| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiaxin Liu, Shuai Zhou, Xiying Qian, Yueting Zhang, Jianhua Zha. [Over-expressed Bax inhibitor 1 (BI-1) inhibits apoptosis of hippocampal neurons via endoplasmic reticulum IRE1-JNK pathway in rats with subarachnoid hemorrhage]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 10. 2018-05-15. PMID:29169414. |
[over-expressed bax inhibitor 1 (bi-1) inhibits apoptosis of hippocampal neurons via endoplasmic reticulum ire1-jnk pathway in rats with subarachnoid hemorrhage]. |
2018-05-15 |
2023-08-13 |
rat |
| Fangfang Huang, Yinwen Jing, Guofang Ding, Zuisu Yan. Isolation and purification of novel peptides derived from Sepia ink: Effects on apoptosis of prostate cancer cell PC‑3. Molecular medicine reports. vol 16. issue 4. 2018-05-14. PMID:28731187. |
shp‑induced apoptosis was accompanied by the activation of cellular tumor antigen p53 and caspase‑3, the upregulation of apoptosis regulator bax, and the downregulation of apoptosis regulator bcl‑2. |
2018-05-14 |
2023-08-13 |
Not clear |
| Fatemeh Alikarami, Majid Safa, Mohammad Faranoush, Parisa Hayat, Ahmad Kazem. Inhibition of DNA-PK enhances chemosensitivity of B-cell precursor acute lymphoblastic leukemia cells to doxorubicin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-14. PMID:28821159. |
apoptosis induction by the combined treatment was associated with marked reduction of bcl-2 and survivin and a significant increase of bax mrna expression levels. |
2018-05-14 |
2023-08-13 |
Not clear |
| Sepideh Zununi Vahed, Abolfazl Barzegari, Yalda Rahbar Saadat, Ali Goreyshi, Yadollah Omid. Leuconostoc mesenteroides-derived anticancer pharmaceuticals hinder inflammation and cell survival in colon cancer cells by modulating NF-κB/AKT/PTEN/MAPK pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-14. PMID:28821160. |
based on our findings, l. mesenteroides promoted apoptosis in colon cancer cell line by upregulation of mapk1, bax, and caspase 3, and downregulation of akt, nf-κb, bcl- |
2018-05-14 |
2023-08-13 |
Not clear |
| Marzieh Moeinifard, Zuhair Mohammad Hassan, Faranak Fallahian, Maryam Hamzeloo-Moghadam, Mohammad Taghikhan. Britannin induces apoptosis through AKT-FOXO1 pathway in human pancreatic cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-14. PMID:28821161. |
additionally, by using western blot and real-time pcr, we observed that britannin induced apoptosis by decreasing the expression of bcl-2 and increasing the expression of bax. |
2018-05-14 |
2023-08-13 |
human |
| Wonyong Cho, Jie Young Song, Se Won Oh, Myung Gyu Kim, Yoon Sook Ko, Hee Yong Lee, Sang Kyung J. Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury. Journal of Korean medical science. vol 32. issue 10. 2018-05-14. PMID:28875605. |
the clearance of neutrophils was delayed in the bax knockout (ko)(bm) → wild-type (wt) chimera in which bone marrow derived cells are partially resistant to apoptosis, compared to wt(bm) → wt mice. |
2018-05-14 |
2023-08-13 |
mouse |
| Xiaoni Liu, Jianji Xu, Shuang Wang, Xiaoxiao Yu, Boxin Kou, Mengyin Chai, Yunjin Zang, Dexi Che. Synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 and oxaliplatin via p53-independent pathway in vitro and in vivo. International journal of oncology. vol 51. issue 4. 2018-05-14. PMID:28902369. |
aspp2 induced apoptosis protein expression in aspp2-ad and combination groups, the aspp2, bax and activation of caspase-3 expression increased greatly both in vitro and in vivo. |
