| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuang Zhang, Yanan Liu, Zhenglian Wang, Jingxian Liu, Zhengtao Gu, Qiulin Xu, Lei S. PAR1‑mediated c‑Jun activation promotes heat stress‑induced early stage apoptosis of human umbilical vein endothelial cells. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447716. |
when the par1 inhibitor, sch79797 (sch), or a small interfering rna (sirna) targeting par1 were used to inhibit par1 signaling, a marked decrease in cell apoptosis, caspase‑3 activity and the expression of the pro‑apoptotic protein b‑cell lymphoma 2 (bcl‑2) associated x (bax), as well as increased expression of the anti‑apoptotic bcl‑2 family member, myeloid cell leukemia 1 (mcl‑1), were observed. |
2018-02-16 |
2023-08-13 |
human |
| Shuang Zhang, Yanan Liu, Zhenglian Wang, Jingxian Liu, Zhengtao Gu, Qiulin Xu, Lei S. PAR1‑mediated c‑Jun activation promotes heat stress‑induced early stage apoptosis of human umbilical vein endothelial cells. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447716. |
in addition, heat stress‑induced apoptosis, caspase‑3 activity and the expression of bax were significantly increased following administration of the par1 agonist, tfllr‑nh2 or adenovirus overexpression of par1. |
2018-02-16 |
2023-08-13 |
human |
| Yiyao Wang, Yu Li, Qunzhi Xing, Xuechan G Han, Xu Dong, Yiping Lu, Mintao Zho. Sevoflurane anesthesia in pregnant rats negatively affects nerve function in offspring potentially via inhibition of the Wnt/β-catenin pathway. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447764. |
western blot and reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) analyses were used to examine the expression of multiple critical factors associated with the proliferation and apoptosis of nerve cells, including ki67, nestin, b cell leukemia/lymphoma 2 (bcl-2), bcl2 associated x (bax) and caspase‑3. |
2018-02-16 |
2023-08-13 |
mouse |
| Roshini A, Srikanth Jagadeesan, Young-Jae Cho, Jong-Hwan Lim, Kyung Hyun Cho. Synthesis and evaluation of the cytotoxic and anti-proliferative properties of ZnO quantum dots against MCF-7 and MDA-MB-231 human breast cancer cells. Materials science & engineering. C, Materials for biological applications. vol 81. 2018-02-15. PMID:28888009. |
furthermore, our data suggested that zno qds regulated apoptosis via bax and bcl-2 proteins as validated by immunofluorescence and western blot. |
2018-02-15 |
2023-08-13 |
human |
| Hui-Fang Guo, Myeong-Hyeon Wan. Dichloromethane fraction of Asiasarum heterotropoides induces S phase arrest and apoptosis in KB oral epithelial carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-14. PMID:28254667. |
undergoing mechanism was detected by western blot, the upregulated expression of bax, cleaved caspase-3, and -9 meantime downregulation of bcl-2 explained it induced apoptosis by the intrinsic pathway. |
2018-02-14 |
2023-08-13 |
Not clear |
| Zhibing Wu, Saisai Jing, Yanhong Li, Yabo Gao, Shuhuan Yu, Zhitian Li, Yanyan Zhao, Jigang Piao, Shenglin Ma, Xufeng Che. The effects of SAHA on radiosensitivity in pancreatic cancer cells by inducing apoptosis and targeting RAD51. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-14. PMID:28267674. |
it was associated with the g2-m phase arrest and apoptosis via modulation of bax and bcl-2 expression. |
2018-02-14 |
2023-08-13 |
Not clear |
| Jing Liu, Yaochi W. Electro-acupuncture-modulated miR-214 prevents neuronal apoptosis by targeting Bax and inhibits sodium channel Nav1.3 expression in rats after spinal cord injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-14. PMID:28298073. |
