| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Zhang, Wan Hong He, Ling Lin Feng, Hao Guang Huan. Effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. Regulatory toxicology and pharmacology : RTP. vol 86. 2018-04-12. PMID:28219713. |
results indicated that doxorubicin could induce apoptosis of granulosa cells (p < 0.01); increase ros generation (p < 0.05 or p < 0.01); decrease mitochondrial membrane potential (p < 0.05); increase mrna expression levels of bax, bcl-2, and p53 (p < 0.001); enhance mrna expression level of star (p < 0.01 or p < 0.001); and inhibit mrna expression level of p450scc in granulosa cells (p < 0.05 or p < 0.001). |
2018-04-12 |
2023-08-13 |
mouse |
| Ting Zhang, Wan Hong He, Ling Lin Feng, Hao Guang Huan. Effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. Regulatory toxicology and pharmacology : RTP. vol 86. 2018-04-12. PMID:28219713. |
in addition, cell apoptosis was regulated by bax, bcl-2, and p53, and hormone generation could be influenced by star and p450scc. |
2018-04-12 |
2023-08-13 |
mouse |
| Wan-Yong Zhao, Shao-Bo Chen, Jing-Jing Wang, Chao Xu, Ming-Liang Zhao, Hua-Jiang Dong, Hai-Qian Liang, Xiao-Hong Li, Yue Tu, Sai Zhang, Chong Chen, Hong-Tao Su. Establishment of an ideal time window model in hypothermic-targeted temperature management after traumatic brain injury in rats. Brain research. vol 1669. 2018-04-12. PMID:28629741. |
the apoptosis levels in the ipsilateral hippocampi and cortex were examined with antibodies against the apoptotic proteins bcl-2, bax, and cleaved caspase-3 by the immunofluorescence and western blotting. |
2018-04-12 |
2023-08-13 |
rat |
| Derong Cui, Hanbing Shang, Xiaoli Zhang, Wei Jiang, Xiaofeng Ji. Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways. Scientific reports. vol 6. 2018-04-11. PMID:27273382. |
the expression of tumor suppressor protein 53 (p53) and its target genes: bax, p53-upregulated modulator of apoptosis (puma), and damage-regulated autophagy modulator (dram) were upregulated following ca. |
2018-04-11 |
2023-08-13 |
rat |
| Jeong-Hyeon Ko, Jae Hwi Lee, Sang Hoon Jung, Seok-Geun Lee, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Woong Mo Yang, Jae-Young Um, Gautam Sethi, Kwang Seok Ah. 2,5-Dihydroxyacetophenone Induces Apoptosis of Multiple Myeloma Cells by Regulating the MAPK Activation Pathway. Molecules (Basel, Switzerland). vol 22. issue 7. 2018-04-10. PMID:28696369. |
it was discovered that dhap downregulated the expression of oncogenic gene products like bcl-xl, bcl-2, mcl-1, survivin, cyclin d1, iap-1, cyclin e, cox-2, and mmp-9, and upregulated the expression of bax and p21 proteins, consistent with the induction of g2/m phase cell cycle arrest and apoptosis in u266 cells. |
2018-04-10 |
2023-08-13 |
Not clear |
| Thoria I K Donia, Maria N Gerges, Tarek M Mohame. Amelioration effect of Egyptian sweet orange hesperidin on Ehrlich ascites carcinoma (EAC) bearing mice. Chemico-biological interactions. vol 285. 2018-04-10. PMID:29481770. |
moreover, hesperidin induced apoptosis of tumor cells which appeared as dna fragmentation by down-regulation of bcl2 as anti-apoptotic gene and stimulation of caspase3 and bax genes expression as apoptotic genes. |
2018-04-10 |
2023-08-13 |
mouse |
| Rahul Bhattacharyya, Pooja Gupta, Sandip K Bandyopadhyay, Birija Sankar Patro, Subrata Chattopadhya. Coralyne, a protoberberine alkaloid, causes robust photosenstization of cancer cells through ATR-p38 MAPK-BAX and JAK2-STAT1-BAX pathways. Chemico-biological interactions. vol 285. 2018-04-10. PMID:29486184. |
silencing of bax conferred a significant protection against cuva-induced apoptosis. |
