| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thangavelu Soundara Rajan, Sabrina Giacoppo, Francesca Diomede, Patrizia Ballerini, Michele Paolantonio, Marco Marchisio, Adriano Piattelli, Placido Bramanti, Emanuela Mazzon, Oriana Trubian. The secretome of periodontal ligament stem cells from MS patients protects against EAE. Scientific reports. vol 6. 2018-06-12. PMID:27924938. |
in addition, apoptosis related stat1, p53, caspase 3, and bax expressions were attenuated. |
2018-06-12 |
2023-08-13 |
mouse |
| Rashd M El-Ferjani, Musa Ahmad, Summaya M Dhiyaaldeen, Farah Wahida Harun, Mohamed Yousif Ibrahim, Hoyam Adam, Bohari Mohd Yamin, Mazen M Jamil Al-Obaidi, Rami Al Batra. In vivo Assessment of Antioxidant and Wound Healing Improvement of a New Schiff Base Derived Co (II) Complex in Rats. Scientific reports. vol 6. 2018-06-12. PMID:27958299. |
bax staining was less intense in treated groups compared to the vehicle group, suggesting that cmla and intrasite gel provoked apoptosis, responsible for the development of granulation tissue into a scar. |
2018-06-12 |
2023-08-13 |
rat |
| Lei Zheng, Yizhi Liu, Jingxuan Pa. Inhibitory effect of pyrvinium pamoate on uveal melanoma cells involves blocking of Wnt/β-catenin pathway. Acta biochimica et biophysica Sinica. vol 49. issue 10. 2018-06-12. PMID:28981601. |
treatment with pyrvinium pamoate induced intrinsic pathway-dependent apoptosis accompanied with a decline of anti-apoptotic xiap and survivin, and an overt increase of pro-apoptotic bax. |
2018-06-12 |
2023-08-13 |
Not clear |
| Li Luo, Tinghe Yu, Dingqun Bai, Lina H. [Induction of Apoptosis of Human Cisplatin-resistance Lung Cancer Cells with MPPa-photodynamic Therapy]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 33. issue 4. 2018-06-12. PMID:29714913. |
lung cancer is the leading cause of cancer-related deaths worldwide.despite the development and use of several targeting drugs for lung cancer therapy,the five-year survival rate has remained as low as 15%for the past three decades.cisplatin-based chemotherapy is considered the first-line therapeutic strategy for lung cancer.however,developments of chemoresistance is a major obstacle for the successful treatment.therefore,the development of novel therapy against cisplatin-resistance lung cancer is imperative.photodynamic therapy(pdt),which is a non-invasive combinatorial therapeutic modality using light,photosensitizer(ps)and oxygen,may provide an unprecedented tool to develop more effective treatments.to provide experimental basis for its application in cisplatin-resistance lung cancer,we will discuss the biological effects of mppa-photodynamic therapy in human cisplatin-resistance lung cancer cells in this article.human cisplatin-resistance lung cancer cells a549/ddp were co-cultured with mppa(0,1,2,4,8,16μmol/l)and exposed to light(0,0.6,1.2,2.4,3.6,4.8j/cm2),and cell viability was determined with cck-8assay.flow cytometry was used to detect apoptosis,dcfh-da staining was employed to observe reactive oxygen species(ros),and western blot was used to detect the expressions of b-cell lymphoma-2(bcl-2)protein and bcl-2associated x protein(bax).the proliferation of a549/ddp cells was suppressed by pdt.the apoptotic rate in the pdt group was significantly higher than that in the control,mppa or light group(p<0.05).the level of ros was increased.the expression of bax was increased,and that of bcl-2was decreased.mppa-photodynamic therapy can significantly suppress cell viability,and induce apoptosis in human cisplatin-resistance lung cancer cells. |
2018-06-12 |
2023-08-13 |
human |
| M A Rahman, S H Park, I J Y. Dog Sperm Cryopreservation in Glucose-Fructose or Sucrose Supplemented Glycerol-Free Tris: Effect of Post-Thaw Incubation Time on Gene Expression Related to Apoptosis and Motility. Cryo letters. vol 39. issue 1. 2018-06-12. PMID:29734414. |