electro-acupuncture-modulated mir-214 prevents neuronal apoptosis by targeting bax and inhibits sodium channel nav1.3 expression in rats after spinal cord injury. |
2018-02-14 |
2023-08-13 |
rat |
| Jing Liu, Yaochi W. Electro-acupuncture-modulated miR-214 prevents neuronal apoptosis by targeting Bax and inhibits sodium channel Nav1.3 expression in rats after spinal cord injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-14. PMID:28298073. |
importantly, we validated both apoptosis related protein bax and pain related protein nav1.3 as two functional targets of mir-214 in vitro and vivo. |
2018-02-14 |
2023-08-13 |
rat |
| Gui-Cun Zhao, Yan-Ling Yuan, Feng-Rong Chai, Fa-Jing J. Effect of Melilotus officinalis extract on the apoptosis of brain tissues by altering cerebral thrombosis and inflammatory mediators in acute cerebral ischemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-14. PMID:28320101. |
moreover biochemical parameters in plasma such as 6-keto-pgf1α and txb2 and concentration of cytokine, oxidative stress, apoptosis ratio and protein expressions of bcl2 & bax were estimated in the brain tissues. |
2018-02-14 |
2023-08-13 |
rat |
| Qing-Tao Meng, Rong Chen, Cheng Chen, Ke Su, Wei Li, Ling-Hua Tang, Hui-Min Liu, Rui Xue, Qian Sun, Yan Leng, Jia-Bao Hou, Yang Wu, Zhong-Yuan Xi. Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice. International journal of molecular medicine. vol 40. issue 6. 2018-02-14. PMID:29039475. |
in the present study, iir was identified to cause significant intestinal injury and apoptosis, with high expression levels of inflammatory cytokines, as well as the apoptotic proteins b-cell lymphoma 2 (bcl-2)-associated x protein (bax) and caspase-3, while simultaneously decreasing the protein levels of bcl-2. |
2018-02-14 |
2023-08-13 |
mouse |
| Qing-Tao Meng, Rong Chen, Cheng Chen, Ke Su, Wei Li, Ling-Hua Tang, Hui-Min Liu, Rui Xue, Qian Sun, Yan Leng, Jia-Bao Hou, Yang Wu, Zhong-Yuan Xi. Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice. International journal of molecular medicine. vol 40. issue 6. 2018-02-14. PMID:29039475. |
t-butylhydroquinone, an nrf2 activator, significantly attenuated iir-induced intestinal injury and apoptosis, with inhibition of the overexpression of the inflammatory cytokines, bax and caspase-3 protein and partial restoration of bcl-2 protein expression. |
2018-02-14 |
2023-08-13 |
mouse |
| Ji Won Choi, Andriy Synytsya, Peter Capek, Roman Bleha, Radek Pohl, Yong Il Par. Structural analysis and anti-obesity effect of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.). Carbohydrate polymers. vol 146. 2018-02-13. PMID:27112865. |
js-mp-1 reduced dose-dependently the viability of 3t3-l1 pre-adipocyte cells, significantly stimulated the cleavage of caspases 9 and 3 and poly (adp-ribose) polymerase (parp) and decreased the ratio of bcl-2 to bax expression level that led to mitochondrial dysfunction and apoptosis in pre-adipocyte cells. |
2018-02-13 |
2023-08-13 |
Not clear |
| Yajun He, Quan Mo, Biao Luo, Yan Qiao, Ruiguang Xu, Zhicai Zuo, Junliang Deng, Xiang Nong, Guangneng Peng, Wei He, Yahui Wei, Yanchun H. Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat. Oncotarget. vol 7. issue 34. 2018-02-13. PMID:27391155. |
moreover, the translocation of bax and cyt c between mitochondria and cytosol triggering the forming of apoptosome proved that the mitochondria-mediated apoptosis was triggered by e. adenophorum. |
2018-02-13 |
2023-08-13 |
Not clear |
| Julian C Bahr, Robert W Robey, Victoria Luchenko, Agnes Basseville, Arup R Chakraborty, Hanna Kozlowski, Gary T Pauly, Paresma Patel, Joel P Schneider, Michael M Gottesman, Susan E Bate. Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. vol 7. issue 43. 2018-02-13. PMID:27634878. |
