| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huankai Yao, Zhenhai Yuan, Guangming Wei, Chun Chen, Jingyu Duan, Yan Li, Yunru Wang, Chunping Zhang, Yuanhua Li. Thevetiaflavone from Wikstroemia indica ameliorates PC12 cells injury induced by OGD/R via improving ROS‑mediated mitochondrial dysfunction. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28990067. |
furthermore, thevetiaflavone inhibits apoptosis in pc12 cells through upregulating the expression of bcl‑2 and downregulating that of bax and caspase‑3 in addition to increasing the activity of caspase‑3. |
2018-06-26 |
2023-08-13 |
Not clear |
| Qing-Fang Zhan. Ulinastatin inhibits renal tubular epithelial apoptosis and interstitial fibrosis in rats with unilateral ureteral obstruction. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28990075. |
terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) staining, and immunohistochemical detection of apoptosis regulator bax (bax), apoptosis regulator bcl‑2 (bcl‑2) and caspase‑3 were performed to observe the presence of renal tubular epithelial cell apoptosis. |
2018-06-26 |
2023-08-13 |
mouse |
| Chuanxia Ju, Jianjun Gao, Lin Hou, Lei Wang, Fang Zhang, Fusheng Sun, Tingting Zhang, Pingping Xu, Zhenyan Shi, Fang Hu, Congxiao Zhan. Neuroprotective effect of chondroitin sulfate on SH‑SY5Y cells overexpressing wild‑type or A53T mutant α‑synuclein. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28990084. |
cs also significantly attenuated wt and a53t mutant α‑syn‑induced dysfunction, including decrease of mitochondrial membrane potential, decrease of bcl‑2 expression, and increase of bax expression, release of cyt‑c from the mitochondria and activation of caspase‑3 and caspase‑9, which demonstrated that cs suppressed α‑syn‑induced apoptosis possibly through mitochondria protection. |
2018-06-26 |
2023-08-13 |
Not clear |
| Ting Lin, Li Zhang, Shuangxin Liu, Yuanhan Chen, Hong Zhang, Xingchen Zhao, Ruizhao Li, Qianmei Zhang, Ruyi Liao, Zongshun Huang, Bin Zhang, Wenjian Wang, Xinling Liang, Wei Sh. WWC1 promotes podocyte survival via stabilizing slit diaphragm protein dendrin. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28990091. |
the loss‑of‑function assay indicated that knockdown of wwc1 gene in vitro promoted podocyte apoptosis, accompanied with increased levels of the pro‑apoptotic protein bax and decreased levels of the anti‑apoptotic protein bcl‑2. |
2018-06-26 |
2023-08-13 |
Not clear |
| Liman Qiu, Jinxiao Chen, Jing Lin, Da Wo, Jianfeng Chu, Jun Pen. Baicalin alleviates H2O2‑induced injury of H9c2 cardiomyocytes through suppression of the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:29039516. |
furthermore, western blotting analysis demonstrated that baicalin markedly attenuated h2o2‑induced cell apoptosis, as demonstrated by the down‑regulation of cleaved caspase‑3 and the increase in the apoptosis regulator bcl‑2 (bcl‑2)/apoptosis regulator bax (bax) ratio following baicalin treatment in h2o2‑treated h9c2 cells. |
2018-06-26 |
2023-08-13 |
Not clear |
| Xingyang Zhu, Xiaoling Song, Kun Xie, Xue Zhang, Wei He, Fubao Li. Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma. International journal of molecular medicine. vol 40. issue 4. 2018-06-25. PMID:28902342. |
osthole also significantly induced mitochondrial-dependent apoptosis by upregulating bax, cleaved caspase-3, cleaved caspase-9, and cleaved poly adp-ribose polymerase expression, and by downregulating bcl-2 expression. |
2018-06-25 |
2023-08-13 |
Not clear |
| Han-Yu Chou, Fu-Shin Chueh, Yi-Shih Ma, Rick Sai-Chuen Wu, Ching-Lung Liao, Yung-Lin Chu, Ming-Jen Fan, Wen-Wen Huang, Jing-Gung Chun. Bufalin induced apoptosis in SCC‑4 human tongue cancer cells by decreasing Bcl‑2 and increasing Bax expression via the mitochondria‑dependent pathway. Molecular medicine reports. vol 16. issue 6. 2018-06-25. PMID:28983595. |