2018-05-14 |
2023-08-13 |
human |
| Xing Lu, Yi-Ming Wu, Jing-Mei Yang, Feng-E Ma, Liang-Ping Li, Sheng Chen, Ye Zhang, Qing-Ling Ni, Ying-Ming Pan, Xue Hong, Yan Pen. Preparation of Rhodium(III) complexes with 2(1H)-quinolinone derivatives and evaluation of their in vitro and in vivo antitumor activity. European journal of medicinal chemistry. vol 151. 2018-05-14. PMID:29614419. |
complex 9 also up-regulated the proapoptotic proteins bak, bax, and bim, which altogether activated caspase-3/9 to initiate cell apoptosis. |
2018-05-14 |
2023-08-13 |
mouse |
| Shao-Ming Zhu, Ting Rao, Xiao Yang, Jin-Zhuo Ning, Wei-Ming Yu, Yuan Ruan, Run Yuan, Cheng-Long Li, Kun Jiang, Wei Hu, Hao-Yong Li, Fan Chen. Autophagy may play an important role in varicocele. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849201. |
furthermore, western blot analysis revealed that the protein expression of bcl‑2 decreased and apoptosis regulator bax increased. |
2018-05-11 |
2023-08-13 |
rat |
| Lei Yang, Yan Li, Xiaojing Wang, Yuling Liu, Lingzhu Yan. MicroRNA‑320a inhibition decreases insulin‑induced KGN cell proliferation and apoptosis by targeting PCGF1. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849208. |
furthermore, mrna and protein expression levels of b‑cell lymphoma 2 apoptosis regulator (bcl‑2) and bcl‑2 associated protein x apoptosis regulator (bax) were examined using rt‑qpcr and western blotting. |
2018-05-11 |
2023-08-13 |
Not clear |
| Jianming Tang, Bingshu Li, Shasha Hong, Cheng Liu, Jie Min, Ming Hu, Yang Li, Yaodan Liu, Li Hon. Punicalagin suppresses the proliferation and invasion of cervical cancer cells through inhibition of the β-catenin pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-10. PMID:28586031. |
pun led to a number of effects on the hela cells, including the inhibition of cell proliferation and cell migration, downregulation of mmp‑2 and mmp‑9, upregulation of timp‑2 and timp‑3, cell‑cycle arrest in the g1 phase, induction of apoptosis via alterations of bcl‑2 and bax, and downregulation of β‑catenin and its downstream proteins, cyclin d1 and c-myc. |
2018-05-10 |
2023-08-13 |
human |
| Hong-Yan Lu, Xiao-Qing Chen, Wei Tang, Qiu-Xia Wang, Jie Zhan. GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-10. PMID:28586043. |
the overexpression of chop downregulated b‑cell lymphoma (bcl)‑2 expression levels, upregulated bcl2 associated x (bax), and increased apoptosis of a549 cells under conditions of hyperoxia. |
2018-05-10 |
2023-08-13 |
human |
| Enrico Gugliandolo, Roberta Fusco, Flavia Biundo, Ramona D'Amico, Filippo Benedetto, Rosanna Di Paola, Salvatore Cuzzocre. Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury. Pharmacological research. vol 123. 2018-05-10. PMID:28676456. |
in this study we demonstrated that pea/pld combination treatment reduces vessel damage, adhesion molecules expression such as intercellular adhesion molecules-1(icam-1) and vascular cell adhesion molecules-1(v-cam), proinflammatory cytokines production (tumor necrosis factor alpha (tnf-α) and interleukin 1 beta (il-1β), the inducible nitric oxide synthase (inos) and poly (adp-ribose) polymerase (par), formation, nuclear factor kappa-b expression and apoptosis (bax, fas-ligand) activation. |
2018-05-10 |
2023-08-13 |
Not clear |
