosis by regulation of cyclic amp responsive element-binding protein (creb), bax, bcl-2, and caspase-3. |
2018-03-14 |
2023-08-13 |
rat |
| X Qian, C Tan, B Yang, F Wang, Y Ge, Z Guan, J Ca. Astaxanthin increases radiosensitivity in esophageal squamous cell carcinoma through inducing apoptosis and G2/M arrest. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 30. issue 6. 2018-03-14. PMID:28475750. |
it was shown that atx improved radiosensitivity of escc cells and induced apoptosis and g2/m arrest via inhibiting bcl2, cyclinb1, cdc2, and promoting bax expression. |
2018-03-14 |
2023-08-13 |
Not clear |
| Fu-Qing Zhang, Wei Lu, Wen-Xiao Yuan, Xin L. Regulation of c-Jun N-Terminal Protein Kinase (JNK) Pathway in Apoptosis of Endothelial Outgrowth Cells Induced by Asymmetric Dimethylarginine. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-13. PMID:28546532. |
supplementation of jnk-specific inhibitor (sp600125) decreased expression of bax and cleaved caspase 3/9, and alleviated adma-induced apoptosis. |
2018-03-13 |
2023-08-13 |
Not clear |
| Teng-Fei Xue, Xu Ding, Juan Ji, Hui Yan, Ji-Ye Huang, Xu-Dong Guo, Jin Yang, Xiu-Lan Su. PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats. Journal of pharmacological sciences. vol 135. issue 3. 2018-03-13. PMID:29113791. |
simultaneously, we observed pd149163 ameliorated apoptosis characterized by down-regulated caspase-3 and bax, but elevated bcl-2. |
2018-03-13 |
2023-08-13 |
rat |
| Bisher Abuyassin, Mohammad Badran, Najib T Ayas, Ismail Lahe. Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea. PloS one. vol 13. issue 2. 2018-03-13. PMID:29389945. |
cellular apoptosis was also investigated by measuring cortical antiapoptotic b-cell lymphoma 2 (bcl-2) and apoptotic bcl-2-associated x (bax) proteins by western blotting. |
2018-03-13 |
2023-08-13 |
mouse |
| Patricia G Tremblay, Marc-André Sirar. Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28383663. |
gene associations with seven major ovarian functions were identified: prostaglandin- endoperoxide synthase 2 (ptgs2), interleukin 8 (il8), and interleukin 6 (il6) with inflammation; steroidogenic acute regulatory protein (star), cytochrome p450scc (cyp11a1), and cytochrome p450 family 19 subfamily a member 1 (cyp19a1) with steroidogenesis; vascular endothelial growth factor c (vegfc), vascular endothelial growth factor a (vegfa), and c-x-c chemokine receptor type 4 (cxcr4) with angiogenesis; amphiregulin (areg), epidermal growth factor receptor (egfr), and sprouty rtk signaling antagonist 2 (spry2) with differentiation, bcl2 associated x (bax), bcl2 like 12 (bcl2l12), and caspase 1(casp1) with apoptosis, cyclin d1 (ccnd1), cyclin b1 (ccnb1), and cyclin b2 (ccnb2) with division; and matrix metalloproteinase-1 (mmp1), matrix metallopeptidase 9 (mmp9), and timp metallopeptidase inhibitor 1 (timp1) with ovulation. |
2018-03-12 |
2023-08-13 |
human |
| Md Mostafizur Rahman, Rachael A Uson-Lopez, Md Tajuddin Sikder, Gongxun Tan, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasak. Ameliorative effects of selenium on arsenic-induced cytotoxicity in PC12 cells via modulating autophagy/apoptosis. Chemosphere. vol 196. 2018-03-12. PMID:29324385. |
furthermore, western blot analyses revealed that simultaneous exposure of both metals significantly inhibited autophagy which further suppressed apoptosis through positively regulation of key proteins; p-mtor, p-akt, p-foxo1a, p62, and expression of ubiquitin, bax, bcl2, nfкb, and caspases 3 and 9, although those are negatively regulated by arsenic. |
2018-03-12 |
2023-08-13 |
human |
| Sharad Verma, Aditi Singh, Anchala Kumari, Chetna Tyagi, Sukriti Goyal, Salma Jamal, Abhinav Grove. Natural polyphenolic inhibitors against the antiapoptotic BCL-2. Journal of receptor and signal transduction research. vol 37. issue 4. 2018-03-09. PMID:28264627. |
the apoptotic mechanism is regulated by the bcl-2 family of proteins, such as bcl-2 or bcl-xl, which block apoptosis while bad, bak, bax, bid, bim or hrk induce apoptosis. |
2018-03-09 |
2023-08-13 |
Not clear |
| Yali Chen, Qianxiang Zhou, Lei Zhang, Yuxu Zhong, Guanwei Fan, Zhe Zhang, Ran Wang, Meihua Jin, Yuling Qiu, Dexin Kon. Stellettin B induces apoptosis in human chronic myeloid leukemia cells via targeting PI3K and Stat5. Oncotarget. vol 8. issue 17. 2018-03-09. PMID:28423649. |
the stel b-induced apoptosis might be in mitochondrial pathway, with increase of bad and bax, decrease of bcl-2 and activation of caspase-9. |
2018-03-09 |
2023-08-13 |
human |