2018-04-10 |
2023-08-13 |
human |
| Rahul Bhattacharyya, Pooja Gupta, Sandip K Bandyopadhyay, Birija Sankar Patro, Subrata Chattopadhya. Coralyne, a protoberberine alkaloid, causes robust photosenstization of cancer cells through ATR-p38 MAPK-BAX and JAK2-STAT1-BAX pathways. Chemico-biological interactions. vol 285. 2018-04-10. PMID:29486184. |
further, our results revealed that a dual signaling axis e.g., atr-p38 mapk and jak2-stat1 pathways functioned upstream of bax activation in apoptosis response. |
2018-04-10 |
2023-08-13 |
human |
| Vicente Andreu-Fernández, Mónica Sancho, Ainhoa Genovés, Estefanía Lucendo, Franziska Todt, Joachim Lauterwasser, Kathrin Funk, Günther Jahreis, Enrique Pérez-Payá, Ismael Mingarro, Frank Edlich, Mar Orzáe. Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 2. 2018-04-09. PMID:28028215. |
the bcl-2 (b-cell lymphoma 2) protein bax (bcl-2 associated x, apoptosis regulator) can commit cells to apoptosis via outer mitochondrial membrane permeabilization. |
2018-04-09 |
2023-08-13 |
Not clear |
| Jiaxin Liu, Yueting Zhang, Li Chen, Fei Yu, Xiaojin Li, Dan Tao, Jianhua Zhao, Shuai Zho. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta biochimica et biophysica Sinica. vol 49. issue 6. 2018-04-09. PMID:28449039. |
ppi induced g2/m phase arrest and apoptosis, and it upregulated the expressions of bax, cytochrome c, and p-jnk, but downregulated the expression of the anti-apoptotic protein bcl-2 in u251 cells. |
2018-04-09 |
2023-08-13 |
human |
| Elçin Telli, Hatice Genç, Burcugül Altuğ Tasa, S Sinan Özalp, A Tansu Kopara. In vitro evaluation of combination of EGCG and Erlotinib with classical chemotherapeutics on JAR cells. In vitro cellular & developmental biology. Animal. vol 53. issue 7. 2018-04-09. PMID:28462491. |
in addition, significant increase was observed in the apoptotic bax gene, but no notable protein synthesis occurred in the western blot analysis, which suggests that combination of erlotinib and egcg with classical chemotherapeutics acd or mtx may lead the jar cells to apoptosis, but not by a mitochondrial pathway. |
2018-04-09 |
2023-08-13 |
human |
| Yingchun Liu, Jiangguo Tang, Xiaoxiao Gao, Min Wang, Jie Shen, Xiaoqing Yo. Effect of retinoid X receptor-α nuclear export inhibition on apoptosis of neurons in vivo and in vitro. Molecular medicine reports. vol 16. issue 2. 2018-04-09. PMID:28627642. |
in addition, the apoptosis and viability of n2a cells was detected using flow cytometry and mtt assays, respectively, and the expression of b cell lymphoma 2 (bcl‑2) and bcl‑2 associated x (bax) was quantified by western blotting. |
2018-04-09 |
2023-08-13 |
mouse |
| Xiliang Guo, Xuezheng Li. Nogo receptor knockdown and ciliary neurotrophic factor attenuate diabetic retinopathy in streptozotocin-induced diabetic rats. Molecular medicine reports. vol 16. issue 2. 2018-04-09. PMID:28656312. |
we found that ngr sirna or cntf injection alone significantly increased cell count in gcl in diabetic rats, inhibited ganglion cell apoptosis, elevated bcl‑2, f‑actin and gap‑43, and decreased bax, caspase‑3, ngr, rhoa and rock1 levels. |
2018-04-09 |
2023-08-13 |
rat |
| Qing Yang, Suoyuan Li, Zeze Fu, Binhui Lin, Zifei Zhou, Zhuoying Wang, Yingqi Hua, Zhengdong Ca. Shikonin promotes adriamycin‑induced apoptosis by upregulating caspase‑3 and caspase‑8 in osteosarcoma. Molecular medicine reports. vol 16. issue 2. 2018-04-06. PMID:28627658. |