bufalin induced apoptosis in scc‑4 human tongue cancer cells by decreasing bcl‑2 and increasing bax expression via the mitochondria‑dependent pathway. |
2018-06-25 |
2023-08-13 |
human |
| Qian-Ling Hou, Yan Wang, Ying-Bo Li, Xue-Lian Hu, Sha-Li Wan. [Protective effect of notoginsenoside R1 on neuron injury induced by OGD/R through ATF6/Akt signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 6. 2018-06-25. PMID:29027434. |
they were treated with ngr1 and estrogen receptor inhibitor ici-182780 respectively, then the neuronal survival, cell membrane integrity and apoptosis were assessed by mtt assay,lactate dehydrogenase test(ldh) and hoechst 33342 stain respectively, while the protein expression levels of atf6α,p-akt,akt,bax and cleaved caspase-3 were measured by western blotting. |
2018-06-25 |
2023-08-13 |
Not clear |
| Qian-Ling Hou, Yan Wang, Ying-Bo Li, Xue-Lian Hu, Sha-Li Wan. [Protective effect of notoginsenoside R1 on neuron injury induced by OGD/R through ATF6/Akt signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 6. 2018-06-25. PMID:29027434. |
results indicated that as compared with the blank control group,ogd/r could induce cell injury and apoptosis(p<0.05), reduce relative integrity of cell membrane(p<0.05), decrease protein expression of atf6α,p-akt(p<0.05), and increase protein expression of bax and cleaved caspase-3(p<0.05) in the primary cortical cells. |
2018-06-25 |
2023-08-13 |
Not clear |
| Qian-Ling Hou, Yan Wang, Ying-Bo Li, Xue-Lian Hu, Sha-Li Wan. [Protective effect of notoginsenoside R1 on neuron injury induced by OGD/R through ATF6/Akt signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 6. 2018-06-25. PMID:29027434. |
after ngr1 treatment, the expression levels of atf6α,p-akt were obviously increased, and the expression levels of bax and cleaved caspase-3 and the apoptosis of neuron were decreased(p<0.05). |
2018-06-25 |
2023-08-13 |
Not clear |
| b' Elisabeth Holen, Pedro Araujo, Nini H Sissener, Grethe Rosenlund, Rune Waagb\\xc3\\xb. A comparative study: Difference in omega-6/omega-3 balance and saturated fat in diets for Atlantic salmon (Salmo salar) affect immune-, fat metabolism-, oxidative and apoptotic-gene expression, and eicosanoid secretion in head kidney leukocytes. Fish & shellfish immunology. vol 72. 2018-06-25. PMID:29080687.' |
instead, peroxisome proliferator activated receptor β1 (pparβ1), acyl coenzyme a (aco), apoptosis regulator (bax) and superoxide dismutase (sod) were upregulated in leukocytes in vitro, while head kidney tissue transcription of a dendritic marker (cd83) was lower than measured in tissues from fish fed the other diets. |
2018-06-25 |
2023-08-13 |
Not clear |
| Xiao-Gang Chen, Fu Hua, Shou-Guo Wang, Hong-Hui Tan. Albumin-Conjugated Lipid-Based Multilayered Nanoemulsion Improves Drug Specificity and Anti-Inflammatory Potential at the Spinal Cord Injury gSite after Intravenous Administration. AAPS PharmSciTech. vol 19. issue 2. 2018-06-22. PMID:28875455. |
immunoflorescence assay reveals explicit decline in mitochondrial-mediated apoptosis by sub-cellular upregulation of bax at spinal cord injury site. |
2018-06-22 |
2023-08-13 |
human |
| Subhadip Hajra, Abhishek Basu, Somnath Singha Roy, Arup Ranjan Patra, Sudin Bhattachary. Attenuation of doxorubicin-induced cardiotoxicity and genotoxicity by an indole-based natural compound 3,3'-diindolylmethane (DIM) through activation of Nrf2/ARE signaling pathways and inhibiting apoptosis. Free radical research. vol 51. issue 9-10. 2018-06-22. PMID:28922986. |
in connection with that, dim significantly attenuated dox-induced apoptosis by upregulation of bcl-2 expression and downregulation of bax and caspase-3 expression. |
2018-06-22 |
2023-08-13 |
mouse |
| Meng-Qiao Zhou, Ling Shao, Jing Wu, Na Peng, Lu-Ping Jin, Guo-Zhen Wei, Wei Cheng, Chang-Jin Den. Dihydromyricetin protects against lipopolysaccharide‑induced cardiomyocyte injury through the toll‑like receptor‑4/nuclear factor‑κB pathway. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:29039483. |