objective: the study evaluated the effects of glucose-fructose or sucrose supplementation in glycerol-free tris (gft) solution on motility, viability, the level of reactive oxygen species (ros), as well as the level of apoptosis (bax and bcl2) and motility (smcp)-related gene expression of dog spermatozoa. |
2018-06-12 |
2023-08-13 |
dog |
| Mark Xiang Li, Iris K L Tan, Stephen B Ma, Colin Hockings, Tobias Kratina, Michael A Dengler, Amber E Alsop, Ruth M Kluck, Grant Dewso. BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 29. 2018-06-08. PMID:28673969. |
bak and bax are the essential effectors of apoptosis because without them a cell is resistant to most apoptotic stimuli. |
2018-06-08 |
2023-08-13 |
Not clear |
| Mark Xiang Li, Iris K L Tan, Stephen B Ma, Colin Hockings, Tobias Kratina, Michael A Dengler, Amber E Alsop, Ruth M Kluck, Grant Dewso. BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 29. 2018-06-08. PMID:28673969. |
bak and bax undergo conformation changes to homooligomerize then permeabilize the mitochondrial outer membrane during apoptosis. |
2018-06-08 |
2023-08-13 |
Not clear |
| Xiao-Jing Li, Zhi-Feng Li, Jiu-Jiang Wang, Zhao Han, Zhao Liu, Bao-Guo Li. Effects of microRNA-374 on proliferation, migration, invasion, and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway. Bioscience reports. vol 37. issue 4. 2018-06-08. PMID:28679648. |
the mir-374 inhibitors group exhibited decreased expression of mir-374, p73, p16, bax caspase-3 and caspase-9, and increased expression of gadd45a, p53, c-myc, and bcl-2, enhanced cell proliferation, migration, and invasion, and reduced apoptosis compared with the blank and nc groups; the mir-374 mimics group followed opposite trends. |
2018-06-08 |
2023-08-13 |
human |
| Xiao-Jing Li, Zhi-Feng Li, Jiu-Jiang Wang, Zhao Han, Zhao Liu, Bao-Guo Li. Effects of microRNA-374 on proliferation, migration, invasion, and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway. Bioscience reports. vol 37. issue 4. 2018-06-08. PMID:28679648. |
compared with the blank and nc groups, the mir-374 inhibitors + sirna-gadd45a group showed decreased mir-374 level; the sirna-gadd45a group showed elevated levels of p73, p16, bax, caspase-3 and caspase-9, decreased levels of gadd45a, p53, c-myc, and bcl-2, reduced cell proliferation, migration, and invasion, and accelerated apoptosis. |
2018-06-08 |
2023-08-13 |
human |
| Xuehua Xu, Chengliang Luo, Zhixiang Zhang, Jun Hu, Xiangting Gao, Yuanyi Zuo, Yun Wang, Shaohua Zh. Mdivi‑1 attenuates sodium azide‑induced apoptosis in H9c2 cardiac muscle cells. Molecular medicine reports. vol 16. issue 5. 2018-06-07. PMID:28849092. |
in addition, the expression of drp1 and of the apoptosis‑related proteins bcl2 apoptosis regulator (bcl‑2), and bcl2 associated x (bax) was determined by western blotting. |
2018-06-07 |
2023-08-13 |
Not clear |
| Yang Liu, Lei Wang, Yang Du, Zhiyuan Chen, Jia Guo, Xiaodong Weng, Xiao Wang, Min Wang, Danyang Chen, Xiuheng Li. Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-07. PMID:28962085. |
cell viability, cell apoptosis and expression of p-jak2, p-stat3, bcl-2, bax and caspase-3 were examined in nrk-52e culture after i/r. |
2018-06-07 |
2023-08-13 |
rat |
| Tássia C de Lima E Silva, Livia T R da Silveira, Mariana F Fragoso, Flávia R M da Silva, Meire F Martinez, Joyce R Zapaterini, Odair H G Diniz, Wellerson R Scarano, Luis F Barbisa. Maternal Resveratrol Treatment Reduces the Risk of Mammary Carcinogenesis in Female Offspring Prenatally Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Hormones & cancer. vol 8. issue 5-6. 2018-06-06. PMID:28786001. |
two days after first mnu administration, some genes associated with apoptosis were altered in the mammary tissue from the tcdd group (bax and caspase 3 down- and bcl-2 upregulated) but were also partially reestablished by maternal res. |