the survival rate of cells decreased significantly in a dose‑ and time‑dependent manner when treated with a combination of sk and adm. western blot analysis revealed increased expression levels of bax, caspase‑3, caspase‑8 and parp in u2os and mg63 cells 48 h following treatment with sk and adm. flow cytometric analysis showed that the combined treatment of sk and adm significantly induced apoptosis in the osteosarcoma cells. |
2018-04-06 |
2023-08-13 |
Not clear |
| Qian Sun, Na-Na Lu, Lei Fen. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Biochemical and biophysical research communications. vol 498. issue 1. 2018-04-06. PMID:29408335. |
its role in apoptosis induction was through reducing bcl-2, and enhancing bax, caspase-9/-3 and poly adp-ribose polymerase (parp) cleavage. |
2018-04-06 |
2023-08-13 |
human |
| Manisha Kumari, L Ray, M P Purohit, S Patnaik, A B Pant, Y Shukla, P Kumar, K C Gupt. Curcumin loading potentiates the chemotherapeutic efficacy of selenium nanoparticles in HCT116 cells and Ehrlich's ascites carcinoma bearing mice. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 117. 2018-04-05. PMID:28499854. |
the therapeutic effect on hct116 was primarily attributed to an elevated level of autophagy and apoptosis as evident from significant up-regulation of autophagy associated (lc3b-ii) and pro-apoptotic (bax) proteins, down-regulation of anti-apoptotic (bcl-2) protein and cytochrome c (cyt c) release from mitochondria along with reduced nfκb signaling and emt based machineries marked by downregulation of inflammation (nfκb, phospho-nfκb) and epithelial-mesenchymal transition (cd44, n-cadherin) associated proteins. |
2018-04-05 |
2023-08-13 |
mouse |
| Udaiyar Muruganathan, Subramani Srinivasan, Veerasamy Vinothkuma. Antidiabetogenic efficiency of menthol, improves glucose homeostasis and attenuates pancreatic β-cell apoptosis in streptozotocin-nicotinamide induced experimental rats through ameliorating glucose metabolic enzymes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28549291. |
these effects were mediated by suppressing pancreatic β-cells apoptosis and were associated with increased anti-apoptotic bcl-2 expression and reduced pro-apoptotic bax expression. |
2018-04-03 |
2023-08-13 |
rat |
| Zeinab Akbarnejad, Hossein Eskandary, Luciana Dini, Cristian Vergallo, Seyed Noureddin Nematollahi-Mahani, Alireza Farsinejad, Maryam Fekri Soofi Abadi, Meysam Ahmad. Cytotoxicity of temozolomide on human glioblastoma cells is enhanced by the concomitant exposure to an extremely low-frequency electromagnetic field (100Hz, 100G). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28551545. |
co-treatment synergistically enhanced apoptosis in u87 and t98g cells, by increasing the expression of p53, bax, and caspase-3 and decreasing that of bcl-2 and cyclin-d1. |
2018-04-03 |
2023-08-13 |
human |
| Longwei Huo, Xiaobin Bai, Yafei Wang, Maode Wan. Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28554130. |
activation of apoptosis was found in glioma cells when the cells were exposed to b10, as evidenced by increased number of tunel-stained cells, increased caspase 3 and 9 activities, and bax and cleaved parp expression. |
2018-04-03 |
2023-08-13 |
mouse |
| Phatchawan Arjinajarn, Nuttawud Chueakula, Anchalee Pongchaidecha, Krit Jaikumkao, Varanuj Chatsudthipong, Sugunya Mahatheeranont, Orranuch Norkaew, Nipon Chattipakorn, Anusorn Lungkaphi. Anthocyanin-rich Riceberry bran extract attenuates gentamicin-induced hepatotoxicity by reducing oxidative stress, inflammation and apoptosis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28558354. |
liver inflammation and apoptosis were observed in gentamicin-treated rats as indicated by the increases in nf-κb, tnf-αr1, cox2, and inos, caspase-3, bax, and decrease in bcl-xl expressions. |
2018-04-03 |
2023-08-13 |
rat |