furthermore, lps treatment downregulated the expression of b‑cell lymphoma 2 apoptosis regulator (bcl‑2) and induced increased expression of bcl‑2‑associated x apoptosis regulator (bax). |
2018-06-22 |
2023-08-13 |
Not clear |
| Meng-Qiao Zhou, Ling Shao, Jing Wu, Na Peng, Lu-Ping Jin, Guo-Zhen Wei, Wei Cheng, Chang-Jin Den. Dihydromyricetin protects against lipopolysaccharide‑induced cardiomyocyte injury through the toll‑like receptor‑4/nuclear factor‑κB pathway. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:29039483. |
additionally, dhm treatment reversed lps‑induced changes in bcl‑2 expression and bax expression in cardiomyocytes, and rescued cells from apoptosis. |
2018-06-22 |
2023-08-13 |
Not clear |
| Yan Cai, Wei Jiang, Ai-Ling Zhou, Min Zhou, Ling X. [Effect of oxymatrine on apoptosis of hippocampal neurons by p38/JNK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 4. 2018-06-21. PMID:28959845. |
hoechst 33342 staining was used to observe the apoptotic morphology of hippocampal neurons.the mrna expression levels of bax, bcl-2, and caspase-3 were detected by real-time quantitative pcr(rt-qpcr), and the protein expression levels of p38, p-p38, jnk, p-jnk, bax, bcl-2 and caspase-3 were detected by western blot.the results showed that, hippocampal neurons all grew well after treatment by different doses (0.37-6.0 g•l⁻¹) of omt for 24 h. stimulation from lps increased the release of ldh(p<0.01), improved the jnk and p38 phosphorylation levels(p<0.01), increased the proportion of bax/bcl-2 and the expression of caspase-3(p<0.01), and promoted the apoptosis of hippocampal neurons. |
2018-06-21 |
2023-08-13 |
Not clear |
| Ying Zou, Jiantao Lin, Wenyang Li, Zhuguo Wu, Zhiwei He, Guoliang Huang, Jian Wang, Caiguo Ye, Xiaoyan Cheng, Congcong Ding, Xuebao Zheng, Honggang Ch. Huangqin-tang ameliorates dextran sodium sulphate-induced colitis by regulating intestinal epithelial cell homeostasis, inflammation and immune response. Scientific reports. vol 6. 2018-06-19. PMID:27982094. |
moreover, hqt-treated mice demonstrated significant changes in cell apoptosis, expression of apoptosis-associated genes such as caspase-3, bax, bcl-2, and intestinal permeability. |
2018-06-19 |
2023-08-13 |
mouse |
| Zi-Gang Zhen, Shao-Hua Ren, Hong-Ming Ji, Jiu-Hong Ma, Xin-Min Ding, Fu-Qiang Feng, Shing-Li Chen, Peng Zou, Jin-Rui Ren, Lu Ji. Linarin suppresses glioma through inhibition of NF-κB/p65 and up-regulating p53 expression in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-19. PMID:28858735. |
our data indicated that linarin suppressed glioma cell proliferation and migration by inducing apoptosis, which was through reducing cell cycle-related signals, including survivin, p-rb, and cyclin d1, while promoting p21, bax, caspase-3 and poly (adp-ribose) polymerase (parp) activation. |
2018-06-19 |
2023-08-13 |
human |
| Leiwen Du, Zhenghua Fei, Shuichuan Song, Nan We. Antitumor activity of Lobaplatin against esophageal squamous cell carcinoma through caspase-dependent apoptosis and increasing the Bax/Bcl-2 ratio. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-19. PMID:28865364. |
lobaplatin significantly inhibited the growth of kyse-410 and ec-109 cells in a dose- and time-dependent manner and induced cell apoptosis by increasing expressions of cleaved-caspase-3, cleaved-caspase-8, cleaved-caspase-9 and bax, decreasing expression of bcl-2. |
2018-06-19 |
2023-08-13 |
mouse |
| JiangFeng Fan, SiJiu Yu, Yan Cui, Gengquan Xu, Libin Wang, Yangyang Pan, Honghong H. Bcl-2/Bax protein and mRNA expression in yak (Bos grunniens) placentomes. Theriogenology. vol 104. 2018-06-13. PMID:28806624. |
bcl-2 and bax proteins are key apoptosis regulators and are considered to play an important role in the maintenance of both dynamic balance and integrity of many tissues. |
2018-06-13 |
2023-08-13 |
human |