| Si-Jie Li, Chun-Shui Liu, Hai-Jun Li, Yan Li, Lei Zhou, Jin-Cheng Li, Yi-Chang Chen, Tian-Qi Su, De-Hai Y. A novel engineered interferon-α hybrid molecule increases anticancer efficacy of doxorubicin in breast cancer chemotherapy. International journal of oncology. vol 51. issue 3. 2018-05-10. PMID:28677808. |
additionally, imbp potentiated the therapeutic efficacy of doxorubicin-based breast cancer chemotherapy via the activation of cell cycle arrest and cell apoptosis pathway genes including p53, p21, cdk2, cyclin a, caspase 9, bcl-2 and bax. |
2018-05-10 |
2023-08-13 |
Not clear |
| Yonghao Liang, Qisheng Li, Keli Chen, Wen Ni, Zetao Zhan, Feng Ye, Yiyi Li, Yuan Fang, Fengjiao Zhang, Longhua Chen, Yi Din. Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma. Oncology reports. vol 38. issue 4. 2018-05-10. PMID:28765950. |
consistently, key regulators in apoptosis, such as caspase-3, bax and bcl-2 were also regulated by znf307. |
2018-05-10 |
2023-08-13 |
mouse |
| Sishi Tang, Bingqing Cheng, Nana Zhe, Dan Ma, Jibing Xu, Xinyao Li, Yongling Guo, Weibing Wu, Jishi Wan. Histone deacetylase inhibitor BG45-mediated HO-1 expression induces apoptosis of multiple myeloma cells by the JAK2/STAT3 pathway. Anti-cancer drugs. vol 29. issue 1. 2018-05-10. PMID:29049036. |
treatment with bg45 induced apoptosis by downregulating bcl-2 and bcl-xl, upregulating bax and other antiapoptotic proteins and activating poly(adp-ribose)polymerase, and decreasing protein levels of p-jak2 and p-stat3. |
2018-05-10 |
2023-08-13 |
Not clear |
| Xiujin Shen, Hong Jiang, Meike Ying, Zhoutao Xie, Xiayu Li, Haibing Wang, Jie Zhao, Chuan Lin, Yucheng Wang, Shi Feng, Jia Shen, Chunhua Weng, Weiqiang Lin, Huiping Wang, Qin Zhou, Yan Bi, Meng Li, Lingyan Wang, Tongyu Zhu, Xiaoru Huang, Hui-Yao Lan, Jing Zhou, Jianghua Che. Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models. Scientific reports. vol 6. 2018-05-08. PMID:27580845. |
treatment with csa and fk506 also inhibited pan-induced podocytes apoptosis, which was associated with the induction of bcl-xl and inhibition of bax, cleaved caspase 3, and cleaved parp expression. |
2018-05-08 |
2023-08-13 |
mouse |
| Satoko Arakawa, Masatsune Tsujioka, Tatsushi Yoshida, Hajime Tajima-Sakurai, Yuya Nishida, Yosuke Matsuoka, Ikuyo Yoshino, Yoshihide Tsujimoto, Shigeomi Shimiz. Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice. Cell death and differentiation. vol 24. issue 9. 2018-05-07. PMID:28574506. |
members of the bcl2 family regulate apoptosis, among which bax and bak act as a mitochondrial gateway. |
2018-05-07 |
2023-08-13 |
mouse |
| Shu Li, Binbin Cheng, Lixin Hou, Lanwei Huang, Yongkang Cui, Duo Xu, Xiaoping Shen, Shuang L. Dioscin inhibits colon cancer cells' growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways. Anti-cancer drugs. vol 29. issue 3. 2018-05-07. PMID:29389802. |
dioscin induces apoptosis and reactive oxygen species (ros) generation, promoting the disruption of mitochondrial membrane potential, bax translocation to the mitochondria, cytochrome c release to cytosol, activations of caspase-9/3, parp cleavage, and subsequent apoptosis. |
2018-05-07 |
2023-08-13 |
human |
| Hsin-Ling Yang, Varadharajan Thiyagarajan, Jiunn-Wang Liao, Yu-Lin Chu, Chia-Ting Chang, Pei-Jane Huang, Chih-Jung Hsu, You-Cheng Hse. Toona sinensis Inhibits Murine Leukemia WEHI-3 Cells and Promotes Immune Response In Vivo. Integrative cancer therapies. vol 16. issue 3. 2018-05-03. PMID:27151590. |
ts may disturb the bcl-2 and bax protein ratio and induce apoptosis. |
2018-05-03 |
2023-08-13 |
mouse |