the observed apoptosis was caspase-dependent and required bak and bax expression. |
2018-02-13 |
2023-08-13 |
Not clear |
| Jianlin Qiao, Yulu Wu, Yun Liu, Xiaoqian Li, Xiaoqing Wu, Na Liu, Feng Zhu, Kunming Qi, Hai Cheng, Depeng Li, Hongchun Li, Zhenyu Li, Lingyu Zeng, Ping Ma, Kailin X. Busulfan Triggers Intrinsic Mitochondrial-Dependent Platelet Apoptosis Independent of Platelet Activation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 22. issue 9. 2018-02-12. PMID:27292166. |
isolated human platelets were incubated with busulfan followed by analysis of platelet apoptosis by flow cytometry or western blot, including mitochondrial depolarization, expression of bcl-2, and bax and caspase 3 activation. |
2018-02-12 |
2023-08-13 |
mouse |
| Huidan Deng, Ping Kuang, Hengmin Cui, Lian Chen, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Ling Zha. Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice. Oncotarget. vol 7. issue 42. 2018-02-12. PMID:27655720. |
the splenic lymphocytes were isolated from 3 weeks old male icr mice and exposed to naf (0, 100, 200, and 400 μmol/l) in vitro for 24 and 48 h. when compared to control group, flow cytometry assay and hoechst 33258 staining showed that naf induced lymphocytes apoptosis, which was promoted by decrease of mitochondria transmembrane potential, up-regulation of bax, bak, fas, fasl, caspase 9, caspase 8, caspase 7, caspase 6 and caspase 3 protein expression (p < 0.05 or p <0.01), and down-regulation of bcl-2 and bcl-xl protein expression (p <0.05 or p <0.01). |
2018-02-12 |
2023-08-13 |
mouse |
| V Lakshma Nayak, Narayana Nagesh, A Ravikumar, Chandrakant Bagul, M V P S Vishnuvardhan, Vunnam Srinivasulu, Ahmed Kama. 2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway. Apoptosis : an international journal on programmed cell death. vol 22. issue 1. 2018-02-12. PMID:27770267. |
apoptosis induction in mcf-7 cells was further confirmed by loss of mitochondrial membrane potential (∆Ψm), release of cytochrome c from mitochondria, an increase in the level of apoptosis inducing factor (aif), generation of reactive oxygen species (ros), up regulation of proapoptotic protein bax and down regulation of anti apoptotic protein bcl-2. |
2018-02-12 |
2023-08-13 |
human |
| Rachel T Uren, Martin O'Hely, Sweta Iyer, Ray Bartolo, Melissa X Shi, Jason M Brouwer, Amber E Alsop, Grant Dewson, Ruth M Kluc. Disordered clusters of Bak dimers rupture mitochondria during apoptosis. eLife. vol 6. 2018-02-12. PMID:28182867. |
during apoptosis, bak and bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitochondrial outer membrane via an unknown mechanism. |
2018-02-12 |
2023-08-13 |
Not clear |
| Xiuge Gao, Yani Zheng, Xiangchun Ruan, Hui Ji, Lin Peng, Dawei Guo, Shanxiang Jian. Salinomycin induces primary chicken cardiomyocytes death via mitochondria mediated apoptosis. Chemico-biological interactions. vol 282. 2018-02-09. PMID:29331652. |
furthermore, caspase-3 and caspase-9 were activated at gene and protein level rather than caspase-8, along with the up-regulation of apoptosis genes bax, cytochrome c, apoptotic peptidase activating factor 1 (apaf-1) and the down-regulation of bcl-2. |
2018-02-09 |
2023-08-13 |
human |
| Jingying Zhang, Xianmei Zhou, Jiping Zh. Beauveria attenuates asthma by inhibiting inflammatory response and inducing lymphocytic cell apoptosis. Oncotarget. vol 7. issue 46. 2018-02-08. PMID:27801673. |
the expression of apoptosis related molecules bax, caspase-3 and bcl-2 was examined by western blotting analysis. |
2018-02-08 |
2023-08-13 |
mouse |