2018-06-06 |
2023-08-13 |
rat |
| Jibin Sha, Bo Sui, Xiaoqing Su, Qingfang Meng, Chenggang Zhan. Alteration of oxidative stress and inflammatory cytokines induces apoptosis in diabetic nephropathy. Molecular medicine reports. vol 16. issue 5. 2018-06-06. PMID:28944839. |
cell apoptosis levels were significantly increased, and bcl‑2 was significantly decreased in the diabetes model group in contrast with that of the sham group; however, bax and caspase‑3 were significantly increased. |
2018-06-06 |
2023-08-13 |
Not clear |
| Xu Yang, Sun Yang, Chen Hong, Wang Yu, Wang Guonia. Panax Notoginseng Saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway. Molecular medicine reports. vol 16. issue 5. 2018-06-06. PMID:28944861. |
furthermore, cell apoptosis and the protein expression of caspase‑3, caspase‑9 and bax were significantly increased, while the expression of bcl‑2 was decreased in the sevoflurane group compared with normal control. |
2018-06-06 |
2023-08-13 |
Not clear |
| Jun-Feng Li, Su-Jun Zheng, Li-Li Wang, Shuang Liu, Feng Ren, Yu Chen, Li Bai, Mei Liu, Zhong-Ping Dua. Glucosylceramide synthase regulates the proliferation and apoptosis of liver cells in vitro by Bcl‑2/Bax pathway. Molecular medicine reports. vol 16. issue 5. 2018-06-06. PMID:28944894. |
reverse transcription‑quantitative polymerase chain reaction was used to detect the gene expression apoptosis regulator bcl‑2 (bcl‑2), apoptosis regulator bax (bax) and caspase-3. |
2018-06-06 |
2023-08-13 |
Not clear |
| Chenyi Liao, Zhi Zhang, Justin Kale, David W Andrews, Jialing Lin, Jianing L. Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation. Scientific reports. vol 6. 2018-06-04. PMID:27381287. |
the corroborating evidence from simulations and experiments suggests that, helix α9 assists bax activation via the dimer heterogeneity and interactions with specific mom lipids, which eventually facilitate proteolipidic pore formation in apoptosis regulation. |
2018-06-04 |
2023-08-13 |
Not clear |
| Joachim Lauterwasser, Franziska Todt, Ralf M Zerbes, Thanh Ngoc Nguyen, William Craigen, Michael Lazarou, Martin van der Laan, Frank Edlic. The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation. Scientific reports. vol 6. 2018-06-04. PMID:27620692. |
the pro-apoptotic bcl-2 protein bax can permeabilize the outer mitochondrial membrane and therefore commit human cells to apoptosis. |
2018-06-04 |
2023-08-13 |
human |
| Pallab Ray, Deblina Guha, Juni Chakraborty, Shuvomoy Banerjee, Arghya Adhikary, Samik Chakraborty, Tanya Das, Gaurisankar S. Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. Scientific reports. vol 6. 2018-06-04. PMID:27622714. |
both bax and t-bid converge at mitochondria to alter the transmembrane potential thereby leading to caspase-9 and caspase-3-mediated apoptosis. |
2018-06-04 |
2023-08-13 |
Not clear |
| Vermont P Dia, Hari B Krishna. BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells. Scientific reports. vol 6. 2018-06-04. PMID:27628414. |
the molecular mechanistic explanation in the apoptosis inducing property of bg-4 is due to reduced expression of bcl-2 and increased expression of bax leading to increased expression of caspase-3 and affecting the expression of cell cycle proteins p21 and cdk2. |
2018-06-04 |
2023-08-13 |
human |
| Abu Musa Md Talimur Reza, Yun-Jung Choi, Hideyo Yasuda, Jin-Hoi Ki. Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells. Scientific reports. vol 6. 2018-06-04. PMID:27929108. |
furthermore, hamsc-cm-derived exosomes induced apoptosis signalling by upregulating different pro-apoptotic signalling molecules, such as bax, casp9, and casp3, as well as downregulating the anti-apoptotic protein bcl2. |
2018-06-04 |
2023-08-13 |
human |